Popular Liver Failure News and Current Events

Popular Liver Failure News and Current Events, Liver Failure News Articles.
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AI 'scientist' finds that toothpaste ingredient may help fight drug-resistant malaria
An ingredient commonly found in toothpaste could be employed as an anti-malarial drug against strains of malaria parasite that have grown resistant to one of the currently used drugs. This discovery, led by researchers at the University of Cambridge, was aided by Eve, an artificially intelligent 'robot scientist.' (2018-01-18)

Stealth virus for cancer therapy
Scientists from the University of Zurich have redesigned an adenovirus for use in cancer therapy. To achieve this they developed a new protein shield that hides the virus and protects it from being eliminated. Adapters on the surface of the virus enable the reconstructed virus to specifically infect tumor cells. (2018-01-31)

Big data studies scrutinize links between fatty liver disease and how cells make energy
Three recent studies investigate changes in mitochondria, the cell's energy producers, as fatty liver disease (NAFLD) progresses to steatohepatosis (NASH). The first two studies illuminate how mitochondrial energy production stutters and fails; the third describes how changes to the liver during disease progression affect the organ's use of nutrients to produce energy. (2018-09-14)

Physical activity may ward off heart damage
Physical activity can lower the risk of heart damage in middle-aged and older adults and reduce the levels of heart damage in people who are obese, according to research published today in JACC: Heart Failure. (2017-04-24)

UH Cancer Center researchers develop algorithm to find precise cancer treatments
University of Hawai'i Cancer Center researchers developed a computational algorithm to analyze 'Big Data' obtained from tumor samples to better understand and treat cancer. (2016-08-09)

Diabetes medicine reduces liver fat in nonalcoholic fatty liver disease
In people with type 2 diabetes, nonalcoholic fatty liver disease (NAFLD) is common and can progress to a severe liver disease known as nonalcoholic steatohepatitis (NASH). Now a study has found that empagliflozin, a newer treatment for type 2 diabetes, reduces liver fat in patients with NAFLD and diabetes. Results of the randomized controlled study, called the E-LIFT Trial, will be presented Monday at the Endocrine Society's 100th annual meeting in Chicago, Ill., during a late-breaking abstracts session. (2018-03-19)

Heart failure after first heart attack may increase cancer risk
People who develop heart failure after their first heart attack have a greater risk of developing cancer when compared to first-time heart attack survivors without heart failure, according to a study today in the Journal of the American College of Cardiology. (2016-07-11)

Activated T-cells drive post-heart attack heart failure
Chronic inflammation after a heart attack can promote heart failure and death. University of Alabama at Birmingham researchers have now shown that activated T-cells -- part of the immune system's inflammatory response -- are both necessary and sufficient to produce such heart failure. (2017-02-27)

Purest yet liver-like cells generated from induced pluripotent stem cells
A team of researchers from the Medical University of South Carolina and elsewhere has found a better way to purify liver cells made from induced pluripotent stem cells. This new methodology could facilitate progress toward an important clinical goal: the treatment of patients with disease-causing mutations in their livers by transplant of unmutated liver cells derived from their own stem cells. (2016-08-29)

ICU care for COPD, heart failure and heart attack may not be better
Does a stay in the intensive care unit give patients a better chance of surviving a chronic obstructive pulmonary disease (COPD) or heart failure flare-up or even a heart attack, compared with care in another type of hospital unit? Unless a patient is clearly critically ill, the answer may be no, according to University of Michigan researchers who analyzed more than 1.5 million Medicare records. (2017-02-17)

Heart failure: The Alzheimer's disease of the heart?
Similar to how protein clumps build up in the brain in people with some neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, protein clumps appear to accumulate in the diseased hearts of mice and people with heart failure, according to a team led by Johns Hopkins University researchers. (2018-05-09)

1 in 4 patients develop heart failure within 4 years of first heart attack
One in four patients develop heart failure within four years of a first heart attack, according to a study in nearly 25,000 patients presented today at Heart Failure 2016 and the 3rd World Congress on Acute Heart Failure by Dr. Johannes Gho, a cardiology resident at the University Medical Center Utrecht, in Utrecht, the Netherlands. Risk factors included older age, greater socioeconomic deprivation, and comorbidities such as diabetes. (2016-05-24)

New technique improves outcome for living donor liver transplants
Thanks to a review paper done at the University of Alberta radiologists at the University of Alberta Hospital are now using CT imaging for living-donor liver transplantation. CT imaging allows surgeons to plan the operation more accurately, which increases the likelihood for organ graft survival in recipients and reduces complication rates in donors. (2008-03-18)

Obesity impacts liver health in kids as young as 8 years old
A new study found that weight gain, obesity can put children as young as age 8 at risk for a serious liver disease. (2018-04-04)

New methods find undiagnosed genetic diseases in electronic health records
Researchers at Vanderbilt University Medical Center have found a way to search genetic data in electronic health records to identify undiagnosed genetic diseases in large populations so treatments can be tailored to the actual cause of the illness. (2018-03-15)

Fat cells may influence how the body reacts to heart failure, study shows
University of Alberta researchers have found that limiting the amount of fat the body releases into the bloodstream from fat cells when in heart failure could help improve outcomes for patients. (2021-02-23)

Experts provide insights on the body's stress response during critical illness
Critical illness causes the body to initiate a stress response, which activates the hypothalamus-pituitary-adrenal axis to increase the availability of the stress hormone cortisol. (2018-01-10)

First transcatheter implant for diastolic heart failure successful
Researchers at The Ohio State University Wexner Medical Center have come up with a new device, proven safe and effective, to treat diastolic heart failure. (2017-11-15)

Amount or intensity? Study examines potential benefits of exercise for patients with heart failure
Physical activity can benefit patients with heart failure with preserved ejection fraction, a common condition with no pharmacological treatment, but no clear recommendations exist on the optimal amount or intensity of physical activity for these patients. (2017-12-06)

For some, high blood pressure associated with better survival
Patients with both type 2 diabetes and acute heart failure face a significantly lower risk of death but a higher risk of heart failure-related hospitalizations if they had high systolic blood pressure on discharge from the hospital compared to those with normal blood pressure, according to a study scheduled for presentation at the American College of Cardiology's 66th Annual Scientific Session. (2017-03-08)

Researchers reverse heart failure in Marfan mice
In experiments with mice that have a rodent form of Marfan syndrome, Johns Hopkins researchers report that even modestly increasing stress on the animals' hearts -- at levels well-tolerated in normal mice -- can initiate heart failure. The findings, described August 4 in the Journal of Clinical Investigation Insight, revealed a novel cellular pathway in heart tissue that leads to heart failure and may serve as a model for a new standard of treatment for children with this aggressive form of Marfan syndrome. (2017-11-14)

How does the environment affect obesity?
Researchers will be examining how agricultural and food processing practices may affect brown fat activity directly or indirectly. Research will look at how toxicants such as pesticides or herbicides and artificial sweeteners or high fructose corn syrups could alter brown fat (BAT). (2016-05-02)

Discovery of molecular nets inside heart muscles hold promise for new treatment
Local researchers have discovered that a group of molecules, called chondroitin sulfate, normally found only in connective tissues such as the cartilage, accumulates and causes inflammation in the hearts of patients with heart failure. The discovery was made jointly by the National University Health System (NUHS), A*STAR's Genome Institute of Singapore (GIS) and the National University of Singapore (NUS) Yong Loo Lin School of Medicine, and is now published in Circulation, a journal from the American Heart Association. (2018-01-31)

Scarring molecule in fat tissue links obesity with distressed fat
The fat of obese people becomes distressed, scarred and inflamed, which can make weight loss more difficult, research at the University of Exeter has found. (2018-01-12)

Understanding vitamin D trends in children with non-alcoholic fatty liver disease
New research charts vitamin D levels and variations in genes that determine vitamin D status in UK children diagnosed with non-alcoholic fatty liver disease. (2018-05-15)

Preventive drug therapy may increase right-sided heart failure risk in patients who receive heart devices
Patients treated preemptively with drugs to reduce the risk of right-sided heart failure after heart device implantation may experience the opposite effect and develop heart failure and post-operative bleeding more often than patients not receiving the drugs. The findings highlight the need for a prospective study of the role of the routine use of this approach before left-ventricular assist device implantation. (2019-06-11)

Citrus fruits could help prevent obesity-related heart disease, liver disease, diabetes
Oranges and other citrus fruits are good for you -- they contain plenty of vitamins and substances, such as antioxidants, that can help keep you healthy. Now a group of researchers reports that these fruits also help prevent harmful effects of obesity in mice fed a Western-style, high-fat diet. The researchers are presenting their work today at the 252nd National Meeting & Exposition of the American Chemical Society. (2016-08-21)

Premature hearts less able to cope with exercise
The hearts of people born prematurely are less able to cope with the pressures of exercise in adulthood, according to a new study published in the Journal of the American College of Cardiology and part-funded by the British Heart Foundation. (2018-03-19)

New hope for treating heart failure
Heart failure patients who are getting by on existing drug therapies can look forward to a far more effective medicine in the next five years or so, thanks to University of Alberta researchers. (2017-03-07)

How the enzyme lipoxygenase drives heart failure after heart attacks
Heart failure after a heart attack is a global epidemic leading to heart failure pathology. Ganesh Halade, Ph.D., is seeking ways to delay or reverse this heart failure, which comes from non-resolved chronic inflammation. In a study in Metabolism: Clinical and Experimental, Halade and colleagues detail the profound lipidomic and metabolic signatures and the modified leukocyte profiling that delay heart failure progression and provide improved survival in 12/15 lipoxygenase-deficient mice. (2019-05-31)

Phase 2 studies of two novel treatments for primary biliary cholangitis report encouraging results
Ongoing Phase 2 studies of tropifexor and seladelpar report promising preliminary efficacy, safety and tolerability results, paving the way for longer-term studies in patients with primary biliary cholangitis (2018-04-13)

Loosen up!
Generally, exercise is considered good for you. However, physicians and medical doctors previously prescribed bedrest to people with heart failure, fearing exercise could potentially lead to additional health problems. (2019-10-22)

Northeastern researchers identify 36 new genes implicated in cardiac disease
A Northeastern University professor has developed a new personalized method to discover genes implicated in complex diseases. One of the ultimate goals of the research is to create personalized therapeutic drugs to reverse heart disease. (2018-03-07)

A Web-based lifestyle intervention supports weight loss in patients with non-alcoholic fatty liver disease
A remote lifestyle modification intervention shown to be as effective as a face-to-face group program for weight loss and improved liver health. (2018-04-13)

NGM282 -- an engineered analogue of FGF19 -- shows promise in patients with primary sclerosing cholangitis
A Phase 2, randomized, double-blind, placebo-controlled study reports significant improvements in markers of disease activity and fibrosis with subcutaneous NGM282 in patients with primary sclerosing cholangitis. (2018-04-13)

NYU Abu Dhabi researchers unlock the secrets of liver regeneration
In a recent study published in the journal Developmental Cell, NYU Abu Dhabi researchers have reported a new way in which the liver is primed to regenerate itself. They found that by stripping parts of the epigenome, which play a primary role in repressing 'jumping genes' (i.e. transposable elements), other epigenetic marks were redistributed. (2019-06-20)

Modulation of Fgf21 gene in early-life ameliorates adulthood diet-induced obesity
The nutritional environment in early life can lead to epigenetic changes in the genome that influence the risk of obesity in later life. In a new study, Tokyo Medical and Dental University (TMDU) researchers showed that the Fgf21gene undergoes PPARĪ±-dependent DNA demethylation in the liver during the postnatal period and its status may persist into adulthood. Fgf21 methylation represents a form of epigenetic memory, and may play a role in the developmental programming of obesity. (2018-03-09)

Nonalcoholic fatty liver disease increases risk of liver, colorectal, and breast cancers
Nonalcoholic fatty liver disease (NAFLD) is one of the more common chronic liver diseases worldwide. It is associated with metabolic syndrome (i.e. insulin resistance and diabetes) and predisposes to cardiovascular disease. In a new study published in the Journal of Hepatology, researchers identified links not only between NAFLD and hepatocellular carcinoma (HCC), which have been well established, but also to cancers outside the liver, including colorectal and breast cancer. (2017-11-13)

Statins associated with reduced morbidity and mortality in patients with primary sclerosing cholangitischolangi
An award-winning register-based study reports a reduced risk of all-cause mortality, liver transplantation, liver cancer, and variceal bleeding in patients with primary sclerosing cholangitis exposed to statins. (2018-04-12)

Fatty liver disease contributes to cardiovascular disease and vice versa
For the first time, researchers have shown that a bi-directional relationship exists between fatty liver disease and cardiovascular disease. Fatty liver disease can lead to increased cardiovascular disease risk and vice versa. (2016-11-10)

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