A potential drug for ischemia/reperfusion related liver injury

December 23, 2008

Hepatic injury caused by ischemia/reperfusion (I/R) has been proposed as a key clinical problem associated with liver transplantation and major liver surgery. The production of reactive oxygen species (ROS), including superoxide, hydrogen peroxide, and hydroxyl radical, has been demonstrated in reperfusion injury. Resveratrol has been reported to have several biologic effects such as a potent antioxidative effect via prevention of lipid peroxidation.

A research team led by Ercan Gedik from Turkey evaluated the possible protective effect of resveratrol against I/R-induced hepatic injury, using biochemical and histological parameters. This will be published on December 14, 2008 in the World Journal of Gastroenterology.

A total of 40 male Sprague-Dawley rats weighing 240-290 g were randomized into four groups of ten: (1) controls: data from unmanipulated animals; (2) sham group: rats subjected to the surgical procedure, except for liver I/R, and given saline; (3) I/R group: rats underwent liver ischemia for 45 min followed by reperfusion for 45 minutes; (4) I-R/Resveratrol group: rats pretreated with resveratrol (10 μmol/L, iv). Serum liver enzymes and histological changes were studied. They found that Plasma aminotransferase activities were higher in the I/R group than in the I-R/Resveratrol group. Malondialdehyde levels and the hepatic injury score decreased, while superoxide dismutase, catalase, and glutathione peroxidase levels increased in group 4 compared to group 3. In group 4, histopathological changes were significantly attenuated in resveratrol treated livers.

These results suggest that resveratrol has protective effects against hepatic I/R injury, and is a potential therapeutic drug for ischemia reperfusionrelated liver injury
-end-
Reference: Gedik E, Girgin S, Ozturk H, Obay BD, Ozturk H, Buyukbayram H. Resveratrol attenuates oxidative stress and histological alterations induced by liver ischemia/reperfusion in rats. World J Gastroenterol 2008; 14(46): 7101-7106 http://www.wjgnet.com/1007-9327/14/7101.asp

Correspondence to: J Ercan Gedik, Assistant Professor in General Surgery, Department of General Surgery, Medical School, Dicle University, Diyarbakir 21280, Turkey. ercan.gedik@yahoo.com.tr Telephone: +90-412-2488001-4679 Fax: + 90-412-2488440

About World Journal of Gastroenterology

World Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H pylori infection and provides a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health. ISI JCR 2003-2000 IF: 3.318, 2.532, 1.445 and 0.993. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th day of every month. WJG is supported by The National Natural Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the name of China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998.

About The WJG Press

The WJG Press mainly publishes World Journal of Gastroenterology

World Journal of Gastroenterology

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