Popular Cystic Fibrosis News and Current Events

Popular Cystic Fibrosis News and Current Events, Cystic Fibrosis News Articles.
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A 'virtual heart' to simulate arrhythmia
A group of researchers from MIPT and Ghent University have proposed a mathematical model which is able to determine the factors responsible for the formation of different fibrosis patterns, which are believed to cause arrhythmia. To reproduce the formation of cardiac tissue, the researchers took a mathematical model -- one that is widely applied to study tissue growth -- and optimized it using the previously collected experimental data. (2017-09-06)

The Lancet journals: Papers at ERS Congress 2019
The following papers will be presented at the ERS Congress 2019, organised by the European Respiratory Society, in Madrid and published simultaneously in either The Lancet or The Lancet Respiratory Medicine journals. All papers are under embargo until the stated time. Contact details for corresponding authors are provided in the Articles and linked Comments. Funding information is listed on the first page of each Article. (2019-09-30)

New research finds novel method for generating airway cells from stem cells
Researchers have developed a new approach for growing and studying cells they hope one day will lead to curing lung diseases such as cystic fibrosis through 'personalized medicine.' (2017-03-30)

From Genome Research: Pathogen demonstrates genome flexibility in cystic fibrosis
Chronic lung infections can be devastating for patients with cystic fibrosis (CF), and infection by Burkholderia cenocepacia, one of the most common species found in cystic fibrosis patients, is often antibiotic resistant. In a study published today in Genome Research, scientists sequenced and phenotyped multiple B. cenocepacia isolates from 16 CF patients. They found extensive variation among isolates during chronic lung infection as well as changes in clinically relevant bacterial phenotypes. (2017-03-21)

New methods find undiagnosed genetic diseases in electronic health records
Researchers at Vanderbilt University Medical Center have found a way to search genetic data in electronic health records to identify undiagnosed genetic diseases in large populations so treatments can be tailored to the actual cause of the illness. (2018-03-15)

A Web-based lifestyle intervention supports weight loss in patients with non-alcoholic fatty liver disease
A remote lifestyle modification intervention shown to be as effective as a face-to-face group program for weight loss and improved liver health. (2018-04-13)

NGM282 -- an engineered analogue of FGF19 -- shows promise in patients with primary sclerosing cholangitis
A Phase 2, randomized, double-blind, placebo-controlled study reports significant improvements in markers of disease activity and fibrosis with subcutaneous NGM282 in patients with primary sclerosing cholangitis. (2018-04-13)

Nonalcoholic fatty liver disease increases risk of liver, colorectal, and breast cancers
Nonalcoholic fatty liver disease (NAFLD) is one of the more common chronic liver diseases worldwide. It is associated with metabolic syndrome (i.e. insulin resistance and diabetes) and predisposes to cardiovascular disease. In a new study published in the Journal of Hepatology, researchers identified links not only between NAFLD and hepatocellular carcinoma (HCC), which have been well established, but also to cancers outside the liver, including colorectal and breast cancer. (2017-11-13)

Children's Hospital scientists identify possible target for prevention and treatment of pneumonia
Researchers at Children's Hospital of Pittsburgh of UPMC have identified a key protein target that may be a crucial factor in the development of a vaccine to prevent and new therapies to treat pneumonia, the leading killer of children worldwide. (2008-02-11)

Research paves the way for treatment strategies of multidrug-resistant chronic infections
A new study published in Cell Press finds that antibiotic treatment of chronic infections can be optimized by targeting vulnerabilities of antibiotic-resistant pathogens paving the way for more effective treatment strategies. (2018-01-05)

Icelandic program seeks to eliminate HCV
A new Journal of Internal Medicine study describes an innovative program to eliminate hepatitis C virus (HCV) as a public health threat in Iceland. (2018-03-07)

New study may show how to forestall a fatal, virus-caused immune-system meltdown
Researchers at the University of Texas Medical Branch at Galveston believe they've found a way to spot the biochemical profile of an inappropriate immune response to viral infection -- an important step toward developing new therapies that may stop the fatal immune system meltdowns caused by such deadly pathogens as the Ebola, Marburg and Lassa fever viruses, as well as the virus strain responsible for the 1918 flu pandemic. (2007-02-14)

University of Minnesota researchers replicate FSH muscular dystrophy in mice
A new study published in the journal Nature Communications describes a breakthrough in research related to facioscapulohumeral muscular dystrophy (FSHD). The debilitating genetic disease -- which has no approved treatment -- affects an estimated 38,000 Americans and causes muscle degeneration. Scientists inserted into mice a gene called DUX4, which is believed to cause FSHD in humans. When they activated the gene in mice skeletal muscle cells, the animals developed a muscular dystrophy with key features of FSHD. (2017-09-15)

Test for antibiotic associated kidney damage in children with cystic fibrosis identified
New research, published in Nature Scientific Reports, conducted by the University and partners highlights effective methods for identifying a common side effect in children receiving drug treatments for Cystic fibrosis. (2018-03-28)

Bioinformatics technology developed at Argonne provides new insight into microbial activities
Scientists may gain a new insight into the relationship between viruses and their environments thanks to a new computational technology developed by researchers at the US Department of Energy's Argonne National Laboratory. This technology has already been used to identify subtle differences in the metabolic processes of microbial communities (2008-03-14)

New work from Ron Crystal's lab on treating hereditary adrenal disorders
A new study has definitively shown that a single treatment with gene therapy using adeno-associated viral (AAV) vector gene delivery to replace the defective gene responsible for congenital adrenal hyperplasia (CAH) will only temporarily alleviate the hereditary disorder. (2018-03-29)

Fat hormone linked to progression of fatty liver disease may hold key to new treatments
The rising obesity epidemic has brought with it an army of maladies. One, in particular, is threatening to outpace many of the disorders that accompany obesity, in terms of occurrence and severity: nonalcoholic fatty liver disease. (2017-11-06)

Huntington's Disease Mouse Model To Be Distributed By Jackson Laboratory
The first strain of mouse genetically engineered to model major symptoms of Huntington's disease -- an inherited, degenerative brain disease that affects an estimated 30,000 Americans -- is now undergoing processing at The Jackson Laboratory for distribution to researchers worldwide (1997-04-02)

Finding long strands of RNA in skin development and disease
Researchers from Case Western Reserve University School of Medicine have discovered how unusually long pieces of RNA work in skin cells. The RNA pieces, called 'long non-coding RNAs' or 'lncRNAs,' help skin cells modulate connective tissue proteins, like collagen, and could represent novel therapeutic targets to promote skin repair. (2017-12-06)

Screening for hepatocellular carcinoma in patients with hepatitis C-related cirrhosis achieving sustained virological response is likely to be cost effective
A Canadian study suggests that biannual or annual ultrasound screening for HCC is likely to be cost effective after a sustained virological response in those with hepatitis C-related cirrhosis, but not in those with advanced fibrosis without cirrhosis. (2018-04-12)

New HSS study finds hope in understanding and better treating scleroderma
Researchers at HSS find a potential cause and treatment lead for scleroderma. (2018-01-10)

CNIO researchers cure lung fibrosis in mice with a gene therapy that lengthens telomeres
Idiopathic pulmonary fibrosis is a potentially lethal disease associated with the presence of critically short telomeres, currently lacking effective treatment. The Telomere and Telomerase Group at the Spanish National Cancer Research Centre (CNIO) has succeeded in curing this disease in mice using a gene therapy that lengthens the telomeres. This work constitutes a (2018-01-30)

Lung transplant patients face elevated lung cancer risk
In an American Journal of Transplantation study, lung cancer risk was increased after lung transplantation, especially in the native (non-transplanted) lung of single lung transplant recipients. (2018-12-19)

New AI technology significantly improves human kidney analysis
The ability to quantify the extent of kidney damage and predict the life remaining in the kidney, using an image obtained at the time when a patient visits the hospital for a kidney biopsy, now is possible using a computer model based on artificial intelligence (AI). (2018-01-11)

Study identifies new molecular target for treating deadly lung disease IPF
Scientists searching for a therapy to stop the deadly and mostly untreatable lung disease, idiopathic pulmonary fibrosis (IPF), found a new molecular target that slows or stops the illness in preclinical laboratory tests. Researchers at Cincinnati Children's Hospital Medical Center report their data in the journal Cell Reports. Studying mice with IPF and donated human cells, they identify a gene called FOXF1 that inhibits the IPF disease process. (2018-04-10)

Germany: compensated cirrhosis substantially increases comorbidities and healthcare costs for patients with non-alcoholic fatty liver disease/non-alcoholic steatohepatitis
Compensated cirrhosis substantially increases comorbidities and healthcare costs for patients with non-alcoholic fatty liver disease/non-alcoholic steatohepatitis. (2018-04-13)

Major 'missed' biochemical pathway emerges as important in virtually all cells
Researchers at Duke University Medical Center have published a study in Science that provides compelling evidence that the nitric oxide system in cells is very broad-based and important, resembling in its essence the much-studied system of phosphorylation. The findings may offer new insights into how cells work and the basis of many diseases. (2008-05-22)

Breaking cell symmetry
A team of researchers from the Mechanobiology Institute, Singapore at the National University of Singapore, along with colleagues from Temasek Life Sciences Laboratory and A*STAR's Institute of Molecular and Cell Biology in Singapore, has uncovered a novel mechanism for establishing cell polarity that relies on tension force induced clustering of proteins. (2017-11-06)

Newly found immune defence could pave way to treat allergies
Scientists have made a fundamental discovery about how our body's immune system clears harmful infections. (2017-11-16)

Lower levels of microRNA 29 may protect from cardiac fibrosis rather than causing it
Cardiac fibrosis involves an increase of connective tissue in the cardiac muscle, causing a loss of function. Researchers at the Technical University of Munich (TUM) have now discovered that fibrosis occurs less frequently when microRNA 29 (miR-29) is suppressed in cardiac muscle cells. Older studies had suggested that it was in fact low levels of miR-29 that caused fibrosis. The new insights point to potential new approaches for developing drugs against fibrotic diseases. (2017-11-22)

A new mutation in kidney disease
Osaka University researchers find an unexpected mutation in proteins of the exosome could be a valuable biomarker for diagnosing the risk of kidney disease. (2017-06-14)

Defect in zinc supply mechanism affects pathology of intractable pulmonary diseases
Japanese researchers revealed that abnormal delivery of zinc to lung cells contributes to obstructive pulmonary diseases. They further showed that mRNA splicing abnormalities are involved in the detailed mechanism. So far, the importance of zinc in the lung has only been understood from a nutritional aspect. This discovery is thought to be the first to clarify zinc's effects on the regulation of mRNA ligation (splicing), and its involvement in the onset of pulmonary diseases. (2017-12-28)

Superbug genome sequenced
The genome of a newly-emerging superbug, commonly known as Steno, has just been sequenced. The results reveal an organism with a remarkable capacity for drug resistance. The research was carried out by scientists at the Wellcome Trust Sanger Institute near Cambridge and the University of Bristol. (2008-05-07)

Tamoxifen and raloxifene slow down the progression of muscular dystrophy
Steroids are currently the only available treatment to reduce the repetitive cycles of inflammation and disease progression associated with functional deterioration in patients with muscular dystrophy (MD). A study reported in The American Journal of Pathology showed that a new treatment approach using the selective estrogen receptor modulators (SERMs) tamoxifen and raloxifene significantly improved cardiac, respiratory, and skeletal muscle functions and increased bone density in both male and female mice with the same gene defects as a subset of patients with MD. (2018-03-20)

Engineers create an inhalable form of messenger RNA
In an advance that could lead to new treatments for lung disease, MIT researchers have now designed an inhalable form of mRNA. This aerosol could be administered directly to the lungs to help treat diseases such as cystic fibrosis, the researchers say. (2019-01-04)

Brief psychotherapy benefits women caring for children with severe health issues
Brief cognitive behavioral therapy significantly improved the mental health of women overwhelmed by caring for children with severe chronic health conditions, researchers at the University of Louisville have found. After five therapy sessions, study participants reported significantly decreased depressive symptoms, negative thinking and chronic stressors, and experienced improved sleep quality, according to Lynne Hall, Dr.P.H., R.N., associate dean of research and professor at the UofL School of Nursing. (2018-09-14)

Long-term obeticholic acid treatment leads to reversal or stabilization of fibrosis/cirrhosis in patients with PBC
After three years of treatment with obeticholic acid, 85 percent of patients with PBC and an incomplete response to UDCA experienced stabilization or regression of fibrosis/cirrhosis in the POISE biopsy sub-study. (2018-04-13)

ATS publishes new clinical guideline on home oxygen for children
The American Thoracic Society has developed a new clinical practice guideline for home oxygen therapy for children. The guideline appears in the Feb. 1 edition of the Society's American Journal of Respiratory and Critical Care Medicine. (2019-02-01)

Eat your vegetables (and fish): Another reason why they may promote heart health
Elevated levels of trimethylamine N-oxide (TMAO) -- a compound linked with the consumption of fish, seafood and a primarily vegetarian diet -- may reduce hypertension-related heart disease symptoms. New research in rats finds that low-dose treatment with TMAO reduced heart thickening (cardiac fibrosis) and markers of heart failure in an animal model of hypertension. (2018-11-06)

Scientists make a major breakthrough to treat fibrotic diseases that cause organ failure
Scientists at Duke-NUS and National Heart Centre Singapore make a breakthrough discovery and show that the critical protein interleukin 11 (IL11) causes fibrosis and widespread organ damage (2017-11-13)

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