Popular Chromatin News and Current Events | Page 20

Popular Chromatin News and Current Events, Chromatin News Articles.
Sort By: Most Relevant | Most Recent
Page 20 of 21 | 822 Results
Activation of microRNA inhibits cancer gene in human cancer cells
Scientists report that tumor cells display a dramatic reduction of cancer-causing genes when a newly discovered method is used to activate the expression of protective microRNAs in the cancer cell genome. The research, published in the June issue of Cancer Cell, demonstrates that agents known to regulate gene expression can also impact regulatory RNAs that may function as tumor suppressors in normal cells and proposes a novel strategy for treating human cancers. (2006-06-12)

Stowers study hints that stem cells prepare for maturity much earlier than anticipated
Unlike less versatile muscle or nerve cells, embryonic stem cells are by definition equipped to assume any cellular role. Scientists call this flexibility (2012-12-27)

Protein complex may play role in preventing many forms of cancer, Stanford study shows
Researchers at the Stanford University School of Medicine have identified a group of proteins that are mutated in about one-fifth of all human cancers. The finding suggests that the proteins, which are members of a protein complex that affects how DNA is packaged in cells, work to suppress the development of tumors in many types of tissues. (2013-05-05)

Solving the mechanism of Rett Syndrome
For the first time a human disease has been linked to specific defects in the three-dimensional folding of chromatin. Young girls affected with Rett Syndrome become withdrawn and anxious and develop autistic-like behaviors. The devastating neurological disease was recently tracked to mutations in a gene on the X chromosome, MECP2. How the mutated gene causes the disorder has now been revealed by a team of scientists with the Department of Energy's Lawrence Berkeley National Laboratory. (2004-12-19)

PBX1 identified as a new pioneer factor underlying progression in breast cancer
The presence of a new pioneer factor, known as PBX1, can guide the response to estrogen in breast cancer cells according to researchers at Dartmouth-Hitchcock Norris Cotton Cancer Center in results published on Nov. 17 in the open-access journal PLoS Genetics. (2011-11-17)

Newly identified molecules contribute to normal silencing of most human genes
Most of the time, most of the estimated 35,000 genes in the human genome are silent, securely stored away in the tightly coiled structure of chromatin, which makes up chromosomes. Now, a team of researchers at The Wistar Institute reports discovery of a family of molecular complexes involved in the repression of extensive sets of tissue-specific genes throughout the body. The new findings may have relevance for understanding certain forms of cancer and other diseases. (2003-03-07)

Learning to read the genome
As part of the National Institutes of Health's (2010-12-22)

UD leads $5.3-million research project on rice epigenetics
Using a novel (2007-09-10)

SMU and UNC researchers make an advance in our understanding of gene regulation
Researchers from Southern Methodist University and the University of North Carolina have made an important advance in our understanding of gene regulation. The new insight comes from discovering the biochemical mechanisms by which an important protein works to silence genes. (2002-09-26)

FANTOM findings boost for biologists
Genomic regulatory blocks have unique features that may explain their ability to respond to regulatory inputs from very long distances, according to a special thematic series of companion articles from the FANTOM4 consortium. This research, to be published across a number of BioMed Central's open-access journals, including Genome Biology and BMC Bioinformatics, provide further insight into HCNE (highly conserved noncoding element) mediated long-range gene regulation at the core of animal multicellularity regulation. (2009-04-20)

Berkeley Lab scientists create first 3-D model of a protein critical to embryo development
Berkeley Lab researchers have constructed the first detailed and complete picture of a protein complex that is tied to human birth defects as well as the progression of many forms of cancer. Knowing the architecture of this protein, PRC2, should be a boon to its future use in the development of new and improved therapeutic drugs. (2012-09-14)

Researchers identify a potentially universal mechanism of aging
Researchers have uncovered what may be a universal cause of aging, one that applies to both single cell organisms such as yeast and multicellular organisms, including mammals. This is the first time that such an evolutionarily conserved aging mechanism has been identified between such diverse organisms. The mechanism probably dates back more than 1 billion years. The study shows how DNA damage eventually leads to a breakdown in the cell's ability to properly regulate which genes are switched on and off in particular settings. (2008-11-26)

UVa-led team uncovers important secret in gene replication
A team of researchers led by University of Virginia Health System geneticists has uncovered a major secret in the mystery of how the DNA helix replicates itself time after time. It turns out that it is not just the sequence of the bases -- building blocks -- in the DNA, but also how loosely or tightly the chromatin -- the material that makes up chromosomes -- is packed at different points of the chromosome that is critical. (2007-06-13)

When every photon counts
The photoreceptor cells in the retinas of nocturnal mammals have a unique nuclear organization and act as light-guiding micro-lenses. This improves nocturnal vision. (2009-04-20)

UBC researchers discover 'instruction manual' that tells cancers how to hide from immune system
A mechanism that creates an (2007-11-08)

UNC researchers identify important step in sperm reprogramming
A study from the University of North Carolina at Chapel Hill School of Medicine gives stem cell researchers critical information as they try to reprogram adult cells to mimic the curative and self-renewing properties of stem cells. (2011-09-22)

Gene packaging tells story of cancer development
To decipher how cancer develops, Johns Hopkins Kimmel Cancer Center investigators say researchers must take a closer look at the packaging. (2008-12-04)

Young Investigator Award winners announced by Anatomy Society
The American Association of Anatomist's Young Investigator Awards combine three long-standing AAA awards -- Bensley, Herrick, and Mossman -- with the Morphological Sciences Award, all recognizing investigators in the early stages of their careers who have made important contributions to biomedical science through their research in cell/molecular biology, developmental biology, comparative neuroanatomy, or the morphological sciences. (2012-12-11)

NCI renewal grant to develop new cancer therapies
A Virginia Commonwealth University Massey Cancer Center research team has received a renewal grant totaling nearly $1.3 million from the National Cancer Institute to improve the activity of a novel class of agents, known as histone deacetylase inhibitors, in the treatment of leukemia and other blood malignancies. (2007-12-04)

Tools used to decipher 'histone code' may be faulty
Recent research from the University of North Carolina at Chapel Hill has found a number of issues with histone antibodies, the main tools used to decipher this code, suggesting they may need more rigorous testing. (2010-12-16)

Flies can turn off their immune response
After a role in initiating an NF-êB-mediated innate immune response to microbial challenge, AP-1 and STAT act to form part of a repressosome to down-regulate the transcription of antimicrobial peptides and thus to resolve the immune response. (2007-09-03)

Epilepsy drug shows potential for Alzheimer's treatment
A drug commonly used to treat epilepsy could help clear the plaques in the brain associated with Alzheimer's disease, according to researchers at the University of Leeds. The plaques are known to lead to the progressive death of nerve cells in the brain linked to many forms of dementia. (2008-12-08)

Cancer cells' DNA repair disrupted to increase radiation sensitivity
Shortening end caps on chromosomes in human cervical cancer cells disrupts DNA repair signaling, increases the cells' sensitivity to radiation treatment and kills them more quickly, according to a study in Cancer Prevention Research. Researchers would to like see their laboratory findings -- published in the journal's Dec. 5 print edition -- lead to safer, more effective combination therapies for hard-to-treat pediatric brain cancers. To this end, they are starting laboratory tests on brain cancer cells. (2011-12-01)

Selective imprinting: How the wallaby controls growth of its young
Marsupial mothers regulate the composition of their milk so that it is optimal for the development stage of their young. New research published in BioMed Central's open access journal Epigenetics & Chromatin shows that, similar to the human placenta, which regulates embryonic growth and development, insulin appears to be imprinted in the marsupial mammary gland. (2012-08-27)

Molecular partners required for appropriate neuronal gene repression
A new study by researchers at The Wistar Institute offers insights into the intricate biochemistry governing gene regulation, while simultaneously pointing to the importance of investigating the complex biology of life at different levels of organization. The findings may also have long-term implications for treating depression and other psychiatric disorders. (2005-08-03)

White House to honor UNC School of Medicine scientist for 'early career' achievement
Dr. Brian Strahl, assistant professor of biochemistry and biophysics at the University of North Carolina at Chapel Hill School of Medicine, will attend a White House ceremony Thursday (Sept. 9) afternoon in honor of his selection for the Presidential Early Career Award for Scientists and Engineers. The annual award is the highest honor bestowed by the U.S. government on outstanding scientists and engineers who are beginning their independent careers. (2004-09-09)

Mechanism of mutant histone protein in childhood brain cancer revealed
Researchers have shown how a mutated histone protein inhibits an enzyme, which normally keeps cell growth in check, and causes a rare form of pediatric brain cancer called DIPG. Their findings reveal a mechanism for inhibiting enzymes and could lead to the development of pharmaceuticals that mimic the action of these mutant proteins. (2013-04-01)

Forgotten by evolution?
For a fairly long time, adult stem cells have been a point of scientific interest. Besides the question of how to use them therapeutically, researchers have been investigating what exactly their physiological function could be. (2005-11-02)

Protein believed to control formation of memory identified by Scripps & UCSD scientists
Scientists at The Scripps Research Institute and the University of California, San Diego (UCSD) School of Medicine have demonstrated that the action of a protein called CBP is essential for the stabilization of long-term memory, a discovery that may help children with a rare but debilitating developmental disorder. (2004-06-23)

EU research suggests that PCBs damage sperm - but finds no dramatic effect on male fertility
Research by an EU-supported international team of scientists has show polychlorinated biphenyls (PCBs) - synthetic organic chemicals found widely in the environment and absorbed in the diet - may damage sperm. The study, reported in Human Reproduction (Thursday 13 October), found no dramatic effects on human fertility and did not reveal any serious public health threat. However, authors say the findings are a warning and further research is needed. (2005-10-12)

High-fat diet and lack of enzyme can lead to heart disease in mice
It's no secret that a high-fat diet isn't healthy. Now researchers have discovered a molecular clue as to precisely why that is. Mice lacking a gene-expression-controlling enzyme fed a high-fat diet experience rapid thickening of the heart muscle and heart failure. This link -- at least in mice -- has implications for people on so-called Western diets and combating heart disease. Modulating the enzyme's activity could be a new pharmaceutical target. (2011-09-12)

Spinning-disk microscope offers window into the center of a cell
A new method of imaging cells is allowing scientists to see tiny structures inside the (2013-10-09)

Effects of aging in stem cells
In highly purified hematopoietic stem cells from mice aged 2 to 21 months, gene expression analysis indicates a deficit in function, yet an increase in stem cell number with advancing age. (2007-07-23)

Novel gene-hunting method implicates new culprit in pancreatic cancer
Using an innovative approach to identify a cancer's genetic vulnerabilities by more swiftly analyzing human tumors transplanted into mice, researchers have identified a new potential target for pancreatic cancer treatment, published online in Cell Reports. (2016-06-23)

Molecular 'movies' may accelerate anti-cancer drug discovery
Using advanced computer simulations, University of Utah College of Pharmacy researchers have produced moving images of a protein complex that is an important target for anti-cancer drugs. (2012-08-16)

New insights from the modENCODE Project are published in Genome Research
Genome Research publishes six articles online and in print today describing recent advancements from the modENCODE Project. Initially launched in 2007, the goal of the modENCODE Project is to comprehensively characterize functional genomic elements in two model organisms, the fly Drosophila melanogaster, and the worm Caenorhabditis elegans. (2014-07-01)

The evolution of human intellect: Human-specific regulation of neuronal genes
A new study has identified hundreds of small regions of the genome that appear to be uniquely regulated in human neurons. These regulatory differences distinguish us from other primates, including monkeys and apes, and as neurons are at the core of our unique cognitive abilities, these features may ultimately hold the key to our intellectual prowess (and also to our potential vulnerability to a wide range of 'human-specific' diseases from autism to Alzheimer's). (2012-11-20)

New method for reading DNA sheds light on basis of cell identity
By using a new kind of genomic technology, a new study unveils a special code -- not within DNA, but within the so-called (2007-07-01)

Wistar Institute team finds key target of aging regulator
Researchers at the Wistar Institute have defined a key target of an evolutionarily conserved protein that regulates the process of aging. The study provides fundamental knowledge about key mechanisms of aging that could point toward new anti-aging strategies and cancer therapies. (2009-06-10)

Short DNA strands in the genome may be key to understanding human cognition and diseases
Short snippets of DNA found in human brain tissue provide new insight into human cognitive function and risk for developing certain neurological diseases, according to researchers from the Departments of Psychiatry and Neuroscience at Mount Sinai School of Medicine. (2012-11-21)

Page 20 of 21 | 822 Results
   First   Previous   Next      Last   
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.