Bioelectric stimulation to clear skin lesions

December 30, 2019

New Rochelle, NY, December 30, 2019--The delivery of ultrashort pulses of electrical energy represents a promising nonthermal, nonscarring method of inducing regulated cell death in common skin lesions. This and other novel approaches to applying electrical impulses to treat disease are published in Practical Applications of Bioelectric Stimulation, a special issue of Bioelectricity, a peer-reviewed journal from Mary Ann Liebert, Inc. Click here to read the issue free on the Bioelectricity website through January 30, 2019.

Guest Editor of the special issue Richard Nuccitelli, PhD, Pulse Biosciences, Hayward, CA, contributed the article entitled "Nano-Pulse Stimulation Therapy for the Treatment of Skin Lesions") Nano-Pulse Stimulation (NPS) delivers nanosecond pulsed electric fields to cells and tissues. NPS specifically targets cells, generating nanometer wide pores that allow small ions to enter to alter the flow of sodium, potassium and calcium ions in and out of the cells. It can induce cell death in epidermal or dermal lesions, but as it does not affect the dermal collagen it does not cause scarring. Dr. Nuccitelli discusses the characteristics of NPS, its effects on normal skin, on epidermal lesions such as seborrheic keratosis, on dermal lesions, and on warts caused by human papilloma virus.

Also of interest in this special issue is the article entitled "Preventing Ethanol-Induced Brain and Eye Morphology Defects Using Optogenetics") by Vaibhav Pai, Tufts University, Medford, MA and Dany Spencer Adams, Tufts University and Ion Diagnostics, Watertown, MA. Exposure of a fetus to alcohol can lead to defects in brain and eye morphology, as part of fetal alcohol spectrum disorder (FASD). This is also true in the developing tadpole. Pai and Adams used this model system to test the use of optogenetics - light-induced energy - to regulate ion channel function and ion fluxes and to rescue tadpoles from the effects of alcohol. Using controlled membrane voltage modulation, the researchers were able to rescue the ethanol-induced brain and eye defects in the tadpoles. The hyperpolarization effect was required for the full duration of the ethanol exposure. Furthermore, the rescue effect acted at a distance, suggesting that bioelectric modulation to treat ethanol-induced brain and eye defects in human embryos might be possible using existing ion channel drugs.

Research reported in this publication was supported by the National Institutes of Health under Award Number R01HDO81326. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
-end-
About the Journal

Bioelectricity is the only peer-reviewed journal dedicated to the study of the natural electricity within living organisms and how to harness this phenomenon to treat and cure disease. The Journal publishes groundbreaking multidisciplinary research and advances documenting this next step in the evolution of how we study life. For complete tables of content and a sample issue, please visit the Bioelectricity website.

About the Publisher

Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Stem Cells and Development, Tissue Engineering, and The CRISPR Journal. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 90 journals, newsmagazines, and books is available on the Mary Ann Liebert, Inc., publishers website.

Mary Ann Liebert, Inc./Genetic Engineering News

Related Alcohol Articles from Brightsurf:

Alcohol use changed right after COVID-19 lockdown
One in four adults reported a change in alcohol use almost immediately after stay-at-home orders were issued: 14% reported drinking more alcohol and reported higher levels of stress and anxiety than those who did not drink and those whose use stayed the same.

Changes in hospitalizations for alcohol use disorder in US
Changes over nearly two decades in the rate of hospitalizations and in-hospital deaths from alcohol use disorder in the US were examined in this study.

Associations of alcohol consumption, alcohol-induced passing out with risk of dementia
The risk of future dementia associated with overall alcohol consumption and alcohol-induced loss of consciousness in a population of current drinkers was examined in this observational study with more than 131,000 adults.

New alcohol genes uncovered
Do you have what is known as problematic alcohol use?

Does estrogen influence alcohol use disorder?
A new study from researchers at the University of Illinois at Chicago shows that high estrogen levels may make alcohol more rewarding to female mice.

Sobering new data on drinking and driving: 15% of US alcohol-related motor vehicle fatalities involve alcohol under the legal limit
A new study in the American Journal of Preventive Medicine, published by Elsevier, found that motor vehicle crashes involving drivers with blood alcohol concentrations (BACs) below the legal limit of 0.08 percent accounted for 15% of alcohol-involved crash deaths in the United States.

Alcohol-induced deaths in US
National vital statistics data from 2000 to 2016 were used to examine how rates of alcohol-induced deaths (defined as those deaths due to alcohol consumption that could be avoided if alcohol weren't involved) have changed in the US and to compare the results by demographic groups including sex, race/ethnicity, age, socioeconomic status and geographic location.

Cuts in alcohol duty linked to 2000 more alcohol-related deaths in England
Government cuts to alcohol taxes have had dramatic consequences for public health, including nearly 2000 more alcohol-related deaths in England since 2012, according to new research from the University of Sheffield's School of Health and Related Research (ScHARR).

Integrated stepped alcohol treatment for people in HIV care improves both HIV & alcohol outcomes
Increasing the intensity of treatment for alcohol use disorder (AUD) over time improves alcohol-related outcomes among people with HIV, according to new clinical research supported by the National Institutes of Health.

The Lancet:Targets to reduce harmful alcohol use are likely to be missed as global alcohol intake increases
Increasing rates of alcohol use suggest that the world is not on track to achieve targets against harmful alcohol use, according to a study of 189 countries' alcohol intake between 1990-2017 and estimated intake up to 2030, published in The Lancet.

Read More: Alcohol News and Alcohol Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.