Johns Hopkins researchers find more extensive bone defects caused by bladder exstrophy

December 21, 2001

Researchers at Johns Hopkins Children's Center and St. Vincent de Paul's Hospital in Paris have learned that bone defects associated with classic bladder exstrophy are more extensive than previously thought. Their findings, reported in this month's Urology, will enable surgeons to better correct these bone defects that cause the bladder to develop outside of the body.

"We believe surgeons already do a great job," said Children's Center Director of Pediatric Urology John P. Gearhart, M.D., who directed the research. "But this information will further help the few surgeons who do this procedure to provide a long-lasting fix for these children."

Classic bladder exstrophy, which occurs in approximately one of every 30,000 live births, is a defect that affects an infant's pelvic bones, genitorurinary ducts, and leaves a hole in the abdominal wall through which the bladder emerges.

The researchers reviewed abdominal CT scans from seven infants with classic bladder exstrophy as well as CT scans of 26 infants who had them taken for other reasons. The team then compared the geometry of pelvic girdle bones in the bladder exstrophy group of infants with the normal group, looking for statistically significant differences.

The team learned that pelvic girdle bone defects in bladder exstrophy cases were more extensive than previously thought. Among the most pronounced differences were an outward flare of the upper part of the hip bone and a rotation of the entire pelvic girdle from the bottom forward.

Gearhart says the research broadens surgeons' understanding of those bone defects so that more effective adjustments can be made in realigning and repositioning bones of the pelvis. Gearhart also says the findings suggest a possible explanation for the mysterious muscle weakness some women born with bladder exstrophy have shortly after they give birth.

Researchers at the Johns Hopkins School of Medicine and the Department of Pediatric Surgery at St. Vincent de Paul's Hospital in Paris also contributed to the study. It was funded by grants from the National Institutes of Health and the Johns Hopkins Department of Urology.
-end-
Media contact: David Bricker (410)223-1728
Email: dbricker@jhmi.edu

Johns Hopkins Medical Institutions' news releases are available on an EMBARGOED basis on EurekAlert at http://www.eurekalert.org, Newswise at http://www.newswise.com and from the Office of Communications and Public Affairs' direct e-mail news release service. To enroll, call 410-955-4288 or send e-mail to bsimpkins@jhmi.edu.

On a POST-EMBARGOED basis find them at http://www.hopkinsmedicine.org and Quadnet at http://www.quad-net.com

Johns Hopkins Medicine

Related Infants Articles from Brightsurf:

Most infants are well even when moms are infected by COVID-19
Infants born to women with COVID-19 showed few adverse outcomes, according to the first report in the country of infant outcomes through eight weeks of age.

Probiotic may help treat colic in infants
Probiotics -- or 'good bacteria' -- have been used to treat infant colic with varying success.

Deaf infants' gaze behavior more advanced than that of hearing infants
Deaf infants who have been exposed to American Sign Language are better at following an adult's gaze than their hearing peers, supporting the idea that social-cognitive development is sensitive to different kinds of life experiences.

Initiating breastfeeding in vulnerable infants
The benefits of breastfeeding for both mother and child are well-recognized, including for late preterm infants (LPI).

Young infants with fever may be more likely to develop infections
Infants with a high fever may be at increased risk for infections, according to research from Penn State College of Medicine.

Early term infants less likely to breastfeed
A new, prospective study provides evidence that 'early term' infants (those born at 37-38 weeks) are less likely than full-term infants to be breastfeed within the first hour and at one month after birth.

Infants are more likely to learn when with a peer
Researchers at the University of Connecticut and University of Washington looked at the mechanisms involved in language learning among nine-month-olds, the youngest population known to be studied in relation to on-screen learning.

Allergic reactions to foods are milder in infants
Majority of infants with food-induced anaphylaxis present with hives and vomiting, suggesting there is less concern for life-threatening response to early food introduction.

Non-dairy drinks can be dangerous for infants
A brief report published in Acta Paediatrica points to the dangers of replacing breast milk or infant formula with a non-dairy drink before one year of age.

Infants can't talk, but they know how to reason
A new study reveals that preverbal infants are able to make rational deductions, showing surprise when an outcome does not occur as expected.

Read More: Infants News and Infants Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.