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Popular Chromatin News and Current Events, Chromatin News Articles.
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Molecular 'movies' may accelerate anti-cancer drug discovery
Using advanced computer simulations, University of Utah College of Pharmacy researchers have produced moving images of a protein complex that is an important target for anti-cancer drugs. (2012-08-16)

New insights from the modENCODE Project are published in Genome Research
Genome Research publishes six articles online and in print today describing recent advancements from the modENCODE Project. Initially launched in 2007, the goal of the modENCODE Project is to comprehensively characterize functional genomic elements in two model organisms, the fly Drosophila melanogaster, and the worm Caenorhabditis elegans. (2014-07-01)

Novel gene-hunting method implicates new culprit in pancreatic cancer
Using an innovative approach to identify a cancer's genetic vulnerabilities by more swiftly analyzing human tumors transplanted into mice, researchers have identified a new potential target for pancreatic cancer treatment, published online in Cell Reports. (2016-06-23)

UCR chemist part of team identifying new areas of gene regulation
Researcher Kangling Zhang at the University of California, Riverside is part of a team that has discovered a new way that yeast governs genetic expression and repression, a finding that could be repeated in cells of other organisms. (2005-05-06)

Short DNA strands in the genome may be key to understanding human cognition and diseases
Short snippets of DNA found in human brain tissue provide new insight into human cognitive function and risk for developing certain neurological diseases, according to researchers from the Departments of Psychiatry and Neuroscience at Mount Sinai School of Medicine. (2012-11-21)

BU chemist to map DNA's surface, uncovering details that will show how structure abets function
In a second round of funding for technology-related research that will contribute to the international research effort known as ENCODE, the National Human Genome Research Initiative (NHGRI) is supporting a Boston University-based effort to map the topography of the DNA molecule. Prof. Thomas Tullius, chairman of Boston University's Department of Chemistry, has received a three-year, $870,000 NHGRI grant to map the bumps, dips, and turns that characterize the surface of (2004-11-03)

Researchers identify cause of aggressive childhood cancer
Howard Hughes Medical Institute (HHMI) researchers have generated a mouse model of a new type of tumor suppressor gene that triggers malignant rhabdoid tumors, rapidly advancing cancers that affect children. The discovery of the fast-onset cancers that result from inactivation of the gene and the technique used to generate the model will likely prove useful in studying genes involved in other forms of cancer. (2002-11-22)

Missing link found between circadian clock and metabolism
Two new research studies have discovered a long sought molecular link between our metabolism and components of the internal clock that drives circadian rhythms, keeping us to a roughly 24-hour schedule. The findings appear in the July 25 issue of the journal Cell, a publication of Cell Press. (2008-07-24)

Scientists discover tiny RNAs play a big role in controlling genes
PiRNAs, a recently discovered class of tiny RNAs, play an important role in controlling gene function. (2007-10-25)

Protein complex links cellular metabolism to gene expression
Researchers in the Workman Lab at the Stowers Institute for Medical Research have identified a link between cellular metabolism and gene expression, one with potentially far-reaching implications for cancer risk prediction and treatment (2015-10-25)

Something old, something new
The relationship between genome integrity and aging is the subject of a new report in the upcoming issue of Genes & Development. Drs Lin-Quan Sun and Robert Arceci at Johns Hopkins University School of Medicine have developed a novel mouse model to study premature aging, and the genetic events that contribute to normal development and longevity. (2004-04-22)

Flipping a gene switch reactivates fetal hemoglobin, may reverse sickle cell disease
Hematology researchers have manipulated key biological events in adult blood cells to produce a form of hemoglobin normally absent after the newborn period. Because fetal hemoglobin is unaffected by the genetic defect in sickle cell disease, these cell culture findings may open the door to a new therapy for the debilitating blood disorder. (2013-12-08)

Stowers Institute's Workman Lab demonstrates mechanism for decoding histone modification marks
Jerry Workman, Ph.D., investigator, and Bing Li, Ph.D., senior research associate in the Workman Lab, have published evidence demonstrating that a combinatorial action of multiple protein domains is required to read a histone modification. (2007-05-18)

More than 3,000 epigenetic switches control daily liver cycles
When it's dark, and we start to fall asleep, most of us think we're tired because our bodies need rest. Yet circadian rhythms affect our bodies not just on a global scale, but at the level of individual organs, and even genes. (2012-12-10)

Addictive properties of drug abuse may hold key to an HIV cure
A Florida State University researcher is on a mission to explore the gene-controlling effects of addictive drugs in pursuit of new HIV treatments. (2012-09-21)

EuroDYNA leaves healthy genomic research ecosystem as legacy
Europe's position as a major player in genome research has been boosted by the European Science Foundation's three-year EUROCORES program EuroDYNA. As it draws to a close, EuroDYNA (Dynamic Nuclear Architecture and Chromatin Function) is leaving behind a healthy European ecosystem of interacting multidisciplinary research projects focused on the structure of the cellular nucleus and mechanisms governing gene expression. (2008-06-17)

On the trail of the epigenetic code
A test system on Drosophila should provide the key to histone function. (2010-10-11)

'K-to-M' histone mutations: How repressing the repressors may drive tissue-specific cancers
A paper from a laboratory at the Stowers Institute of Medical Research reports the first animal model created to assess the molecular effects of two different histone H3.3 mutations in the fruit fly Drosophila. The study from a team led by Investigator Ali Shilatifard, Ph.D., published in the Aug. 29, 2014, issue of Science, strongly suggests that these mutations actually could drive cancer and identifies interacting partners and pathways that could be targeted for the treatment of cancer. (2014-08-28)

Scripps Research scientists shed light on how DNA is unwound so that its code can be read
Researchers at the Scripps Research Institute have figured out how a macromolecular machine is able to unwind the long and twisted tangles of DNA within a cell's nucleus so that genetic information can be (2008-11-24)

New Finding Suggests "HATs" Are Key To Gene Activation Puzzle
Biologists have uncovered evidence that adds significantly to the developing picture of how genes are activated, reporting the strongest evidence yet to support the widely accepted theory that gene activation is linked to the uncoiling of the tightly would form in which DNA is ususally stored. (1996-12-27)

Untangling DNA regulation
MIT biologists have discovered that the organization of DNA's packing material plays a critical role in directing stem cells to become different types of adult cells. (2008-11-06)

Get in touch
When the genetic material inside a cell's nucleus starts to fall apart, a protein called ATM takes charge and orchestrates the rescue mission. Surprisingly, for ATM to kick into full gear, the stretches of DNA flanking a chromosomal break are just as important as the damaged site itself, report scientists at the Salk Institute for Biological Studies. (2007-10-29)

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