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Overcoming hurdles in CRISPR gene editing to improve treatment
The new gene-editing tool CRISPR/Cas9 holds promise for new treatment of such genetic diseases as cystic fibrosis, muscular dystrophy and hemophilia. But to work well, it must be delivered across the cell membrane and into its nucleus, a process that can trigger cell defenses and 'trap' CRISPR/Cas9, reducing its treatment potential. Now, Vincent Rotello's laboratory at UMass Amherst has designed a delivery system using nanoparticles to assist CRISPR/Cas9 across the membrane and avoid entrapment by cellular machinery. (2017-02-07)

3-D 'organoids' grown from patient tumors could personalize drug screening
Three-dimensional cultures (or 'organoids') derived from the tumors of cancer patients closely replicate key properties of the original tumors, reveals a study published May 7 in Cell. These 'organoid' cultures are amenable to large-scale drug screens for the detection of genetic changes associated with drug sensitivity and pave the way for personalized treatment approaches that could optimize clinical outcomes in cancer patients. (2015-05-07)

Stem cell pioneer Elaine Fuchs wins cell biologists' highest science honor
Hailed as a pioneer in exploring the basic principles of stem cell biology, Elaine Fuchs of Rockefeller University has been named the winner of the 2015 E.B. Wilson Medal, the highest scientific honor awarded by the American Society for Cell Biology. (2015-04-21)

Happy hospitals make happy patients
Imagine a hospital where morale is high, employee turnover is low and patient call buttons rarely go unanswered -- and if they do, you can call the hospital's CEO. (2009-02-09)

Enhanced test for urinary tract infections detects more bacteria than standard test
One of the primary ways physicians diagnose urinary tract infections is with a test that detects bacteria in urine. A new enhanced test, developed at Loyola University Chicago, detects significantly more bacteria than the standard test, according to a study presented at a meeting of the American Society for Microbiology in New Orleans. (2017-06-03)

'Mixed' family moms ensure minority culture continues in the home
The mothers of Britain's (2012-05-15)

Faster eye responses in Chinese people not down to culture
New research from University of Liverpool scientists has cast doubt on the theory that neurological behavior is a product of culture in people of Chinese origin. (2014-04-07)

When it comes to making patients safer, is a hospital's 'safety culture' that important?
If you work in a hospital these days, you've probably gotten the invitation: Take a survey about how well you, your team and your hospital do at protecting patients from harm, and how empowered you feel to do the right thing. Together, the results provide a hospital's 'patient safety culture' score. But a new study questions whether such surveys actually measure how well a hospital is doing at keeping patients safe. (2016-06-03)

1.6 million euros from the DFG: Nok culture study enters its third round
The scientific team of the Institute for Archaeological Sciences, which has been researching the Nok culture in Nigeria since 2005, can continue its successful work: the German Research Foundation will support the total 12-year duration of the planned long-term project for another three years with 1.6 million euros. (2015-01-31)

Researchers discover how leukaemia virus spreads through the body
Researchers from Imperial College London, University of Oxford, Kagoshima University (Japan) and University of the Ryukyus (Japan) have discovered the mechanism by which human T-lymphotropic virus type 1 (HTLV-1), the virus which causes adult T-cell leukaemia, spreads through the body. (2003-02-13)

Researchers gain detailed insight into failing heart cells using new nano technique
Researchers have been able to see how heart failure affects the surface of an individual heart muscle cell in minute detail, using a new nanoscale scanning technique developed at Imperial College London. The findings may lead to better design of beta-blockers, the drugs that can slow the development of heart failure, and to improvements in current therapeutic approaches to treating heart failure and abnormal heart rhythms. (2010-02-25)

Stem cells yield nature's blueprint for body's vasculature
A team led by Igor Slukvin, a University of Wisconsin-Madison professor of pathology and laboratory medicine, and cell and regenerative biology, describes the developmental pathway that gives rise to the different types of cells that make up human vasculature. (2017-05-30)

Ingestible capsule that could help demystify the gut-brain axis
A team of University of Maryland experts from engineering, neuroscience, applied microbiology, and physics has been making headway on building a platform that can monitor and model the real-time processing of gut microbiome serotonin activity. (2020-10-15)

Top story for cancer research
A team of researchers led by Dr. Friederike J. Gruhl and Professor Andrew C. B. Cato at Karlsruhe Institute of Technology (KIT) are developing a three-dimensional model for prostate cancer research based on cryogels. The model will be used to reproduce natural processes and above all to examine the development and the progression of tumors. A current paper on this project published in the scientific journal Small (DOI: 10.1002/smll.201600683). (2016-06-24)

Go for the good deal -- and get a dose of spirituality
Israeli backpackers find themselves hosted by Christian missionaries in New Zealand because of the good lodging deals that they offer; but during their stay, these Israelis also get unique spiritual experiences. This has been illustrated in a new study carried out at the University of Haifa's Center for Tourism, Pilgrimage and Recreation. (2010-01-19)

Regulating cell shape in mycobacteria
Dr. Robert Husson and colleagues have found two serine threonine kinase genes (pknA and pknB) that regulate cell shape, and possibly cell division, in the bacterial pathogen, Mycobacterium tuberculosis. (2005-07-14)

UIC chemists identify compound that inhibits cell migration
A high-throughput assay developed at University of Illinois-Chicago has led to discovery of a small organic compound that shows ability to inhibit cell migration. (2002-10-22)

Latchkey Youth At Much Greater Risk For Alcohol And Drug Use
About half of middle-school-age kids routinely spend time home alone after school, according to estimates. Those who do are much more likely to experiment with alcohol or drugs, says a University of Illinois researcher, based on a survey of fifth through seventh-graders work in three communities. (1996-11-07)

Consortium formed around stem cell research in inland Southern California
Stem cell research laboratories at the University of California, Riverside, Loma Linda University and the California State University at San Bernardino have formed the (2012-05-04)

Scripps Florida scientists uncover potential drug target to block cell death in Parkinson's disease
Oxidative stress is a primary villain in a host of diseases that range from cancer and heart failure to Alzheimer's disease, amyotrophic lateral sclerosis and Parkinson's disease. Now, scientists from the Florida campus of the Scripps Research Institute have found that blocking the interaction of a critical enzyme may counteract the destruction of neurons associated with these neurodegenerative diseases, suggesting a potential new target for drug development. (2013-01-10)

BUSM study: Obesity may be impacted by stress
A new study shows that stress may play a role in the development of obesity. Using experimental models, researchers at Boston University School of Medicine showed that adenosine, a metabolite released when the body is under stress or during an inflammatory response, stops the process of adipogenesis, when adipose stem cells differentiate into adult fat cells. (2014-07-15)

Ethnic identity expressed in clothing is good for adolescents' mental health
Young people who dress according to the customs of their own ethnic group are less likely to have subsequent mental health problems than those who don't, suggests research in the Journal of Epidemiology and Community Health. (2008-04-14)

Hydrolyzed or non-hydrolyzed collagen: which one is suitable for nerve cell culture?
Hydrolyzed or non-hydrolyzed collagen: which one is suitable for nerve cell culture? (2013-09-05)

Local perception of US military buildup in Guam
University of Guam assistant professor Amy Owen and her students recently completed a research project on the perception of local residents regarding the US military buildup in Guam and related immigration issues. (2010-04-22)

New procedure allows long-term culturing of adult stem cells
A new procedure developed at Massachusetts General Hospital may revolutionize the culturing of adult stem cells. The approach has successfully generated and expanded airway stem cells from the sorts of samples collected during routine treatment of lung disorders and may be applicable to several other tissue types, including skin and the linings of the gastrointestinal and reproductive tracts. (2016-06-16)

Viral life cycle of malignant catarrhal fever explained
The mysterious life cycle of a sheep virus that causes malignant catarrhal fever has been discovered by Agricultural Research Service scientists and their university collaborators -- the first step in developing a vaccine against the disease. (2010-04-05)

New DNA stain lights up living cells
EPFL scientists have developed a new DNA stain that can be used to image living cells. (2015-10-01)

Freedom's just another word for employee satisfaction
Workers who feel they have autonomy -- that they are free to make choices in the workplace and be accountable for them -- are happier and more productive according to an extensive research literature review. Yet there's no universal cross-cultural definition of autonomy. (2011-01-24)

Wait for it: How do wealth and culture guide international product rollouts?
How do wealth and culture affect the international success of a new product, especially for those nations that have to wait? According to a new study in the Journal of International Marketing, national wealth and cultural characteristics such as individualism play a large part in citizens' enthusiasm and patience for new products. (2014-12-09)

Early study finds antibody that 'neutralizes' Zika virus
Researchers studied Zika survivors and made human monoclonal antibodies from their B cells that kill the virus. In mouse models of infection including pregnant mice, some of the antibodies protect against infection and disease including the fetuses. (2016-11-07)

Component of plastic stimulates growth of certain prostate cancer cells
An estrogen-like chemical commonly used to synthesize plastic food containers has been shown to encourage the growth of a specific category of prostate cancer cell, potentially affecting the treatment efficacy for a subset of prostate cancers. (2005-01-03)

New screening tool could speed development of ovarian cancer drugs
Researchers have built a model system that uses multiple cell types from patients to rapidly test compounds that could block the early steps in the spread of ovarian cancer. Their 3-D cell culture system has enabled them to identify small molecules that can inhibit adhesion and invasion, hallmarks of cancer metastasis. (2015-02-09)

U. of Colorado team solves mystery of carcinogenic mothballs
Chemical compounds in household products like mothballs and air fresheners can cause cancer by blocking the normal process of (2006-06-20)

WHO-recommended disinfectants are effective against novel coronavirus
When used correctly, both alcohol-based hand disinfectants recommended by the World Health Organization (WHO) are effective against the novel coronavirus Sars-Cov-2, as confirmed by an international research team headed by Professor Stephanie Pfänder from the Department of Molecular and Medical Virology at Ruhr-Universität Bochum (RUB). The journal Emerging Infectious Diseases published the relevant article in its online edition on April 13, 2020. (2020-04-16)

'R.E.A.L.' offers multicultural approaches to substance-abuse prevention among middle-schoolers
The program (2004-03-10)

Low-dose naltrexone (LDN): Tricking the body to heal itself
Researchers at the Pennsylvania State University College of Medicine, have discovered the mechanism by which a low dose of the opioid antagonist naltrexone (LDN) can suppress cell proliferative-related disorders such as cancer and autoimmune diseases. LDN causes a compensatory increase in an endogenous opioid, the opioid growth factor (OGF, [Met5]-enkephalin), and the OGF receptor (OGFr). (2011-09-02)

CU-Boulder Students To Excavate Ancient Pueblo Site In Four Corners
University of Colorado at Boulder students will begin a major excavation this June at an ancient Pueblo Site in the Four Corners region which appears to be linked to the mysterious Chaco culture that once dominated much of the Southwest. (1996-05-30)

Spicy molecule inhibits growth of breast cancer cells
Capsaicin, an active ingredient of pungent substances such as chilli or pepper, inhibits the growth of breast cancer cells. This was reported by a team headed by the Bochum-based scent researcher Hanns Hatt and Lea Weber, following experiments in cultivated tumor cells. The experiments were carried out with the SUM149PT cell culture, a model system for a particularly aggressive type of breast cancer, i.e. the triple-negative type. Chemotherapy is currently the only available treatment for this type of cancer. (2016-12-20)

New book aims to clear up 'hookup culture' confusion
As students return to campus post-holiday break, a Michigan State University professor has released an e-book she hopes will demystify the 'hookup culture' that often accompanies the college social scene. (2015-01-08)

International space station plays host to innovative infectious disease research
Nickerson, a microbiologist at Arizona State University's Biodesign Institute, is using the ISS platform to pursue new research into the effects of microgravity on disease-causing organisms. (2013-02-18)

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