Popular Atpase News and Current Events

Popular Atpase News and Current Events, Atpase News Articles.
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Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity
The researchers have recently identified the tumor suppressor tuberous sclerosis complex 1 as a new co-chaperone of Hsp90 that affects Hsp90 binding to its inhibitors. Their findings suggest that TSC1 status may predict response to Hsp90 inhibitors in patients with bladder cancer, and co-targeting HDACs can sensitize tumors with Tsc1 mutations to Hsp90 inhibitors. (2019-10-10)

Flipping lipids for cell transport-tubules
An enzyme that flips lipids from the outer to the inner layer of the cell membrane launches the process that permits cells to engulf external substances. (2018-03-29)

Reversing aging now possible!
DGIST's research team identified the mechanism of reversible recovery of aging cells by inducing lysosomal activation. The team opened a new horizon of aging recovery research by changing the irreversibility paradigm of aging. (2017-04-03)

Discovery of compounds that keep plants fresh
A team of scientists at Nagoya University has discovered new compounds that can control stomatal movements in plants. Some of the compounds have shown to prevent leaves from drying up and suppress withering when sprayed onto rose and oat leaves. (2018-04-08)

Anticancer mechanism revealed in yeast experiments
Scientists uncover how important enzymes in both fission yeast and human cancer cells interact to boost cell proliferation. (2019-02-05)

Global first determination of crystal structure of gastric proton pump
Nagoya University-centered researchers determined the first crystal structure the gastric proton pump H+, K+-ATPase responsible for acidifying gastric juice down to pH1. The team presented crystal structures of the H+, K+-ATPase in complex with two blockers, vonoprazan and SCH28080, at 2.8 Å resolution. This provides important information for refinement of existing drugs and discovery of new drugs. It also reveals the underlying mechanisms of how the highly acidic environment in the stomach is created. (2018-04-17)

Electrical signals in plants affect photosynthetic activity
Plants are constantly exposed to various stressors, including drought, fluctuations in temperature and light intensity, attacks by insects, etc. Since plants have an attached lifestyle, the only way to survive the impact of the stress factor is to quickly adapt their metabolism to the changing conditions. In the case when stressors (for example, strong light or mechanical damage) only act on certain parts of the plant organism, special stress signals propagate in the plant. (2018-05-03)

Molecular biophysics -- the ABC of ribosome recycling
Ribosomes, the essential machinery used for protein synthesis is recycled after each one round of translation. An enzyme called ABCE1 is responsible for this process and turns out to be remarkably plastic as Ludwig-Maximilians-Universitaet (LMU) in Munich biophysicists report. (2019-07-25)

Marshall School of Medicine research team defines possible anti-aging intervention
New research demonstrates that Na/K-ATPase oxidant amplification loop (NAKL) is intimately involved in the aging process and may serve as a target for anti-aging interventions. (2018-06-26)

Toxic toad invasion puts Madagascar's predators at risk, genetic evidence confirms
The recent introduction of the common Asian toad to Madagascar has led to fears that the toxic amphibian could wreak havoc on the island's already severely threatened fauna. Now, researchers report genetic evidence in the journal Current Biology on June 4 showing that those fears are well founded: virtually all predators native to Madagascar are highly sensitive to toad toxins. If they should eat the toads, it would be a potentially fatal mistake. (2018-06-04)

Biomolecular motors with propellers can live inside cells
Nanobiotechnologists at Cornell University have built and pilot-tested the first biomolecular motors the size of virus particles with tiny metal propellers. (Science Nov. 24, 2000) (2000-11-22)

A calcium pump caught in the act
Researchers at Aarhus University have described one of the cell's key enzymes, the calcium pump, in its decisive moment -- a so-called transition state. These findings provide a very detailed picture of how one of the most energy-consuming processes in the body takes place. Calcium pumps are intimately involved in the activity of muscle, such as the heart, and therefore they are considered important targets for development of new drugs for cardiovascular diseases. (2016-05-09)

AgriLife scientists uncover a new face of a famous protein, SWI2/SNF2 ATPase
A team of Texas A&M and Texas A&M AgriLife Research scientists now have a deeper understanding of a large switch/sucrose non-fermentable (SWI/SNF) protein complex that plays a pivotal role in plant and human gene expression that causes life-threatening diseases such as cancer. (2018-05-17)

Mechanism identified behind enzyme involved in liver and other human cancers
To understand what has gone wrong when cancer occurs and to create new possibilities for treatment, it is important to understand the molecular mechanisms behind what is happening at the cellular level. New research, which is now published in the journal Molecular Cell, explains how the motor of an enzyme in DNA damage repair is switched on and off and how these processes might go awry in cancer. (2017-12-07)

Prospective birth control pill for men has its origin in an arrow poison
Women have many options for oral contraceptives that are safe, effective and reversible, but despite decades of research, men have none. Now, scientists report a rat study in ACS' Journal of Medicinal Chemistry that shows they finally have a good lead for a male birth control pill. It's based on ouabain, a plant extract that African warriors and hunters traditionally used as a heart-stopping poison on their arrows. (2018-01-17)

Direct visualization of dynamic structures of protein disaggregation molecular machines
ClpB, an ATP-fueled protein molecular machine, disentangles and reactivates aggregated proteins. By using high-speed atomic force microscopy, conformational dynamics of ClpB was visualized for the first time. ClpB forms open- and closed-ring, and the closed-ring was further classified into three forms; round, spiral, and twisted-half-spiral. These structures transformed each other during ATPase-cycle to perform protein disaggregation. This research will help to treat protein aggregations, which are related to various diseases and cause problems in industry. (2018-06-01)

Biophysics: Making patterns robust
Correct protein localization is crucial for many fundamental cellular processes. LMU physicists have now asked how to confer robustness against variations in protein concentrations on pattern formation mechanisms. (2018-04-17)

Heredity matters: Ancestral protease functions as protein import motor in chloroplasts
Japanese researchers identified a large novel protein complex in the inner chloroplast membrane that functions as a motor to import proteins into the chloroplast. Components of the complex evolved from a protein of the endosymbiont cyanobacterium-like ancestor of chloroplasts that lost its protein-degrading function but retained its motor ability. These findings solve a longstanding mystery surrounding this protein translocation system that uniquely evolved in photosynthetic eukaryotes. (2018-10-22)

Targeting protein homeostasis holds potential to treat solid tumors and blood cancers
In data published in two journals as well as to be presented at the American Society of Hematology Annual Meeting & Exposition, scientists identified an orally available molecule, CB-5083, that targeting protein homeostasis has the potential to treat solid tumors and blood cancers. (2015-12-03)

Promising new compound protects neurons and vision in mice with glaucoma
Early tests of a novel compound in mice with glaucoma should come as welcome news to millions of people around the world now suffering with this leading cause of vision loss. Researchers reporting in the journal Heliyon have shown that a compound they've developed might help to prevent the nerve damage that leads people with glaucoma to lose their sight. (2016-04-19)

Hormone might cause dangerous pregnancy complication
Researchers at the University of Cincinnati (UC) Academic Health Center have found evidence of a hormone they say is responsible for certain types of high blood pressure (hypertension), and could also cause preeclampsia, a potentially dangerous condition that occurs during pregnancy. (2005-10-17)

Journal issue honors 20th anniversary of Marshall University researcher's discovery
Twenty years ago, Zijian Xie, Ph.D., director of the Marshall Institute for Interdisciplinary Research and professor at Marshall University Joan C. Edwards School of Medicine, discovered the scaffolding/signaling function of the Na/K-ATPase sodium pump. In honor of this milestone and the impact of Xie's discovery on cell biology, the International Journal of Molecular Sciences released a special issue featuring articles related to this scaffolding/signaling function. (2018-10-02)

Researchers from Aarhus solve the mystery of the acid pump
Researchers at Aarhus University in Denmark have succeeded in identifying the mechanisms involved in what is known as the acid pump, which at the cellular level pumps acid into the stomach -- in some cases leading to gastric ulcers and gastroesophageal reflux disease. The research results emanate from Jens Chr. Skou's sodium-potassium pump, for which he was awarded the Nobel Prize twenty years ago. (2017-03-07)

How sperm find their way
Researchers have found that a protein in the cell membranes of sperm plays a key role in how they find their way to eggs. The PMCA protein may also help explain how egg cells only interact with sperm from the same species. PMCA may even be a target of drug discovery. (2018-11-15)

Researchers discover a tumor suppressor gene in a very aggressive lung cancer
The Genes and Cancer Group at the Cancer Epigenetics and Biology Program of the IDIBELL has found that the MAX gene, which encodes a partner of the MYC oncogene, is genetically inactivated in small cell lung cancer. Reconstitution of MAX significantly reduced cell growth in the MAX-deficient cancer cell lines. These findings show that MAX acts as a tumor suppressor gene in one of the more aggressive types of lung cancer. (2014-01-09)

New research shows promise for improving vascular access for hemodialysis patients
Hemodialysis requires repeated access to the blood. Failure to maintain adequate access to the vasculature is a major cause of medical complications and, potentially, death for these patients. A new study in The American Journal of Pathology provides information about the mechanisms underlying failure of the most common type of hemodialysis vascular access, the arteriovenous fistula. Despite being the preferred approach, there is currently limited understanding of the mechanisms involved in fistula maturation failure. (2017-08-16)

Bad brakes
A study in human and mouse heart cells identifies a faulty molecular brake in the most common form of hypertrophic cardiomyopathy, a leading cause of sudden cardiac death in young people and athletes and the most common genetic disease of the heart The faulty brake, found about a quarter of all genetic mutations in hypertrophic cardiomyopathy, interferes with the heart muscle's ability to contract and relax,. Treatment with a chemical compound successfully restores normal contractility and relaxation in human heart cells (2019-01-28)

Research reveals role of fat storage cells in anti-obesity intervention
New research from a team at the Marshall University Joan C. Edwards School of Medicine establishes a role of adipocyte Na/K-ATPase signaling in worsening obesity and its companion diseases, including neurodegeneration and non-alcoholic steatohepatitis (NASH), that was enhanced by specific targeting of NaKtide, an antagonist of Na/K-ATPase signaling, to the adipocyte. (2019-05-31)

Artificial cells act more like the real thing
Protocells -- artificial cells -- that are active and mimic living cells by moving independently and that are biocompatible and enzymatically active are now possible using an improved method developed by Penn State researchers. (2019-12-05)

Fat pumps generate electrical power
A previously unknown electrical current develops in the body's cells when the vital fat pump function of the flippases transfers ('flips') lipids from the outer to the inner layer of the body's cell membranes. This electrical current may be important for a range of other cell mechanisms, and in this way also for human well-being and health. This is shown by a study from Aarhus University, Denmark. (2019-08-27)

Researchers use a pump-induced disease to define underlying molecular mechanism
A Texas Tech University Health Sciences Center research study investigated a pump-induced disease and defined the molecular mechanism that triggers it. Researchers presented the study of the functional effects of specific mutations of the Na/K pump found in tumors that induce primary aldosteronism (Conn's syndrome). (2017-10-26)

Discovery of a host mRNA that inhibits immune functions of antiviral protein RIG-I
This study shows that, upon HCV infection, mRNA of selenoprotein P (SeP), a secretory protein produced primarily in the liver, binds to and inhibits the action of RIG-I, an antiviral protein, thus regulating innate immunity. RIG-I-mediated induction of interferon production is repressed by SeP mRNA, a host mRNA, affecting its antiviral activity. These results should lead to further elucidation of mechanisms underlying the association between metabolic disorders and virus-induced innate immunity dysfunction. (2019-04-10)

New clues into how 'trash bag of the cell' traps and seals off waste
The mechanics behind how an important process within the cell traps material before recycling it has puzzled scientists for years. But Penn State researchers have gained new insight into how this process seals off waste, much like a trash bag. (2018-08-15)

DNA repair: Opening the hatch to heal the break
Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have determined the structure of a key enzyme complex that is involved in DNA repair, and traced the cycle of conformational changes that it undergoes while performing its biochemical function. (2019-09-04)

Biophysics: Self-centered
Rod-shaped bacterial cells normally divide by constriction midway along their long axis. LMU physicists have developed a theoretical model to explain how Myxococcus xanthus localizes the plane of division to mid-cell. (2018-08-31)

First detailed look at how molecular Ferris wheel delivers protons to cellular factories
All cells with nuclei, from yeast to humans, use molecular machines called proton pumps to regulate the acidity of organelles - compartments where various types of work are done. A new study reveals a key step in how these Ferris wheel-like pumps operate. (2020-10-07)

Newly discovered receptor helps to sneak a peek at evolution
Certain proteins call for unusual ways to get incorporated into membranes, because the signal sequence required for this process is located at their rear end instead of at the front. The relevant mechanism and its components are well-known and well-studied in yeast and mammals. Scientists have already hypothesised that it also occurs in plants, but there was no evidence of an indispensable receptor, until now. (2020-12-22)

Biosensing nanodevice to revolutionize health screenings
One day soon a biosensing nanodevice developed by Arizona State University researcher Wayne Frasch may eliminate long lines at airport security checkpoints and revolutionize health screenings for diseases like anthrax, cancer and antibiotic resistant Staphylococcus aureus. Even more incredible than the device itself, is that it is based on the world's tiniest rotary motor: a biological engine measured on the order of molecules. (2008-03-25)

New details on how a viral protein puts the brakes on virus replication
Researchers used computational chemistry, biochemistry and virology to uncover new information on how viruses such as West Nile, dengue and Zika replicate. (2020-02-07)

The role of calcium handling mechanisms in reperfusion injury
Cardiovascular diseases, such as stroke and myocardial infarction (MI) remain the major cause of death and disability worldwide.The overall goal of this review is to describe the different pathways that lead to I/R injury via Ca2+ overload, focus on recent discoveries and highlight prospects for therapeutic strategies for clinical benefit. (2018-12-19)

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