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Popular Hepatocytes News and Current Events, Hepatocytes News Articles.
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Possible new treatment strategy for fatty liver disease
Researchers at Karolinska Institutet in Sweden have identified a molecular pathway that when silenced could restore the normal function of immune cells in people with fatty liver disease. The findings could lead to new strategies for treating the condition, which is a major health risk for people with obesity. The study is published in the scientific journal Science Translational Medicine. (2020-02-26)

Liver fully recovers from a low protein diet
Damage caused to the liver by a low protein diet can be repaired, a new study just published in the prestigious journal Nutrition has found. (2017-03-27)

Tissue model reveals how RNA will act on the liver
MIT researchers have shown an engineered model of human liver tissue can be used to investigate nucleic acid-based therapies, such as RNA interference, before testing them in patients. (2019-03-05)

One more piece in the puzzle of liver cancer identified
Manuela Baccarini and her team at the Max F. Perutz Laboratories (MFPL) of the University of Vienna and Medical University of Vienna are one step closer to unraveling the mechanisms behind liver cancer. The researchers discovered that RAF1, a protein known as an oncogene in other systems, unexpectedly acts as a tumor suppressor in hepatocellular carcinoma. The study is published in the renowned journal Nature Communications. (2016-12-21)

BUSM researchers uncover liver's role in preventing dissemination of lung infection
Researchers at Boston University School of Medicine have discovered the regulation and functional significance of the acute phase response during a lung infection. (2012-04-02)

First successful organ donation from newborn carried out in UK
The very first successful organ donation from a newborn carried out in the UK is reported in the Fetal & Neonatal Edition of Archives of Disease in Childhood. (2015-01-19)

Scientists reveal endocardial origin of liver vasculature
On March 29, Nature Genetics published a research article entitled 'Genetic lineage tracing identifies endocardial origin of liver vasculature,' from Prof. ZHOU Bin's lab. Taking advantage of genetic lineage tracing and tissue specific gene knockout technology, they found that part of liver vasculature is derived from endocardium in the developing heart. (2016-04-05)

Cell transplantation procedure may one day replace liver transplants
In an effort to find therapeutic alternatives to whole liver transplantation and improve the outcomes of hepatocyte transplantation, researchers tested the efficacy and feasibility of transplanting multi-layered sheets of hepatocytes and fibroblasts into the subcutaneous cavity of laboratory rats modeled with end stage liver failure. The cells in the multi-layered hepatocyte sheets survived better than cells transplanted by traditional methods and the cells proliferated, maintaining liver function in the animals for at least two months. (2015-08-26)

The liver increases by half during the day
In mammals, the liver reaches its maximum efficiency when they are active and feed. Biologists from the University of Geneva (UNIGE), Switzerland, showed in mice that the size of the liver increases by almost half before returning to its initial dimensions, according to the phases of activity and rest. This fluctuation disappears when the normal biological rhythm is reversed. The disruption of our circadian clock probably has important repercussions on our liver functions. (2017-05-04)

Snakes reveal the origin of skin colours
The skin colour of vertebrates depends on chromatophores. A team from the University of Geneva is studying the variety of colours within the corn snake species. The research, demonstrates that the dull colour of the lavender variant of corn snake is caused by the mutation of a gene involved in forming lysosomes enough to affect every skin colour. The UNIGE study marks a step forward in our understanding of the origin of skin colours. (2020-10-05)

A human liver microphysiology platform for studying physiology, drug safety, and disease
Currently available animal and human liver models provide limited predictions of human drug efficacy and toxicity, primarily due to metabolic differences and the limited ability of simple 2-D models to recapitulate the complex cellular interactions that lead to toxicity. To fill this gap we have developed a novel 4 cell type, 3-D, microfluidic, human liver model with the ability to monitor multiple cellular toxicity and human disease related functions over at least 28 days. (2016-02-29)

New study questions the safety of caspase inhibitors for the treatment of liver disease
Many acute and chronic liver diseases, including alcoholic hepatitis, result from apoptotic (programmed) cell death mediated by the enzyme caspase. Caspase inhibitors have therapeutic potential to treat and prevent apoptosis-mediated liver injury, and some are currently in clinical trials. However, a new study published in The American Journal of Pathology raises serious safety concerns regarding the clinical use of caspase inhibitors by demonstrating the occurrence of delayed-onset necrotic, non-caspase-dependent liver cell injury. (2016-10-20)

Liver metabolism study could help patients awaiting transplants
In a new study that could help doctors extend the lives of patients awaiting liver transplants, a Rice University-led team of researchers examined the metabolic breakdown that takes place in liver cells during late-stage cirrhosis and found clues that suggest new treatments to delay liver failure. (2014-03-03)

Supply and demand
In a study published today in Cell Metabolism, scientists at the European Molecular Biology Laboratory in Heidelberg, Germany, have discovered that a group of proteins called IRPs ensure that iron balance is kept and as such are essential for cell survival. More specifically, they found that IRPs are required for the functioning of mitochondria, the cell's energy factories. (2010-08-04)

Quantum chemical computations provide insight into liver toxicity
By systematic computational studies on 55 hydrocarbons Balasubramanian and Basak have ranked the toxicity of halocarbons on the basis of the electron affinity and proton-extraction propensity from the lipid membrane of the liver. (2016-05-06)

Researchers identify human protein that aids development of malaria parasite
Researchers in Japan have discovered that the Plasmodium parasites responsible for malaria rely on a human liver cell protein for their development into a form capable of infecting red blood cells and causing disease. The study, which will be published June 12 in the Journal of Experimental Medicine, suggests that targeting this human protein, known as CXCR4, could be a way to block the parasite's life cycle and prevent the development of malaria. (2019-06-12)

Penn State College of Medicine research isolates liver cancer stem cells prior to tumor formation
Penn State College of Medicine researchers, in collaboration with colleagues at the University of Southern California, have taken an important step in understanding the role of stem cells in development of liver cancer. Using a unique approach that involves study of individual cells, the team, led by C. Bart Rountree, M.D., has demonstrated for the first time a population of cancer stem cells in the liver prior to tumor formation. (2009-09-17)

In vivo RNAi screening identifies new regulators of liver regeneration
This study establishes a unique system to perform in vivo RNAi screens for genetically dissecting the cellular signaling networks that regulate hepatocyte proliferation during chronic liver damage. (2011-04-01)

Liver transplants could be redundant with discovery of new liver cell
Researchers at King's College London have used single cell RNA sequencing to identify a type of cell that may be able to regenerate liver tissue, treating liver failure without the need for transplants. (2019-07-26)

A human liver cell atlas
The cellular composition of the liver is incompletely understood. Researchers at the Max Planck Institute for Immunobiology and Epigenetics have created a comprehensive map of all cell types in the healthy human liver using a method named single-cell RNA sequencing. They discovered new subpopulations of liver cell types and demonstrated the usefulness of their human liver cell atlas as a resource to reveal how cells change in liver cancer. The study was published in Nature. (2019-07-10)

BUSM study shows potential of differentiated iPS cells in cell therapy without immune rejection
A new study from Boston University School of Medicine shows that tissues derived from induced pluripotent stem (iPS) cells in an experimental model were not rejected when transplanted back into genetically identical recipients. (2013-01-25)

Clay supplements in dairy cows improve immune response to aflatoxin challenge, study says
In the fight against aflatoxin, dairy producers often turn to sequestering agents such as clay to reduce transference of the toxin into milk. It's an effective tactic, but a new study from the University of Illinois shows that clay has additional benefits for overall cow health. (2018-10-11)

Lymphocyte-hepatocyte interactions: hepatitis C virus changes the rules
New data presented at the International Liver Congress today show the existence of novel interactions between T cells and hepatocytes that are regulated by HCV infection, providing a novel understanding of how HCV persists in the liver. (2011-03-31)

How hepatitis B and delta viruses establish infection of liver cells
Princeton University researchers have developed a new, scalable cell culture system that allows for detailed investigation of how host cells respond to infection with hepatitis B (HBV) and delta virus (HDV). The paper describing their findings was published online on June 18, 2019 in the journal Hepatology. (2019-06-18)

Magnetic nanomaterials become an effective treatment against liver fibrosis
Fibrosis may affect different body organs. It develops as a reaction to long-time inflammation and is supposed to isolate the inflammation site from surrounding tissues. For example, chronic liver fibrosis may occur if the liver is constantly influenced by toxins, viruses, or metabolic disturbances. Liver damage is caused by the hepatocytes death, the main type of liver cells that secure the functioning of the organ. (2020-01-20)

Study shows proof of concept of BioIVT HEPATOPAC cultures with targeted assay to evaluate bioactivation potential and drug-induced liver injury (DILI) risk
New in vitro Bioactivation Liver Response Assay used HEPATOPAC model to demonstrate utility of in vitro transcriptomic signature-based strategy in preclinical DILI risk assessment. (2020-10-12)

A new model of liver regeneration
Harvard Stem Cell Institute scientists at Boston Children's Hospital have new evidence in mice that it may be possible to repair a chronically diseased liver by forcing mature liver cells to revert back to a stem cell-like state. (2014-06-05)

Study introduces mRNA-LNP as a safe therapeutic intervention for liver regeneration
When severely or chronically injured, the liver loses its ability to regenerate. A new study led by researchers at the Center for Regenerative Medicine at Boston University School of Medicine (BUSM) and Boston Medical Center (BMC) now describes a safe new potential therapeutic tool for the recovery of liver function in chronic and acute liver diseases. (2021-01-27)

Duke study: Cold needed to preserve livers for transplant also can kill certain cells
A team of Duke University Medical Center researchers has figured out why donated livers can suffer a mysterious injury that damages their ability to perform well once transplanted. (1999-12-29)

Researchers convert cirrhosis-causing cells to healthy liver cells in mice
A team of researchers led by UC San Francisco scientists has demonstrated in mice that it is possible to generate healthy new liver cells within the organ itself, making engraftment unnecessary. What's more, they did it by converting the very cells that drive liver disease, thereby reducing liver damage and improving liver function at the same time. (2016-06-02)

Type 2 diabetes, it all starts in the liver
Among the detrimental effects of obesity is the risk of developing type 2 diabetes. If the strong links between obesity and type 2 diabetes are well known, the cellular and molecular mechanisms were so far poorly understood. Scientists from the University of Geneva unravel the factors linking obesity and insulin resistance. By deciphering how the protein PTPR-γ inhibits insulin receptors located at the surface of liver cells, they open door to potential news therapeutic strategies. (2017-11-28)

Induced liver regeneration enhances CRISPR/Cas9-mediated gene repair
Use of thyroid hormone to boost hepatocyte proliferation enhanced the efficiency of CRISPR/Cas9-mediated gene correction in the mouse liver. This dietary induction of hepatocyte regeneration may be a viable clinical strategy to enhance gene repair in the liver. (2020-11-10)

Microexons: Small fragments of genes, essential for neurone maturation
Study led by researchers from the University of Toronto and involving the Centre for Genomic Regulation in Barcelona has described a group of small DNA fragments that are key in neurone regulation and maturity. The discovery reveals the importance of these small fragments and their relationship with autism. CRG Researcher and first author of the work Manuel Irimia has just received a 1.5 million euro grant from the European Research Council to continue studying this phenomenon. (2014-12-18)

A potential breakthrough in obesity medicine with the help of gold nanoparticles
A team of researchers in Korea believes to have discovered a synthetic gold-based compound which may help patients with obesity. The nanoparticles were tested in both 3T3-L1 and HepG2 cell lines, which are two known candidates for studying obesity and related disease models. (2020-04-14)

UC San Diego and Samsara Sciences team up to advance liver tissue models
Researchers at University of California, San Diego School of Medicine and Samsara Sciences, Inc., a wholly-owned subsidiary of Organovo Holdings, Inc., have entered into an agreement focused on the development of techniques and methods for the isolation and characterization of liver cells that will help drive new research on liver biology, drug safety and efficacy, and the treatment of liver diseases. (2016-01-14)

Japanese scientists show 'new' liver generation using hepatocyte cell transplantation
Hepatocyte cells, comprising the main tissues of the liver and involved in protein synthesis and storage, can be retrieved and propagated for the purposes of creating a new liver system. This study demonstrates the feasibility of propagating mouse hepatocytes by creating a vascularized platform using a growth factor releasing device, and by creating uniform hepatocyte (2012-06-11)

What is the role of the omentum in regenerating the liver?
Although the liver is a unique tissue which can regenerate after an acute injury it has been a challenge to induce such regeneration after chronic liver disease. It is therefore important to study mechanisms of liver regeneration in order to devise new approaches to regenerate the liver following damage from chronic disease. Dr. Singh and his group from Chicago recently reported a novel methodology that can potentially induce new liver growth. (2009-03-07)

Stopping liver cancer in its tracks
A University of Tokyo research group has discovered that AIM (apoptosis inhibitor of macrophage), a protein that plays a preventive role in obesity progression, can also prevent tumor development in mice liver cells. This discovery may lead to a therapy for hepatocellular carcinoma, the most common type of liver cancer and the third most common cause of cancer deaths. (2014-10-02)

Pigs grow new liver in lymph nodes, study shows
Hepatocytes -- the chief functional cells of the liver - are natural regenerators, and the lymph nodes serve as a nurturing place where they can multiply. Researchers demonstrated that large animals with ailing livers can grow a new organ in their lymph nodes from their own hepatocytes. (2020-08-24)

Food or nutrient restriction offers insight into cancer prevention and metabolic disease
Could limiting food intake be a valid treatment strategy for certain types of cancers? New research in The FASEB Journal suggests 'maybe.' (2016-11-16)

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