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Popular Drug Development News and Current Events, Drug Development News Articles.
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EASL-AASLD Special Conference on Therapy of Hepatitis C
The European Association for the Study of the Liver and the American Association for the Society of Liver Diseases bring you a Special Conference on the Therapy of Hepatitis C: Clinical Application and Drug Development. The conference to be held in Prague from Sept. 14-16 features leading international speakers, and hot-topic debates such as the usefulness of genomics in HCV therapy. (2012-06-28)

Intensive behavioral interventions needed to reduce amphetamine use, which is linked to HIV risk
The fifth paper in the Lancet series on HIV in people who use drugs looks at the relationship between amphetamine drug use and HIV. Among the conclusions are that because of the increased HIV risk associated with amphetamine use, amphetamine users should have ready access to HIV prevention interventions, including HIV testing. (2010-07-20)

Researchers develop device that simulates gastro-intestinal tract
A breakthrough in drug testing developed by a University of Huddersfield lecturer could lead to cheaper, more effective medicines. Dr. Hamid Merchant is a member of the team that has created a device which accurately simulates the gastro-intestinal tract and how it absorbs medication. This means that the cost of clinical trials could be greatly reduced, with savings passed on to customers. (2014-03-31)

Discovery of new IRAP inhibitors to improve cognitive functions
Researchers have discovered three new inhibitors of insulin-regulated aminopeptidase (IRAP), compounds shown to improve cognitive functions in animal models of human disorders. The new inhibitors are able to block human IRAP at low concentrations with rapid reversibility, as described in a study published in ASSAY and Drug Development Technologies. (2016-06-01)

The Scripps Research Institute enters major five-year $100 million collaboration with Pfizer
The Scripps Research Institute today announced it has entered into a five year research collaboration with Pfizer Global Research and Development to advance scientific knowledge of uncured diseases and novel ways to treat them, making full use of emerging technologies and resident talent from both organizations. (2006-11-30)

Sussex Drug Discovery Centre & ReViral reach clinical trial with lung virus treatment
Sussex Drug Discovery Centre & ReViral reached a clinical trial with a 'game changer' treatment for respiratory syncytial virus. (2017-03-21)

Researchers apply fat cells to deliver drug to suppress tumor growth
UCLA researchers have identified a new drug delivery pathway that may help stop tumor growth and keep cancer from coming back in mice. (2019-09-25)

IKBFU Scientists study molecular elements effective in countering malaria
The scientists research a building block of organic molecules needed for medical chemistry development. Spirocycles in nature is an element, that chemists are crazy about. This element presents in artemisinin, the most effective group of drugs against malaria. (2019-12-20)

Pharmaceutical research: when active substance and target protein 'embrace' each other
Scientists at Goethe University Frankfurt, together with colleagues from Darmstadt, Heidelberg, Oxford and Dundee (UK), have investigated how the fit of potent inhibitors to their binding sites can be optimised so that they engage longer with their target proteins. Long target residency has been associated with more efficient pharmacological responses e.g. in cancer therapy. In future, the researchers want to use computer simulations to predict the residence time of inhibitors during drug development. (2021-01-28)

Trial demonstrates new drug's effectiveness against psoriasis
A rheumatoid arthritis drug can successfully treat moderate to severe cases of the skin disease psoriasis, according to the results of a randomised trial published in this week's issue of The Lancet. (2005-10-13)

Jefferson researchers find drug may give some cardiac protection 24 hours after heart attack
A drug has been shown to provide some protection to the heart from injury even if given as much as 24 hours after a heart attack, Jefferson Medical College researchers report. Darbepoietin, a long-acting cousin of erythropoietin (EPO), offered significant protection to heart tissue from injury from ischemia, and even helped improve cardiac function. (2005-11-16)

Obese children metabolize drugs differently than healthy weight children
Researchers have provided the first evidence-based data on changes in drug metabolism in obese children as compared to healthy weight children. (2010-04-27)

Pfizer contributes critical data to URMC drug safety initiative
Pfizer Inc. has agreed to provide the University of Rochester Medical Center with a unique set of electrocardiographic data that will help researchers develop new methods to ensure the safety of experimental drugs. This is the first time a major pharmaceutical company has agreed to publicly share anonymous data from one of its drug safety trials, including data from the drug that was being evaluated. (2009-01-12)

Risk for drug abuse in adopted children appears influenced by family, genetics
In a national Swedish adoption study, the risk for drug abuse appears to be increased among adopted children whose biological parents had a history of drug abuse, according to a report published Online First by Archives of General Psychiatry, one of the JAMA/Archives journals. (2012-03-05)

The next anti-tuberculosis drug may already be in your local pharmacy
Testing thousands of approved drugs, EPFL scientists have identified an unlikely anti-tuberculosis drug: the over-the-counter antacid lansoprazole (Prevacid). (2015-07-07)

Drug-eluting balloons are a promising tool in treatment of narrowed metal stents
A drug-coated balloon inserted in a narrowed bare metal stent is a promising therapy for restoring blood flow, according to research presented at the American Heart Association's Scientific Sessions 2011. (2011-11-16)

Vision test gives insight into the effect of prenatal exposure to recreational drugs
Children exposed to marijuana in the womb show a significant improvement in their ability to track moving objects at age four, according to new vision research. But researchers are warning that the results do not mean marijuana has a beneficial effect on fetal development. (2015-11-19)

Nanotechnology helps track and improve drug action in pancreatic cancer
Scientists from Sydney's Garvan Institute of Medical Research, in collaboration with colleagues from the Beatson Institute for Cancer Research in Glasgow UK, have been able to show ways in which we can markedly improve drug targeting of solid tumors, using tiny 'biosensors' along with new advanced imaging techniques. In real time and in three dimensions, these technologies can show us how cancers spread and how active cancer cells respond to a particular drug. (2013-06-12)

Study shows parental alcoholism creates risk factors for substance abuse in emerging adults
The impacts of parental alcoholism in children are well known, particularly the alcohol consumption habits of children of alcoholics (COA's). However, until now, little research has been conducted on the correlation between parental alcoholism and illicit drug use in emerging adults. A new study shows that parental alcoholism represents a risk factor for maladaptive behaviors in adulthood that extend beyond alcoholism and into illicit drug use. (2006-01-23)

Nanotech system, cellular heating may improve treatment of ovarian cancer
The combination of heat, chemotherapeutic drugs and an innovative delivery system based on nanotechnology may significantly improve the treatment of ovarian cancer while reducing side effects from toxic drugs, researchers report in a new study. (2013-10-17)

Leading researchers and experts gather to discuss latest advancements in drug discovery
More than 2,500 researchers and professionals in the area of biomolecular science and drug discovery are expected to attend the 14th Annual Conference and Exhibition of the Society for Biomolecular Sciences to discuss advances in biotechnology, challenges and automation solutions in the field. (2008-01-08)

How do data exclusivity periods affect pharmaceutical innovation?
A new study in the January 2011 issue of Health Affairs is the first to calculate the financial and social costs of limiting access to trial data -- and finds that extending the term of exclusive access will lead to higher drug costs in the short term but also to more than 200 extra drug approvals and to greater life expectancy in the next several decades. (2011-01-06)

University of Arizona College of Pharmacy researcher to study street drug ecstasy
The National Institute on Drug Abuse has awarded a researcher at The University of Arizona College of Pharmacy $1.7 million for a nearly five-year study of the long-term adverse effects of the street drug ecstasy, also known as the (2008-11-14)

Targeted testing offers treatment hope for ovarian cancer patients
Women with ovarian cancer could be helped by a new test that identifies the specific type of tumor they have, a conference will hear this week. (2011-05-30)

New computational technique can predict drug side effects
Early identification of adverse effects of drugs before they are tested in humans is crucial in developing new therapeutics, as unexpected effects account for a third of all drug failures during the development process. Now researchers at the University of California-San Diego have developed a novel technique using computer modeling to identify potential side effects of pharmaceuticals, and have used the technique to study a class of drugs that includes tamoxifen. (2007-12-11)

IOP announces 2009 award winners
Successful business applications such as drug screening technologies, flat-panel displays and solar-cell designs are amongst the achievements in physics recognised by the Institute of Physics' 2009 awards, announced today (Wednesday, July 1), along with leading research in a wide range of fields from astronomy to optical physics, and excellence in engaging the general public with physics. (2009-07-01)

UWM research offers hope for treatment of cocaine addiction
Cocaine is one of the worst drug addictions to kick. But now UWM researchers have found that a common beta blocker can prevent the retrieval of memories associated with cocaine addiction, a major reason many addicts experience relapse. In addition, the work has identified primary players in the brain responsible for (2010-11-17)

A closer look at oral controlled release
The AAPS 41st Annual Pharmaceutical Technologies Arden Conference on Oral Controlled Release Development and Technology will focus on the breaking research and development of oral controlled release pharmaceutical products. (2006-01-10)

Hypertension and atherosclerosis may have a common cause, researchers say
The same hormone that causes high blood pressure may promote the development of atherosclerosis, reported researchers from Wake Forest University Baptist Medical Center today at the national meeting of the American Heart Association (1999-11-09)

Inhaled anti-rejection drug preserves lung function in lung transplant patients
Lung transplant patients who received an inhaled version of the anti-rejection drug cyclosporine had significantly better lung function than those who inhaled a placebo drug in the two years after transplant, according to a study to be presented at the American Thoracic Society International Conference on May 22. (2006-05-22)

Near-atomic resolution of protein structure by electron microscopy holds promise
A new study shows that it is possible to use an imaging technique called cryo-electron microscopy to view, in near-atomic detail, the architecture of a metabolic enzyme bound to a drug that blocks its activity. This advance provides a new path for solving molecular structures that may revolutionize drug development, noted the researchers. (2015-05-07)

Scientists find popular acne drug leads to depression-related behavior in mice
A drug commonly used to treat severe acne can lead to depression-related behavior in mice, according to research published in the journal Neuropsychopharmacology by scientists from the University of Texas at Austin and the University of Bath. (2006-09-21)

Inhibition of tau protein aggregation by rhodanine-based compounds
Several peptide-polymer conjugates were synthesized to enhance the uptake of compounds into cells and thus to improve their biomedical application. The aim of this study was to test whether the peptide-inhibitor complexes still retain their inhibitory activity on Tau aggregation. (2017-06-30)

Guidelines stress caution when combining anti-epileptic, HIV drugs
New guidelines from the American Academy of Neurology will help physicians better choose seizure drugs for people on HIV/AIDS medication, avoiding deadly drug interactions and preventing critical anti-HIV drugs from becoming less effective, possibly leading to a more virulent strain of the disease. (2012-01-04)

Drug-target database lets researchers match old drugs to new uses
A study recently published in the journal Bioinformatics describes a new database and pattern-matching algorithm that allows researchers to evaluate rational drugs and drug combinations, and also recommends a new drug combination to treat drug-resistant non-small cell lung cancer. (2014-05-21)

OU researchers receive OCAST awards for health research projects
Four University of Oklahoma Norman campus researchers were awarded OCAST grants for health research projects on subjects that range from the development of bone grafts using adult stem cells to the identification of genes to block parasite development in mosquitoes to new drug development pipelines to improvements in limb movement. (2013-07-08)

Postcode prescribing is alive and well in Scotland
Drug availability in Scotland continues to depend on local health board decisions, despite one of the intentions of the National Institute for Clinical Excellence (NICE) being to ensure that NHS patients have equitable access, argue doctors from Lothian in this week's BMJ. (2002-07-11)

Experimental agent blocks prostate cancer in animal study
An experimental drug has blocked the progression of prostate cancer in an animal model with an aggressive form of the disease, new research shows. The agent, OSU-HDAC42, belongs to a new class of drugs called histone deacetylase (HDAC) inhibitors, compounds designed to reactivate genes that normally protect against cancer but are turned off by the cancer process. The study showed that the agent kept mice with a precancerous condition from developing advanced prostate cancer. (2008-05-22)

Researchers are on their way to predicting what side effects you'll experience from a drug
Researchers at the University of California, San Diego have developed a model that could be used to predict a drug's side effects on different patients. The proof of concept study is aimed at determining how different individuals will respond to a drug treatment and could help assess whether a drug is suitable for a particular patient based on measurements taken from the patient's blood. (2015-11-02)

Novel anti-cancer drug, ONC201, focus of alliance between Oncoceutics and MD Anderson
Oncoceutics Inc. and the University of Texas MD Anderson Cancer Center today announced the initiation of a strategic alliance and research collaboration agreement for the clinical development of ONC201, a novel anti-cancer drug. (2015-01-05)

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