Oliguridylation-mediated histone mRNA decay

December 31, 2007

In the January 1st issue of G&D, Drs. Thomas Mullen and William Marzluff (UNC Chapel Hill) lend new insight into the degradation of mammalian histone mRNA.

Histone mRNA is rapidly degraded at the end of S phase, but the mechanism by which this occurs has remained elusive, as metazoan histone mRNAs have a unique, conserved 3' stem-loop structure rather than the canonical 3' poly(A) tail.

Drs. Mullen & Marzluff demonstrate that uridine residues are added to the 3' end of histone mRNAs, after which the transcript is decapped and degraded at both ends by components of the general mRNA decay machinery.

This work represents the first example of the half-life of a specific mammalian mRNA transcript being regulated by oligouridylation.
-end-


Cold Spring Harbor Laboratory

Related Histone Mrna Articles from Brightsurf:

Treating cystic fibrosis with mRNA therapy or CRISPR
The potential for treating cystic fibrosis (CF) using mRNA therapies or CRISPR gene editing is possible regardless of the causative mutation.

Oncotarget: ATM inhibition overcomes resistance to histone deacetylase inhibitor
The cover for issue 37 of Oncotarget features Figure 7, ''The combination of romidepsin and KU60019 is synergistic in a xenograft model of MCL,'' by Scotto, et al. which reported that the antiproliferative effect induced by histone deactylase inhibitors is associated with the up-regulated expression of the cyclin-dependent kinase inhibitor p21.

Another mRNA-based vaccine candidate protects animals against SARS-CoV-2
An experimental messenger RNA (mRNA)-based vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) elicits protective immune responses in mice and non-human primates, researchers report on July 23rd in the journal Cell.

The secret double life of histone H3 as a copper reductase enzyme
In a study that takes another look at histones' origins, researchers report these proteins, known for DNA-packing, may have evolutionary roots in early life in helping to maintain the use of metals like copper - fundamental for biological processes, but which became toxic to eukaryotes as they adapted to global oxygenation.

Strahl lab decodes another piece of the histone code puzzle
Published in the journal Cell Reports, this research reinforces the notion that the multiple chemical modifications placed on histones by a single enzyme ensures multiple and distinct functions -- an idea that was postulated by Strahl and his former mentor, David Allis, Ph.D., and was called the Histone Code hypothesis.

Moffitt researchers discover novel role of specific histone deacetylase in lung cancer
Researchers at Moffitt Cancer Center are trying to identify alternative strategies to treat non-small cell lung cancer (NSCLC).

Controlling the messenger with blue light
IBS scientists have developed a new optogenetic tool to visualize and control the position of specific messenger RNA (mRNA) molecules inside living cells.

Key molecular machine in cells pictured in detail for the first time
Scientists at Columbia, UNC-Chapel Hill, and Rockefeller University, in a study published in Science, used biochemical experiments and cryo-electron microscopy (cryo-EM) to determine the atomic structure of a complex assembly of molecules known as the histone mRNA three-prime (3') end-processing machine.

Scientists reveal function of histone variant H2A.Z in DNA replication selection
The research published in Nature on Dec. 25th, 2019, led by Dr.

Histone modifications are the influencers of zygotic genome awakening
Scientists at Tokyo Institute of Technology (Tokyo Tech) observed changes to the gene-regulating factors during zebrafish development and discovered that modifications to 'histone H3', one of the proteins around which DNA is bound, play an important role in 'zygotic genome activation' or transition of control of zebrafish embryonic development from maternal material to the zygote.

Read More: Histone Mrna News and Histone Mrna Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.