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Popular Hepatocytes News and Current Events, Hepatocytes News Articles.
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Rethinking reverse cholesterol transport
The protective role of HDL, the so-called (2001-09-12)

Humans can regrow liver from bone marrow
Researchers have shown for the first time that the human liver can regenerate its tissue with a cell type from outside the organ -- and they present the first compelling evidence that those stem cells are human bone marrow. (2000-06-25)

Insulin in heart development
Given the profound effects of insulin on energy metabolism and gene expression, it is not surprising that systemic deficiency in the insulin receptor (IR) leads to the early postnatal death of IR-deficient mice. However, a skeletal muscle-specific IR knockout (MIRKO) mice have been available for several years, and animals lacking the receptor in th pancreas or liver have been described. Belke et al. have now developed a mouse lacking the IR specifically in the heart. (2002-02-27)

Reprogramming a patient's eye cells may herald new treatments against degenerative disease
Scientists have overcome a key barrier to the clinical use of stem cells with a technique which transforms regular body cells into artificial stem cells without the need for introducing foreign genetic materials, which could be potentially harmful. The research, published in Stem Cells, suggests that cells taken from a patient's eye can be (2009-10-22)

Study may improve survival of transplanted livers
New research at the University of North Carolina at Chapel Hill School of Medicine shows that treatment with nitric oxide after storage may dramatically improve the viability of transplanted livers. (2004-05-24)

OHSU scientists first to grow liver stem cells in culture, demonstrate therapeutic benefit
For decades scientists around the world have attempted to regenerate primary liver cells known as hepatocytes because of their numerous biomedical applications, including hepatitis research, drug metabolism and toxicity studies, as well as transplantation for cirrhosis and other chronic liver conditions. But no lab in the world has been successful in identifying and growing liver stem cells in culture -- using any available technique -- until now. (2013-02-25)

A gene that fights cancer, but causes it too
An international team of researchers, led by scientists at the University of California, San Diego School of Medicine, and the Eastern Hepatobiliary Surgery Hospital in China, say a human gene implicated in the development of leukemia also acts to prevent cancer of the liver. (2011-05-16)

Scientists create functional liver cells from stem cells
Evaluating drug-induced liver injury is a critical part of pharmaceutical drug discovery and must be carried out on human liver cells. Now, in research published on the cover of Hepatology journal, Hebrew University of Jerusalem scientists report that they produced large amounts of functional liver cells from human embryonic and genetic engineered stem cells. The cells can detect the toxic effect of over a dozen drugs with greater than 97 percent accuracy. (2015-07-30)

Mature liver cells may be better than stem cells for liver cell transplantation therapy
Stem or progenitor cells have shown they can be cryopreserved for a long time and expanded in vitro. However, a comparison between the repopulation efficiency of immature hepatic stem/progenitor cells and mature hepatocytes transplanted into liver-injured rats concluded that mature hepatocytes offered better repopulation efficiency than stem/progenitor cells. The growth of the stem/progenitor cells was faster than the mature hepatocytes, but most of the stem/progenitor cells soon died while mature hepatocytes survived and proliferated. (2012-06-04)

Interaction between lymph and liver cells may affect immune response
A new study on the ability of liver cells to interact with T cells (lymph cells that play a role in regulating the immune response) found that such interactions do occur and demonstrated the mechanism by which they may take place. The results may help explain the altered immune responses that occur with aging and other conditions and may be useful in developing therapies for viral hepatitis and autoimmune diseases. (2006-11-01)

MicroRNAs grease the cell's circadian clockwork
In the June 1 issue of G&D, Dr. Ueli Schibler and colleagues reveal a role for the liver-specific microRNA, miR-122, in the circadian regulation of lipid metabolism. (2009-05-31)

Newly discovered cells regenerate liver tissue without forming tumors
The mechanisms that allow the liver to repair and regenerate itself have long been a matter of debate. Now researchers at University of California, San Diego School of Medicine have discovered a population of liver cells that are better at regenerating liver tissue than ordinary liver cells, or hepatocytes. The study is the first to identify these so-called 'hybrid hepatocytes,' and show that they are able to regenerate liver tissue without giving rise to cancer. (2015-08-13)

Bone Marrow Gives Rise To Functioning Liver Cells, University Of Pittsburgh Scientists Discover
Bone marrow-derived cells give rise to fully functional liver cells, states a University of Pittsburgh study published May 14 in Science, yielding the first report that bone marrow- derived cells provide a lineage for cells of solid organs and suggesting that they could eventually repair or replace injured or diseased livers. (1999-05-14)

What cause alanine aminotransferase levels to elevate persistently among Iranian general population?
A team led by Dr. A Pourshams from the University of Medical Sciences/University of Tehran with collaboration of the Iranian Blood Transfusion Research Center in Tehran, has determined the prevalence and causes of persistently elevated alanine aminotransferase levels among general population in northern of Iran. (2008-05-14)

New vaccine for nicotine addiction
Researchers at Weill Cornell Medical College have developed and successfully tested in mice an innovative vaccine to treat nicotine addiction. (2012-06-27)

How does radial flow bioreactor system apply in the fields of bioartificial liver?
A team led by Dr. Yuji Ishii from the Jikei University School of Medicine has reported the hepatic reconstruction from fetal porcine liver cells using a radial flow bioreactor. The authors evidenced that cells organized in organoids with the presence bile duct like structure. They also showed that hepatocytes growth factor favored differentiation and survival of cells in the bioreactor. (2008-05-07)

New source of cells for modeling malaria
MIT researchers have discovered a way to grow liver-like cells from induced pluripotent stem cells. (2015-02-05)

Critical link in cell death pathway revealed
The role of a protein called XIAP in the regulation of cell death has been identified by Walter and Eliza Hall Institute researchers and has led them to recommend caution when drugs called IAP inhibitors are used to treat cancer patients with underlying liver conditions. (2009-07-22)

Is liver damage down the TRAIL for a promising cancer therapy?
Although TRAIL is a protein that is considered a promising cancer therapeutic because it can kill tumor cells, controversy surrounds whether or not it affects nontumor cells. A new study now shows that TRAIL alone does not kill mouse liver cells in vitro, but it does enhance both in vitro and in vivo liver cell death induced by signaling through another liver cell protein, indicating that TRAIL-based therapeutics might cause liver damage. (2006-09-01)

Inhibition of enzyme NOX4 prevents liver fibrosis
Researchers at the Bellvitge Biomedical Research Institute have led a study published in PLOS ONE showing that the inhibition of a family member of NADPH oxidase enzyme, NOX4, plays an important role in liver fibrosis. (2012-11-05)

Mass. General-based research center will investigate why immune system fails to control hepatitis C
A research consortium based at Massachusetts General Hospital has been awarded $15 million from the National Institute of Allergy and Infectious Diseases to investigate how the hepatitis C virus resists suppression and clearance by the immune system. (2009-07-22)

What is the role of reactive oxygen species in ethanol-mediated cell death of polarized hepatic cells?
The clinical progression of alcoholic liver disease is associated with an increase in hepatocellular damage that may involve the promotion and execution of apoptotic death mechanisms. A liver research group in Nebraska has reported that the signaling and selection of apoptotic over necrotic cell death mechanisms involves particular factors such as the level of oxidative stress in the hepatocyte as well as the ability antioxidant defenses of the cell have in coping with oxidative damage. (2009-06-12)

Improved culture system for hepatitis C virus infection
A University of California, San Diego School of Medicine researcher has developed the first tissue culture of normal, human liver cells that can model infection with the hepatitis C virus and provide a realistic environment to evaluate possible treatments. The novel cell line will allow pharmaceutical companies to effectively test new drug candidates or possible vaccines for the HCV infection, which afflicts about 170 million people worldwide. (2008-07-15)

MiR-122 micromanages liver function
Emerging research suggests that microRNAs (miRNAs) they have diverse roles in normal physiology and disease. In this issue, two groups investigated the role of the predominant liver miRNA, miR-122, and determined that the molecule was critically involved in modulating fat and cholesterol metabolism, and may also have a tumor suppressive function in hepatocytes. (2012-07-23)

Genetic Engineering and Biotechnology News reports on early ADMET use
Biotech and pharma companies are increasingly utilizing novel technologies to assess the druggability of test compounds early in the development cycle to avoid costly late clinical-stage attrition, according to Genetic Engineering and Biotechnology News. By identifying absorption, distribution, metabolism, excretion, and toxicity issues early, pharma also has the opportunity to increase the probability of success of its new drug development activities and reduce the time to market, reports the May 1 issue of GEN. (2008-05-05)

Transplanted liver cells function in older animals but do not proliferate as much as in younger ones
Hepatocyte transplantation has been successful in a number of animal models, raising hopes that use of cells could overcome the shortage of donor livers and the problems of surgery, but the procedure has not been as successful in humans. Was the problem related to the age of the donor? Scientists at the Martin Luther University Hale-Wittenberg, Germany, believe they know the answer. Age of the donor makes no difference, but age of the recipient makes a big one. (2009-04-19)

Stem cell, artificial liver research receives Coulter Foundation funding at NJIT
Two NJIT biomedical researchers have received the prestigious Coulter Foundation Translational Awards for promising patent applications that may some day extend peoples' lives. (2010-08-10)

Scientists develop novel method to generate functional hepatocytes for drug testing
Scientists have for the first time produced liver cells from adult skin cells using the induced pluripotent stem cell technology. The study, led by the University of Edinburgh's MRC Centre for Regenerative Medicine, paves the way for the creation of a stem cell library that can be used for in vitro hepatic disease models. (2009-10-20)

JCI online early table of contents: June 15, 2009
This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, June 15, 2009, in the JCI: (2009-06-15)

New chimeric mouse model for human liver diseases, drug testing
Cells cultured in the lab are like a fish out of water. Often, their behavior does not reflect their biological function within an entire organ or organism, which, for example, turns studying human liver cells into a big challenge. (2007-12-03)

Cycles of cell death, proliferation key to liver cancer
School of Medicine shows that liver cancer is likely caused by cycles of liver cell death and renewal. The research, appearing online the week of June 19 in advance of publication in the journal Proceedings of the National Academy of Sciences (2006-06-22)

The 'S' stands for surprise
Protein S, a well-known anticoagulant protein, keeps the blood flowing in more than one way, discovered researchers at the Salk Institute for Biological Studies. The protein contributes to the formation and function of healthy blood vessels. (2009-09-01)

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