Ironing out the link between H. pylori infection and gastric cancer

December 21, 2012

H. pylori frequently causes gastric ulcers and is also one of the greatest risk factors for gastric cancer. H. pylori infection is also associated with another gastric cancer risk factor, iron deficiency. In this issue of the Journal of Clinical Investigation, researchers led by Richard Peek at Vanderbilt University investigated the influence of iron on H. pylori-induced gastric cancer. Peek and colleagues found that low iron accelerated the development of H. pylori-associated cancerous lesions in gerbils. Further, H. pylori strains isolated from a human population at high risk for gastric cancer were more virulent and produced greater inflammation if they came from patients with low iron levels. In an accompanying article, El-Omar Emad of Aberdeen University discusses how iron levels could be used to identify patients that are at a higher risk for gastric cancer after H. pylori infection.

TITLE:
Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humans

AUTHOR CONTACT:
Richard M. Peek, Jr.
Vanderbilt University School of Medicine, Nashville, TN, USA
Phone: 615-322-5200; Fax: 615-343-6229; E-mail: richard.peek@vanderbilt.edu

View this article at: http://www.jci.org/articles/view/64373?key=95552f8a58ca300dd6bc

ACCOMPANYING ARTICLE

TITLE:
Iron deficiency and H. pylori-induced gastric cancer: too little, too bad

AUTHOR CONTACT:
Emad El-Omar
Aberdeen University, Foresterhill, Aberdeen, , GBR
Phone: +44 (0)1224 437548; E-mail: e.el-omar@abdn.ac.uk

View this article at: http://www.jci.org/articles/view/67200?key=98b2d035a72beb6365c9
-end-


JCI Journals

Related Gastric Cancer Articles from Brightsurf:

Immune protein IL-17A responsible for lethal side effects of gastric cancer
The formation of scar tissue, or fibrosis, as gastric cancer disseminates throughout the peritoneum can be more lethal than the cancer itself and can interfere with chemotherapy.

New method to help spot gastric cancer cells
Researchers from the Shenyang Institute of Automation (SIA) of the Chinese Academy of Science (CAS) and City University of Hong Kong (CityU), in cooperation with doctors from the First Hospital of China Medical University, jointly proposed an optically induced electrokinetics (OEK) microfluidic method for label-free separation and characterization of gastric cancer cells.

Taking aim at gastric cancer
A novel drug, named 'FerriIridium,' can simultaneously help diagnose and treat gastric cancer.

More interventions follow gastric bypass than gastric sleeve, large study shows
A study involving tens of thousands of bariatric surgery patients found that gastric bypass patients were significantly more likely than gastric sleeve patients to end up back in the hospital in the years following surgery.

Discoveries detail role of stem cell in deadly gastric cancer
A Cornell study provides important new insights into a common and deadly type of gastric cancer.

Comparing future risks associated with gastric bypass and gastric sleeve surgery
Research from the Harvard Pilgrim Health Care Institute finds that gastric bypass is associated with a higher risk of additional operations or other invasive procedures, compared to a gastric sleeve procedure.

Gastric cancer susceptibility marker discovered
Gastric cancer is often associated with a poor prognosis because it tends to be diagnosed at an advanced stage.

Eliminating common bacterial infection significantly decreases gastric cancer risk
Penn researchers are first to assess Helicobacter pylori infection and gastric cancer risk in Americans, certain demographics and ethnic groups.

New study explains how inflammation causes gastric cancer
Researchers from Kanazawa University and the Japan Agency for Medical Research and Development have solved the decades-old mystery of how stomach bacterium Helicobacter pylori causes gastric cancer.

Cardiff University researchers shed light on development of gastric cancer
Cardiff University researchers have uncovered new information about the underlying mechanisms for gastric cancer, providing hope of potential new therapies in the future.

Read More: Gastric Cancer News and Gastric Cancer Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.