Hormones increase frequency of inherited form of migraine in women

December 22, 2008

Familial hemiplegic migraine (FHM) is an inherited form of severe migraine that is accompanied by visual disturbances known as aura. As with other types of migraine, it affects women more frequently than men. Most cases of FHM are caused by mutations in the CACNA1A gene, but whether these lead to spreading depression, the event in the brain that suppresses nerve cell activity and that has been linked to nongenetic forms of migraine with aura, has not been determined. However, Cenk Ayata and colleagues, at Massachusetts General Hospital, have now generated data in mice that address this issue as well as provide insight into the reasons why FHM affects women more frequently than men.

In the study, mice expressing either one of two different CACNA1A mutations that lead to FHM in humans were found to have an increased susceptibility to spreading depression. Interestingly, the mutation linked to more severe FHM caused a greater increase in susceptibility to spreading depression than the mutation linked to a milder form of FHM. As with humans, female mice were more susceptible to spreading depression than male mice. This difference was reversed if the female mice had their ovaries removed, and then partially restored by replacement of the hormone estrogen. The authors therefore conclude that both genetic and hormonal factors modulate an individual's susceptibility to migraines with aura.

In an accompanying commentary, Takahiro Takano and Maiken Nedergaard, at the University of Rochester, Rochester, explain the importance of these data, highlighting the implications for the serious complications that can accompany FHM.
-end-
TITLE: Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1

AUTHOR CONTACT:
Cenk Ayata
Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
Phone: (617) 726-8021; Fax: (617) 726-2547; E-mail: cayata@partners.org.

View the PDF of this article at: https://www.the-jci.org/article.php?id=36059

ACCOMPANYING COMMENTARY
TITLE: Deciphering migraine

AUTHOR CONTACT:
Maiken Nedergaard
University of Rochester, Rochester, New York, USA.
Phone: (585) 273-2868; Fax: (585) 275-0550; E-mail: nedergaard@urmc.rochester.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=38051

JCI Journals

Related Migraine Articles from Brightsurf:

Disparities in migraine by sexual orientation
Survey data were used to examine the association between sexual orientation (exclusively heterosexual, mostly heterosexual, lesbian, gay or bisexual) and migraine.

Can you paint your migraine?
'Can you draw me a picture of your headache?' may sound like an unusual question - but drawings of headache pain provide plastic surgeons with valuable information on which patients are more or less likely to benefit from surgery to alleviate migraine headaches.

Acupuncture can reduce migraine headaches
Acupuncture can reduce migraine headaches compared to both sham (placebo) acupuncture and usual care, finds a new trial from China published by The BMJ today.

Migraine rats, medical facts
Migraine mechanisms are still far from being fully understood. Escalating data from animal models are 'fact-checking' the neurophysiological and behavioral correlates of the migraine experience in humans, and how they may be affected by current anti-migraine drugs or might translate into new therapies.

Connecting the dots in the migraine brain
This dMRI study pointed to the structural strengthening of connections involving subcortical regions associated with pain processing and weakening in connections involving cortical regions associated with hyperexcitability may coexist in migraine.

Predictors of chronic migraine
A review and meta-analysis found predictors of chronic migraine. Depression, high frequency attacks, medication overuse and allodynia increased the chances for new onset chronic migraine, while annual income -- US$ 50,000 showed a protective effect.

On nitroglycerin, cardiovascular homeostasis and...bam, migraine!
Researchers in Leiden, The Netherlands, found an exaggerated cardiovascular response to nitroglycerin infusion in migraine patients, suggesting an elevated systemic sensitivity to this compound in this population.

All roads lead to migraine
Dr. Samaira Younis, from the Danish Headache Center in Copenhagen, Denmark, shares her research results, which suggests there are no differences between migraine attacks clinical characteristics following administration of 2 different compounds in patients, CGRP and sildenafil, meaning they share common cellular signaling pathways.

Running away from exercise: The curious case of migraine
In spite of the widespread recommendation for regular physical activity as a strategy to manage migraine, for some patients, exercise can instead trigger migraine attacks.

Migraine prevention in children and adolescents
Two medicines already used to prevent migraine in adults also showed efficacy in adolescents with migraine.

Read More: Migraine News and Migraine Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.