Popular Disease Therapy News and Current Events

Popular Disease Therapy News and Current Events, Disease Therapy News Articles.
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Maintenance therapy with rucaparib shows clinical responses in a subgroup of patient with pancreatic cancer
Maintenance treatment with the PARP inhibitor rucaparib (Rubraca) was well tolerated and provided clinical responses among patients with advanced BRCA- or PALB2-mutated pancreatic cancer sensitive to platinum-based chemotherapy, according to results from an interim analysis of an ongoing phase II clinical trial presented at the AACR Annual Meeting 2019, March 29-April 3. (2019-04-02)

Certain heart fat associated with higher risk of heart disease in postmenopausal women
For the first time, researchers have pinpointed a type of heart fat, linked it to a risk factor for heart disease and shown that menopausal status and estrogen levels are critical modifying factors of its associated risk in women. (2017-01-30)

Rheumatoid arthritis meets precision medicine
Scientists are bringing precision medicine to rheumatoid arthritis for the first time by using genetic profiling of joint tissue to see which drugs will work for which patients, reports a new multi-site study. In the near future, patients won't have to waste time and be disappointed with months of ineffective therapy, scientists said. Currently $2.5 billion a year is wasted on therapy that doesn't work. (2018-03-19)

Light therapy could save bees from deadly pesticides
Treating bees with light therapy can counteract the harmful effects of neonicotinoid pesticides and improve survival rates of poisoned bees, finds a new UCL study. (2016-11-15)

Promising gene replacement therapy moves forward at Ohio State
Research led by Dr. Krystof Bankiewicz, who recently joined The Ohio State University College of Medicine, shows that gene replacement therapy for Niemann-Pick type A disease is safe for use in nonhuman primates and has therapeutic effects in mice. These findings will publish online in the journal Science Translational Medicine. Prior to joining Ohio State as a professor of neurosurgery, Bankiewicz conducted this translational gene therapy research at the University of California at San Francisco. (2019-08-21)

For patients with esophageal cancer, status of lymph nodes after preoperative therapy determines survival
The status of lymph nodes rather than the status of the primary tumor following preoperative neoadjuvant chemotherapy or chemoradiation therapy is the most important factor that determines whether patients with locally advanced esophageal cancer will survive. The study presented at the AATS 98th Annual Meeting indicates that while preoperative chemotherapy and radiation therapy improve survival of patients with esophageal cancer, patients with malignant lymph nodes following therapy were less likely to survive than patients with no cancer in the lymph nodes. (2018-05-01)

Heart attack treatment might be in your face
Researchers at the University of Cincinnati have received $2.4 million in federal funding to pursue research on a novel cell therapy that would repair heart damage using modified cells taken from the patient's own facial muscle. (2017-02-07)

A protein makes the difference
It is well-established knowledge that blood vessels foster the growth of tumors. Preventing the formation of tumors is a standard part of cancer therapy. A study by researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg has discovered a new, surprising role played by blood vessels: under certain conditions they can inhibit tumor growth. (2016-10-18)

Nuclear protein causes neuroblastoma to become more aggressive
Aggressive forms of neuroblastoma contain a specific protein in their cells' nuclei that is not found in the nuclei of more benign forms of the cancer, and the discovery, made through research from the University of Rochester Medical Center, could lead to new forms of targeted therapy. (2016-10-06)

Surgery & combination therapy optimizes results in aggressive prostate cancer management
Results published today in JAMA Oncology suggest post-operative radiation and hormone therapy, before cancer recurrence, as a new prostate cancer treatment option for men with a Gleason Score of 9 or 10. (2018-11-15)

Advanced therapy offers cure for relapsed cancer patient
Testicular cancer patients who do not respond to traditional therapy can be cured with high-dose chemotherapy and a stem cell transplant, according to an Indiana University School of Medicine study by Lawrence Einhorn, M.D.; Stephen Williams, M.D.; Rafat Abonour, M.D., and colleagues published in the July 26 issue of the New England Journal of Medicine. Although the number of relapsed testicular cancer patients in the US is small, the IU Simon Cancer Center treats a majority of them. (2007-07-25)

Early physical therapy for low back pain reduces costs, resources
A study in the scientific journal BMC Health Services Research shows that early and guideline adherent physical therapy following an initial episode of acute, nonspecific low back pain resulted in substantially lower costs and reduced use of health care resources over a two-year period. (2015-04-09)

Asthma Controller Step Down Yardstick -- treatment guidance for when asthma improves
The focus for asthma treatment is often stepping up treatment, but clinicians need to know how to step down therapy when symptoms improve. (2019-01-25)

Testosterone replacement therapy may slow the progression of COPD
GALVESTON, Texas -- Researchers from The University of Texas Medical Branch at Galveston found that testosterone replacement therapy may slow disease progression of chronic obstructive pulmonary disease. The paper is currently available in Chronic Respiratory Disease. (2018-09-13)

Is breast conserving therapy or mastectomy better for early breast cancer?
Young women with early breast cancer face a difficult choice about whether to opt for a mastectomy or breast conserving therapy (BCT). New research presented at the ESTRO 35 conference has shown young women, who had early stage breast cancer that had not spread to the lymph nodes and who opted for BCT with radiation therapy, had a 13 percent higher risk of developing a local recurrence of their disease over a 20-year period than women who had a mastectomy and no radiation therapy. (2016-04-29)

New recommendations for endoscopic eradication therapy in Barrett's esophagus
A new guideline by the ASGE Standards of Practice Committee offers evidence-based recommendations and clinical guidelines addressing key issues related to Endoscopic Eradication Therapy (EET) in the management of Barrett's esophagus (BE)-related lesions. (2018-04-06)

Lipid nanoparticles for gene therapy
Twenty-five years have passed since the publication of the first work on solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) as a system for delivering drugs. So the European Journal of Pharmaceutics and Biopharmaceutics has prepared a special edition for which it asked the PharmaNanoGene group of the UPV/EHU-University of the Basque Country to produce a piece of work. (2017-02-14)

Physical therapy as effective as surgery for torn meniscus and arthritis of the knee
A New England Journal of Medicine study showing that physical therapy is just as effective as surgery in patients with meniscal tears and arthritis of the knee should encourage many health care providers to reconsider their practices in the management of this common injury, according to the American Physical Therapy Association. (2013-03-21)

Hormone replacement therapy associated with lower mortality
Women using hormone replacement therapy to relieve the symptoms of menopause faced a lower risk of death and showed lower levels of atherosclerosis, or plaque buildup in the heart's arteries, compared to women not using hormone therapy, according to a single-center study scheduled for presentation at the American College of Cardiology's 66th Annual Scientific Session. (2017-03-08)

ZMapp antibody delivered by viral vector protects against Ebola infection
A new study comparing the effectiveness of individual ZMapp antibodies versus a cocktail of antibodies, administered to mice using recombinant adeno-associated virus (rAAV) delivery vectors, showed the ability to achieve 100% protection against infection by Ebola virus. (2018-03-09)

New tool for prognosis and choice of therapy for rheumatoid arthritis
In rheumatoid arthritis, antibodies are formed that affect the inflammation in the joints. In an article published today in the journal Annals of the Rheumatic Diseases, researchers at Uppsala University show that antibodies against the cartilage protein collagen II are associated with a good prognosis. (2017-03-23)

Cancer risk slightly higher for women in discontinued hormone treatment trial
A follow up study of participants in the Women's Health Initiative clinical trial led by a University of North Carolina at Chapel Hill researcher has found that women who were taking the combined hormone therapy of estrogen plus progestin may have an increased risk of cancer since the intervention was stopped, compared to participants in the trial's placebo group. (2008-03-04)

Interview with CAR T cell expert Dr. Michel Sadelain in Human Gene Therapy
Michel Sadelain, M.D., Ph.D., Director, Center for Cell Engineering, Memorial Sloan-Kettering Cancer Center in New York City, offers a fascinating perspective on the re-markable progress being made in the field of chimeric antigen receptor (CAR) engineered T-cell therapies to treat cancer. (2018-05-21)

Shedding light on new treatment options for perimenopausal depression and sleep problems
Light therapy has long been a recognized treatment option for depression. But can it help perimenopausal women struggling with depression and sleep problems as the result of hormone changes? A new study from the University of California suggests that it can by altering a woman's natural sleep/wake cycle. Preliminary study results will be presented during The North American Menopause Society (NAMS) Annual Meeting in San Diego, Oct. 3-6, 2018. (2018-10-03)

Are adolescents with mental health conditions more likely to receive opioids?
Adolescents with a wide range of preexisting mental health conditions and treatments were more likely to progress from an initial opioid prescription to long-term opioid therapy than adolescents without those conditions, although long-term opioid therapy was uncommon overall. (2018-03-12)

Treatment for male anti-NMDA receptor encephalitis patients
Treatments for the anti-NMDA receptor encephalitis usually include steroids, intravenous immunoglobulin, plasma exchange, plasmapheresis, rituximab, cyclophosphamide and tumor resection. The researchers aimed to compare the efficacy of the treatments including intravenous immunoglobulin, plasma exchange, plasmapheresis, rituximab or cyclophosphamide for male anti-NMDA receptor encephalitis patients without tumor and to discuss potential biomarkers for this disease. (2018-03-14)

New work from Ron Crystal's lab on treating hereditary adrenal disorders
A new study has definitively shown that a single treatment with gene therapy using adeno-associated viral (AAV) vector gene delivery to replace the defective gene responsible for congenital adrenal hyperplasia (CAH) will only temporarily alleviate the hereditary disorder. (2018-03-29)

Additional therapy after surgical removal of rare tumors may not increase survival
Results of an analysis from the University of Cincinnati (UC) College of Medicine show that additional therapy, or adjuvant therapy, delivered after surgical removal of a rare type of gastrointestinal tumor does not increase survival rates for patients. (2018-03-24)

CNIO researchers cure lung fibrosis in mice with a gene therapy that lengthens telomeres
Idiopathic pulmonary fibrosis is a potentially lethal disease associated with the presence of critically short telomeres, currently lacking effective treatment. The Telomere and Telomerase Group at the Spanish National Cancer Research Centre (CNIO) has succeeded in curing this disease in mice using a gene therapy that lengthens the telomeres. This work constitutes a (2018-01-30)

Sit, stay, heal: Study finds therapy dogs help stressed university students
Therapy dog sessions for stressed-out students are an increasingly popular offering at North American universities. Now, new research from the University of British Columbia confirms that some doggy one-on-one time really can do the trick of boosting student wellness. (2018-03-12)

Stephanie Faubion, M.D., talks genitourinary syndrome of menopause
A new article in Mayo Clinic Proceedings reviews options for women going through genitourinary syndrome of menopause -- an encompassing term for vaginal dryness, itching, dyspareunia and urinary tract infections brought on by low estrogen levels after menopause. (2017-12-01)

Vitiligo treated successfully with arthritis drug and light therapy
Building on prior research that examined the use of an arthritis medication to treat vitiligo, a team of Yale dermatologists has successfully applied a novel combination therapy -- the medication and light -- to restore skin color in patients. (2018-01-31)

Injection of novel gene therapy vector prolonged survival in mouse model of Pompe disease
A new study has shown that a single injection of a novel adeno-associated vector (AAV)-based therapy can result in improved enzyme activity and glycogen clearance as well as prolonged survival in a mouse model of Pompe disease. (2018-08-13)

Shorter course of radiation therapy effective in treating men with prostate cancer
A new UCLA-led study shows that men with low- or intermediate-risk prostate cancer can safely undergo higher doses of radiation over a significantly shorter period of time and still have the same, successful outcomes as from a much longer course of treatment. (2019-02-08)

New CAR T case study shows promise in acute myeloid leukemia
According to a case study from trial published online ahead of print in the journal Haematologica, a patient has remained cancer free for nine months after being treated with CYAD-01, followed by a bone marrow transplant. (2018-05-09)

Researchers develop a novel RNA-based therapy to target West Nile virus
A Yale-led research team developed a new RNA therapy, delivered through the nose, to treat mice infected with West Nile Virus. The innovative approach reduced the virus in the brain, allowing the immune system to destroy the virus and develop long-term protection against West Nile Virus disease, the researchers said. (2018-03-29)

New focus on where heart disease and breast cancer treatment meet
The American Heart Association has released the first scientific statement about heart disease and breast cancer, calling for more research and collaboration between the fields of oncology and cardiology to treat and prevent both diseases. (2018-02-01)

ATS publishes new clinical guideline on home oxygen for children
The American Thoracic Society has developed a new clinical practice guideline for home oxygen therapy for children. The guideline appears in the Feb. 1 edition of the Society's American Journal of Respiratory and Critical Care Medicine. (2019-02-01)

Combined stenting and photodynamic therapy improves survival in late stage liver cancer patients
A combined therapeutic approach of stenting and photodynamic therapy may improve survival rates for patients suffering from advanced liver bile duct cancer, according to a study published this month in Clinical Gastroenterology and Hepatology. (2008-03-11)

Study results may lead to improved diagnostics for breast cancer
A study in Molecular Oncology indicates that examining the protein and RNA in leftover materials from routine diagnostic tests for breast cancer may lead to more accurate diagnoses. (2018-07-18)

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