Popular Angiogenesis News and Current Events

Popular Angiogenesis News and Current Events, Angiogenesis News Articles.
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A protein makes the difference
It is well-established knowledge that blood vessels foster the growth of tumors. Preventing the formation of tumors is a standard part of cancer therapy. A study by researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg has discovered a new, surprising role played by blood vessels: under certain conditions they can inhibit tumor growth. (2016-10-18)

Blood vessels sprout under pressure
It is blood pressure that drives the opening of small capillaries during angiogenesis. A team of researchers led by Prof. Holger Gerhardt of the MDC observed the process for the first time and published their findings in Nature Cell Biology (Joint press release by the Berlin Institute of Health (BIH), Charité, German Center for Cardiovascular Research (DZHK) and Max Delbrück Center for Molecular Medicine (MDC)). (2016-02-29)

HKBU Chinese medicine scholars develop HKBU Chinese medicine scholars develop
Chinese Medicine scholars at Hong Kong Baptist University (HKBU) have succeeded in developing a novel targeted delivery system for CRISPR/Cas9 to achieve therapeutic genome editing of VEGFA in osteosarcoma (OS). (2017-11-10)

How bone cells promote lung cancer growth
A certain type of cell in the bone marrow can help promote tumor growth in mice with early stage lung cancer, a new study finds. (2017-11-30)

Researchers find a promising new approach for treating liver cirrhosis
In a study in The American Journal of Pathology, investigators report that treatment with aleglitazar, a dual peroxisome proliferator-activated receptor-alpha/gamma (PPARα/γ) agonist, reduced inflammation, vasoconstriction, angiogenesis, mucosal disruption, and tumor necrosis factor (TNF)-α overproduction in cirrhotic rats with PH. This suggests a promising new approach for treating liver cirrhosis. (2018-06-18)

Likely new treatment target identified for diabetic retinopathy
In oxygen-compromising conditions like diabetes, the body grows new blood vessels to help, but the result is often leaky, dysfunctional vessels that make bad matters worse. Now scientists have identified a new target for reducing that dysfunctional blood vessel development in the eye in a common condition called diabetic retinopathy, the leading cause of blindness in working-age adults. (2017-10-10)

New RNAi treatment targets eye inflammation
Scientists have developed a new RNA interference (RNAi) therapeutic agent that safely blocked ocular inflammation in mice, potentially making it a new treatment for human uveitis and diabetic retinopathy. (2017-02-13)

Regenerating blood vessels gets $2.7 million grant
Biomedical engineers in the Cockrell School of Engineering at The University of Texas at Austin have received $2.7 million in funding to advance a treatment that regenerates blood vessels. (2016-04-26)

Researchers identify new cell targets for preventing growth of breast and other tumors
Researchers at the Lineberger Comprehensive Cancer Center at the University of North Carolina at Chapel Hill have discovered new targets for cancer treatment aimed at blocking a key step in tumor progression. (2008-04-23)

Blood vessel-on-a-chips show anti-cancer drug effects in human cells
Researchers at the Institute of Industrial Science, the University of Tokyo, and LIMMS/CNRS-IIS a joint French - Japanese research laboratory between the CNRS and the University of Tokyo, report new organ-on-a-chip technology to observe sprouting angiogenesis from a single blood vessel. VEGF stimulated new capillaries from the single vessel by activating NOTCH signaling, recapitulating biochemical events of the human angiogenesis. The chip also confirmed the effects of two FDA-approved anti-angiogenic drugs, demonstrating its applicability to drug discovery. (2018-01-30)

80% cut in liver metastasis by restricting the blood vessels supplying it
The International Journal of Cancer has just published the results of an experimental therapy tested on mice. The research, led by the Signaling Lab research group of the UPV/EHU's Faculty of Medicine and Pharmacy and the Department of Pharmacology, Pharmacy and Pharmaceutical Technology of the University of Santiago de Compostela, achieved an 80% reduction in liver metastasis brought about by colon cancer. (2018-03-16)

Biomarker helps identify 'window of opportunity' for cancer chemotherapy timing
Angiogenesis, the formation of new blood vessels, is essential for tumor growth. A new study reported in The American Journal of Pathology describes a vascular stabilization biomarker that can visualize blood vessel activity, thus optimizing the timing of anticancer therapies including anti-angiogenics. (2018-04-09)

Looking for the origins of schizophrenia
Schizophrenia may be related to neurodevelopment changes, including brain's inability to create the appropriate vascular system, according to new study resulted from a partnership between the D'Or Institute for Research and Education, the University of Chile and the Federal University of Rio de Janeiro (UFRJ). The results broaden the understanding about the causes of this severe and disabling disorder, which affects about 1 percent of the world's population. (2018-02-22)

Sleep apnea may make lung cancer more deadly
A team of researchers from the University of Chicago and the University of Barcelona has found that intermittent hypoxia, or an irregular lack of air experienced by people with sleep apnea, can increase tumor growth by promoting the release of circulating exosomes. Their results are published in the current issue of the journal CHEST. (2016-11-17)

New gene therapy for pseudarthrosis trialed at Kazan University
A team headed by Professor Albert Rizvanov, director of the Gene and Cell Technologies Open Lab, created a gene therapy drug that encodes growth factors for the stimulation of blood vessel and bone formation. (2016-12-02)

New immunotherapy combination tolerable, effective in patients with advanced kidney cancer
Combining an anti-angiogenesis agent, which blocks blood vessel formation, with an immunotherapy agent, was found to have promising anti-tumor activity and no unexpected side effects in an early-phase clinical trial in patients with advanced kidney cancer. (2018-02-10)

UEA research could help fine-tune cancer treatment
Cancer therapies that cut off blood supply to a tumour could be more effective in combination with existing chemotherapeutic drugs -- according to new research from the University of East Anglia. New research published today in the journal EMBO Reports reveals that tumour growth is better-reduced in mice when the expression of a particular protein called Beta3-integrin is targeted in combination with drugs that are already used in cancer patients. (2018-05-25)

A new way to cut the power of tumors
Instead of tackling tumors head-on, a team of researchers from the University of Geneva and the Amsterdam UMC, location VUmc chose to regulate their vascularization by intervening with cellular receptor overexpressed specifically in cancer blood vessels. By acting on the development of the blood vessels within the tumor, scientists hope to modulate vasculature and deliver the treatments extremely accurately, and even if necessary 'cut the food' to the tumor, much like you'd close a tap. (2018-12-20)

'Hopeful technology' could change detection, diagnosis of deadly ovarian cancer
Ovarian cancer claims the lives of more than 14,000 women in the U.S. each year, ranking fifth among cancer deaths in women. A multidisciplinary team at Washington University has found an innovative way to use sound and light to diagnose ovarian tumors, which may lead to a promising new diagnostic imaging technique to improve current standard of care. (2018-11-14)

The mechanics of anti-tumor activity outlined
Inhibiting the growth and the angiogenic properties of cancer is an important modality for cancer treatment and research. In an article published today in the April issue of Cancer Cell (Vol. 3, No. 4, pg. 363), Winship Cancer Institute (WCI) researchers report that 2-methoxyestradiol (2ME2) inhibits tumor growth and angiogenesis by suppressing hypoxia-inducible factor-1 (HIF). (2003-04-22)

How a tumor grows can predict response to cancer therapy
Individual tumors respond differently to cancer drugs, if at all. Until now, it remained a mystery why tumors have different reactions to the exact same therapy. But a new study at the USC Viterbi School of Engineering finds that tumor growth properties can influence response to cancer drugs. (2017-12-21)

Sulfur amino acid restriction diet triggers new blood vessel formation in mice
Putting mice on a diet containing low amounts of the essential amino acid methionine triggered the formation of new blood vessels in skeletal muscle, according to a new study from Harvard T.H. Chan School of Public Health. The finding adds insight to previous research showing that a methionine-restricted diet extends lifespan and healthspan, suggesting that improved vascular function may contribute to these benefits. (2018-03-22)

New targets found to reduce blood vessel damage in diabetes
In diabetes, both the tightly woven endothelial cells that line our blood vessels and the powerhouses that drive those cells start to come apart as early steps in the destruction of our vasculature. (2018-07-09)

Promising research shows blood vessel growth key to healthy fat tissue
research led by York University's Faculty of Health shows that inhibiting a protein within blood vessels stimulates new blood vessel growth, resulting in healthier fat tissue (adipose) and lower blood sugar levels. The findings provide key insight into how improving blood vessel growth could help to mitigate serious health problems that arise with obesity, such as diabetes. (2018-12-04)

Cancer Slowed When Blood Vessel Growth In Tumors Blocked
Researchers at Duke University Medical Center have been able to significantly slow the growth of tumors on rats by preventing the tumors from (1997-10-15)

The microenvironment of diabetic retinopathy supports lymphatic neovascularization
'We asked whether proliferative diabetic retinopathy involves the growth of new lymphatic vessels in addition to blood vessels -- and, indeed, we found expression of lymphatic markers in the PDR tissues.' The new study, conducted at the University of Helsinki, Finland, was published in the Journal of Pathology. (2018-03-29)

Researchers identify key compounds to resolve abnormal vascular growth in AMD
A compound of specific bioactive products from a major family of enzymes reduced the severity of age-related macular degeneration (AMD) in a preclinical model, according to a new study led by Massachusetts Eye and Ear researchers. (2017-08-21)

FDA-approved drug may block resistance to anti-angiogenesis therapy
A Massachusetts General Hospital research team has identified a potential strategy for improving the efficacy of angiogenesis inhibitors, drugs that help fight cancer by blocking the formation of new blood vessels. (2017-09-13)

Stem cells from muscle could address diabetes-related circulation problems
Stem cells taken from muscle tissue could promote better blood flow in patients with diabetes who develop peripheral artery disease, a painful complication that can require surgery or lead to amputation. A new study in mice at the University of Illinois found that an injection of the stem cells prompted new blood vessels to grow, improving circulation in the affected tissues and function in the affected limbs. (2017-11-06)

Starving tumors: New target discovered
Actively growing tumors have a high demand for oxygen and nutrients. Therefore, they stimulate the growth of blood vessels. This process is called angiogenesis. If tumor-associated angiogenesis is suppressed, this may limit tumor growth. Scientists from the German Cancer Research Center and the European Center for Angioscience at Heidelberg University have now discovered a new target for anti-angiogenic tumor therapy (2018-01-23)

Scientists shed light on a tumor-suppressive protein in metastases
?A new study conducted at the VIB-KU Leuven Center for Cancer Biology in Belgium has labeled the protein Caveolin-1 as a high-potential pursuit in the fight against cancer. Many research projects have already implicated this protein in both tumor-promotive and suppressive functions, but its exact role remained elusive. By examining macrophages at the sites of metastases, the scientists have now described the 'anti-metastatic surveillance' role of Caveolin-1 for the first time. (2017-12-05)

Reviving the protector: new tactic against medulloblastoma
Scientists have a new tactic with potential for fighting medulloblastoma, the most common and most aggressive form of brain tumor in children. (2018-06-11)

Recruitment of miR-8080 by luteolin inhibits AR-V7 in castration-resistant prostate cancer
Patients with castration-resistant prostate cancer (CRPC) have a poor clinical response to drugs for CRPC, including enzalutamide. Recently, an mRNA splice variant of the androgen receptor (AR), called AR-V7, that lacks a functional ligand-binding domain has been highlighted as a major resistance mechanism in CRPC. This important study describes a novel mechanism for down-regulation of AR-V7 by miR-8080, which suppresses the tumor growth and enhances the therapeutic efficacy of enzalutamide in CRPC. (2019-12-05)

Systemic treatment before surgery for kidney cancer prolongs patients' survival
Preliminary results from a phase II clinical trial have provided the first evidence that treating people with kidney cancer with bevacizumab and erlotinib before surgery is safe, effective and may prolong patients' survival, the 18th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics heard on Thursday. (2006-11-09)

Healing molecule discovery could reduce limb amputations for diabetes patients
Scientists have discovered new insights into a molecule which is part of the body's tissue repair system, in a finding which could help treat non-healing wounds and injuries, such as diabetic foot. (2017-10-04)

New tool for cell-free therapy based on artificial membrane vesicles
Scientists at Kazan Federal University's Institute of Fundamental Medicine and Biology, led by Professor Albert Rizvanov, have shown that artificial membrane vesicles generated by cytochalasin B treatment of human cells retain angiogenic activity. (2017-09-12)

Fighting cancer with aspirin?
When looking for new weapons in the war on cancer, scientists should turn to their medicine cabinets for an age-old remedy -- aspirin. Scientists at the University of Newcastle have determined that aspirin has cancer-fighting effects extending beyond Cox inhibitors. This finding, appearing in the October 2006 issue of the FASEB Journal, allows researchers to pursue new lines of investigation that could ultimately yield a new type of cancer-fighting drug. (2006-10-02)

3 papers present fresh paths to ponder Akt1 in the heart
Three JCI papers plus an accompanying commentary explore Akt1 in the heart. Two provide new insights into how Akt1 can be maladaptive in the heart. The third paper finds that Akt1 is responsible for mediating adaptive angiogenesis after ischemia. A commentary discussing all says (2005-08-01)

Texas A&M team develops new way to grow blood vessels
Formation of new blood vessels, a process also known as angiogenesis, is one of the major clinical challenges in wound healing and tissue implants. To address this issue, researchers from Texas A&M University have developed a clay-based platform to deliver therapeutic proteins to the body to assist with the formation of blood vessels. (2018-08-17)

Cutting off tumor supplies
Preventing tumour vascularization is therefore an interesting anti-tumour therapy that has been explored over the last ten years. But how to be truly effective? By identifying two cytokines, key factors in the recruitment of blood cells essential to the formation of new blood vessels, and above all by deciphering how these factors interact simultaneously with blood vessels, researchers at UNIGE are highlighting an additional way of controlling tumour progression. (2018-02-02)

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