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Study shows tight diabetes control does not impact cognitive ability in type 1 diabetes
National Joslin-led study shows tight blood glucose control in people with type 1 diabetes does not negatively impact cognitive ability. (2007-05-02)

Glucowatch Biographer reported to improve diabetes control in children
A study published in the current issue of Pediatrics showed that children who wore the GlucoWatch Biographer had greater detection of hypoglycemic events, and reduced levels of the metabolic marker, HbA1c (also known as A1c), compared to those using conventional glucose monitoring. The study is the first to demonstrate that diabetes management with the Biographer and appropriate therapy could affect HbA1c levels--a key marker in the quest for better disease control. (2003-04-25)

College students with diabetes at risk for complications, depression, low quality of life
The study surveyed 173 people with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM), who worked at or attended a university. High levels of diabetes distress were reported by 27% of those with T1DM and 30% of those with T2DM. Participants who reported high diabetes distress also indicated a lower diabetes quality of life. Researchers found 19% of those with T1DM and 17% of those with T2DM screened positive for severe depression. (2019-08-26)

Merck Animal Health announces Vetsulin
Merck Animal Health today announced that Vetsulin (porcine insulin zinc suspension), the only FDA-approved insulin for use in both dogs and cats is now available to veterinarians throughout the United States. (2013-04-29)

Case Western Reserve receives Helmsley Trust grant to develop new glucose-sensitive insulin
Case Western Reserve University's School of Medicine has received a nearly $1 million grant from The Leona M. and Harry B. Helmsley Charitable Trust's Type 1 diabetes program to support research on a rapid-acting, glucose-responsive insulin. (2013-03-14)

Neural stem cells derived from human embryonic stem cells carry abnormal gene expression
Neural stem cells grown from one of the federally approved human embryonic stem cell lines proved to be inferior to neural stem cells derived from fetal tissue donated for research, a UCLA study has found. (2006-08-04)

Chemical in brain acts like a fuel gauge
The neurotransmitter norepinephrine can alert the brain to dangerously low blood sugar levels, according to a new study. Finding has implications for diabetes research. (2007-07-05)

Study of new treatment for short stature underway at Rush University Medical Center
Rush University Medical Center is participating in a clinical trial to evaluate the potential benefit of the first major innovation in 20 years for the treatment of growth failure. The drug, called Increlex, was approved by the FDA August 31 for the most severe form of short stature due to a deficiency of Insulin-like Growth Factor-1 (IGF-1). Ongoing trials will determine if the drug may be used for less severe growth disease. (2005-09-19)

Study finds near-term infants at risk for significant health problems
In their report in the August issue of Pediatrics, researchers from MassGeneral Hospital for Children describe finding that babies born at 35 or 36 weeks gestation were more likely to have jaundice, low blood sugar, difficulty maintaining body temperature, and other problems than were full-term infants. (2004-08-11)

Positive results from first human clinical trials of a first-generation artificial pancreas system is significant step forward for millions with type 1 diabetes
Results from the first feasibility study of an advanced first-generation artificial pancreas system indicated that the Hypoglycemia-Hyperglycemia Minimizer (HHM) System was able to automatically predict a rise and fall in blood glucose and correspondingly increase and/or decrease insulin delivery safely. The HHM System included a continuous, subcutaneous insulin pump, a continuous glucose monitor and special software used to predict changes in blood glucose. (2012-06-10)

Honey shines in athletic research, has scientific community abuzz
Results of a three-phase study at the University of Memphis Exercise and Sport Nutrition Laboratory demonstrate that honey is a carbohydrate option for athletes based on its low glycemic index, positive metabolic response, and effective energy production. (2001-09-24)

Discovery of fruit fly pancreas points to possible diabetes cures, say Stanford researchers
Almost two years ago Seung Kim, MD, PhD, assistant professor of developmental biology and of medicine at the Stanford University School of Medicine, and colleagues including then-postdoctoral scholar Eric Rulifson, PhD, found cells in the fruit fly brain that make insulin. (2004-09-15)

Glucose triggers brain cell death in rats after hypoglycemic coma
Brain damage that was thought to be caused by hypoglycemic coma actually occurs when glucose is administered to treat the coma, according to a study in rodents led by researchers at the San Francisco VA Medical Center. (2007-04-04)

Standardized treatment protocol reduces deaths from malnutrition by 47%
Malnutrition is responsible, at least in part, for nearly 6 million deaths in children under five each year. Scientists at the Centre for Health and Population Research (ICDDR,B) in Dhaka, Bangladesh have outlined a standardized protocol to treat severely malnourished children which reduces mortality by 47%. (1999-06-04)

Physical activity linked to improved glucose control in children with type 1 diabetes
Children with type 1 diabetes who exercise regularly may have improved blood glucose levels compared with those who do not, and regular physical activity does not appear to increase the risk of severe hypoglycemia (low blood glucose levels), according to a report in the June issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals. (2006-06-05)

New publications examine treatment outcomes for infantile hemangiomas
In an ongoing effort to find better and safer treatment for complicated infantile hemangiomas, researchers at the Medical College of Wisconsin and Children's Hospital of Wisconsin, report outcomes on two treatment options. The first study examined the effects of oral steroids on a group of patients and the second highlights possible complication/side effect from propranolol, a novel therapy for hemangioma. Both studies published in the Archives of Dermatology, will facilitate safer therapy. (2010-07-19)

Diabetes drug target identified
New research from the University of Cincinnati points to the naturally produced protein apolipoprotein A-IV as a potential target for a new diabetes therapeutic. (2012-05-21)

New post-hoc analysis shows patients with type 2 diabetes undergoing intensification of insulin therapy experienced less nighttime hypoglycemia while being treated with Januvia (Sitagliptin) compared to placebo
New post-hoc analysis shows patients with type 2 diabetes undergoing intensification of insulin therapy experienced less nighttime hypoglycemia while being treated with Januvia compared to placebo. (2014-06-14)

Association between hypoglycemia, dementia in older adults with diabetes
A study of older adults with diabetes mellitus suggests a bidirectional association between hypoglycemic (low blood glucose) events and dementia, according to a report published Online First by JAMA Internal Medicine, a JAMA Network publication. (2013-06-10)

Implantable Pump Has Advantages Over Insulin Injections
Many diabetics may get insulin easier and more effectively from a small automatic pump put inside their bodies than from daily injections, according to a cooperative study by researchers at Veterans Affairs Medical Centers and Johns Hopkins. (1996-10-23)

Annals of Internal Medicine tip sheet for July 10, 2012, online issue
This press release contains information about articles being published in the July 10 issue of Annals of Internal Medicine. (2012-07-09)

Yale to launch new Center for the Study of Hypoglycemia with $5 million JDRF award for research
Yale School of Medicine recently opened the Juvenile Diabetes Research Foundation (JDRF) Center for the Study of Hypoglycemia at Yale University with a five-year, $5 million JDRF grant. The funds will be used to advance multidisciplinary research into the effects of hypoglycemia--low blood sugar--on the brain and how to prevent it. (2000-11-13)

Study finds mechanisms of early insulin treatment for diabetes may produce better outcomes
A pilot study of 23 adults with newly diagnosed type 2 diabetes found early insulin therapy to be as effective as 15 months of oral therapy and may improve the body's ability to produce insulin. (2015-10-17)

ACP issues recommendations for management of high blood glucose in hospitalized patients
High blood glucose is associated with poor outcomes in hospitalized patients, and use of intensive insulin therapy (IIT) to control hyperglycemia is a common practice in hospitals. But the recent evidence does not show a consistent benefit and even shows harms associated with the use of IIT, according to the American College of Physicians. (2013-05-24)

Study shows metabolic strategy of stressed cell
Investigators at St. Jude Children's Research Hospital have mapped out many of the dynamic genetic and biochemical changes that make up a cell's response to a shortage of a molecule called Coenzyme A (CoA), a key player in metabolism. (2007-03-23)

UI Study Suggests Promising Treatment For Diabetic Pregnancies
Pregnant women with diabetes deal with the costly and difficult tasks of checking their glucose levels and taking insulin several times daily to ensure their babies are born without birth defects. However, there may be a better way of handling diabetes during pregnancies, according to a University of Iowa study. (1999-05-04)

Experimental insulin drug prevents low blood sugar
An experimental insulin drug prevented low blood sugar among diabetic patients more often than a popular drug on the market, a new study finds. The results will be presented Sunday at the Endocrine Society's 94th Annual Meeting in Houston. (2012-06-24)

Five new studies at major medical meeting further demonstrate clinical experience for JANUVIA™ (sitagliptin)
New data analyses presented at the 44th Annual Meeting of the European Association for the Study of Diabetes showed initial combination therapy with the dipeptidyl peptidase-4 (DPP-4) inhibitor, Januvia (sitagliptin), and metformin provided improvements in blood sugar levels (as measured by A1C) over two years of treatment and was generally well tolerated. (2008-09-09)

Severe hypoglycemia is rare after islet transplantation
Episodes of dangerously low blood glucose, or hypoglycemia, were greatly reduced in people who received an islet transplant for poorly controlled type 1 diabetes, according to an analysis of outcomes in 138 patients who had the procedure at 19 medical centers in the United States and Canada. This is one of the conclusions of the Collaborative Islet Transplant Registry (CITR), which tracks many factors affecting the success of this experimental procedure in people with severe type 1 diabetes. (2005-09-06)

Joslin study pinpoints role of insulin on glucagon levels
Researchers at the Joslin Diabetes Center have shown for the first time that insulin plays a key role in suppressing levels of glucagon, a hormone involved in carbohydrate metabolism and regulating blood glucose levels. (2009-04-07)

Hypoglycemia may affect newborn's brain cell function, says Hopkins researcher
Hypoglycemia, or low blood sugar, may have a significant effect on activity patterns in a newborn's brain, say researchers at Johns Hopkins Children's Center and St. Christopher's Hospital for Children in Philadelphia. Their study of piglet brains, which are metabolically and structurally close to that of humans, is reported in this month's Brain Research. (2002-02-14)

Life without insulin is possible
Several millions of people around the world suffer from insulin deficiencies. Insulin is a hormone, secreted by the beta cells in the pancreas, which plays a major role in the regulation of energy substrates such as glucose. This insufficiency, primarily caused by diabetes (types 1 and 2), has lethal consequences if it is not treated. As of now, only daily insulin injections allow patients to survive. (2013-09-03)

First CVD outcome trial of a GLP-1 agonist ginds no cardiac risk or benefit
One member of a widely prescribed class of drugs used to lower blood glucose levels in people with diabetes has a neutral effect on heart failure and other cardiovascular problems, according to the first clinical trial to examine cardiovascular safety in a GLP-1 receptor agonist, presented at the American Diabetes Association's 75th Scientific Sessions. (2015-06-08)

Murine model of human hyperinsulinism
Scientists have developed a mouse model of human familial hyperinsulinism that will serve as an invaluable tool in the design and testing of therapeutic strategies to combat familial hyperinsulinism. (2001-06-30)

Is there such a thing as too much sugar?
Treatment with insulin can cause hypoglycemia (low levels of glucose in the blood), which, if prolonged, can lead to neuronal death, brain injury and coma. In a new study, researchers found that in hypoglycemic mice, neuronal death is triggered by treatment with glucose rather than by the hypoglycemia. This suggests that it might be best to treat individuals in hypoglycemic coma by gradually increasing their blood glucose levels rather than by restoring glucose levels rapidly. (2007-04-02)

Findings challenge common practice regarding glucose control for critically ill patients
An analysis of randomized trials indicates that for critically ill adults, tight glucose control is not associated with a significantly reduced risk of death in the hospital, but is associated with an increased risk of hypoglycemia, calling into question the recommendation by many professional societies for tight glucose control for these patients, according to an article in the Aug. 27 issue of JAMA. (2008-08-26)

Alzheimer's and low blood sugar in diabetes may trigger a vicious cycle
Diabetes-associated episodes of low blood sugar may increase the risk of developing dementia, while having dementia or even milder forms of cognitive impairment may increase the risk of experiencing low blood sugar, according to a UC San Francisco scientist who led a new study published online June 10 in JAMA Internal Medicine. (2013-06-10)

New study shows diabetes patients prefer prefilled NovoLog(R) Mix 70/30 FlexPen(R) disposable pen
In the current issue of Diabetes Care, study results find the NovoLog Mix 70/30 FlexPen was rated higher than prior treatments for type 2 diabetes patients. (2004-09-27)

The artificial pancreas shown to improve the treatment of type 1 diabetes
The world's first clinical trial comparing three alternative treatments for type 1 diabetes was conducted in Montreal by researchers at the institut de recherches cliniques de Montreal and the University of Montreal. The study confirms that the external artificial pancreas improves glucose control and reduces the risk of hypoglycemia compared to conventional diabetes treatment. (2014-11-26)

Annals of Internal Medicine tip sheet for Oct. 18, 2005
The current issue for the Annals of Internal Medicine includes the following two articles: 1. Two new diabetes treatments may provide options for type 2 diabetes. Lifestyle changes are still the treatments of first defense; 2. New medicare drug programs carry out-of-pocket drug costs, so drug company assistance programs may still be needed. (2005-10-17)

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