Popular Liver News and Current Events

Popular Liver News and Current Events, Liver News Articles.
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AI 'scientist' finds that toothpaste ingredient may help fight drug-resistant malaria
An ingredient commonly found in toothpaste could be employed as an anti-malarial drug against strains of malaria parasite that have grown resistant to one of the currently used drugs. This discovery, led by researchers at the University of Cambridge, was aided by Eve, an artificially intelligent 'robot scientist.' (2018-01-18)

Stealth virus for cancer therapy
Scientists from the University of Zurich have redesigned an adenovirus for use in cancer therapy. To achieve this they developed a new protein shield that hides the virus and protects it from being eliminated. Adapters on the surface of the virus enable the reconstructed virus to specifically infect tumor cells. (2018-01-31)

Big data studies scrutinize links between fatty liver disease and how cells make energy
Three recent studies investigate changes in mitochondria, the cell's energy producers, as fatty liver disease (NAFLD) progresses to steatohepatosis (NASH). The first two studies illuminate how mitochondrial energy production stutters and fails; the third describes how changes to the liver during disease progression affect the organ's use of nutrients to produce energy. (2018-09-14)

UH Cancer Center researchers develop algorithm to find precise cancer treatments
University of Hawai'i Cancer Center researchers developed a computational algorithm to analyze 'Big Data' obtained from tumor samples to better understand and treat cancer. (2016-08-09)

Diabetes medicine reduces liver fat in nonalcoholic fatty liver disease
In people with type 2 diabetes, nonalcoholic fatty liver disease (NAFLD) is common and can progress to a severe liver disease known as nonalcoholic steatohepatitis (NASH). Now a study has found that empagliflozin, a newer treatment for type 2 diabetes, reduces liver fat in patients with NAFLD and diabetes. Results of the randomized controlled study, called the E-LIFT Trial, will be presented Monday at the Endocrine Society's 100th annual meeting in Chicago, Ill., during a late-breaking abstracts session. (2018-03-19)

Purest yet liver-like cells generated from induced pluripotent stem cells
A team of researchers from the Medical University of South Carolina and elsewhere has found a better way to purify liver cells made from induced pluripotent stem cells. This new methodology could facilitate progress toward an important clinical goal: the treatment of patients with disease-causing mutations in their livers by transplant of unmutated liver cells derived from their own stem cells. (2016-08-29)

New technique improves outcome for living donor liver transplants
Thanks to a review paper done at the University of Alberta radiologists at the University of Alberta Hospital are now using CT imaging for living-donor liver transplantation. CT imaging allows surgeons to plan the operation more accurately, which increases the likelihood for organ graft survival in recipients and reduces complication rates in donors. (2008-03-18)

How does the environment affect obesity?
Researchers will be examining how agricultural and food processing practices may affect brown fat activity directly or indirectly. Research will look at how toxicants such as pesticides or herbicides and artificial sweeteners or high fructose corn syrups could alter brown fat (BAT). (2016-05-02)

Obesity impacts liver health in kids as young as 8 years old
A new study found that weight gain, obesity can put children as young as age 8 at risk for a serious liver disease. (2018-04-04)

Scarring molecule in fat tissue links obesity with distressed fat
The fat of obese people becomes distressed, scarred and inflamed, which can make weight loss more difficult, research at the University of Exeter has found. (2018-01-12)

Citrus fruits could help prevent obesity-related heart disease, liver disease, diabetes
Oranges and other citrus fruits are good for you -- they contain plenty of vitamins and substances, such as antioxidants, that can help keep you healthy. Now a group of researchers reports that these fruits also help prevent harmful effects of obesity in mice fed a Western-style, high-fat diet. The researchers are presenting their work today at the 252nd National Meeting & Exposition of the American Chemical Society. (2016-08-21)

Phase 2 studies of two novel treatments for primary biliary cholangitis report encouraging results
Ongoing Phase 2 studies of tropifexor and seladelpar report promising preliminary efficacy, safety and tolerability results, paving the way for longer-term studies in patients with primary biliary cholangitis (2018-04-13)

Understanding vitamin D trends in children with non-alcoholic fatty liver disease
New research charts vitamin D levels and variations in genes that determine vitamin D status in UK children diagnosed with non-alcoholic fatty liver disease. (2018-05-15)

A Web-based lifestyle intervention supports weight loss in patients with non-alcoholic fatty liver disease
A remote lifestyle modification intervention shown to be as effective as a face-to-face group program for weight loss and improved liver health. (2018-04-13)

NGM282 -- an engineered analogue of FGF19 -- shows promise in patients with primary sclerosing cholangitis
A Phase 2, randomized, double-blind, placebo-controlled study reports significant improvements in markers of disease activity and fibrosis with subcutaneous NGM282 in patients with primary sclerosing cholangitis. (2018-04-13)

NYU Abu Dhabi researchers unlock the secrets of liver regeneration
In a recent study published in the journal Developmental Cell, NYU Abu Dhabi researchers have reported a new way in which the liver is primed to regenerate itself. They found that by stripping parts of the epigenome, which play a primary role in repressing 'jumping genes' (i.e. transposable elements), other epigenetic marks were redistributed. (2019-06-20)

Modulation of Fgf21 gene in early-life ameliorates adulthood diet-induced obesity
The nutritional environment in early life can lead to epigenetic changes in the genome that influence the risk of obesity in later life. In a new study, Tokyo Medical and Dental University (TMDU) researchers showed that the Fgf21gene undergoes PPARα-dependent DNA demethylation in the liver during the postnatal period and its status may persist into adulthood. Fgf21 methylation represents a form of epigenetic memory, and may play a role in the developmental programming of obesity. (2018-03-09)

Fatty liver disease contributes to cardiovascular disease and vice versa
For the first time, researchers have shown that a bi-directional relationship exists between fatty liver disease and cardiovascular disease. Fatty liver disease can lead to increased cardiovascular disease risk and vice versa. (2016-11-10)

Nonalcoholic fatty liver disease increases risk of liver, colorectal, and breast cancers
Nonalcoholic fatty liver disease (NAFLD) is one of the more common chronic liver diseases worldwide. It is associated with metabolic syndrome (i.e. insulin resistance and diabetes) and predisposes to cardiovascular disease. In a new study published in the Journal of Hepatology, researchers identified links not only between NAFLD and hepatocellular carcinoma (HCC), which have been well established, but also to cancers outside the liver, including colorectal and breast cancer. (2017-11-13)

Statins associated with reduced morbidity and mortality in patients with primary sclerosing cholangitischolangi
An award-winning register-based study reports a reduced risk of all-cause mortality, liver transplantation, liver cancer, and variceal bleeding in patients with primary sclerosing cholangitis exposed to statins. (2018-04-12)

Mediterranean-style diet improves gut microbial diversity and reduces hospitalization
ILC 2018: Diets rich in vegetables, fermented milk products, tea, coffee and chocolate may improve outcomes in patients with liver cirrhosis. (2018-04-12)

New regulator of liver metabolism discovered
Researchers from Charité - Universitätsmedizin Berlin have identified an enzyme that has a major effect on glucose utilization in liver cells. The enzyme, retinol saturase, helps these cells adapt to variations in glucose levels. However, when glucose levels are consistently too high, retinol saturase appears to exert a damaging effect on cells. Results from this study have been published in the journal Nature Communications*. (2017-09-29)

Researchers link defects in a nuclear receptor in the brain to autism spectrum disorders
University of Houston researchers link autism spectrum disorders to defects in a nuclear receptor inside the brain. And just like that, this world-renown team advances the understanding of autism. (2018-03-14)

Radiation therapy algorithm could reduce side effects, maintain effect against tumors
A mathematical model for computing radiation therapy treatments could substantially reduce patient side effects while delivering the same results as conventional radiation therapy. (2018-01-05)

Researchers find a promising new approach for treating liver cirrhosis
In a study in The American Journal of Pathology, investigators report that treatment with aleglitazar, a dual peroxisome proliferator-activated receptor-alpha/gamma (PPARα/γ) agonist, reduced inflammation, vasoconstriction, angiogenesis, mucosal disruption, and tumor necrosis factor (TNF)-α overproduction in cirrhotic rats with PH. This suggests a promising new approach for treating liver cirrhosis. (2018-06-18)

Selective internal radiation therapy (SIRT) fails to extend survival in the SORAMIC study palliative cohort
ILC 2018: The addition of SIRT to sorafenib in patients with advanced hepatocellular carcinoma was associated with no overall survival benefits compared with sorafenib alone, but may offer benefits in some subgroups of patients (2018-04-13)

Combating childhood obesity by preventing 'fatty liver' in fetus
New research published in The Journal of Physiology indicates that an obese pregnant mother and exposure to a high fat, high sugar diet during pregnancy produces a 'fatty liver' in the fetus, potentially predisposing children to obesity, metabolic and cardiovascular disorders later in life. (2018-03-07)

New receptor genes turn T-cells into powerful liver cancer foes
Mouse genes that make human T cells powerful at fighting liver cancer could one day help patients do the same, scientists report. Georgia Cancer Center scientists exposed mice genetically manipulated to respond to human antigens to a common antigen found in human liver cancer. (2018-04-03)

Gut check: Metabolites shed by intestinal microbiota keep inflammation at bay
Researchers have elucidated a mechanism by which 'good' bacteria that reside in our gastrointestinal tract can help protect us from inflammation, and how their disruption (dysbiosis) can increase the susceptibility of the liver to more harmful forms of disease. Their study, now available in the journal Cell Reports, identified two key metabolites produced by the bacteria in mice that modulate inflammation in the host and could ultimately reduce the severity of non-alcoholic fatty liver disease. (2018-05-04)

How to select anti-hepatitis B virus agents for drug-resistance patients?
Chronic hepatitis B virus (HBV) infection remains a global public health problem. Nucleoside analogs play an important role in antiviral therapy for chronic hepatitis B patients. However, many patients with a certain nucleoside analogs therapy for a period of time may be resistant to this antiviral agent. This article described a useful strategy to select anti-HBV agents for drug-resistance patients. (2008-09-24)

Hepatitis C virus screening rates remain low among baby boomers
Despite the steady increase of liver cancer incidence in the United States in recent decades, data from 2015 indicates that less than 13 percent of individuals born between 1945 and 1965 are estimated to have undergone screening for hepatitis C virus (HCV). (2018-03-27)

Scientists caution that a rare childhood liver cancer can spread to the brain
A new report details three cases of secondary brain tumors in people with fibrolamellar hepatocellular carcinoma. The researchers say imaging tests could improve treatment for patients whose cancer spreads to the brain from the liver. (2018-03-19)

Screening for hepatocellular carcinoma in patients with hepatitis C-related cirrhosis achieving sustained virological response is likely to be cost effective
A Canadian study suggests that biannual or annual ultrasound screening for HCC is likely to be cost effective after a sustained virological response in those with hepatitis C-related cirrhosis, but not in those with advanced fibrosis without cirrhosis. (2018-04-12)

Fat hormone linked to progression of fatty liver disease may hold key to new treatments
The rising obesity epidemic has brought with it an army of maladies. One, in particular, is threatening to outpace many of the disorders that accompany obesity, in terms of occurrence and severity: nonalcoholic fatty liver disease. (2017-11-06)

Texas A&M-led collaborative study takes aim at non-alcoholic fatty liver disease
Texas A&M University System researchers in collaboration with the Department of Veterans Affairs and Baylor Scott & White Research Institute have completed a study identifying one of the mechanisms leading to the development of non-alcoholic fatty liver disease, or NAFLD, providing new possibilities for prevention and treatment of the disease. (2018-02-26)

Cause of cancer form in the liver identified
In a new study, researchers from the University of Copenhagen have identified the two genes whose mutation cause a serious cancer form found in the liver. The result sets concrete goals for future treatment of the otherwise incurable disease. (2017-10-12)

Liver study offers insights into hard-to-treat diseases
A key cell process that could cause damage to bile ducts and help explain some liver diseases has been identified by scientists. (2018-03-09)

Vitamin D deficiency common in patients with IBD, chronic liver disease
The 73rd Annual Scientific Meeting of the American College of Gastroenterology in Orlando found patients with inflammatory bowel disease or chronic liver disease were at increased risk of developing Vitamin D deficiencies. Two separate studies highlight the importance of regular Vitamin D checkups in the evaluation of patients with certain digestive diseases. (2008-10-06)

Study shows liver cells with whole genome duplications protect against cancer
Researchers at the Children's Medical Center Research Institute (CRI) at UT Southwestern have discovered that cells in the liver with whole genome duplications, known as polyploid cells, can protect the liver against cancer. (2018-02-09)

Slowing down -- Is aging caused by decreased cellular metabolism?
University of Tsukuba researchers have uncovered new information regarding the effects of impaired expression of the gene SHMT2 in genetically modified mice. They found that suppression of SHMT2 expression of SHMT2 altered activity in metabolic pathways, which in turn inhibited growth and impaired mitochondrial respiration, which is a critical cellular function that has been linked to human aging and age-related illnesses. Activation of SHMT2 may have future potential as a treatment for age-related illness. (2019-11-20)

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