Nav: Home

Vitamin D improves gut flora and metabolic syndrome

December 21, 2016

It is well known that a diet high in fat can trigger a metabolic syndrome, a group of symptoms that pose as risk factors for diabetes and heart disease. Scientists have now discovered that vitamin D deficiency is necessary for this syndrome to progress in mice, with underlying disturbances in gut bacteria.

If these findings can be validated in humans, sun bathing and vitamin D supplements may be feasible and affordable approaches to improve or even prevent metabolic syndrome.

"Based on this study, we believe that keeping vitamin D levels high, either through sun exposure, diet or supplementation, is beneficial for prevention and treatment of metabolic syndrome," says Professor Stephen Pandol, at Cedars-Sinai Medical Center, USA, who collaborated with Yuan-Ping Han's research group at Sichuan University, China in the study.

Metabolic syndrome affects nearly a quarter of the world's adult population, and it is defined by a group of risk factors that put you on the road to diabetes and heart disease. The characteristic symptoms include obesity around the waistline and at least two of the following: high blood sugar levels, high blood pressure or high cholesterol. Sufferers usually also have excess fat in their liver.

The main cause of metabolic syndrome appears to be a diet high in fat or carbohydrate. However, observational studies have also linked metabolic syndrome to vitamin D deficiency, which affects 30-60% of the world's population.

The research team made important advances in understanding the causative role of vitamin D in this syndrome. "A sufficient dietary vitamin D supplement can partially but significantly antagonize metabolic syndrome caused by high fat diet in mice," says Pandol. "These are amounts equivalent to the dietary recommendations for humans."

More specifically, they have shown that a high fat diet affects the balance between good and bad bacteria in the gut. This induces modest fatty liver and slightly raises blood sugar levels in mice. Remarkably, an insufficient supply of vitamin D aggravates the imbalance in gut flora, contributing to full-scale fatty liver and metabolic syndrome.

Vitamin D deficiency decreases the production of defensins, which are anti-microbial molecules essential to maintain healthy gut flora. As expected, an oral supply of a synthetic defensin recovers gut bacteria balance, decreases blood sugar levels and improves fatty liver.

In summary, a high fat diet alone is not enough to cause metabolic syndrome but it is needed in combination with vitamin D deficiency. Accordingly, vitamin D supplementation improves metabolic syndrome in mice. The next step would be to validate the results in humans.

"Few studies have indicated that vitamin D supplementation may not improve metabolic disorders in humans. However, these studies are largely based on long-term surveys, which may be hampered by poor compliance and insufficient dosage," says Hans.

He remains optimistic that the results of their study can be confirmed in humans. "We are planning a clinical study to confirm the link of vitamin D deficiency with gut bacteria disruption, and its association with metabolic syndrome," says Han.
-end-
The study was supported by grants from National Natural Science Foundation of China (31571165), and Science and Technology Department of Sichuan Province (2014SZ0194) to YH, NIH R01 AA019954 P01 CA163200 (AL, SP). Department of Veterans Affairs grants: 5IO BX001991-02F (HT), and I01BX001484 (SP).

Read the full article in Frontiers in Physiology: 'Vitamin D Signaling through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal Models'

Frontiers

Related Diabetes Articles:

Tele-diabetes to manage new-onset diabetes during COVID-19 pandemic
Two new case studies highlight the use of tele-diabetes to manage new-onset type 1 diabetes in an adult and an infant during the COVID-19 pandemic.
Genetic profile may predict type 2 diabetes risk among women with gestational diabetes
Women who go on to develop type 2 diabetes after having gestational, or pregnancy-related, diabetes are more likely to have particular genetic profiles, suggests an analysis by researchers at the National Institutes of Health and other institutions.
Maternal gestational diabetes linked to diabetes in children
Children and youth of mothers who had gestational diabetes during pregnancy are at increased risk of diabetes themselves, according to new research published in CMAJ (Canadian Medical Association Journal).
Two diabetes medications don't slow progression of type 2 diabetes in youth
In youth with impaired glucose tolerance or recent-onset type 2 diabetes, neither initial treatment with long-acting insulin followed by the drug metformin, nor metformin alone preserved the body's ability to make insulin, according to results published online June 25 in Diabetes Care.
People with diabetes visit the dentist less frequently despite link between diabetes, oral health
Adults with diabetes are less likely to visit the dentist than people with prediabetes or without diabetes, finds a new study led by researchers at NYU Rory Meyers College of Nursing and East Carolina University's Brody School of Medicine.
Diabetes, but not diabetes drug, linked to poor pregnancy outcomes
New research indicates that pregnant women with pre-gestational diabetes who take metformin are at a higher risk for adverse pregnancy outcomes -- such as major birth defects and pregnancy loss -- than the general population, but their increased risk is not due to metformin but diabetes.
New oral diabetes drug shows promise in phase 3 trial for patients with type 1 diabetes
A University of Colorado Anschutz Medical Campus study finds sotagliflozin helps control glucose and reduces the need for insulin in patients with type 1 diabetes.
Can continuous glucose monitoring improve diabetes control in patients with type 1 diabetes who inject insulin
Two studies in the Jan. 24/31 issue of JAMA find that use of a sensor implanted under the skin that continuously monitors glucose levels resulted in improved levels in patients with type 1 diabetes who inject insulin multiple times a day, compared to conventional treatment.
Complications of type 2 diabetes affect quality of life, care can lead to diabetes burnout
T2D Lifestyle, a national survey by Health Union of more than 400 individuals experiencing type 2 diabetes (T2D), reveals that patients not only struggle with commonly understood complications, but also numerous lesser known ones that people do not associate with diabetes.
A better way to predict diabetes
An international team of researchers has discovered a simple, accurate new way to predict which women with gestational diabetes will develop type 2 diabetes after delivery.
More Diabetes News and Diabetes Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Climate Mindset
In the past few months, human beings have come together to fight a global threat. This hour, TED speakers explore how our response can be the catalyst to fight another global crisis: climate change. Guests include political strategist Tom Rivett-Carnac, diplomat Christiana Figueres, climate justice activist Xiye Bastida, and writer, illustrator, and artist Oliver Jeffers.
Now Playing: Science for the People

#562 Superbug to Bedside
By now we're all good and scared about antibiotic resistance, one of the many things coming to get us all. But there's good news, sort of. News antibiotics are coming out! How do they get tested? What does that kind of a trial look like and how does it happen? Host Bethany Brookeshire talks with Matt McCarthy, author of "Superbugs: The Race to Stop an Epidemic", about the ins and outs of testing a new antibiotic in the hospital.
Now Playing: Radiolab

Speedy Beet
There are few musical moments more well-worn than the first four notes of Beethoven's Fifth Symphony. But in this short, we find out that Beethoven might have made a last-ditch effort to keep his music from ever feeling familiar, to keep pushing his listeners to a kind of psychological limit. Big thanks to our Brooklyn Philharmonic musicians: Deborah Buck and Suzy Perelman on violin, Arash Amini on cello, and Ah Ling Neu on viola. And check out The First Four Notes, Matthew Guerrieri's book on Beethoven's Fifth. Support Radiolab today at Radiolab.org/donate.