Popular Chagas Disease News and Current Events

Popular Chagas Disease News and Current Events, Chagas Disease News Articles.
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UTEP team advances in developing vaccine for cutaneous leishmaniasis
A research team at The University of Texas at El Paso is one step closer to developing an effective human vaccine for cutaneous leishmaniasis. During the team's more than four years of research at UTEP's Border Biomedical Research Center, they discovered a vaccine formulation that resulted in a 96 percent decrease in the lesions caused by the illness and showed an 86 percent protection rate from the disease in mice. (2017-11-15)

New safety data for the most commonly used drug to treat Chagas disease
The frequency of adverse reactions to benznidazole is high when treating chronic Chagas patients, although they were mostly mild effects, according to a study led by ISGlobal, in collaboration with the Hospital Clinic of Barcelona. The results point to the need of finding drug combinations or dosages in order to maintain efficacy but decrease its toxicity. (2018-02-20)

Seroprevalence and disease burden of chagas disease in south Texas
A paper published in PLOS Neglected Diseases led by researchers at the National School of Tropical Medicine at Baylor College of Medicine suggests that the disease burden in southern Texas is much higher than previously thought. Considering up to 30 percent of people infected with Trypanosoma cruzi can develop fatal cardiomyopathy, this study's findings carry important implications to the health of the population of south Texas. (2016-11-10)

Discovering potential therapeutic protein inhibitors for Chagas disease
Scientists at Tokyo Institute of Technology (Tokyo Tech), Nagasaki University have identified four potential protein inhibitors and unlocked drug discovery strategies for the treatment of Chagas disease by using advanced three-dimensional computer simulation by supercomputer TSUBAME in combination with in vitro experiments and X-ray crystallography. Through this (2017-09-26)

Study describes enzyme's key role in immune response to Chagas disease parasite
A study shows that the expression of PI3Kγ protein increases during infection by T. cruzi, an essential response in avoiding excessive inflammation and controlling parasitemia. Heart tissue analyses involving human patients who developed cardiopathy in the disease's chronic stage also provided results. The next challenge is to devise treatment for Chagas using molecules capable of modulating the cellular signaling pathway mediated by PI3Kγ. (2018-07-13)

New enzyme-mapping advance could help drug development
Scientists at MIT and the University of São Paulo in Brazil have identified the structure of an enzyme that could be a good target for drugs combatting three diseases common in the developing world. (2016-08-15)

Biomarkers may predict Zika-related birth defects
The highest risk of birth defects is from Zika virus infection during the first and second trimester. A prenatal test has the potential to relieve the concerns of many expectant mothers (2018-11-02)

Mobile device by UCLA makes the detection of parasitic infections faster and more sensitive
Researchers at the UCLA Henry Samueli School of Engineering have developed an inexpensive and portable platform that can rapidly detect motile parasites in bodily fluids automatically. Using their platform, more than 3 mL of a bodily fluid sample can be imaged and analyzed within 20 min, providing a throughput that is orders of magnitude better than traditional optical microscopy-based examination. (2018-12-13)

New center to study deadly microbial pathogens
The Keck Center for Functional, Structural, and Chemical Genomics of Microbial Pathogens will unite 20 UW faculty to exploit the full medical potential of existing and forthcoming microbial genome sequences. In addition, the Keck Center will attract new faculty in the areas of mass spectrometry, crystallography, and proteomics. In the United States, the rate of deaths caused by infectious disease has grown from 36 per 100,000 in 1981 to at least 63 per 100,000. (2002-03-06)

OneWorld Health licenses compounds from Yale, U of Washington to treat major parasitic diseases
The Institute for OneWorld Health has licensed highly potent azole compounds from Yale and the University of Washington that could result in new medicines for parasitic diseases, initially for Chagas, in the developing world, and new antifungals for the developed world. The compounds broaden OneWorld Health's product portfolio for Chagas disease, which afflicts up to 18 million people in Latin America, and at least 50,000 to 100,000 in the U.S. The license also creates a unique dual market opportunity. (2003-07-08)

Deciphering the early stages of Parkinson's disease is a matter of time
Researchers at the Federal University of Rio de Janeiro, Brazil, and the University of Virginia School of Medicine, USA, identified for the first time the initial steps of alpha-synuclein protein aggregates related to early onsets of hereditary Parkinson cases. The results may help the understanding of the early stages of the disease and how it develops over time. (2019-10-11)

Antimicrobial used in toiletries could become option against malaria
Not only it inhibits enzymes essential to Plasmodium's survival in two key stages of its lifecycle in humans, but triclosan also performed well in tests against resistant parasites, an international study reveals. The efficiency of malaria treatment with mostly used drugs is undermined by resistant lineages and by the fact that patients present severe side effects in 10 percent of the cases. (2018-03-22)

Seeking the secret ingredient in the original smallpox vaccine
Thanks to a secret vaccine ingredient as well as a net of worldwide researchers and successful vaccination campaigns, smallpox was finally eradicated in 1977. A new study entitled 'Revisiting Jenner's mysteries, the role of the Beaugency lymph in the evolutionary path of ancient smallpox vaccines' and published in The Lancet Infectious Diseases, provides an in-depth investigation of the mysteries associated with the development of smallpox vaccine and is a rich and interesting account of how the vaccine lymph was spread worldwide. (2017-08-18)

Potential Zika vaccine protects against pregnancy transmission and testicular damage
For the first time, a collaborative team led by The University of Texas Medical Branch at Galveston has shown that a potential Zika vaccine quickly can protect fetuses against infection as well as protect males against testicular infection and injury. It also prevents a lowered sperm count after one vaccination. The findings are currently available in Nature Communications. (2017-09-26)

Patients with chagas disease are often infected with an intestinal parasite
In patients with Chagas Disease, the odds of being infected by the intestinal worm Strongyloides stercoralis increases by two-fold, according to a study led by the Barcelona Institute for Global Health (ISGlobal). The study, published in Plos Neglected Tropical Diseases, underlines the potential benefits of performing a combined screening for both infections among Latin American adults living in Europe. (2018-02-14)

Artificial intelligence identifies 'kissing bugs' that spread Chagas disease
A University of Kansas researcher publishes proof-of-concept research showing artificial intelligence can recognize 12 Mexican and 39 Brazilian species of kissing bugs with high accuracy by analyzing ordinary photos -- an advantage for officials looking to cut the spread of Chagas disease. (2019-06-20)

Leeches ferry infection among newts
Parasite-carrying bloodsucking leeches may be delivering a one-two punch to newts, according to biologists, who say the discovery may provide clues to disease outbreaks in amphibians. (2007-01-31)

Tapeworm brain infection 'serious health concern'
Tapeworm infections of the brain, which can cause epileptic seizures, appear to be increasing in Mexico and bordering southwestern states, Loyola University Health System researchers report. (2010-04-13)

Central America 'kissing bug' carries two main subtypes of Chagas disease parasite
Trypanosoma cruzi, the parasite that causes Chagas disease, is divided into six strains, each of which differs in where they are found and in how important they are in human infections. Now, researchers have found that most T. cruzi parasites in Central America belong to just two of those strains. The results are detailed this week in PLOS Neglected Tropical Diseases. (2017-09-28)

Zika virus successfully diagnosed from semen
Research presented at ASM Microbe 2017 by experts at the Fertility and Cryogenics Lab shows a reliable clinical assay that can detect the Zika virus from semen samples. (2017-06-04)

UK scientists opening up access to science through DIY equipment
Scientists at the University of Sussex have developed a piece of hardware to demonstrate how our brains function, as part of a growing range of equipment which uses DIY and 3D printable models to open up access to science education. (2018-11-08)

Study finds multiple neglected tropical diseases effectively treated with drugs
The neglected tropical diseases are a group of 13 infectious diseases, including elephantiasis, hookworm, African sleeping sickness and trachoma, which affect more than one billion people worldwide, most of whom live in extreme poverty. In a study published in the most recent Journal of the American Medical Association, Madhuri Reddy, MD, MSc, a geriatrician at Hebrew SeniorLife in Boston, says that treating two or more of them simultaneously for only pennies per dose can facilitate treatment of these diseases. (2007-10-25)

Alzheimer's drug also treats parasitic Chagas disease
The drugs currently used to treat Chagas disease, a neglected tropical disease, have serious side effects and limited use in those with chronic disease. Now, researchers have reported in PLOS Neglected Tropical Diseases that memantine, a drug currently used to treat Alzheimer's disease, can diminish the number of parasites in mice with Chagas disease, and increase the survival rate of the animals. (2019-09-19)

NMR structure of a key anticoagulant protein may help prevent thrombosis
A group of researchers from Brazil and the United States describes for the first time the structure of Ixolaris, an important anticoagulant protein found in tick saliva, and its interaction with Factor Xa, a key enzyme in the process of blood clotting. The results may benefit cancer patients, of whom approximately 20% will develop thrombosis during the disease progression. (2019-05-27)

Shorter treatment for Chagas disease could be just as effective, and significantly safer
A two-week treatment course for adult patients with chronic Chagas disease showed, when compared to placebo, similar efficacy and significantly fewer side effects than the standard treatment duration of eight weeks, according to the results of a clinical trial in Bolivia led by the Drugs for Neglected Diseases initiative (DNDi). (2019-03-14)

Study shows promising safety results for anti-aging drug
A recent study published in the November issue of the journal Aging showed minimal metabolic side effects after continuous, long-term treatment with encapsulated rapamycin in a marmoset (monkey) model. Results lead to new research grant to study efficacy. (2016-02-09)

Drugs for Neglected Diseases initiative unveils new plan for neglected patients
After having built the world's largest drug development pipeline for the most neglected diseases, the Drugs for Neglected Diseases initiative has unveiled plans for a more flexible, dynamic portfolio approach, integrating various operating models to better respond to the needs of patients, notably in low- and middle-income countries. The plan also paves the way for new diseases to be taken up in DNDi's portfolio. (2015-09-08)

Scans show immune cells intercepting parasites
Researchers may have identified one of the body's earliest responses to a group of parasites that causes illness in developing nations and are now infecting US soldiers on patrol in Iraq and Afghanistan. (2008-12-10)

Scientists identify a key gene in the transmission of deadly African sleeping sickness
An international team of life scientists has identified a key gene in the transmission of African sleeping sickness -- a severe disease transmitted by the bite of an infected, blood-sucking tsetse fly, which is common in Sub-Saharan Africa. The disease is fatal if untreated. Tens of millions of people in 36 countries are at risk. There is no vaccine, and conventional drug treatments are not very effective and have severe side effects. (2019-04-10)

Targets and patented drugs for chemotherapy of Chagas disease
Chagas disease is a parasitic infection typically spread by triatomine vectors, affecting millions of people all over Latin America. Existing chemotherapy is centered on benznidazole and nifurtimox, providing unsatisfactory results and substantial side effects. The transmission of the disease by people migration has determined the emergence as a public health problem elsewhere in non-endemic countries of the word. So, the finding of novel ways to challenge this neglected disease is a main priority. (2017-01-16)

Celgene joins DNDi's 'Drug Discovery Booster'
The biopharmaceutical company Celgene has become the fifth company to join the 'Neglected Tropical Diseases Drug Discovery Booster' consortium, a new initiative to accelerate and cut the cost of early stage drug discovery for two of the world's most neglected diseases, leishmaniasis and Chagas disease. (2016-06-15)

Zika virus infects the adult human brain and causes memory deficits in animal models
A new study conducted by Brazilian researchers found that Zika virus infects and replicates in adult human brain tissue. Scientists also found that infection causes long-lasting learning and memory deficits in adult mice. The results demonstrate that the adult brain (and not only the developing brain, as previously thought) is attacked and damaged by ZIKV, and indicate the need to investigate memory and cognitive deficits as potentially serious comorbidities in ZIKV-infected adults. (2019-09-05)

New clues about the origins of familial forms of Amyotrophic lateral sclerosis
A Brazilian study made important progress in understanding the accumulation of one of the proteins involved in amyotrophic lateral sclerosis (ALS). Scientists were able to gain insight into the interaction between normal and mutant forms of a protein known as superoxide dismutase 1 (Sod1). The process alters protein accumulation in the cell, but also impairs the function of Sod1 protein, thus contributing to the development of the disease. (2019-12-02)

The Lancet Infectious Diseases: Experts warn of a surge in vector-borne diseases as humanitarian crisis in Venezuela worsens
The ongoing humanitarian crisis in Venezuela is accelerating the re-emergence of vector-borne diseases such as malaria, Chagas disease, dengue, and Zika virus, and threatens to jeopardize public health gains in the country over the past two decades, warn leading public health experts. The conclusion comes from a Review paper that provides the most comprehensive assessment of the impact of the crisis in Venezuela, published in The Lancet Infectious Diseases journal. (2019-02-21)

Chagas disease, caused by a parasite, has spread outside of...
Chagas disease is caused by a parasite, transmitted by a blood-sucking insect -- Trypanosoma cruzi -- and less frequently, from mother to fetus or by contaminated food or drink. About one third of infected individuals develop chronic heart disease. Though mostly found in Central and South America, Chagas disease has become more common worldwide, including an estimated 300,000 infected persons in the United States. (2018-08-20)

Resveratrol reverses heart damage in mice with Chagas disease
Resveratrol is the antioxidant found in red wine and famous as a food supplement capable of mimicking the effects of exercise and low calorie diets in the heart. Now Vilar-Pereira and colleagues show that treatment with resveratrol reverses heart damage and improves heart function in mice with Chagas disease, in a new study published in PLOS Pathogens. The findings open up a new potential pathway to better treatments in humans. (2016-10-27)

Does Chagas disease present a health risk to Canadians?
Believe it or not, a tropical blood parasite native to Latin America could be harmful to Canadians. Infectious diseases like malaria or Zika may have dominated recent headlines but Chagas -- the 'Kissing Bug' disease -- is in the spotlight following the publication of a new case study in the Canadian Medical Association Journal. Experts from Winnipeg and Montreal warn natives of Latin America and their offspring are at risk of contracting Chagas disease. (2017-12-13)

IDRI contributes to first point-of-care Chagas disease diagnostic for US
With Chagas disease becoming more prevalent in the United States, a diagnostic to quickly and easily detect infection is needed. Today, IDRI (Infectious Disease Research Institute) announces that a fusion antigen it developed and patented is being used as part of a Chagas disease diagnostic test created by InBios and recently approved by the US Food & Drug Administration (FDA) for use in the United States. This marks the first point-of-care diagnostic test for Chagas disease available in the United States. (2017-01-12)

Tips from the journals of the American Society for Microbiology
The following are tips from the journals of the American Society for Microbiology: (2010-08-20)

Laying sleeping sickness to rest
The parasite that leads to sleeping sickness can be lulled to sleep itself using a newly discovered pathway, according to research published online this week in EMBO reports. Trypanosoma brucei is a parasite that causes sleeping sickness resulting in neurological damage and death. (2007-03-19)

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