Popular Antibodies News and Current Events

Popular Antibodies News and Current Events, Antibodies News Articles.
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Microglia turned on
Part of the immune system in the brain is made up of so-called microglia cells. Korean and Singaporean researchers have now developed a fluorescent probe that specifically labels this type of macrophage. The cells were visualized in cell culture and in the live brains of rodents. As detailed in the journal Angewandte Chemie, a gene product expressed in microglia triggers the probe into a fluorescing state, which is detected through live-cell fluorescence imaging. (2019-05-27)

Enhanced glow
Tumor cells circulating in blood are markers for the early detection and prognosis of cancer. However, detection of these cells is challenging because of their scarcity. In the journal Angewandte Chemie, scientists have now introduced an ultrasensitive method for the direct detection of circulating tumor cells in blood samples. It is based on the amplified, time-resolved fluorescence measurement of luminescent lanthanide ions released from nanoparticles that bind specifically to tumor cells. (2019-08-07)

Investigational drug with immunotherapy may provide new therapeutic opportunity for patients previously treated for kidney and lung cancer
Investigational drug with immunotherapy may provide new therapeutic opportunity for patients previously treated for kidney and lung cancer. Pegilodecakin with pembrolizumab and nivolumab shown to be safe in Phase 1B study (2019-09-25)

'Pulling' bacteria out of blood
Magnets instead of antibiotics could provide a possible new treatment method for blood infection. This involves the blood of patients being mixed with magnetic iron particles, which bind the bacteria to them after which they are removed from the blood using magnets. The initial laboratory tests at Empa in St. Gallen have been successful, and seem promising. (2016-12-07)

Researchers develop new technology platform for cancer immunotherapy
Johns Hopkins scientists invent multifunctional antibody-ligand traps (Y-traps), a new class of cancer immunotherapeutics. They develop Y-traps comprising an antibody targeting an immune checkpoint (CTLA-4 or PD-L1) fused to a TGFβ trap. In humanized mouse models, these Y-traps reverse immune suppression and inhibit growth of tumors that do not respond to current immune checkpoint inhibitors. (2018-02-22)

Maternal vaccination again influenza associated with protection for infants
How long does the protection from a mother's immunization against influenza during pregnancy last for infants after they are born? (2016-07-05)

Bad antibodies made good: The immune system's secret weapon uncovered
The 'bad apples' of the immune system are also its secret weapon, according to major Australian research published today in the world-leading journal Science. In a world first, scientists from Sydney's Garvan Institute of Medical Research have revealed how a population of 'bad' antibodies in the immune system -- which are usually 'silenced' because they can harm the body -- can provide crucial protection against invading microbes. (2018-04-12)

New vaccine technology shows promise as a tool to combat the opioid crisis
An experimental heroin vaccine induced antibodies that prevented the drug from crossing the blood-brain barrier in mice and rats. (2017-12-18)

Combination therapy targets latent reservoir of HIV
In a new study, Dan H. Barouch, MD, PhD, Director of the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center, and colleagues demonstrate that administering broadly neutralizing antibodies (bNAb) designed to target HIV in combination with agents that stimulate the innate immune system delayed viral rebound following discontinuation of ART in monkeys. The findings suggest that this two-pronged approach represents a potential strategy for targeting the viral reservoir. (2018-10-03)

New vaccine technique effectively fights breast cancer in mice
The body's own immune system can effectively fight breast cancer with the help of a new vaccine technique, researchers from the University of Copenhagen show in mice trials. The technique holds great potential if the effect translates to humans, the researchers find. (2017-11-30)

MGH team engineers anti-inflammatory antibodies that may treat autoimmune disease
A team of Massachusetts General Hospital investigators has found a way to engineer antibodies within an organism, converting autoantibodies that attack 'self' tissues into anti-inflammatory antibodies in animal models of two autoimmune diseases. (2017-12-21)

Ludwig researchers unravel novel mechanism by which tumors grow resistant to radiotherapy
A Ludwig Cancer Research study has uncovered a key mechanism by which tumors develop resistance to radiation therapy and shown how such resistance might be overcome with drugs that are currently under development. (2017-11-23)

ZMapp antibody delivered by viral vector protects against Ebola infection
A new study comparing the effectiveness of individual ZMapp antibodies versus a cocktail of antibodies, administered to mice using recombinant adeno-associated virus (rAAV) delivery vectors, showed the ability to achieve 100% protection against infection by Ebola virus. (2018-03-09)

Gluten intolerance appears largely undiagnosed in Canada
Research on a large sample of Canadians suggests that most people with celiac disease don't know they have it. (2017-10-06)

A review on the therapeutic antibodies for spinal cord injury
Spinal cord injury (SCI) causes long-lasting damage in the spinal cord that leads to paraparesis, paraplegia, quadriplegia and other lifetime disabilities. The emergence of antibody treatment has paved a new pathway for the management of SCI. In this current review, Professor Weijiang Zhao and Doctor Danyang Tang summarize the experimentally therapeutic application of antibodies in SCI. (2016-10-03)

New tool for prognosis and choice of therapy for rheumatoid arthritis
In rheumatoid arthritis, antibodies are formed that affect the inflammation in the joints. In an article published today in the journal Annals of the Rheumatic Diseases, researchers at Uppsala University show that antibodies against the cartilage protein collagen II are associated with a good prognosis. (2017-03-23)

Researchers discover first human antibodies that work against all ebolaviruses
After analyzing the blood of a survivor of the 2013-16 Ebola outbreak, a team of scientists from academia, industry and the government has discovered the first natural human antibodies that can neutralize and protect animals against all three major disease-causing ebolaviruses. The findings, published online today in the journal Cell, could lead to the first broadly effective ebolavirus therapies and vaccines. (2017-05-18)

A combination of cancer immunotherapies could save more lives
Scientists at the University of Southampton have discovered a new combination of cancer immunotherapy treatment that could improve patients' survival rates. (2018-03-27)

UV light improving chances of fighting cancer
Scientists at Newcastle University have developed a cancer fighting technology which uses UV light to activate antibodies which very specifically attack tumours. (2007-10-30)

Dengue virus infection may cause severe outcomes following Zika virus infection during pregnancy
This study is the first to report a possible mechanism for the enhancement of Zika virus progression during pregnancy in an animal model. (2019-02-08)

New study shows potential to treat or prevent viral cancers
A new study, presented at the SNM 55th Annual Meeting, shows that radioimmunotherapy targeting viral antigens offers a novel option to treat -- or even prevent -- many viral cancers by targeting cancer cells expressing viral antigens or infected cells before they convert into malignancy. (2008-06-16)

Tumor-dwelling immune cells thwart cancer immunotherapy
Researchers have caught tumor-associated immune cells called macrophages in the act of stealing checkpoint inhibitor antibodies away from their intended T cell targets, and blocking this thievery led to improved therapeutic responses in tumor-bearing mice. (2017-05-10)

Ebola vaccines provide immune responses after 1 year
Immune responses to Ebola vaccines at one year after vaccination are examined in a new study appearing in the March 14 issue of JAMA. (2017-03-14)

A hair-trigger for cells fighting infection
In response to infection the immune system produces unique antibodies to target each illness. To make these new antibodies, cells in the immune system must intentionally damage their own genes, meaning they run the risk of becoming cancer cells. New research from the Babraham Institute reveals how a proteins called Tia1 acts as a hair-trigger for DNA repair, allowing the immune system to walk the line between health and harm. (2017-09-13)

Disease diagnosis in just 15 minutes
Testing for diseases such as cancer and multiple sclerosis could soon be as simple as using a pregnancy testing kit. A team led by scientists at the University of Leeds has developed a biosensor technology that uses antibodies to detect biomarkers - molecules in the human body which are often a marker for disease -- much faster than current testing methods. (2008-10-01)

Discovering the early age immune response in foals
Researchers at the Cornell University College of Veterinary Medicine have discovered a new method to measure tiny amounts of antibodies in foals, a finding described in the May 16 issue of PLOS ONE. The methodology will help understand how fast a foal starts producing its own antibodies, which in turn will help optimize recommendations for young horse vaccination schedules, said Dr. Julia Felippe, associate professor of large animal medicine, and research associate Rebecca Tallmadge. (2017-06-29)

Efficacy of antibody targeting Devic's disease proven in new animal model
Neuromyelitis optica (NMO) is an autoimmune disease associated with NMO immunoglobulin G (NMO-IgG). A cure for NMO remains elusive. Osaka University researchers recently established a localized NMO rat model by injecting NMO-IgG into the spinal cord, and assessed the efficacy of anti-repulsive guidance molecule-a (RGMa) antibody in treating NMO. They found anti-RGMa antibody delayed the onset and attenuated the severity of clinical symptoms of NMO, suggesting that humanized anti-RGMa antibody is a potentially valid therapeutic approach for NMO. (2018-01-18)

Study advances efforts to screen all children for Type 1 diabetes
Researchers from the Johns Hopkins University School of Medicine, Stanford University and the University of Florida report the development of a novel antibody detection technology that holds promise for improving the accuracy of diagnostic tests for type 1 diabetes in young children and making populationwide screening practical. (2017-09-13)

Certain flu virus mutations may compensate for fitness costs of other mutations
Seasonal flu viruses continually undergo mutations that help them evade the human immune system, but some of these mutations can reduce a virus's potency. According to new research published in PLOS Pathogens, certain mutations in the genome of influenza A may help counteract the weakening effects of other mutations. (2018-01-18)

Long-term prevention of organ rejection
The Konstanz immunologist Professor Marcus Groettrup and his team have developed a procedure for preventing organ rejection in rats after renal transplantation, and for suppressing the creation of antibodies in the recipients' immune systems. Immunoproteasome inhibition, which suppresses the production of antibodies, is crucial to this process. The research results were published in Kidney International. The title of the original publication is: 'Immunoproteasome inhibition prevents chronic antibody-mediated allograft rejection in renal transplantation.' (2017-12-08)

Limiting tumors' ability to hide from the immune system
Scientists have discovered a way to stop tumors from shedding certain proteins that the immune system uses to identify and attack tumors. (2018-03-29)

Antibodies as 'messengers' in the nervous system
Antibodies are able to activate human nerve cells within milliseconds and hence modify their function -- that is the surprising conclusion of a study carried out at Human Biology at the Technical University of Munich (TUM). This knowledge improves our understanding of illnesses that accompany certain types of cancer, above all severe intestinal malfunctions. (2017-01-27)

New technology enables identification of biomarkers for a wide range of diseases
Scientists have developed a way to identify biomarkers for a wide range of diseases by assessing the antibodies we are making to the complex sugars coating our cells. The new, highly sensitive Luminex Multiplex Glycan Array enables the kind of volume needed to establish associations between antibody levels in our blood to these complex sugars, or glycans, and conditions from cancer to autoimmune disease and dementia, they report in the journal Nature Communications. (2018-02-12)

Malaria: Cooperating antibodies enhance immune response
Scientists from the German Cancer Research Center (DKFZ) in Heidelberg, Germany, and from The Hospital for Sick Children (SickKids) in Toronto, Canada, have studied how the human immune system combats malaria infections. In this study, the researchers discovered a previously unnoticed characteristic of antibodies against the malaria parasite: They can cooperate with each other, thus binding even stronger to the pathogens and improving the immune response. The results, now published in Science, are expected to help develop a more effective vaccine against the disease. (2018-06-07)

Broadly acting antibodies found in plasma of Ebola survivors
Recent Ebola virus disease (EVD) outbreaks highlight the need for licensed treatments. ZMapp, an experimental therapy, has shown promise in a clinical trial, but targets only one of five known species of Ebola virus. Now NIAID-supported scientists have discovered powerful, broadly neutralizing antibodies (bNAbs) in the blood of EVD survivors. In animal studies, two of these antibodies provided substantial protection against disease caused by the three species known to cause fatal human illness. (2018-07-17)

Training human antibodies to protect against HIV
During HIV infection, the virus mutates too rapidly for the immune system to combat, but some people produce antibodies that can recognize the virus even two years after infection. With an eye towards developing a vaccine, in four related papers from multiple groups publishing Sept. 8 in Cell and Immunity, researchers describe a multi-step method for 'training' the immune system to produce these antibodies in genetically engineered mice. (2016-09-08)

LSTM and Imperial College Researchers design new anti-influenza drugs
Researchers at LSTM and Imperial College London have designed drugs which could help combat any potential new flu pandemic, by targeting the receptors of the cells by which the virus gains entry to the human body. (2019-01-25)

TSRI scientists discover workings of first promising Marburg virus treatment
Scientists at The Scripps Research Institute have discovered the workings of the first promising treatment for Marburg virus, a pathogen with the same pandemic potential as Ebola virus. (2018-01-10)

New Lyme disease tests could offer quicker, more accurate detection
New diagnostic methods offer a better chance for more accurate detection of the infection from the Lyme bacteria, the most common tick-borne infection in North America and Europe. (2017-12-07)

Fewer laboratory animals thanks to secondary nanobodies
Max Planck researchers develop sustainable alternative to the most widely used antibodies and their controversial production in animals. (2017-12-21)

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