Popular Liver Transplant News and Current Events

Popular Liver Transplant News and Current Events, Liver Transplant News Articles.
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AI 'scientist' finds that toothpaste ingredient may help fight drug-resistant malaria
An ingredient commonly found in toothpaste could be employed as an anti-malarial drug against strains of malaria parasite that have grown resistant to one of the currently used drugs. This discovery, led by researchers at the University of Cambridge, was aided by Eve, an artificially intelligent 'robot scientist.' (2018-01-18)

Stealth virus for cancer therapy
Scientists from the University of Zurich have redesigned an adenovirus for use in cancer therapy. To achieve this they developed a new protein shield that hides the virus and protects it from being eliminated. Adapters on the surface of the virus enable the reconstructed virus to specifically infect tumor cells. (2018-01-31)

Big data studies scrutinize links between fatty liver disease and how cells make energy
Three recent studies investigate changes in mitochondria, the cell's energy producers, as fatty liver disease (NAFLD) progresses to steatohepatosis (NASH). The first two studies illuminate how mitochondrial energy production stutters and fails; the third describes how changes to the liver during disease progression affect the organ's use of nutrients to produce energy. (2018-09-14)

The Lancet HIV: Study suggests a second patient has been cured of HIV
A study of the second HIV patient to undergo successful stem cell transplantation from donors with a HIV-resistant gene, finds that there was no active viral infection in the patient's blood 30 months after they stopped anti-retroviral therapy, according to a case report published in The Lancet HIV journal and presented at CROI (Conference on Retroviruses and Opportunistic Infections). (2020-03-10)

UH Cancer Center researchers develop algorithm to find precise cancer treatments
University of Hawai'i Cancer Center researchers developed a computational algorithm to analyze 'Big Data' obtained from tumor samples to better understand and treat cancer. (2016-08-09)

Lung transplant patients face elevated lung cancer risk
In an American Journal of Transplantation study, lung cancer risk was increased after lung transplantation, especially in the native (non-transplanted) lung of single lung transplant recipients. (2018-12-19)

Diabetes medicine reduces liver fat in nonalcoholic fatty liver disease
In people with type 2 diabetes, nonalcoholic fatty liver disease (NAFLD) is common and can progress to a severe liver disease known as nonalcoholic steatohepatitis (NASH). Now a study has found that empagliflozin, a newer treatment for type 2 diabetes, reduces liver fat in patients with NAFLD and diabetes. Results of the randomized controlled study, called the E-LIFT Trial, will be presented Monday at the Endocrine Society's 100th annual meeting in Chicago, Ill., during a late-breaking abstracts session. (2018-03-19)

Purest yet liver-like cells generated from induced pluripotent stem cells
A team of researchers from the Medical University of South Carolina and elsewhere has found a better way to purify liver cells made from induced pluripotent stem cells. This new methodology could facilitate progress toward an important clinical goal: the treatment of patients with disease-causing mutations in their livers by transplant of unmutated liver cells derived from their own stem cells. (2016-08-29)

Scientists take aging cardiac stem cells out of semiretirement to improve stem cell therapy
With age, the chromosomes of our cardiac stem cells compress as they move into a state of safe, semiretirement. (2016-10-03)

Small changes to organ procurement system could lead to more life-saving transplants
Slight changes to the system for allocating deceased-donor kidneys could result in higher rates of organ procurement and lead to more kidney transplants across the country, according to new research co-authored by an Indiana University Kelley School of Business professor. (2017-11-17)

New technique improves outcome for living donor liver transplants
Thanks to a review paper done at the University of Alberta radiologists at the University of Alberta Hospital are now using CT imaging for living-donor liver transplantation. CT imaging allows surgeons to plan the operation more accurately, which increases the likelihood for organ graft survival in recipients and reduces complication rates in donors. (2008-03-18)

How does the environment affect obesity?
Researchers will be examining how agricultural and food processing practices may affect brown fat activity directly or indirectly. Research will look at how toxicants such as pesticides or herbicides and artificial sweeteners or high fructose corn syrups could alter brown fat (BAT). (2016-05-02)

Moffitt researchers identify new target to reduce risk of GVHD
Moffitt Cancer Center researchers are trying to identify new drug targets to reduce the risk of GVHD. Their new study, published last week in the Proceedings of the National Academy of Sciences, shows a drug that targets the protein JAK2 may reduce the risk of GVHD. (2018-02-05)

Obesity impacts liver health in kids as young as 8 years old
A new study found that weight gain, obesity can put children as young as age 8 at risk for a serious liver disease. (2018-04-04)

Updates on new therapies in development for rare liver diseases
Long-term data with sebelipase alfa for lysosomal acid lipase deficiency and preliminary data for investigational RNAi therapeutics for acute intermittent porphyria and alpha-1 antitrypsin deficiency add continued hope for the future management of metabolic and rare liver diseases. (2018-04-14)

Scarring molecule in fat tissue links obesity with distressed fat
The fat of obese people becomes distressed, scarred and inflamed, which can make weight loss more difficult, research at the University of Exeter has found. (2018-01-12)

Mutations in bone cells can drive leukemia in neighboring stem cells
DNA mutations in bone cells that support blood development can drive leukemia formation in nearby blood stem cells. This neighbor cell effect was observed in a mouse model of Noonan syndrome. In mice, drugs can stop the effect and potentially could combat leukemia progression/recurrence. (2016-10-26)

Phase 2 studies of two novel treatments for primary biliary cholangitis report encouraging results
Ongoing Phase 2 studies of tropifexor and seladelpar report promising preliminary efficacy, safety and tolerability results, paving the way for longer-term studies in patients with primary biliary cholangitis (2018-04-13)

Citrus fruits could help prevent obesity-related heart disease, liver disease, diabetes
Oranges and other citrus fruits are good for you -- they contain plenty of vitamins and substances, such as antioxidants, that can help keep you healthy. Now a group of researchers reports that these fruits also help prevent harmful effects of obesity in mice fed a Western-style, high-fat diet. The researchers are presenting their work today at the 252nd National Meeting & Exposition of the American Chemical Society. (2016-08-21)

New hope for treating heart failure
Heart failure patients who are getting by on existing drug therapies can look forward to a far more effective medicine in the next five years or so, thanks to University of Alberta researchers. (2017-03-07)

Scientists use gene editing to eliminate viruses in live pigs
Scientists have edited the pig genome to deactivate a family of retroviruses. The results hold important implications for transplant medicine in humans. (2017-08-10)

Advanced therapy offers cure for relapsed cancer patient
Testicular cancer patients who do not respond to traditional therapy can be cured with high-dose chemotherapy and a stem cell transplant, according to an Indiana University School of Medicine study by Lawrence Einhorn, M.D.; Stephen Williams, M.D.; Rafat Abonour, M.D., and colleagues published in the July 26 issue of the New England Journal of Medicine. Although the number of relapsed testicular cancer patients in the US is small, the IU Simon Cancer Center treats a majority of them. (2007-07-25)

Understanding vitamin D trends in children with non-alcoholic fatty liver disease
New research charts vitamin D levels and variations in genes that determine vitamin D status in UK children diagnosed with non-alcoholic fatty liver disease. (2018-05-15)

A Web-based lifestyle intervention supports weight loss in patients with non-alcoholic fatty liver disease
A remote lifestyle modification intervention shown to be as effective as a face-to-face group program for weight loss and improved liver health. (2018-04-13)

What is known -- and not known -- about heart muscle diseases in children
Cardiomyopathies (heart muscle diseases) in children are the focus of a new scientific statement from the American Heart Association that provides insight into the diagnosis and treatment of the diseases as well as identifying future research priorities. It is published in the American Heart Association's journal Circulation. (2019-05-28)

NGM282 -- an engineered analogue of FGF19 -- shows promise in patients with primary sclerosing cholangitis
A Phase 2, randomized, double-blind, placebo-controlled study reports significant improvements in markers of disease activity and fibrosis with subcutaneous NGM282 in patients with primary sclerosing cholangitis. (2018-04-13)

Fatty liver disease contributes to cardiovascular disease and vice versa
For the first time, researchers have shown that a bi-directional relationship exists between fatty liver disease and cardiovascular disease. Fatty liver disease can lead to increased cardiovascular disease risk and vice versa. (2016-11-10)

Modulation of Fgf21 gene in early-life ameliorates adulthood diet-induced obesity
The nutritional environment in early life can lead to epigenetic changes in the genome that influence the risk of obesity in later life. In a new study, Tokyo Medical and Dental University (TMDU) researchers showed that the Fgf21gene undergoes PPARα-dependent DNA demethylation in the liver during the postnatal period and its status may persist into adulthood. Fgf21 methylation represents a form of epigenetic memory, and may play a role in the developmental programming of obesity. (2018-03-09)

NYU Abu Dhabi researchers unlock the secrets of liver regeneration
In a recent study published in the journal Developmental Cell, NYU Abu Dhabi researchers have reported a new way in which the liver is primed to regenerate itself. They found that by stripping parts of the epigenome, which play a primary role in repressing 'jumping genes' (i.e. transposable elements), other epigenetic marks were redistributed. (2019-06-20)

Nonalcoholic fatty liver disease increases risk of liver, colorectal, and breast cancers
Nonalcoholic fatty liver disease (NAFLD) is one of the more common chronic liver diseases worldwide. It is associated with metabolic syndrome (i.e. insulin resistance and diabetes) and predisposes to cardiovascular disease. In a new study published in the Journal of Hepatology, researchers identified links not only between NAFLD and hepatocellular carcinoma (HCC), which have been well established, but also to cancers outside the liver, including colorectal and breast cancer. (2017-11-13)

Mediterranean-style diet improves gut microbial diversity and reduces hospitalization
ILC 2018: Diets rich in vegetables, fermented milk products, tea, coffee and chocolate may improve outcomes in patients with liver cirrhosis. (2018-04-12)

Researchers shed light on why exercise slows progression of Parkinson's disease
While vigorous exercise on a treadmill has been shown to slow the progression of Parkinson's disease in patients, the molecular reasons behind it have remained a mystery. (2017-12-22)

Statins associated with reduced morbidity and mortality in patients with primary sclerosing cholangitischolangi
An award-winning register-based study reports a reduced risk of all-cause mortality, liver transplantation, liver cancer, and variceal bleeding in patients with primary sclerosing cholangitis exposed to statins. (2018-04-12)

Researchers link defects in a nuclear receptor in the brain to autism spectrum disorders
University of Houston researchers link autism spectrum disorders to defects in a nuclear receptor inside the brain. And just like that, this world-renown team advances the understanding of autism. (2018-03-14)

Researchers find a promising new approach for treating liver cirrhosis
In a study in The American Journal of Pathology, investigators report that treatment with aleglitazar, a dual peroxisome proliferator-activated receptor-alpha/gamma (PPARα/γ) agonist, reduced inflammation, vasoconstriction, angiogenesis, mucosal disruption, and tumor necrosis factor (TNF)-α overproduction in cirrhotic rats with PH. This suggests a promising new approach for treating liver cirrhosis. (2018-06-18)

U of M begins nation's first clinical trial using T-reg cells from cord blood in leukemia treatment
University of Minnesota researchers have initiated a ground breaking clinical trial to determine the optimal dose and safety of T regulatory cells (T-regs) to decrease the risk of immune reactions common in patients undergoing blood and marrow transplantation. (2007-09-05)

New regulator of liver metabolism discovered
Researchers from Charité - Universitätsmedizin Berlin have identified an enzyme that has a major effect on glucose utilization in liver cells. The enzyme, retinol saturase, helps these cells adapt to variations in glucose levels. However, when glucose levels are consistently too high, retinol saturase appears to exert a damaging effect on cells. Results from this study have been published in the journal Nature Communications*. (2017-09-29)

Radiation therapy algorithm could reduce side effects, maintain effect against tumors
A mathematical model for computing radiation therapy treatments could substantially reduce patient side effects while delivering the same results as conventional radiation therapy. (2018-01-05)

Selective internal radiation therapy (SIRT) fails to extend survival in the SORAMIC study palliative cohort
ILC 2018: The addition of SIRT to sorafenib in patients with advanced hepatocellular carcinoma was associated with no overall survival benefits compared with sorafenib alone, but may offer benefits in some subgroups of patients (2018-04-13)

Slowing down -- Is aging caused by decreased cellular metabolism?
University of Tsukuba researchers have uncovered new information regarding the effects of impaired expression of the gene SHMT2 in genetically modified mice. They found that suppression of SHMT2 expression of SHMT2 altered activity in metabolic pathways, which in turn inhibited growth and impaired mitochondrial respiration, which is a critical cellular function that has been linked to human aging and age-related illnesses. Activation of SHMT2 may have future potential as a treatment for age-related illness. (2019-11-20)

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