Study shows significant sex, age differences for nonfatal opioid overdoses in youth

December 22, 2020

Boston - Results of a national study show significant sex and age-based differences among youth and young adults who experience a nonfatal opioid overdose. Female youth between the ages of 11 and 16 have a higher incidence of nonfatal opioid overdose compared to male youth of the same age. That reverses at age 17, however, as males between 17 and 24 have a higher incidence of nonfatal opioid overdose compared to their female peers. Led by researchers from the Grayken Center for Addiction at Boston Medical Center and published in JAMA Network Open, the study reveals specific sex-based risk factors that could be used to develop more effective strategies to screen for and prevent opioid overdoses in adolescents and young adults.

A study published in 2018 shows alarming trends related to opioid overdoses among adolescents between the ages of 15 and 19. There was a 404 percent increase in opioid overdoses from 1999 to 2016, and the mortality for opioid overdoses increased 268 percent during that time period. Yet, many youth and young adults diagnosed with a substance use disorder, or opioid use disorder, do not receive medication to treat their condition.

"We know that adolescents and young adults are impacted by the opioid overdose epidemic, but there are not enough data about how or if their risks may be different from adults," said Sarah Bagley, MD, MSc director of Boston Medical Center's adolescent and young adult addiction treatment program and the study's corresponding author. "In order to help curb this increase, we need to better understand the issues facing our patients so that we can develop tailored approaches to address any underlying conditions that may contribute to the risks for overdose."

This retrospective cohort study examined characteristics of nonfatal opioid overdoses experienced by both males and females, and then compared the incidence of nonfatal opioid overdoses in male and female adolescents and young adults. The study's data was obtained from IBM Marketscan Commercial and included a cohort of 20,312 youth between the ages of 11 and 24 who experienced a nonfatal overdose between January 1, 2006 and December 31, 2017. The median age of individuals included in the cohort was 20, and approximately 42 percent were female, and all were commercially insured.

The research data showed that females had a higher prevalence of anxiety and depression, and a history of self-harm and suicide attempts. Male youth had a higher prevalence of other substance use disorders, including alcohol and cannabis. Between the ages of 11 and 16, females had significantly higher incidence of nonfatal overdoses, but at the age of 17, that changes as males then have higher incidence of nonfatal opioid overdoses.

"The study results provide significant insight into the co-occurring issues impacting our adolescent and young adult patients," added Bagley, who is also an assistant professor of medicine and pediatrics at Boston University School of Medicine. "We hope that this data will serve as a basis for developing targeted interventions to prevent nonfatal opioid overdoses, as well as strategies for more effective access and engagement in treatment for this population."
This study was funded in part by the National Institutes of Health's National Institute on Drug Abuse.

About Boston Medical Center

Boston Medical Center (BMC) is a private, not-for-profit, 514-bed, academic medical center that is the primary teaching affiliate of Boston University School of Medicine. It is the largest and busiest provider of trauma and emergency services in New England. BMC offers specialized care for complex health problems and is a leading research institution, receiving more than $166 million in sponsored research funding in fiscal year 2019. It is the 13th largest funding recipient in the U.S. from the National Institutes of Health among independent hospitals. In 1997, BMC founded Boston Medical Center Health Plan, Inc., now one of the top ranked Medicaid MCOs in the country, as a non-profit managed care organization. Boston Medical Center and Boston University School of Medicine are partners in Boston HealthNet - 12 community health centers focused on providing exceptional health care to residents of Boston. For more information, please visit

Boston Medical Center

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