Popular Ketamine News and Current Events

Popular Ketamine News and Current Events, Ketamine News Articles.
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Why is ketamine an antidepressant?
Delving deep inside the neural circuitry of 'depressed' mice, researchers have revealed how ketamine works in cells to achieve its fast-acting antidepressant effect. (2019-04-11)

Study casts doubt on ketamine nasal sprays for depression
Researchers from UNSW Sydney and the Black Dog Institute have questioned the efficacy and safety of intranasal ketamine for depression, with their pilot trial stopped early due to poor side effects in patients. (2018-03-16)

MDMA users more empathetic than other drug users
Long-term MDMA users have higher levels of empathy than cannabis and other drugs users, new research suggests. (2019-02-08)

Low-dose ketamine may be an effective alternative to opioids
Opioids are commonly prescribed in the emergency department (ED) for the treatment of acute pain, but due to the epidemic of opioid misuse, analgesic alternatives are being explored. A new Academic Emergency Medicine analysis of relevant studies found that low-dose ketamine is as effective as opioids for the control of acute pain in the ED. (2018-07-18)

Ketamine reverses neural changes underlying depression-related behaviors in mice
Researchers have identified ketamine-induced brain-related changes that are responsible for maintaining the remission of behaviors related to depression in mice. Ketamine treatment restored lost dendritic spines and rescued coordinated neural activity in the Prefrontal Cortex of the mice -- findings that may help researchers develop interventions that promote lasting remission of depression in humans. The study was funded by the National Institute of Mental Health (NIMH), part of the National Institutes of Health. (2019-04-11)

Ketamine acts fast to treat depression and its effects last -- but how?
Researchers led by Mark Rasenick in the University of Illinois at Chicago College of Medicine, describe the molecular mechanisms behind ketamine's ability to squash depression and keep it at bay. They report their findings in the journal Molecular Psychiatry. (2018-06-21)

Not all sleep is equal when it comes to cleaning the brain
New research shows how the depth of sleep can impact our brain's ability to efficiently wash away waste and toxic proteins. Because sleep often becomes increasingly lighter and more disrupted as we become older, the study reinforces and potentially explains the links between aging, sleep deprivation, and heightened risk for Alzheimer's disease. (2019-02-27)

Researchers discover a critical receptor involved in response to antidepressants like ketamine
Effective treatment of clinical depression remains a major mental health issue, with roughly 30 percent of patients who do not respond to any of the available treatments. Researchers at the University of Maryland School of Medicine (UMSOM) have discovered a crucial receptor called mGlu2 that is critical to the mechanism of fast-acting antidepressants such as ketamine when used to treat depression. (2019-03-28)

Emergency departments administering more medications through the nose
Administering medications through the nose as an alternative to injections or IVs is becoming increasingly popular in emergency departments and ambulances, according to a paper by Loyola Medicine pharmacists. The intranasal route 'is easy, fast and noninvasive,' emergency department pharmacist Megan A. Rech, Pharm.D., M.S., and colleagues write in the journal Annals of Emergency Medicine. (2017-04-18)

Ketamine works for female rats, too
A first of its kind study in female rats finds that a single, low dose of ketamine promotes resilience to future adverse events as it does in male rats. Published in eNeuro, the research addresses a critical gap in understanding and developing treatments for stress-related disorders, which disproportionately afflict females. (2018-02-26)

Colorectal surgery patients use fewer opioids, report less pain with enhanced recovery after surgery
Colorectal surgery patients who were a part of an enhanced recovery after surgery (ERAS) program had less pain, while using nearly half as many opioids, according to research being presented at the ANESTHESIOLOGY® 2019 annual meeting. (2019-10-19)

PTSD symptoms may be prevented with ketamine
Columbia University researchers have evidence that giving a small dose of ketamine one week before a psychologically traumatic event may help prevent PTSD. The study, in mice, may have implications for soldiers who are at risk for trauma and PTSD. (2017-02-08)

First evidence for higher state of consciousness found
Scientific evidence of a 'higher' state of consciousness has been found in a study led by the University of Sussex. (2017-04-19)

Pilot study examines the effects of virtual reality on reducing anxiety and improving pregnancy rate of women having fertility treatment
New research presented at this year's Euroanaesthesia congress in Copenhagen, Denmark, shows that giving women different types of virtual reality (VR) sessions prior to sedation for IVF treatment (to become pregnant) reduces their anxiety and could improve successful pregnancy rate. (2018-06-01)

Intranasal ketamine has more minor side effects than intranasal fentanyl in children with acute pain
Minor adverse events (e.g., bad taste in the mouth and dizziness) occur more frequently with intranasal ketamine than with intranasal fentanyl in children with suspected extremity fractures. (2017-11-22)

Depressed with a chronic disease? Consider alternative therapies
Scientists are finding more evidence that commonly prescribed antidepressants aren't effective in people battling both depression and a chronic medical disease, raising a critical question of whether doctors should enact widespread changes in how they treat millions of depressed Americans. (2017-11-06)

Study identifies effective ketamine doses for treatment-resistant depression
A study led by Massachusetts General Hospital investigators identifies two subanesthetic dosage levels of the anesthetic drug ketamine that appear to provide significant symptom relief to patients with treatment-resistant depression. (2018-10-11)

One shot of ketamine could reduce problem drinking
A one-off dose of ketamine could help heavy drinkers reduce their alcohol intake, finds a new UCL experimental study published in Nature Communications. (2019-11-26)

A 'communication breakdown' during general anesthesia
When ketamine is used for general anesthesia, two connected parts of the cortex turn to 'isolated cognitive islands.' (2016-05-11)

New research: Ketamine activates opioid system to treat depression
A new study appearing online today from the American Journal of Psychiatry finds that ketamine's acute antidepressant effect requires opioid system activation, the first time that a receptor site has been shown in humans to be necessary for any antidepressant's mechanism of action. While opioids have been used historically to treat depression, they are known to carry a high risk of dependence. (2018-08-29)

New study finds river wildlife contain cocaine, pharmaceuticals and pesticides
For the first time, researchers at King's College London, in collaboration with the University of Suffolk, have found a diverse array of chemicals, including illicit drugs and pesticides in UK river wildlife. The study published today in Environment International, looked at the exposure of wildlife, such as the freshwater shrimp Gammarus pulex, to different micropollutants (chemicals found at exceptionally low levels) and the levels of these compounds in the animals. (2019-04-30)

Paramedics find better drug to tame violent patients
Australian paramedics are using a new drug to quickly calm violent patients and they have the data to prove it works. In a world-first research evaluation, researchers found the sedative, droperidol, was a safer and faster option for paramedics to use compared with the internationally accepted, midazolam. The drug is also easier to administer. Other ambulance services from around the world are now looking to make the change. (2018-05-02)

One in three pain patients suffer side effects after ketamine infusion therapy
As the opioid epidemic continues to devastate the United States, ketamine use has grown as a pain management alternative, yet more than one in three patients may experience side effects such as hallucinations and visual disturbances, suggests new research presented at the ANESTHESIOLOGY® 2019 annual meeting. (2019-10-21)

Study shows fast-acting benefits of ketamine for depression and suicidality
A nasal spray formulation of ketamine shows promise in the rapid treatment of symptoms of major depression and suicidal thoughts, according to a new study published online today in The American Journal of Psychiatry (AJP). The double-blind study compared the standard treatment plus an intranasal formulation of esketamine, part of the ketamine molecule, to standard treatment plus a placebo for rapid treatment of symptoms of major depression, including suicidality, among individuals at imminent suicide risk. (2018-04-16)

Experimental drug shows promise for opioid withdrawal symptoms
While medicines are available to relieve withdrawal symptoms in people recovering from opioid addiction, they cause side effects and can maintain the brain changes that led to addiction in the first place, which can lead to relapse before treatment is completed. New research offers hope that a better solution may be on the horizon. Rapastinel, an experimental drug originally developed as an antidepressant, substantially reversed acute signs of opioid withdrawal in rats in just three days. (2019-04-07)

Antidepressant response within hours? Experts weigh evidence on ketamine as fast-acting treatment for depression in Harvard Review of Psychiatry
Recent studies suggest that ketamine, a widely used anesthetic agent, could offer a wholly new approach to treating severe depression -- producing an antidepressant response in hours rather than weeks. Two reviews of recent evidence on ketamine and related drugs for treating depression appear in the Harvard Review of Psychiatry, published by Wolters Kluwer. (2018-02-22)

Chemsex linked with increased diagnoses of HIV and other sexually transmitted infections
Chemsex -- the use of crystallized methamphetamine, mephedrone, γ-hydroxybutyrate or γ-butyrolactone and to a lesser extent cocaine and ketamine to facilitate sex -- has emerged as a new phenomenon in the UK and across Europe among gay, bisexual and other men who have sex with men (GBMSM). (2018-05-23)

Clinical appearance and unusual imaging findings of pediatric ketamine overdose
Case report on a 10-month-old infant who inadvertently ingested ketamine. The paper offers detailed clinical information and unusual MRI findings. (2017-08-15)

VUMC study may offer answers for treating depression in alcoholics
A study by researchers at Vanderbilt University Medical Center is offering a glimmer of hope to alcoholics who find it hard to remain sober because their abstinence is hounded by stubborn, difficult-to-treat depression. (2016-02-01)

Ketamine has potential therapeutic role in adolescents with treatment-resistant depression
A new study has shown a significant average decrease in the Children's Depression Rating Scale (42.5 percent) among adolescents with treatment-resistant depression (TRD) who were treated with intravenous ketamine. (2018-08-01)

Compound shown to reduce brain damage caused by anesthesia in early study
An experimental drug prevented learning deficits in young mice exposed repeatedly to anesthesia. (2016-06-22)

People are more suggestible under laughing gas
The pain-relieving effects of nitrous oxide -- laughing gas -- may be enhanced by suggestion or hypnosis, according to a new study by UCL. The study's findings -- that people are more suggestible under the gas -- mean that dental patients may benefit from being coached to relax while undergoing sedation. (2009-01-09)

Stress in early life could make people more likely to develop depression
New research by the University of Bristol has found that early life adversity could make an individual more at risk of developing negative thinking, which could lead to major depressive disorder (MDD). The findings provide biological and psychological evidence to support work first proposed in the 1960s. (2019-05-08)

Fingermark imaging for drug detection
In a paper to be published in the forthcoming issue in NANO, researchers from Zhejiang have uncovered a novel method of using nanocarrier-based biological fluorescent probes for detecting amphetamine and ketamine in latent fingermark, in a bid to combat drug abuse. This method has the potential to be extended to other drugs and molecules. (2019-03-14)

New effects of ketamine abuse uncovered
Research conducted by scientists at the University of York has revealed how recreational ketamine abuse damages the bladder. (2016-03-18)

Common genetic link between autism and Tourette's impairs brain communication
Scientists have discovered how a genetic alteration that increases the risk of developing Autism and Tourette's impacts on the brain. Their research also suggests that ketamine, or related drugs, may be a useful treatment for both of these disorders. Deletion of the Neurexin1 gene affects brain areas involved in Autism and Tourette's including the thalamus, a collection of brain regions that play a key role in helping other brain areas communicate with each other. (2019-12-09)

Antibodies: the body's own antidepressants
Antibodies can be a blessing or a curse to the brain -- it all depends on their concentration. (2020-02-24)

Psychedelic drugs promote neural plasticity in rats and flies
Psychedelic drugs may have mind-altering powers in the physical sense, too. A new study, published June 12 in the journal Cell Reports, found psychedelics, specifically DOI, DMT, and LSD, can change brain cells in rats and flies, making neurons more likely to branch out and connect with one another. The work supports the theory that psychedelics could help to fight depression, anxiety, addiction, and post-traumatic stress disorder. (2018-06-12)

Multimodal approach to pain management reduces opioids, prescriptions after joint replacement
A multimodal approach to pain management (using two or more different methods or medications to manage pain) rather than using opioids alone was associated with a decrease in opioid use, opioid prescriptions and common opioid-related complications in patients undergoing total hip or knee replacements, according to a study published today in the Online First edition of Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists (ASA). (2018-03-01)

Ketamine may help treat migraine pain unresponsive to other therapies
Ketamine may help alleviate migraine pain in patients who have not been helped by other treatments, suggests a study being presented at the ANESTHESIOLOGY 2017 annual meeting. (2017-10-21)

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