Rafael Hervada Prize for Biomedical Research

December 23, 2005

This press release is also available in Spanish.

The article, entitled Myocardial Regeneration with Autologous Myoblasts: An Experimental and Clinical Study, whose first author is Dr. Juan José Gavira, of the department of Cardiology and Cardiovascular Surgery of the University Hospital of the University of Navarra, has received the Rafael Hervada Prize for Biomedical Research.

The study began with experiments on a porcine model of myocardial infarction. One month after inducing the disorder, adult stem cells (autologous myoblasts from the animal itself) were implanted by surgical and percutaneous means.

The results of this study revealed that this implantation of stem cells improved the function of the left ventricle: there was observed a significant increase in vasculogenesis and a significant decrease of fibrosis in the zones where the stem cells were injected, which could explain some of the mechanisms by which this treatment provides its benefits.

This experimental approach introduced a new technique: the injection of cells by two mechanisms: surgical and percutaneous (using a special catheter). Given that this technique both offers clinical benefits as well as greater security, in the future the patient may be able to avoid surgery altogether.

In addition, the research was concluded with a clinical trial in 12 patients who manifested antecedents to acute myocardial infarction, who were provided with traditional coronary bypass surgery, as well as an injection of myoblasts (adult stem cells) in the infarcted zone. Based on the results, this treatment is both practical and promising.

The study has included the participation of professionals from the departments of Cardiology and Cardiovascular Surgery of the University Hospital of Navarra, and from the Area of Cellular Therapy and Hematology, as well as the collaboration of Professor Diego Martínez Caro.

Elhuyar Fundazioa

Related Stem Cells Articles from Brightsurf:

SUTD researchers create heart cells from stem cells using 3D printing
SUTD researchers 3D printed a micro-scaled physical device to demonstrate a new level of control in the directed differentiation of stem cells, enhancing the production of cardiomyocytes.

More selective elimination of leukemia stem cells and blood stem cells
Hematopoietic stem cells from a healthy donor can help patients suffering from acute leukemia.

Computer simulations visualize how DNA is recognized to convert cells into stem cells
Researchers of the Hubrecht Institute (KNAW - The Netherlands) and the Max Planck Institute in Münster (Germany) have revealed how an essential protein helps to activate genomic DNA during the conversion of regular adult human cells into stem cells.

First events in stem cells becoming specialized cells needed for organ development
Cell biologists at the University of Toronto shed light on the very first step stem cells go through to turn into the specialized cells that make up organs.

Surprising research result: All immature cells can develop into stem cells
New sensational study conducted at the University of Copenhagen disproves traditional knowledge of stem cell development.

The development of brain stem cells into new nerve cells and why this can lead to cancer
Stem cells are true Jacks-of-all-trades of our bodies, as they can turn into the many different cell types of all organs.

Healthy blood stem cells have as many DNA mutations as leukemic cells
Researchers from the Princess Máxima Center for Pediatric Oncology have shown that the number of mutations in healthy and leukemic blood stem cells does not differ.

New method grows brain cells from stem cells quickly and efficiently
Researchers at Lund University in Sweden have developed a faster method to generate functional brain cells, called astrocytes, from embryonic stem cells.

NUS researchers confine mature cells to turn them into stem cells
Recent research led by Professor G.V. Shivashankar of the Mechanobiology Institute at the National University of Singapore and the FIRC Institute of Molecular Oncology in Italy, has revealed that mature cells can be reprogrammed into re-deployable stem cells without direct genetic modification -- by confining them to a defined geometric space for an extended period of time.

Researchers develop a new method for turning skin cells into pluripotent stem cells
Researchers at the University of Helsinki, Finland, and Karolinska Institutet, Sweden, have for the first time succeeded in converting human skin cells into pluripotent stem cells by activating the cell's own genes.

Read More: Stem Cells News and Stem Cells Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.