Popular Gastroenterology News and Current Events | Page 2

Popular Gastroenterology News and Current Events, Gastroenterology News Articles.
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A new breakthrough in timing of urgent endoscopy for gastrointestinal bleeding patients
Endoscopy plays a major role in the diagnosis and therapy of upper gastrointestinal bleeding. An endoscopic group in Italy investigated whether a simple clinical score prior to endoscopy was efficient in selecting those patients. Their study showed that such an endoscopic triage is strongly associated with the detection of endoscopic signs of recent hemorrhage. (2008-09-10)

Intra-arterial combination chemotherapy induces long-term survival for hepatocellular carcinoma
The prognosis of patients with hepatocellular carcinoma accompanied by portal vein tumor thrombus is generally poor. Ten such patients treated by intra-arterial infusion of etoposide, carboplatin, epirubicin and pharmacokinetic modulating chemotherapy by 5-FU and tegafur/uracil are survival for 457.2 days, an one year survival rate was 70 percent. This combination chemotherapy may induce long-term survival and is an effective treatment in patients for HCC with PVTT. (2007-10-17)

Laparoscopic gastric bypass surgery effectively improves obesity-related health problems
This study examines the positive effect laparoscopic gastric bypass surgery can have on obesity-related health problems. (2004-11-01)

Researchers warn: junk food could be responsible for the food allergy epidemic
Experts at the 52nd Annual Meeting of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition are today presenting the results of a study that show higher levels of advanced glycation end products (AGEs), found in abundance in junk food, are associated with food allergy in children. (2019-06-07)

Some people uncomfortable discontinuing cancer screening even when benefit is low
A new study finds 29 percent of veterans who underwent recommended screening colonoscopies were uncomfortable with the idea of stopping these screenings when the benefit was expected to be low for them personally. (2018-12-07)

New blood test on horizon for the 1 in 10 children who suffer common liver disease
A new blood test could become clinical practice within five years, reducing the need for a liver biopsy in the management of pediatric non-alcoholic fatty liver disease (NAFLD), as a major new international pediatric liver registry collaboration yields early results. (2019-06-07)

Gastrointestinal hormone measurably improved symptoms of non-alcoholic fatty liver disease
Through a randomized, double-blind, placebo-controlled phase II clinical trial, researchers at University of California San Diego School of Medicine report that small doses of NGM282, a non-tumorigenic variant of an endocrine gastrointestinal hormone, can significantly and rapidly decrease liver fat content in patients with non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). The findings represent an important proof-of-concept for the compound as there are currently no Food and Drug Administration-approved treatments for NAFLD and NASH. (2018-03-08)

Histochemistry is the golden standard in the diagnosis of carcinosarcomas
Carcinosarcomas are rare, malignant, biphasic tumors. Those in the upper gastrointestinal tract are observed mostly in the esophagus; stomach localization is less frequently reported. (2007-11-14)

Gut microbiome may predict response to biologic therapy for inflammatory bowel disease
Researchers from Massachusetts General Hospital and the Broad Institute of MIT and Harvard have identified differences in the composition and the function of the gut microbiome between patients for whom treatment with a monclonal antibody-based drug was effective in inducing remission of inflammatory bowel disease symptoms and those for whom it was not. (2017-05-15)

Study identifies a new test to predict severity of inflammatory bowel disease in children
The results from a Norwegian study show that a new genetic test for characterising intestinal microbiota may help to diagnose inflammatory bowel disease (IBD) in children and predict which children will develop the most extensive disease and need early, aggressive intervention. (2017-05-12)

Older people with bowel disease receive older medicines
Inflammatory bowel disease is common amongst older people and there are big differences in the choice of treatment for different age groups. Patients over the age of 60 often receive cortisone drugs instead of more modern medicines that target the immune system. This according to a large registry study from Karolinska Institutet in Sweden published in Gastroenterology. (2017-11-13)

Researchers Find Genetic Clues To Intestinal Disease
In a series of recently published studies, Johns Hopkins researchers have shown that an intestinal disease affecting 400,000 people in the United States is actually a variety of related disorders that can be inherited and cause similar symptoms in close relatives. The findings will help physicians predict who will get the disease, called Crohn's disease, speed diagnosis, and help determine the best treatment for each individual ohns.jh.html:+: -- (1996-10-14)

Colorectal cancer screening should start at 45, new research shows
Scientists in France analyzed over 6,000 colonoscopies and found a 400 percent increase in the detection of neoplasia in patients aged between 45-49 in comparison to aged 40-44. The vast majority of colorectal cancer screening programs throughout Europe commence between the ages of 50 and 55, with some not beginning until the age of 60. (2017-10-29)

Why does aspirin increase the susceptibility of Helicobacter pylori to antimicrobials?
A research group from China investigated the mechanisms of aspirin increasing the susceptibility of Helicobacter pylori (H. pylori) to metronidazole. They found that although aspirin increases the susceptibility of H. pylori to metronidazole, it has no effect on the mutations of rdxA gene of H. pylori. Aspirin increases endocellular concentrations of antimicrobials and probably by altering the expression of the outer membrane proteins of H. pylori. (2009-03-03)

Shifting bacterial communities in the stomach may influence cancer risk
Different changes to the microbial community of the stomach may explain why related conditions are associated with different risk levels and types of gastric tumor, according to a new study in PLOS Pathogens. (2017-11-02)

Artificial intelligence: Is this the future of early cancer detection?
Overall, 306 polyps were assessed real-time by using the AI-assisted system, providing a sensitivity of 94 percent, specificity of 79 percent, accuracy of 86 percent, and positive and negative predictive values of 79 percent and 93 percent respectively, in identifying neoplastic changes. (2017-10-29)

Novel cytokine protects mice from colitis
Inflammatory bowel disease, which affects more than 1 million patients in North America, results from an uncontrolled immune response triggered by environmental factors, such as bacteria, in people genetically predisposed to the disorder. Researchers led by Jesús Rivera-Nieves, M.D., of the Inflammatory Bowel Disease Center, Division of Gastroenterology at the UC San Diego School of Medicine, have discovered that expression of a newly identified human cytokine -- Interleukin 37 -- protects mice from colitis. (2011-08-23)

Researchers identify method to diagnose cancer in patients with early onset diabetes
Patients diagnosed with pancreatic cancer can develop elevated blood sugar levels up to three years before their cancer diagnosis, according to the results of a study by Mayo Clinic researchers published the journal Gastroenterology. (2018-06-20)

Are vitamin supplements effective in celiac disease patients?
A research group from the Netherlands investigated the effect of vitamin supplements on homocysteine levels in patients with celiac disease. They found that homocysteine levels are dependent on Marsh classification and the regular use of B-vitamin supplements is effective in reduction of homocysteine levels in patients with celiac disease and should be considered in disease management. (2009-03-03)

Better methods needed for predicting risk of liver disease
While blood samples can reliably identify people with a low risk of developing severe liver disease, better methods are needed in primary care for identifying people in most need of care. These are some of the conclusions of a large registry-based study by researchers at Karolinska Institutet in Sweden published in the esteemed journal Gastroenterology. (2019-09-27)

A case of post-gastrectomy acute pancreatitis
A clinical research team from Taiwan reported a case of asymptomatic pancreatic divisum who underwent palliative subtotal gastrectomy for an advanced gastric cancer with liver metastasis. They concluded for patients with pancreas divisum or dominant duct of Santorini who fail to follow the normal post-operative course after gastrectomy, clinicians should be alert to the possibility of post-gastrectomy acute pancreatitis as one of the potential diagnoses. (2009-10-16)

Prognosis of intrahepatic cholangiocarcinoma
A research team from China statistically evaluated the clinical characteristics, pathology, treatment and prognosis of patients with intrahepatic cholangiocarcinoma (ICC) to determine whether these parameters could contribute to a better prediction of patient survival. Their study showed that surgical radical resection is still the most effective means to cure ICC. Certain laboratory tests (such as carbohydrate antigen 19-9) can effectively predict the survival of the patients with ICC. (2010-01-15)

Invasive procedures should be reserved for a sub-group of acid reflux patients, study says
As the number of Americans with acid reflux grows, a study by researchers at the University of Colorado Anschutz Medical Campus says invasive procedures to treat those who don't respond to medication should be done for select patients. (2018-05-08)

Liver cell adenoma or hepatocellular carcinoma?
Liver cell adenoma is a benign tumor of the liver parenchyma that is associated with the use of oral contraceptives or with glycogen-storage disease. A group in Japan reported a case of LCA found in a 40-year-old woman without a history of oral contraceptive use in which the sequential alteration of the radiological findings suggested well-differentiated hepatocellular carcinoma. (2009-03-20)

Cholesterol modulates sorting of CEA -- implications for inflammatory bowel disease
Researchers at the University of Heidelberg have shown that carcinoembryonic antigen is missorted to the basolateral membrane after cholesterol depletion. This could be of significant importance as CEA is described to have distinct functions at the apical and basolateral membranes, specifically anti-inflammatory properties in the latter. Since decreased basolateral expression is described in inflammatory bowel disease, influencing the apical-to-basolateral transport ratio might be a tool for influencing the course of IBD. (2008-04-30)

New treatment in development for irritable bowel syndrome with constipation
Researchers devised a plan to treat IBS with constipation by delivering chenodeoxycholic acid in a bilayered capsule, finding that this mode of delivery could decrease colon cramping and thus produce a better patient experience. (2020-12-08)

Long-term aspirin use reduces the incidence of digestive cancers by up to 47 percent
In a study involving over 600,000 people, those prescribed with aspirin showed a 47 percent reduction in liver and esophageal cancer incidence, a 38 percent reduction in gastric cancer incidence, a 34 percent reduction in pancreatic cancer incidence and a 24 percent reduction in colorectal cancer incidence. (2017-10-30)

Large placebo-controlled trial confirms safety of proton pump inhibitors (PPIs)
For patients taking proton pump inhibitors (PPIs) to treat gastroesophageal disease (GERD) or other acid-related conditions, new research puts safety concerns to rest. In a large, multi-year, randomized trial studying the safety of proton pump inhibitors (PPIs), researchers find no evidence to support claims that PPIs cause serious health issues such as pneumonia, chronic kidney disease, diabetes and dementia. This research is published in Gastroenterology, the official journal of the American Gastroenterological Association, as an article in press. (2019-06-06)

What's the current role of liver biopsy in children? Position paper in Journal of Pediatric Gastroenterology and Nutrition
While noninvasive alternatives are increasingly available, liver biopsy still provides essential information in some children with liver disease, according to a new position paper in the Journal of Pediatric Gastroenterology and Nutrition, official journal of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health. (2014-11-14)

'Biosimilars' for children with IBD need more research, ESPGHAN expert panel states
Children with inflammatory bowel disease who are doing well on specific biological medications should not be switched to recently approved 'biosimilar' products, concludes an expert consensus statement of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition. The statement appears in the Journal of Pediatric Gastroenterology and Nutrition, the official journal of the European Society of Paediatric Gatroenterology, Hepatology and Nutrition and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, published by Wolters Kluwer. (2015-07-13)

1 in 5 young colon cancer patients have genetic link
Results of the study indicate a benefit for all young colon cancer patients to undergo genetic testing. But with than half of them exhibiting no family history, will insurers cover the tests? (2017-12-13)

Genetic link to IBS identified in women
New research coordinated by Karolinska Institutet in Sweden links certain DNA variants to increased risk of irritable bowel syndrome (IBS) in women. The findings, published in the scientific journal Gastroenterology, might help explain why IBS is more common in women than in men. (2018-04-05)

Acute pancreatitis and cholangitis: a complication caused by a migrated gastrostomy tube
Percutaneous endoscopic gastrostomy is generally considered to be safe with a low rate of serious complications. However, dislocation of a gastrostomy tube can lead to serious complications. A research group led by Dr. Imamura experienced a very rare complication of acute pancreatitis and cholangitis caused by migrated gastrostomy tube. It is important to secure a PEG-tube at skin level, especially a couple of days after it is replaced. (2007-10-25)

What is the function of NOD2 in colonic epithelial cells?
Mutations in the Nucleotide oligomerisation domain 2 alleles are associated with increased risk of developing Crohn's disease. How NOD2 functions is unclear, particularly in the colon which is affected in CD. A research group in the United Kingdom has now shown that NOD2 is important in regulating colonic epithelial cells growth and survival and, is essential for the survival of epithelial tumor cells. (2008-10-23)

In Fimo, we trust: finally a name for the experimental examination of poop
Why, you might ask, do we need a scientifically accurate term based in Latin for the study of poop? The answer is quite simple: because so many scientific words are based in Latin and there hasn't been one for the experimental study of excrement, even though the scientific study of human waste is now at the forefront of biomedical research. (2019-01-03)

Navigating nonalcoholic fatty liver disease (NAFLD)
Gastroenterology, the official journal of the American Gastroenterological Association (AGA), has released a special issue providing clinicians and researchers an up-to-date resource on the risk factors, natural history, diagnosis and treatment of nonalcoholic fatty liver disease (NAFLD). (2020-05-19)

Characteristics of young age gastric cancer patients
A research team from South Korea evaluated the epidemiologic features of young age gastric cancer (GC). Their results showed hormonal associated factors were more commonly associated with females whereas environmental factors were more commonly associated with males in young age GC patients. (2010-01-18)

Take a coffee or tea break to protect your liver
According to a new study published in the Journal of Hepatology, researchers found that drinking coffee and herbal tea may protect against liver fibrosis, estimated as the degree of liver stiffness, which is high in extensive scarring of the liver. Because these beverages are popular, widely available, and inexpensive, they could have the potential to become important in the prevention of advanced liver disease. (2017-06-06)

Combination therapy advisable for bowel disorder IBS
The more abnormalities in intestinal and brain function that IBS sufferers have, the more severe their symptoms of this functional bowel disorder, and the more adversely their everyday life is affected. This is shown by a Sahlgrenska Academy study indicating that patients with IBS should get treatments for different abnormalities simultaneously, to improve both bowel function and signaling from the brain to the gut. (2019-05-15)

A new light on the anti-tumor mechanisms of Scutellaria barbata
A research group in China investigated the growth inhibitory and apoptotic effects of Scutellaria barbata D.Don (S. barbata) and determined the underlying mechanism of its anti-tumor activity in mouse liver cancer cell line H22. They found that extracts from S. barbata can effectively inhibit the proliferation and induce apoptosis of H22 cells involving loss of mitochondrial transmembrane potential, release of cytochrome C, and activation of caspase-3. (2008-12-31)

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