Popular Hepatocytes News and Current Events

Popular Hepatocytes News and Current Events, Hepatocytes News Articles.
Sort By: Most Relevant | Most Recent
Page 1 of 6 | 232 Results
Hepatitis therapy: Kupffer cells adjust the balance between pathogen control and hepatocyte regenera
Scientists from TWINCORE have now published new insights on the processes involved in liver inflammation in the Journal of Hepatology: Type I interferons, on the one hand, limit viral replication and thereby help the immune cells to control the viral pathogen. On the other hand, type I interferons delay the regeneration of immune cells, which are important to adjust and maintain the immune balance within the liver during acute inflammation. (2018-01-17)

Could the biological clock be a key ally in the fight against inflammatory disease?
What if the symptoms and seriousness of certain inflammatory diseases were linked to time of day? Researchers from Inserm have been working on this hypothesis, after noting that the seriousness and mortality associated with fulminant hepatitis were dependent on the time at which the disease was induced. Their study, conducted on human cells and mice, shows that the anti-inflammatory action of a biological clock protein could prevent the onset of fulminant hepatitis, by alleviating symptoms and increasing survival rates. (2018-01-26)

New study identifies targets to lessen the effects of alcoholic liver disease
Chronic alcohol consumption causes abnormal fat accumulation in liver cells (steatosis) and liver fibrosis, which can lead to hepatitis, cirrhosis, and sometimes liver cancer. A new study in The American Journal of Pathology offers insights into the cellular aging that may trigger excessive fibrosis formation in the liver as well as possible means to inhibit these changes, which may lead to new therapeutic approaches for patients with ALD. (2017-11-08)

CRISPR-carrying nanoparticles edit the genome
MIT researchers have developed nanoparticles that allow for CRISPR genome-editing in adult animals. Using a new nanoparticle-based, nonviral delivery technique, the researchers were able to cut out a disease-causing gene in about 80 percent of liver cells, and permanently lower cholesterol in mice. (2017-11-13)

Liver cancer: Lipid synthesis promotes tumor formation
Lipid, also known as fat, is an optimal energy source and an important cell component. Much is required for the rapid and uncontrolled growth of cancer cells. Researchers from the Biozentrum of the University of Basel and from the University of Geneva have now discovered that the protein mTOR stimulates the production of lipids in liver tumors to satisfy the increased nutrient turnover and energy needs of cancer cells among other functions. (2017-12-11)

New BioIVT research on botanical-drug interactions published in Applied In Vitro Toxicology
This study investigates the potential for clinically-relevant botanical-drug interactions (BDIs) with Boswellia serrata (Indian Frankincense), a botanical that is used as an anti-inflammatory supplement. The popularity of products containing B. serrata extract is growing. US retail sales of B. serrata reached $14.6 million in 2017 and it continues to move up the top 40 list of best-selling herbal supplements; it is currently ranked number 19. (2019-05-02)

Transplanted liver cells protect against liver failure after massive hepatectomy surgery
Because liver failure often occurs after an extensive hepatectomy, researchers using animal models investigated safer ways to transplant liver cells post-extensive hepatectomy found that rather than transplanting cells into the liver portal vein, transplantation into an extra-hepatic site, such as the intra-mesentery, a fold of membranous tissue on the posterior wall of the abdominal cavity attached to the intestinal tract, can help protect against post-operative liver failure and aid in survival of the remaining liver. (2016-04-25)

How liver cancer develops
Researchers at the University of Zurich and the University Hospital Zurich have discovered a major mechanism in the development of liver cancer. In chronic liver diseases, damaged cells die off and are replaced by new ones over a period of years. As time goes on, DNA damage accumulates, furthering the development of cancer. The caspase-8 enzyme plays an important dual role in this process. (2017-09-11)

Telomerase-expressing liver cells regenerate the organ, Stanford researchers find
Liver stem cells that express high levels of telomerase, a protein often associated with resistance to aging, act in mice to regenerate the organ during normal cellular turnover or tissue damage, according to a study by researchers at the Stanford University School of Medicine. (2018-04-04)

A novel molecular link between cholesterol, inflammation and liver cancer
Hepatocellular carcinoma (HCC) is a deadly disease with no effective cure that develops in the context of liver diseases associated with chronic inflammation. New paper describes how important is the protein c-Fos for HCC development, because it affects cholesterol homeostasis in hepatocytes. Using genetically modified mouse models, researchers at the Spanish National Cancer Research Centre (CNIO) experimentally document how c-Fos modulates premalignant hepatocyte transformation and how this is linked to cholesterol and inflammation. (2017-03-29)

'Organs in a dish' pave the way for personalized medicine in gut and liver disease
One of the most exciting advancements in stem cell research has been the development of organoid systems, which are organ-like three-dimensional structures that mimic their corresponding organ in vivo. In this important review in Digestive and Liver Disease, published by Elsevier, scientists highlight some of the established and exciting novel uses for organoids or 'organs in a dish' in gastroenterology and hepatology and look towards the future in this exciting field. (2019-06-03)

Real-time detection of cholesterol in liver-on-chip cultures of human liver cells
In a paper to be published in the September/December 2019 issue of TECHNOLOGY, a team of researchers from the IIT, Chicago, has developed a novel microfluidic device for measuring in real-time the cholesterol secreted from liver tissue-chip containing human hepatocytes. This innovation can help researchers employing microfluidic cultures to study the effects of drugs such as statins on lowering cholesterol in real-time. (2019-01-11)

How viable is your liver after you die?
In a paper to be published in a forthcoming issue of TECHNOLOGY, a group of researchers from Harvard Medical School have done a study on the viability of donated livers and its correlation with donor demographics. The results of this study could reduce the number of livers that are discarded and facilitate development of novel therapeutics and bioengineering for clinical research applications. (2019-05-13)

Percentage of African ancestry affects gene expression
The percentage of African ancestry in a person's genome determines the level that certain genes are expressed, called mRNA, according to a new Northwestern Medicine study. The discovery could offer insight into the different risk of diseases as well as a different response to medications in African Americans. This is the first study to compare gene production between African Americans. Previous studies compared only black and white individuals. (2019-12-02)

New progress in developing an animal model of hepatitis C
Researchers studying hepatitis C virus have introduced small mutations into mouse liver cells to make the animals more susceptible to the virus, a step toward using mice in hepatitis C vaccine research. (2019-05-10)

3D liver tissue implants made from human stem cells support liver function in mice
Stem cells transformed into 3D human liver tissue show promising support of liver function when implanted into mice with a liver disease. The scientists say that in addition to being early-stage progress towards developing human liver tissue implants, it could also reduce the need for animals in research by providing a better platform to study human liver disease and test drugs in the lab. (2018-08-27)

Liver progenitor cells are involved in the development of hepatic tumors
The malignant transformation of hepatocytes is the origin of most hepatocellular carcinomas, an aggressive type of liver cancer with high mortality rates. But these cells do not act alone. Research conducted by scientists at the Spanish National Cancer Research Centre (CNIO) reveals how hepatocytes 'recruit' and 'instruct' liver progenitor cells to contribute to the hepatic lesions. (2017-04-18)

New therapeutic avenue in the fight against chronic liver disease
A recent study, affiliated with South Korea's Ulsan National Institute of Science and Technology (UNIST) has introduced a novel targeted drug delivery system in the fight against cancer. (2019-01-18)

Peptide improves glucose and insulin sensitivity, lowers weight in mice
Treating obese mice with catestatin (CST), a peptide naturally occurring in the body, showed significant improvement in glucose and insulin tolerance and reduced body weight, report University of California San Diego School of Medicine researchers. (2018-02-08)

CeMM PR -- Immunity -- Master regulator of liver metabolism identified during infection
Researchers at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences identified a key mechanism for how antiviral immune responses reprogram liver metabolism. Their recent study, which was published in the renowned scientific journal Immunity, investigated the communication between inflammation and liver metabolism during chronic viral infection. (2019-11-26)

Scientists create most sophisticated human liver model yet
Scientists have developed the most sophisticated mini-livers to date. These organoids can potentially help scientists better understand certain congenital liver diseases as well as speed up efforts to create liver tissue in the lab for transplantation into patients. (2018-02-13)

Simple method rescues stressed liver cells
Isolated human hepatocytes are essential tools in preclinical and clinical liver research, but cell quality is highly variable. Now, researchers from Uppsala University have devised a simple protocol that improves hepatocyte quality and enables cells from a wider quality spectrum to be used in standard and advanced cell culture. The findings are published in Archives of Toxicology. (2018-12-21)

When malaria parasites trick liver cells to let themselves in
A new study led by Maria Manuel Mota, group leader at Instituto de Medicina Molecular, now shows that malaria parasites secrete the protein EXP2 that is required for their entry into hepatocytes. These findings, published today in the scientific journal Nature Communications, open a new avenue for prophylactic anti-malarial strategies, since blocking or decreasing the infection of the liver can prevent the disease. (2020-11-06)

Cancer most frequently spreads to the liver; here's why
When cancer spreads to another organ, it most commonly moves to the liver, and now researchers at the Abramson Cancer Center of the University of Pennsylvania say they know why. (2019-03-06)

Study: Damaged liver cells undergo reprogramming to regenerate
New research conducted by biochemists at the University of Illinois has determined how damaged liver cells repair and restore themselves through a signal to return to an early stage of postnatal organ development. (2018-09-26)

Regeneration mechanism discovered in mice could provide target for drugs to combat chronic liver disease
Researchers at the University of Cambridge have uncovered a novel molecular mechanism that allows damaged adult liver cells to regenerate, paving the way for design of drugs to boost regeneration in conditions such as cirrhosis or other chronic liver diseases where regeneration is impaired. (2019-11-04)

Is 31P MRS a useful tool for evaluating early acute hepatic radiation injury?
31P magnetic resonance spectroscopy (MRS) has been widely used to detect liver metabolism in vivo for decades. A research group from China investigated whether changes of 31P MRS in the liver with early acute radiation injury were related to the liver damage score (LDS) and pathologic changes. They found that 31P MRS is a useful method to evaluate early acute hepatic radiation injury. The relative quantification of hepatic ATP levels is correlated with LDS. (2009-06-23)

Fatty liver disease research set to benefit from stem cell advance
Scientists have developed a lab-based system for studying the most common type of liver disease, paving the way for research into new therapies. The team at the University of Edinburgh has devised a way to probe Non-Alcoholic Fatty Liver Disease, which affects up to one in three people, using cells in a dish. (2018-05-23)

Molecule's role in maintaining liver size and function revealed
Researchers at TMDU found that the YAP molecule is a key mediator in the identification and clearance of damaged cells from the liver. They showed that, in the absence of injury, YAP activation led to hepatocyte proliferation. However, when injury was induced to mouse liver, it instead induced hepatocytes to migrate to the hepatic sinusoids, undergo cell death, and be degraded by the immune system. (2017-08-01)

Liver fix thyself
By studying a rare liver disease called Alagille syndrome, scientists discovered the mechanism behind a form of tissue regeneration that may someday reduce the need for organ transplants. Researchers report in Nature that when disease or injury causes a shortage in one type of liver cell, the organ can instruct another type of liver cell to change identities to provide replacement supplies. The findings one day may lead to a viable treatment for human disease. (2018-05-02)

Hepatitis B: Natural controllers shed light on immunity mechanisms
To improve our understanding of the antibody response conferring protection against HBV infection, scientists from the Institut Pasteur and Inserm, in collaboration with the Roche Innovation Center in Switzerland, produced and characterized human monoclonal antibodies specific to viral envelope antigens, referred as HBsAg, from blood memory B cells isolated from HBV vaccinees and natural controllers. (2020-08-13)

Modeling NAFLD with human pluripotent stem cell derived immature hepatocyte like cells
Researchers from the Institute for Stem Cell Research and Regenerative Medicine at the University Clinic of Düsseldorf have established an in vitro model system for investigating nonalcoholic fatty liver disease (NAFLD). The study led by Professor James Adjaye has now been published in the journal Stem Cells and Development. (2016-06-29)

First successful delivery of mitochondria to liver cells in animals
This experiment marks the first time researchers have ever successfully introduced mitochondria into specific cells in living animals. The study lays the groundwork to address a serious gap in treatment for liver diseases and may even eventually be used to treat other maladies throughout the body affected by mitochondrial malfunction or damage. (2020-06-25)

Discovery of a protein that protects against fatty liver
A team co-headed by scientists at the Institute for Research in Biomedicine and the IDIBAPS Biomedical Research Institute (part of the Hospital Clínic de Barcelona) has revealed the capacity of the CPEB4 protein to prevent fatty liver disease. (2017-01-17)

Licorice is a hot trend in hot flashes, but could interact with medications
Licorice roots have a flavorful history, having been used in ancient Egyptian teas and in traditional Chinese medicines, all the way to today as a flavoring agent and candy. And some women now take licorice extracts as supplements to treat menopausal symptoms. But scientists caution that licorice could pose a health risk by interacting with medications. The researchers are presenting their results today at the 254th National Meeting & Exposition of the American Chemical Society. (2017-08-21)

Food withdrawal results in stabilization of important tumor suppressor
Tumor suppressors stop healthy cells from becoming cancerous. Researchers from Charité - Universitätsmedizin Berlin, the Medical University of Graz and the German Institute of Human Nutrition in Potsdam-Rehbruecke have found that p53, one of the most important tumor suppressors, accumulates in liver after food withdrawal. Results of this study have been published in The FASEB Journal. (2016-12-21)

New progress toward finding best cells for liver therapy
In an important step toward using transplanted cells to treat liver failure, researchers demonstrate successful transplantation of fetal rat liver cells to an injured adult rat liver. (2017-04-26)

Revealing the molecular mystery of human liver cells
A map of the cells in the human liver has been created by University Health Network Transplant Program and University of Toronto researchers, revealing for the first time differences between individual cells at the molecular level which can have a profound impact on their behaviour in tissue, tumours and disease. (2018-10-22)

BioIVT publishes new research on the mechanisms underlying the C-DILI assay
BioIVT, a leading provider of research models and services for drug development, today announced its research into the mechanisms involved in cholestatic drug-induced liver injury (DILI) has been published in Applied In Vitro Toxicology. DILI is one of the primary causes of drug development failures. As a result, sponsors endeavor to identify new drug candidates with a high DILI risk early in the development process. (2018-09-10)

Liver fully recovers from a low protein diet
Damage caused to the liver by a low protein diet can be repaired, a new study just published in the prestigious journal Nutrition has found. (2017-03-27)

Page 1 of 6 | 232 Results
   First   Previous   Next      Last   
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.