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Cold sore linked to mutation in gene, study suggests
Why some people are troubled by cold sores while others are not has finally been explained by scientists. Cold sores affect around one in five people but, until now, no one has been sure why some are more prone to the virus that causes them. (2013-09-16)

Maths and maps make you nervous? It could be in your genes
Our genes play a significant role in how anxious we feel when faced with spatial and mathematical tasks, such as reading a map or solving a geometry problem, according to a new study by researchers from King's College London. (2017-02-21)

Make tomatoes flavorful again
Genetic analyses have revealed which genes are needed to reinstate the rich, original flavor of tomatoes, now absent in many grocery shelf varieties of this fruit. (2017-01-26)

UAlberta medical researchers discover new potential chemotherapy
Medical researchers at the University of Alberta have discovered that knocking out a particular (2012-12-13)

How breast cancer 'expresses itself'
Two Tel Aviv University researchers have found that 'gene regulation,' the process that shuts off certain parts of a cell's DNA code or blueprint in healthy breast tissue cells, may also play a critical role in the development of breast cancer. Their research proves a significant link between breast-specific genes and the pathology of cancer. (2014-05-29)

Scientists perform whole-genome, whole-brain study of Down syndrome
One out of every 1000 babies is born with Down syndrome, the result of receiving an extra copy of chromosome 21 (trisomy). In the December issue of Genome Research, Stylianos Antonarakis and colleagues from the Geneva University Medical School investigate whole genome activity in the brains of trisomy mice. (2000-12-11)

Age of puberty in girls influenced by which parent their genes are inherited from
The age at which girls reach sexual maturity is influenced by 'imprinted' genes, a small sub-set of genes whose activity differs depending on which parent passes on that gene, according to new research published in the journal Nature. (2014-07-23)

Paired genes in stem cells shed new light on gene organization and regulation
Research from Whitehead Institute shows that transcription at the active promoters of protein-coding genes commonly runs in opposite directions. This leads to coordinated production of both protein-coding messenger RNAs and long noncoding RNAs. (2013-02-04)

Technique rapidly reveals individual gene function
A team of researchers led by Leonid Kruglyak have developed a technique using the gene editing system CRISPR to rapidly identify gene variants. (2016-05-05)

Study of glioma susceptibility in dogs may yield insights for humans
A new study of the genetic factors underlying glioma formation in dogs may hold clues to how these common and often untreatable tumors form in humans. The genome study, which was conducted across 25 dog breeds, identified three genes associated with the tumor. The results from this research, led by Katarina Truvé of the Swedish University of Agricultural Sciences and Kerstin Lindblad-Toh of Uppsala University, were published on May 12 in PLOS Genetics. (2016-05-12)

The Association for Molecular Pathology celebrates ruling in DNA patent case
AMP applauds US District Judge Robert Sweet's ruling in favor of the plaintiffs in the lawsuit, Association for Molecular Pathology, et al. v. US Patent and Trademark Office, et al. (2010-04-01)

Researchers discover new aspect of gene regulation and possible target for cancer drugs
The expression of about three-quarters of active genes in a cell is controlled by a process in which the DNA-transcribing enzyme hesitates before going to work. Experiments have identified the complex of proteins that helps restart this enzyme when it stalls, and so helped to explain how some promising cancer drugs work. (2015-12-10)

Intellectual disability is frequently caused by non-hereditary genetic problems
Mutations in a group of genes associated with brain activity frequently cause intellectual disability, according to a study led by scientists affiliated with the University of Montreal and the research centre at the Centre hospitalier universitaire Sainte-Justine. (2011-04-18)

How skates and rays got their wings
The evolution of the striking, wing-like pectoral fins of skates and rays relied on repurposed genes, according to new research by scientists from the University of Chicago. Studying embryonic skates, they discovered that the rear portion of the fin is built by typical limb-development genes; but the front portion develops through a different set of genes that are usually found in the shoulder areas of other species. (2015-12-09)

NanoCAGE reveals transcriptional landscape of the mouse main olfactory epithelium
The problem in biology of how to identify the promoters of olfactory receptor genes has remained unsolved due to the difficulty of purifying sufficient material from the olfactory epithelium. Researchers at the RIKEN Omics Science Center, collaborating with scientists from Italy, Norway, the United States, the United Kingdom and Germany, have now solved this problem using nanoCAGE technology, which enables comprehensive analysis of transcription start sites from tiny biological samples. (2012-01-05)

It's in our genes: Why women outlive men
Scientists are beginning to understand one of life's enduring mysteries - why women live, on average, longer than men. (2012-08-02)

Identification of genes controlling mouthpart development key to insect diversity
Nagoya University-led international research revealed roles for genes responsible for insect limb formation in the development of stag beetle mouthparts. Different genes were shown to control mandible size and generation of inner teeth, and appeared to cooperate with signaling of the insect juvenile hormone, leading to species-specific differences in morphology. These findings advance understanding of insect diversification and are relevant to control of insects as an agricultural pest and disease vector. (2017-03-07)

Mutant gene network in colon cancer identified
The principles of the gene network for colon tumorigenesis have been identified by a KAIST research team. The principles will be used to find the molecular target for effective anti-cancer drugs in the future. Further, this research gained attention for using a systems biology approach, which is an integrated research area of IT and BT. (2017-11-09)

A new tree of life allows a closer look at the origin of species
A group at the European Molecular Biology Laboratory (EMBL) in Heidelberg has developed a computational method that resolves many of the remaining open questions about evolution and has produced what is likely the most accurate tree of life ever. The study, which appears in the current issue of the journal Science, gives some intriguing insights into the origins of bacteria and the last common universal ancestor of all life on earth today. (2006-03-02)

Next-gen sequencing identifies genes associated with speech disorder
A collaborative team of researchers has used next generation sequencing to identify clinically relevant genetic variants associated with a rare pediatric speech disorder. (2013-10-25)

K-State research team receives patent to control destructive parasite
A recently patented invention from a Kansas State University research team aims to control a devastating parasite that causes millions of dollars in soybean crop damage each year. (2010-11-08)

Coming soon: Genetically edited fruit?
Recent advances that allow the precise editing of genomes now raise the possibility that fruit and other crops might be genetically improved without the need to introduce foreign genes, according to researchers writing in the Cell Press publication Trends in Biotechnology on Aug. 13. (2014-08-13)

Researchers identify novel pathway responsible for infection of a common STD pathogen
Researchers from Boston University School of Medicine have for the first time identified a novel pathway that is necessary for infection to occur with the pathogen Neisseria gonorrhoeae, which is responsible for the second most common infectious disease worldwide, gonorrhea. (2012-02-27)

Researchers find human development's first gear
Oxford University researchers are closer to solving a decade-old mystery after discovering that a set of genes they are studying play a key role in early human development. (2016-06-28)

New mutations related to hereditary neuroendocrine tumours
The presence of a germline mutation in the GOT2 gene found in a patient with metastasis gives rise to increased activity of the encoder enzyme. Furthermore, the authors describe extraordinarily rare mutations in two patients: one in the SDHC gene and another in the IDH1. Finally, by way of an extension study focused on more than 60 patients with these neuroendocrine tumours, a new susceptibility gene, IDH3B, associated with the development of paragangliomas was identified. (2017-07-20)

Study discovers abnormal expression of genes in psychopathy
The expression of many genes that have previously been associated with autism is abnormal also in violent psychopathy, a new study shows. The researchers used stem cell technology to analyze the expression of genes and proteins in the brain cells of psychopathic violent offenders. Published in Molecular Psychiatry, the findings may open up new avenues for the treatment of psychopathy. (2019-08-29)

Some brain cells are better virus fighters
Natural immune defenses that resist viral infection are turned on in some brain cells but switched off in others, scientists have learned. (2013-03-06)

Resistance genes discovered in ancestral tomato species
Dutch researcher Marco Kruijt has discovered two resistance genes that were probably present in an ancestral tomato species, prior to the evolution of modern tomato species. The phytopathologist found these same two genes, which provide resistance against a certain fungus, in several wild tomato species. (2004-10-11)

Circadian genes go to sleep every day at the periphery of the nucleus
Mobility between different physical environments in the cell nucleus regulates the daily oscillations in the activity of genes that are controlled by the internal biological clock, according to a study that is published in the journal Molecular Cell. Eventually, these findings may lead to novel therapeutic strategies for the treatment of diseases linked with disrupted circadian rhythm. (2015-08-27)

New finding may compromise aging studies
Scientists found that a hormone they were using to selectively activate genes in flies for life span studies was actually extending the lives of mated female flies by 68 percent. (2015-02-04)

NYU researchers find electricity in biological clock
Biologists from NYU have uncovered new ways our biological clock's neurons use electrical activity to help keep behavioral rhythms in order. The findings also point to fresh directions for exploring sleep disorders and related afflictions. (2012-10-04)

Google-style ranking used to describe gene connectivity
Using the technique known as 'Gene Rank,' Dartmouth investigator Eugene Demidenko, Ph.D., captured and described a new characterization of gene connectivity in 'Microarray Enriched Gene Rank,' published in BioData Mining. The effective computer algorithm can be used to compare tissues across or within organisms at great speed with a simple laptop computer. (2015-02-13)

World first study shows that some microorganisms can bend the rules of evolution
The dominant thinking in evolution focuses on inheritance between parent and offspring - or 'vertical gene transfer (VGT)'. But now scientists are paying more attention to 'horizontal gene transfer (HGT)': the transmission of DNA other than from parent to offspring, as this transfer can tell us about the evolution of a number of other organisms such as bacteria. It can also help us to better understand antibiotic resistance. (2020-10-13)

Health-promoting Nordic diet reduces inflammatory gene activity in adipose tissue
A Nordic study led by the Institute of Public Health and Clinical Nutrition at the University of Eastern Finland discovered that the health-promoting Nordic diet reduces the expression of inflammation-associated genes in subcutaneous adipose tissue. In overweight persons, the expression of these genes reduced without weight loss. To a certain extent, the adverse health effects of overweight are believed to be caused by an inflammatory state in adipose tissue. (2015-01-05)

Team identifies important regulators of immune cell response
In a collaborative study, scientists from the Florida campus of The Scripps Research Institute and the La Jolla Institute for Allergy and Immunology have developed a more effective method to determine how immune cells called T cells differentiate into specialized types of cells that help eradicate infected cells and assist other immune cells during infection. (2014-09-04)

A new strategy for treating psoriasis
Dexamethasone and other steroids used for treating psoriatic skin inflammation probably act in part by inducing I-kB, thus preventing NF-kB from reaching the nucleus and trans-activating its many target genes, including those involved in T cell-dependent inflammation. Zollner and colleagues now propose a different means to this same end: Since the proteasome is responsible for the regulated turnover of I-kB, proteasome inhibitors might also alleviate psoriasis by blocking NF-kB activation. (2002-02-27)

Skin cancer: To each tumor its particularities, to each tumor its treatment
90 percent of the population are at risk to develop a skin cancer, called basal cell carcinoma, one day. Although common, this cancer is rarely fatal and has until now been little studied. But geneticists sequenced the DNA of these skin tumors, in order to determine the genes that are responsible for the cancerogenesis. Their discovery of new cancer genes that cause BCC can pave the way for new treatment methods personalized for each tumor. (2016-03-07)

Screening for complex genetic interactions
In a report published online ahead of the Jan. 15 print edition, Dr. David Amberg (SUNY Upstate Medical University) and colleagues have developed a large-scale reverse genetic screen to identify complex haploinsufficient interactions in S. cerevisiae. (2006-12-27)

Study finds peoples' niceness may reside in their genes
It turns out that the milk of human kindness is evoked by something besides mom's good example. Research by psychologists at the University at Buffalo and the University of California, Irvine, has found that at least part of the reason some people are kind and generous is because their genes nudge them toward it. (2012-04-10)

Scientists isolate genes that delay Alzheimer's
Scientists have identified a network of nine genes that play a key role in the onset of Alzheimer's Disease. The finding could help scientists develop new treatments to delay the onset of the disease, said lead researcher Associate Professor Mauricio Arcos-Burgos from The Australian National University (ANU). (2015-12-01)

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