Popular Antidepressant News and Current Events

Popular Antidepressant News and Current Events, Antidepressant News Articles.
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Talking with the doctor makes it easier to deal with grief and bereavement
In a comprehensive study, researchers from Aarhus University show that grieving patients who receive what is known as talk therapy at the general practitioner shortly after a relative's death, have a lower risk of suicide and psychiatric illness than others. Data from 207,000 million Danes is included in the register-based study, which can contribute to new practices in the preventative area. (2018-09-20)

Starting dose of Lexapro™ as effective as optimally dosed Zoloft® in the treatment of depression
A clinical study showed that LexaproTM is as effective and well tolerated as Zoloft®. The purpose of the study was to evaluate the efficacy of the starting dose of Lexapro, 10 mg/day, compared to the full dosing range of Zoloft, 50 - 200/day. Study results showed that patients receiving a dose of 10 mg per day of Lexapro experienced similar efficacy compared to patients receiving a median dose of Zoloft of 150 mg per day. (2003-12-10)

Studies suggest inflammatory cytokines are associated with depression and psychosis, and that anti-cytokine treatment can reduce depression symptoms
Studies presented at this year's International Early Psychosis Association meeting in Milan, Italy, (Oct. 20-22) suggest that increased levels of inflammatory cytokines are associated with increased rates of depression and psychosis, and that treatment to reduce cytokine levels can reduce symptoms of depression. (2016-10-20)

Targeting depression: Researchers ID symptom-specific targets for treatment of depression
For the first time, physician-scientists at Beth Israel Deaconess Medical Center have identified two clusters of depressive symptoms that responded to two distinct neuroanatomical treatment targets in patients who underwent transcranial magnetic brain stimulation (TMS) for treatment of depression. The team's findings shed new light on the brain circuitry underlying specific symptoms of depression and may facilitate personalized TMS therapy for depression and other psychiatric or neurological disorders. (2020-05-04)

Depression in adults who are overweight or obese
In an analysis of primary care records of 519,513 UK adults who were overweight or obese between 2000-2016 and followed up until 2019, the incidence of new cases of depression was 92 per 10,000 people per year. The risk of depression also rose with higher weight, according to the Obesity analysis. (2020-04-08)

New drug shows potential as a different kind of antidepressant in mouse trials
A potential new antidepressant and antianxiety treatment with a unique mechanism of action has been developed by scientists at the University of Bath. (2017-11-06)

Cocktail tests on toxic waste called for
Surprisingly low concentrations of toxic chemicals -- from fungicides to antidepressants -- can change the way some aquatic creatures swim and feed, according to new research. In addition, depending on the cocktail of toxins they can produce unexpected results. (2017-10-16)

Why is ketamine an antidepressant?
Delving deep inside the neural circuitry of 'depressed' mice, researchers have revealed how ketamine works in cells to achieve its fast-acting antidepressant effect. (2019-04-11)

Some patients stop needing antidepressant medication after having plastic surgery
It has been proven that plastic surgery can improve self-esteem, but can it also act as a natural mood enhancer? A significant number of patients stopped taking antidepressant medication after undergoing plastic surgery, according to a study presented today at the American Society of Plastic Surgeons Plastic Surgery 2006 conference in San Francisco. (2006-10-08)

Interstellar molecules inspire new transformations
When illuminating with LED light, chemists at ICIQ generated carbynes, a highly reactive chemical species that allowed them to modify drugs like anticancer paclitaxel, antidepressant duloxetine and NSAID ibuprofen. The study, led by young chemist Marcos García-Suero, just published in Nature. (2018-01-31)

Treating SSRI-resistant depression
When your antidepressant medication does not work, should you switch to a different medication from the same class or should you try an antidepressant medication that has a different mechanism of action? This is the question asked by researchers in a new report scheduled for publication in Biological Psychiatry on April 1. (2008-03-25)

Study finds only one-third of patients diagnosed with depression start treatment
Despite the wide availability of effective treatments for depression and a growing effort nationwide to detect and begin treating depression during primary care visits, only about one-third of individuals newly diagnosed with depression start treatment, according to a Kaiser Permanente study published today in the Journal of General Internal Medicine. (2018-02-08)

Potential new targets for antidepressant medications
The news about antidepressant medications over the past several years has been mixed. The bad news from large multicenter studies such as STAR*D is that current antidepressant medications are effective, but not as effective as one might hope. (2008-08-27)

Inflammation, depression and antidepressant response: Common mechanisms
In findings published electronically in Molecular Psychiatry, researchers from University of Miami found polymorphisms in inflammation-related genes that are associated with susceptibility to major depression and antidepressant response. Two genes critical for T cell function in the immune system have been associated with susceptibility for major depressive disorder and antidepressant treatment response: PSMB4 (proteasome beta 4 subunit) and TBX21 (T-bet). (2008-05-29)

Depression diversity: Brain studies reveal big differences among individuals
Depressed people may have far fewer of the receptors for some of the brain's (2008-05-07)

Antidepressant use increases hip fracture risk among elderly
Antidepressant use nearly doubles the risk of hip fracture among community-dwelling persons with Alzheimer's disease, according to a new study from the University of Eastern Finland. The increased risk was highest at the beginning of antidepressant use and remained elevated even four years later. The findings were published in the International Journal of Geriatric Psychiatry. (2017-01-11)

Human minibrains reveal effects of psychedelic substance
A Brazilian study, published in Scientific Reports on Oct. 9, 2017, has identified changes in signaling pathways associated with neural plasticity, inflammation and neurodegeneration triggered by a compound from the family of dimethyltryptamine known as 5-MeO-DMT. (2017-10-09)

Older adults with metabolic syndrome may be more resistant to depression treatments
Researchers suspect that having Metabolic Syndrome makes it harder for older adults to respond to therapies for depression. (Metabolic Syndrome is a mix of conditions like increased blood pressure, high blood sugar levels, excess body fat around the waist, and abnormal cholesterol levels). In a new, first of its kind study, published in the Journal of the American Geriatrics Society, researchers examined whether Metabolic Syndrome in depressed older adults affects their response to antidepressant treatment. (2018-01-10)

Childhood methylphenidate treatment predicts antidepressant use during adolescence
A new, 12-year longitudinal study, which monitored 6,830 children from early childhood into adolescence, has shown that consistent treatment with MPH-based medications during childhood increases the risk of antidepressant use during adolescence. The study is the first of its kind to examine the connection between children diagnosed with ADHD and prescribed MPH between the ages of six and eight, and future dispensed prescriptions of antidepressants. (2019-03-27)

Simple EKG can determine whether patient has depression or bipolar disorder
A groundbreaking Loyola Medicine study suggests that a simple 15-minute electrocardiogram could help a physician determine whether a patient has major depression or bipolar disorder. (2017-11-20)

Kaiser Permanente study finds cognitive behavioral therapy is cost-effective
Cognitive behavioral therapy (or CBT) delivered in a primary care setting is a cost-effective way to treat adolescents with depression who decline or quickly stop using antidepressants, according to a Kaiser Permanente study published today in the journal Pediatrics. (2018-01-19)

Ketamine reverses neural changes underlying depression-related behaviors in mice
Researchers have identified ketamine-induced brain-related changes that are responsible for maintaining the remission of behaviors related to depression in mice. Ketamine treatment restored lost dendritic spines and rescued coordinated neural activity in the Prefrontal Cortex of the mice -- findings that may help researchers develop interventions that promote lasting remission of depression in humans. The study was funded by the National Institute of Mental Health (NIMH), part of the National Institutes of Health. (2019-04-11)

Ketamine acts fast to treat depression and its effects last -- but how?
Researchers led by Mark Rasenick in the University of Illinois at Chicago College of Medicine, describe the molecular mechanisms behind ketamine's ability to squash depression and keep it at bay. They report their findings in the journal Molecular Psychiatry. (2018-06-21)

Antidepressants and anti-anxiety drugs linked to increased risk of hip fracture
In a recent study, older individuals who had fallen and broken a hip used antidepressant and anti-anxiety medications more frequently than the general older population. (2017-03-07)

Researchers identify new type of depression
Depression is a mental disorder that affects over 300 million people around the world. While treatments exist, many of them are based on one hypothesis of how depression arises. Patients that do not fit this mold may not be getting benefits. A study led by Hiroshima University (HU), which was published online this May in Neuroscience, shed light on how one protein called RGS8 plays a role in depression behaviors. (2018-06-11)

Researchers discover a critical receptor involved in response to antidepressants like ketamine
Effective treatment of clinical depression remains a major mental health issue, with roughly 30 percent of patients who do not respond to any of the available treatments. Researchers at the University of Maryland School of Medicine (UMSOM) have discovered a crucial receptor called mGlu2 that is critical to the mechanism of fast-acting antidepressants such as ketamine when used to treat depression. (2019-03-28)

Hunger hormone increases during stress, may have antidepressant effect
New research at UT Southwestern Medical Center may explain why some people who are stressed or depressed overeat. (2008-06-15)

Depressed people have an increased risk of atrial fibrillation
Depressed people have an increased risk of atrial fibrillation, according to a study published today in the European Journal of Preventive Cardiology, a European Society of Cardiology (ESC) journal.1 Medication was not responsible for the high frequency of atrial fibrillation in depressed people. The findings are reported during Global AF Aware Week. (2018-11-20)

Why do antidepressants take so long to work?
An episode of major depression can be crippling, impairing the ability to sleep, work, or eat. But the drugs available to treat depression can take weeks or even months to start working. Researchers at the University of Illinois at Chicago have discovered one reason the drugs take so long to work, and their finding could help scientists develop faster-acting drugs in the future. The research was published in the Journal of Biological Chemistry. (2016-07-28)

Possible link between autism and antidepressants use during pregnancy
An international team led by Duke-NUS Medical School has found a potential link between autistic-like behaviour in adult mice and exposure to a common antidepressant in the womb. They also identified a treatment that helped improve memory loss and social interactions, according to the new study published in the journal Molecular Brain. (2019-04-30)

Study examines risk, risk factors for depression after stroke
During the first three months after stroke, the risk for depression was eight times higher than in a reference population of people without stroke, according to an article published online by JAMA Psychiatry. (2016-09-07)

Binge eating and smoking linked to bullying and sexual abuse
People who ever suffered bullying or sexual abuse have a lower quality of life similar to those living with chronic conditions like heart disease, diabetes, depression or severe anxiety, a new study from the University of Adelaide has found. (2019-01-11)

Having an abortion does not lead to depression
Having an abortion does not increase a woman's risk for depression, according to a new University of Maryland School of Public Health-led study of nearly 400,000 women. Previous research has found abortion does not harm women's mental health, yet studies claiming that it does have been used to justify state policies that restrict access to abortion in the US. This study's findings, published in JAMA Psychiatry, suggest those policies are misguided. (2018-05-30)

Trazadone associated with similar risk of falls and major fractures as antipsychotics in seniors with dementia
As physicians attempt to decrease antipsychotic use in seniors with dementia, they need to be aware that trazadone, frequently used as an alternative, is associated with a similar risk of falls and major fractures as atypical antipsychotics, according to new research in CMAJ. (2018-11-26)

Brain structural effects of psychopharmacological treatment in bipolar disorder
Bipolar disorder is associated with subtle neuroanatomical deficits. This review considers evidence that lithium, mood stabilizers, antipsychotic medication and antidepressant medications are associated with neuroanatomical variation. (2016-02-16)

Next-generation metabolomics may facilitate the discovery of new antidepressants
Antidepressants have become one of the most commonly prescribed drugs. With the technical advances in analytical instruments, metabolomics is entering into a 'next generation' phase. Dr. Li and colleagues from the University of California, San Diego, USA have summarized the analytical platforms of next-generation metabolomics (NGM) and its main applications in antidepressant R&D. In particular, they demonstrate the low toxicity and multi-targets of albiflorin using NGM, which might facilitate this botanical medicine to be a new class of antidepressant. (2018-08-06)

Depressed with a chronic disease? Consider alternative therapies
Scientists are finding more evidence that commonly prescribed antidepressants aren't effective in people battling both depression and a chronic medical disease, raising a critical question of whether doctors should enact widespread changes in how they treat millions of depressed Americans. (2017-11-06)

Study challenges previous findings that antidepressants affect breastfeeding
New research does not support the previously observed negative impacts of antidepressant use on breastfeeding. (2018-03-26)

Drug combination for treatment resistant depression no more effective than single
A large clinical trial published in the British Medical Journal today, looked at the effectiveness of adding mirtazapine to an SSRI or SNRI in patients who remain depressed after at least six weeks of conventional (SSRI or SNRI) antidepressant treatment. They found that this combination was no more effective in improving depression than placebo and call on doctors to rethink its use. (2018-11-01)

New study rebuts the claim that antidepressants do not work
A theory that has gained considerable attention in international media, including Newsweek and the CBS broadcast 60 minutes, suggest that antidepressant drugs, such as the SSRIs, do not exert any actual antidepressant effect. A research group at the Sahlgrenska Academy has now analyzed data from clinical trials and can rebut this theory. (2017-08-18)

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