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New approaches in medical genomics: A step forward in Parkinson's disease
Researchers at the Centre for Genomic Regulation (CRG) in Barcelona have discovered a mechanism regulating an important protein that is linked to ParkinsonĀ“s disease and multiple system atrophy (MSA). They have identified factors controlling the production of this protein and revealed mechanisms by which it leads to neurotoxicity. These results, which have been published this week in Nucleic Acids Research, point to new biomarkers that might help in the early detection of these diseases, as well as in exploring possible treatments. (2017-12-19)

Solar hydrogen production by artificial leafs: Scientists analysed how a special treatment improves cheap metal oxide photoelectrodes
Metal oxides are promising candidates for cheap and stable photoelectrodes for solar water splitting, producing hydrogen with sunlight. Unfortunately, metal oxides are not highly efficient in this job. A known remedy is a treatment with heat and hydrogen. An international collaboration has now discovered why this treatment works so well, paving the way to more efficient and cheap devices for solar hydrogen production. (2017-08-28)

One step closer to a DNA vaccine against dengue virus
In a new study, researchers inoculated mice with a new DNA vaccine candidate (pVAX1-D1ME) in order to evaluate its efficiency. They found that the vaccine candidate was able to induce persistent humoral and cellular immune responses and provided efficient protection against lethal challenge from one of the four serotypes of dengue virus (DV1). These results are encouraging for the future development of a tetravalent vaccine that could provide efficient protection against all four serotypes of the virus. (2017-06-29)

Study: Children are interested in politics but need better education from parents and schools
The 2020 election is approaching -- how should we talk with children about this election and about politics more broadly? The findings of a new multisite study of children's reactions to the 2016 US presidential election might inform these conversations. (2019-09-10)

From the Oscars to the Nobel Prize, winners need to choose their friends wisely
Being friends with an award juror can increase a person's chance of being nominated but decrease their chances of being selected as the victor, according to new research published in the Academy of Management Journal. (2019-07-12)

UK MP Twitter abuse increased between 2015 and 2017 general elections
Abuse of politicians online increased substantially in the snap 2017 general election compared to the 2015 general election, according to new research by the University of Sheffield. (2018-08-30)

Left-brained: Study suggests conservative Democrats don't compute for liberal voters
Magnetic Resonance Imaging research finds self-identified liberals more likely to notice when candidates deviate from the party line. Liberals also tend to take longer to react to inconsistent positions from Democrats. In the majority of instances, they evaluated those inconsistent positions as 'bad.' (2017-11-13)

Availability of family and friends key factor in deciding organ transplant suitability
The availability of a supportive network of family and friends is a key factor in deciding on a person's suitability for an organ transplant, reveals research published online in the Journal of Medical Ethics. (2018-06-28)

BODE may overestimate transplant benefit in COPD patients
In a new study published in the journal CHESTĀ®, researchers aimed to determine if patients selected as transplant candidates have a better survival rate than the BODE score indicates. (2018-03-06)

How fast can acute stroke treatment become to still be reliable?
Neurologists around the world are aware that the delivery of thrombolytic treatment for stroke in Helsinki University Hospital, Finland, is freaking fast -- but is it too fast? A new study published on July 11 in the journal Neurology clarified whether the team of neurologists in Helsinki actually have enough time to diagnose stroke correctly before it is treated. (2018-07-13)

Blood test provides clues to bladder cancer patients' prognoses
New research indicates that about one-quarter of patients with bladder cancer treated with radical surgery on curative intent have detectable levels of tumour cells circulating in their blood. The presence of circulating tumour cells was also a predictor of cancer recurrence and death. (2017-02-13)

Researchers develop device that emulates human kidney function
Instead of running tests on live kidneys, researchers at Binghamton, University State University of New York have developed a model kidney for working out the kinks in medicines and treatments. Developed by Assistant Professor Gretchen Mahler and Binghamton biomedical engineering alumna Courtney Sakolish Ph.D. '16, the reusable, multi-layered and microfluidic device incorporates a porous growth substrate, with a physiological fluid flow, and the passive filtration of the capillaries around the end of a kidney, called the glomerulus, where waste is filtered from blood. (2017-02-09)

International team identifies genetic model for predicting primary myelofibrosis outcomes
A group of investigators from Mayo Clinic and multiple academic research centers in Italy have identified a genetic model for predicting outcomes in patients with primary myelofibrosis who are 70 years or younger and candidates for stem cell transplant to treat their disease. The group's findings were presented today at the 59th American Society of Hematology annual meeting in Atlanta by lead authors Alessandro Vannucchi, M.D., from the University of Florence and Ayalew Tefferi, M.D., a hematologist at Mayo Clinic. (2017-12-09)

Flavonoids as P-gp inhibitors: A systematic review of SARs
This review concerned the recent updates on the structure-activity relationships of flavonoids as P-gp inhibitors, the molecular mechanisms of their action and their ability to overcome P-gp-mediated MDR in preclinical studies. (2018-12-26)

Growing number of patients who might benefit from liver transplant removed from wait list
The sickest liver transplant candidates should be first in line when a donor liver becomes available, but transplant centers are increasingly removing these individuals from the waiting list, considering them 'too sick to transplant,' an analysis of nationwide transplant data finds. The study appears online as an 'article in press' on the Journal of the American College of Surgeons website in advance of print publication. (2016-04-28)

Does negative political advertising actually work?
While many may dread campaign season because of pervasiveness of negative political advertising, a new study in the INFORMS journal Marketing Science has found that negative political advertising actually works, but perhaps not in the way that many may assume. (2018-06-04)

Research into tropical eye worm yields new tests to assess safety of anti-filarial drugs
Researchers at the LSTM's Centre for Drugs and Diagnostics, and University of Buea, Cameroon have developed new models of the tropical eye worm, Loa loa for the development of new drugs against filariasis. (2019-03-29)

New model of polarization sheds light on today's politics
Americans are no longer voting for just the candidates who suit them best -- they're also voting strategically to empower their preferred political party in the legislature, and it's driving us apart, according to a new model of electoral competitiveness developed by Vanderbilt economist Mattias Polborn. (2018-10-03)

Social media has remarkably small impact on Americans' beliefs
Social media had only a small influence on how much people believed falsehoods about candidates and issues in the last two presidential elections, a pair of new national studies found. And Facebook -- which came under fire for spreading misinformation in the 2016 campaign -- actually reduced misperceptions by users in that election compared to those who consumed only other social media. (2019-03-27)

Biological engineers discover new antibiotic candidates
Researchers from MIT and the University of Naples Federico II found that fragments of the protein pepsinogen, an enzyme used to digest food in the stomach, can kill bacteria such as Salmonella and E. coli. Such peptides could potentially be developed as new antibiotics. (2018-08-20)

The importance of addressing poor nutrition in patients with liver failure
Poor nutrition is common in patients with liver failure, or cirrhosis, and it can lead to muscle wasting, weakness, fatigue, and worse outcomes before and after patients undergo liver transplantation. (2017-10-26)

Transgender political candidates still likely face an uphill battle, study finds
A new study led by a University of Kansas political scientist found 35 percent-40 percent of adults would oppose a transgender candidate for office, which was higher than the 30 percent who would likely oppose a gay or lesbian candidate. (2017-02-21)

Kepler scientists discover almost 100 new exoplanets
Based on data from NASA's K2 mission an international team of scientists have just confirmed nearly 100 new exoplanets, planets located outside our solar system. This brings the total number of new exoplanets found with the K2 mission up to almost 300. The new results are to be published in the Astronomical Journal. (2018-02-15)

New guidelines label millions more people as having high blood pressure
Adopting new guidelines for high blood pressure (hypertension) would dramatically increase the number of people labeled as having the condition and being recommended for drug treatment, finds a study published by The BMJ today. (2018-07-11)

How the 'I approve' tagline boosts nasty political ads
New research by Berkeley Haas Assoc. Prof. Clayton Critcher finds that adding the required 'I approve this message' tagline to negative campaign ads makes them more credible. (2018-02-22)

Physiological response may explain why some severely obese patients overeat
Severely obese adults respond more slowly to repeated food exposure than normal weight individuals. Delayed response is linked to reduced rates of satiation, or fullness, during a meal. This study is first of its kind to compare severely obese patient and normal weight individuals. (2009-06-09)

A novel molecule could spur new class of drugs for breast cancer
Researchers at Stevens Institute of Technology and colleagues have designed and developed a new class of molecules that use a never-before-known mechanism that may halt or destroy breast cancer tumors, particularly for patients with drug-resistant or dangerously metastatic stages of the disease. (2018-10-03)

Election 2019: Hope for a national pharmacare plan
The 2019 federal election in Canada brings hope for universal pharmacare if Canadians ensure the elected government delivers on the long-delayed promise of universal access to essential medications, argues an editorial in CMAJ (Canadian Medical Association Journal). (2019-10-15)

Presidential debates are mostly positive and emphasize policy
Democrat Barack Obama and Republican John McCain are preparing for their first presidential debate this week. William Benoit, one of the nation's leading experts on political campaigns at the University of Missouri, says presidential debates have become an important part of presidential campaigns since 1960. (2008-09-24)

Researchers closer to gonorrhea vaccine after exhaustive analysis of proteins
In a study of proteins historic in its scope, researchers have pushed closer both to a vaccine for gonorrhea and toward understanding why the bacteria that cause the disease are so good at fending off antimicrobial drugs. (2018-11-08)

Two for the price of one: Mechanistic insights lead to drug repositioning
A University of Tsukuba-led team confirmed that the binding of the cancer-promoting protein stratifin to phosphorylated SKP1 prevents the formation of a ubiquitinating enzyme complex. This hinders the degradation of several oncoproteins, which promotes lung adenocarcinogenesis. The team then used in silico, in vitro, and in vivo analyses to identify and test drugs that inhibit this binding, with two drugs successfully reducing tumor development and progression. This work raises hopes in the fight against lung adenocarcinoma. (2019-03-07)

Pitt, US Army team designs new strategy to find drugs to treat neglected infection
Using an unconventional approach that they designed, University of Pittsburgh drug discoverers and their collaborators at Walter Reed Army Institute of Research have identified compounds that hold promise for treating leishmaniasis, a parasitic infection that many consider one of the world's most overlooked diseases. The findings are available online today in PLoS Neglected Tropical Diseases. (2009-11-02)

Fewer medical tests -- timely listing for transplantation
Younger patients would benefit greatly from kidney transplantation. Their expected remaining lifetime may even be doubled by having a transplant. 'We have to do all we can to get young patients listed for transplantation as soon as possible, preferably pre-emptively', says Professor Luuk Hilbrands, Chair of the DESCARTES working group of the ERA-EDTA. A proposal for the work-up of low-risk kidney transplant candidates has now been published for that reason. (2019-01-22)

Would you vote for a Democrat who behaves like a Republican?
The Bright Line Watch team tested how committed the American public really is to its democracy. Are there universal democratic principles that, if violated by politicians, would generate resistance from the public, and would citizens of all political stripes be equally willing to punish candidates for such violations? The team's finding is striking: partisanship outweighs all other factors for both Republicans and Democrats. (2019-01-07)

Racial disparities in kidney transplantation rates eased by new allocation system
Year-old changes to the system that distributes deceased donor kidneys nationwide have significantly boosted transplantation rates for black and Hispanic patients on waiting lists, reducing racial disparities inherent in the previous allocation formula used for decades, according to results of research led by a Johns Hopkins transplant surgeon. (2016-01-05)

Injection alternative
MIT researchers have created a computer model that can predict how glucose-responsive insulin will affect patients' blood sugar based on chemical traits such as how quickly it becomes activated in the presence of glucose. This could help scientists design insulin that lingers in a patient's bloodstream and becomes active only when needed, such as right after a meal. (2017-09-26)

Why liver transplant waitlists might misclassify high-risk patients
A new study in the journal Gastroenterology reveals that the standard method for ranking patients on the waitlist for lifesaving liver transplantation may not prioritize some of the sickest candidates for the top of the list. (2019-01-24)

Patients who lose significant weight before a transplant are at higher risk of dying
Unexpected weight loss can be the sign of a serious health problem, especially in kidney transplant patients whose body systems are already under duress. But a new study out of Drexel University suggests that even planned and advised weight loss could also be dangerous for kidney transplant candidates if it's not closely monitored. (2019-05-21)

Searching for ingredients of dark matter and dark energy
Two new reports advance efforts to identify components of dark matter and energy, which together comprise about 95 percent of the universe yet leave much to scientists' imaginations. (2015-08-20)

One hit of crystal meth causes birth defects: U of T study
A single prenatal dose of methamphetamine - commonly known as speed - may be enough to cause long-term neurodevelopmental problems in babies, say University of Toronto researchers. (2005-07-26)

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