Forthcoming comprehensive reference guide on deep tissue imaging techniques

December 28, 2016

Innovations in novel optical imaging techniques promise noninvasive deep tissue diagnostic tools that are more powerful and less expensive than existing modalities. A forthcoming reference book for new deep tissue imaging techniques, to be published January 31, 2017 by Pan Stanford, provides a comprehensive guide for researchers and students of multiple disciplines.

Deep Imaging in Tissue and Tissue-Like Media with Linear and Nonlinear Optics is edited by two leaders: one in the field of ultrafast laser spectroscopy--Dr. Robert R. Alfano of the City College of the City University of New York, and other in field of multiphoton imaging--Dr. Lingyan Shi of Columbia University.

This book provides an overview of emerging novel optical imaging techniques, Gaussian beam optics, light scattering, nonlinear optics, and nonlinear optical tomography of tissues and cells. It consists of pioneering works that employ different linear and nonlinear optical imaging techniques for deep tissue imaging, including the new applications of single- and multiphoton excitation fluorescence, Raman scattering, resonance Raman spectroscopy, second harmonic generation, stimulated Raman scattering gain and loss, coherent anti-Stokes Raman spectroscopy, and NIR, SWIR , and MIR supercontinuum spectroscopy.

Dr. Alfano said, "the use of the photon basic unit of light offers an unique opportunity via its many properties to understand various states of matter on more fundamental level. Shi and I believe biomedphotonics will open the door to the underlying mysteries of the brain and cancer."

The use of light for probing and imaging biomedical media is promising for the development of safe, noninvasive, and inexpensive clinical imaging modalities with diagnostic ability of cancer and brain disorders. The advent of ultrafast lasers has enabled applications of nonlinear optical processes, which allow for deeper imaging in biological tissues with higher spatial resolution.

Robert R. Alfano is a distinguished professor of science engineering at the City College of the City University of New York. He received his PhD in physics from New York University and worked at GTE Laboratories (Verizon). He has pioneered many applications of light and photonics technology to the study of biological, biomedical, and condensed matter systems using optical spectroscopy and optical imaging. He has also discovered and used supercontinuum and novel tunable Cr solid state lasers. Dr. Alfano is a fellow of APS, OSA, and IEEE.

Lingyan Shi is a research scientist at Columbia University. Her current research focuses on metabolic imaging with stimulated Raman scattering microscopy. Before joining Columbia University, she was a research associate studying deep brain imaging and drug delivery in the brain at the Institute for Ultrafast Spectroscopy and Lasers Biology ,and Biomedical Engineering Departments at City College of New York (CCNY). Dr. Shi received her PhD in biomedical engineering from CCNY.
The City University of New York is the nation's leading urban public university. Founded in New York City in 1847, the University comprises 24 institutions: 11 senior colleges, seven community colleges, and additional professional schools. The University serves nearly 275,000 degree-credit students and 218,083 adult, continuing and professional education students.

For more information, please contact Shante Booker ( or visit

The City University of New York

Related Brain Articles from Brightsurf:

Glioblastoma nanomedicine crosses into brain in mice, eradicates recurring brain cancer
A new synthetic protein nanoparticle capable of slipping past the nearly impermeable blood-brain barrier in mice could deliver cancer-killing drugs directly to malignant brain tumors, new research from the University of Michigan shows.

Children with asymptomatic brain bleeds as newborns show normal brain development at age 2
A study by UNC researchers finds that neurodevelopmental scores and gray matter volumes at age two years did not differ between children who had MRI-confirmed asymptomatic subdural hemorrhages when they were neonates, compared to children with no history of subdural hemorrhage.

New model of human brain 'conversations' could inform research on brain disease, cognition
A team of Indiana University neuroscientists has built a new model of human brain networks that sheds light on how the brain functions.

Human brain size gene triggers bigger brain in monkeys
Dresden and Japanese researchers show that a human-specific gene causes a larger neocortex in the common marmoset, a non-human primate.

Unique insight into development of the human brain: Model of the early embryonic brain
Stem cell researchers from the University of Copenhagen have designed a model of an early embryonic brain.

An optical brain-to-brain interface supports information exchange for locomotion control
Chinese researchers established an optical BtBI that supports rapid information transmission for precise locomotion control, thus providing a proof-of-principle demonstration of fast BtBI for real-time behavioral control.

Transplanting human nerve cells into a mouse brain reveals how they wire into brain circuits
A team of researchers led by Pierre Vanderhaeghen and Vincent Bonin (VIB-KU Leuven, Université libre de Bruxelles and NERF) showed how human nerve cells can develop at their own pace, and form highly precise connections with the surrounding mouse brain cells.

Brain scans reveal how the human brain compensates when one hemisphere is removed
Researchers studying six adults who had one of their brain hemispheres removed during childhood to reduce epileptic seizures found that the remaining half of the brain formed unusually strong connections between different functional brain networks, which potentially help the body to function as if the brain were intact.

Alcohol byproduct contributes to brain chemistry changes in specific brain regions
Study of mouse models provides clear implications for new targets to treat alcohol use disorder and fetal alcohol syndrome.

Scientists predict the areas of the brain to stimulate transitions between different brain states
Using a computer model of the brain, Gustavo Deco, director of the Center for Brain and Cognition, and Josephine Cruzat, a member of his team, together with a group of international collaborators, have developed an innovative method published in Proceedings of the National Academy of Sciences on Sept.

Read More: Brain News and Brain Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to