Popular Micrornas News and Current Events

Popular Micrornas News and Current Events, Micrornas News Articles.
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Does physical activity influence the health of future offspring?
Physical and mental exercise is not only beneficial for your own brain, but can also affect the learning ability of future offspring -- at least in mice. Researchers from the German Center for Neurodegenerative Diseases (DZNE) report these findings in the journal Cell Reports. (2018-04-10)

Explaining autism
Recognizing a need to better understand the biology that produces Autism Spectrum Disorder (ASD) symptoms, scientists at Duke-NUS Medical School (Duke-NUS) and the National Neuroscience Institute (NNI), Singapore, have teamed up and identified a novel mechanism that potentially links abnormal brain development to the cause of ASDs. This new knowledge will help to improve the diagnosis and development of therapeutic interventions for ASDs. (2016-02-17)

Slowing metabolic rate can prevent detrimental effects of genetic mutations
In a new Northwestern University study, researchers slowed mutant fruit flies' metabolic rates by 50%, and the expected detrimental effects of many mutations never manifested. After experimentally testing fruit flies' many different genetic mutations, the researchers found the same result each time. (2019-07-25)

Combating childhood obesity by preventing 'fatty liver' in fetus
New research published in The Journal of Physiology indicates that an obese pregnant mother and exposure to a high fat, high sugar diet during pregnancy produces a 'fatty liver' in the fetus, potentially predisposing children to obesity, metabolic and cardiovascular disorders later in life. (2018-03-07)

How the heart sends an SOS signal to bone marrow cells after a heart attack
Exosomes are key to the SOS signal that the heart muscle sends out after a heart attack. Exosomes in the bloodstream carry greatly increased amounts of heart-specific microRNAs -- as seen in both mice and humans. These exosomes preferentially go to progenitor cells in the bone marrow. Inside those cells, the microRNAs turn off a specific gene that allows the progenitor cells to leave the bone marrow and travel to the heart to attempt repairs. (2019-03-13)

Comparison of primate brains hints at what makes us human
A detailed comparative analysis of human, chimpanzee and macaque brains reveals elements that make the human brain unique, including cortical circuits underlying production of the neurotransmitter dopamine. (2017-11-23)

Macular degeneration linked to aging immune cells
Studying mice and cells from patients, vision researchers at Washington University School of Medicine in St. Louis found that as immune cells called macrophages get older, they are more likely to contribute to inflammation and abnormal blood vessel growth in the back of the eye. This can damage vision in patients with age-related macular degeneration. (2018-04-05)

Discovery of a new fusion gene class may affect the development of cancer
Cancer researchers at Lund University in Sweden have discovered a new class of fusion genes with properties that affect and may drive the development of cancer. (2017-10-05)

Lower levels of microRNA 29 may protect from cardiac fibrosis rather than causing it
Cardiac fibrosis involves an increase of connective tissue in the cardiac muscle, causing a loss of function. Researchers at the Technical University of Munich (TUM) have now discovered that fibrosis occurs less frequently when microRNA 29 (miR-29) is suppressed in cardiac muscle cells. Older studies had suggested that it was in fact low levels of miR-29 that caused fibrosis. The new insights point to potential new approaches for developing drugs against fibrotic diseases. (2017-11-22)

Metastatic cancer cells modify bone remodeling with small RNA secretion in bone metastasis
Prostate cancer frequently metastasizes and spreads to bone, causing severe pain, fractures, and other complications. The mechanisms that allow cancer cells to modify bone remodeling are incompletely understood. Researchers at Tokyo Medical and Dental University (TMDU) identified a microRNA, miR-940, that is abundant in exosomes secreted by prostate cancer cells and can trigger bone-forming lesions in mice. The findings indicate that microRNAs play a key role in bone metastatic environment and suggest potential novel therapeutic targets for bone metastasis. (2018-03-23)

Scientists discover a key function of als-linked protein
The protein FUS, whose mutation or disruption causes many cases of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), works as a central component of one of the most important regulatory systems in cells, according to a new study in Molecular Cell from scientists at Johns Hopkins Bloomberg School of Public Health. (2018-03-08)

Small molecule plays a big role in reducing cancer's spread
One small molecule that helps regulate gene expression plays a big role in keeping us safe from the machinations of cancer, scientists report. In human lung cancer cells, they have shown low levels of the microRNA, miR-125a-5p, which enables the death of aberrant cells like cancer cells, correlates with high levels of the protein TIMP-1, which is already associated with a poor prognosis in patients with cancer. (2018-01-31)

Nanopore technology with DNA computing easily detects microRNA patterns of lung cancer
Researchers at Tokyo University of Agriculture and Technology (TUAT) have developed a simple technique that allows detection of two independent microRNAs as an early diagnosis marker of Small Cell Lung Cancer (SCLC) , which is very aggressive. In this technique, they combined nanopore and DNA computing technologies as rapid and label-free detection. This method, therefore, could help to identify SCLC in the early stage. (2018-10-05)

Research identifies new breast cancer therapeutic target
Research led by Suresh Alahari, PhD, Professor of Biochemistry and Molecular Biology at LSU Health New Orleans School of Medicine, has shown for the first time that a tiny piece of RNA deregulates energy metabolism, an emerging hallmark of cancer. The finding identifies a new target for therapeutic intervention in breast cancer. (2018-07-18)

Investigators narrow in on a microRNA for treating multiple sclerosis
Investigators from Brigham and Women's Hospital have discovered a microRNA -- a small RNA molecule -- that increases during peak disease in a mouse model of MS and in untreated MS patients. (2019-11-26)

UMass Medical School study safely delivers RNAi-based gene therapy for ALS in animal model
Promising new research by Christian Mueller, Ph.D., and Robert H. Brown Jr., D.Phil., M.D., at the University of Massachusetts Medical School, provides evidence that a therapy using synthetic microRNAs may safely treat patients with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. (2018-10-31)

Premature infants may get metabolic boost from mom's breast milk
The breast milk of mothers with premature babies has different amounts of microRNA than that of mothers with babies born at term, which may help premature babies catch up in growth and development, according to researchers. (2017-09-14)

UK study shows cell signaling interaction may prevent key step in lung cancer progression
New findings from University of Kentucky faculty published in Scientific Reports reveals a novel cell signaling interaction that may prevent a key step in lung cancer progression. (2017-11-09)

Endurance training helpful in recovery from muscle inflammation, new study shows
Endurance training can actually be helpful in dealing with muscle inflammation, according to a new paper co-written by faculty at Binghamton University, State University of New York, and Karolinska Institutet and Karolinska University Hospital in Stockholm, Sweden. (2017-11-08)

Finding the root cause of bronchiolitis symptoms
'By treating all bronchiolitis patients with a single agent, we could be comparing apples with oranges,' says Robert J. Freishtat, M.D., M.P.H., chief of emergency medicine at Children's National Health System. The necessary treatment may differ, depending on the underlying cause: Respiratory syncytial virus, rhinovirus or another virus. (2018-01-24)

Serum micoRNAs may serve as biomarkers for multiple sclerosis
Serum micoRNAs may serve as biomarkers for multiple sclerosis. (2017-01-23)

How parasites hack victims to seize control of genes in plant-to-plant warfare
'Imagine a battle between host and parasite. In this case, dodder is trying to hack into the host's information system and the host is trying to shut it off. MicroRNAs are a new class of weapon being used in the warfare,' said Virginia Tech Professor Jim Westwood, an author of the paper. (2018-01-03)

Protein protects embryonic stem cells' versatility and self-renewal
The protein REST protects the pluripotentiality and self-renewal of embryonic stem cells by suppressing a specific microRNA. The basic finding by researchers at the University of Texas M. D. Anderson Cancer Center has implications for regenerative medicine. The new research builds on earlier work connecting the protein to medulloblastoma -- an aggressive childhood brain cancer. (2008-03-23)

Restoring chemotherapy sensitivity by boosting microRNA levels
By increasing the level of a specific microRNA (miRNA) molecule, researchers have for the first time restored chemotherapy sensitivity in vitro to a line of human pancreatic cancer cells that had developed resistance to a common treatment drug. (2016-05-27)

Resolvin D-1 limits kidney damage after heart attacks
A heart attack triggers an acute inflammatory response at the damaged portion of the heart's left ventricle. If the inflammation lingers, it can lead heart failure. The inflammation can also claim another victim -- the kidneys. New research shows that a bioactive compound called resolvin D-1, injected as a therapeutic dose, is able to limit this collateral damage in the kidneys, as tested in an animal model. This suggests potential application to the clinical setting. (2018-02-20)

MicroRNA predicts and protects against severe lung disease in extremely premature infants
Researchers report discovery of a strong predictive biomarker for bronchopulmonary dysplasia, and they show a role for the biomarker in the pathogenesis of this neonatal lung disease. These results open the path to possible future therapies to prevent or lessen BPD, which is marked by inflammation and impaired lung development, and mortality or morbidity. (2018-03-08)

Research identifies potential targets for treatment of leishmaniasis
Brazilian scientists show that parasite's penetration of host cells increases expression of certain microRNAs capable of inhibiting action of immune system. (2017-10-05)

A role for microRNAs in social behavior
Researchers have uncovered a microRNA cluster that regulates synaptic strength and is involved in the control of social behavior in mammals. The researchers presume that their discovery may point to new therapeutic strategies for the treatment of social deficits in neurodevelopmental disorders such as autism spectrum disorder or schizophrenia. The research is published today in EMBO Reports. (2018-12-14)

Small molecule plays big role in weaker bones as we age
With age, expression of a small molecule that can silence others goes way up while a key signaling molecule that helps stem cells make healthy bone goes down, scientists report. (2018-09-18)

Putting the break on our immune system's response
Researchers have discovered how a tiny molecule known as miR-132 acts as a 'handbrake' on our immune system -- helping us fight infection. (2019-03-04)

MicroRNA helps cancer evade immune system
Salk researchers discover how oxygen-deprived tumors survive body's immune response. (2017-09-18)

Honeybees become workers or queens depending on the plant microRNAs in their diet
Bee larvae develop into workers, in part, because their diet of pollen and honey, called beebread, is rich in plant regulatory molecules called microRNAs, which delay development and keep their ovaries inactive. Xi Chen of Nanjing University in China and colleagues, report these Aug. 31, 2017, in PLOS Genetics. (2017-08-31)

Agricultural parasite takes control of host plant's genes
Dodder, a parasitic plant that causes major damage to crops in the US and worldwide every year, can silence the expression of genes in the host plants from which it obtains water and nutrients. This cross-species gene regulation, which includes genes that contribute to the host plant's defense against parasites, has never before been seen from a parasitic plant. (2018-01-03)

Magnetically applied MicroRNAs could one day help relieve constipation
Micro metal beads and magnets help deliver a biologic where it's needed to improve constipation or rectoanal incontinence in animal models of the disorders. (2018-01-16)

News from the Journal of Lipid Research
Recent articles in the Journal of Lipid Research found a surprising insight into healthy octogenarians' arteries; a microRNA key to the puzzle of killing fat cells; and a change in cultured cell signaling that may affect experimental outcomes. (2018-05-14)

Timing is everything for the mutualistic relationship between ants and acacias
Ant-acacia plants attract ants by offering specialized food and hollow thorns in which the ants live, while the ant colony in turn defends its acacia against herbivores. This mutualistic relationship only occurs in older plants. New findings from University of Pennsylvania plant biologists, identify the genetic pathway that appears to regulate the timing of the acacia's ant-sustaining arsenal. (2019-07-16)

New nanotechnology detects biomarkers of cancer
Researchers at Wake Forest Baptist Medical Center have developed a new technology to detect disease biomarkers in the form of nucleic acids, the building blocks of all living organisms. (2016-02-12)

Protecting cell powerhouse paves way to better treatment of acute kidney injury
For the first time, scientists have described the body's natural mechanism for temporarily protecting the powerhouses of kidney cells when injury or disease means they aren't getting enough blood or oxygen. (2018-12-06)

Control of fertility: A new player identified
Individual small RNAs are responsible for controlling the expression of gonadoliberin or GnRH (Gonadotropin-Releasing Hormone), a neurohormone that controls sexual maturation, the appearance of puberty, and fertility in adults. This has just been demonstrated by the (2016-05-02)

New screening approach reveals importance of microRNAs in papillomavirus life cycle
The discovery of microRNAs encoded by papillomaviruses supports the important role of these small molecules in persistent infection, according to a study published July 26 in the open-access journal PLOS Pathogens. Study author Rachel Chirayil of the University of Texas at Austin and colleagues made this discovery using a new approach that enables microRNA identification for the enormous range of pathogens that have genomic data but cannot be cultured in a laboratory setting. (2018-07-26)

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