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Soil bacteria hormone discovery provides fertile ground for new antibiotics
The discovery of how hormone-like molecules turn on antibiotic production in soil bacteria could unlock the untapped opportunities for medicines that are under our very feet. An international team of scientists working at the University of Warwick, UK, and Monash University, Australia, have determined the molecular basis of a biological mechanism that could enable more efficient and cost-effective production of existing antibiotics, and also allow scientists to uncover new antibiotics in soil bacteria. (2021-02-03)

SARS-CoV-2 under the helium ion microscope for the first time
Scientists at Bielefeld University's Faculty of Physics have succeeded for the first time in imaging the SARS-CoV-2 coronavirus with a helium ion microscope. In contrast to the more conventional electron microscopy, the samples do not need a thin metal coating in helium ion microscopy. This allows interactions between the coronaviruses and their host cell to be observed particularly clearly. The findings have been published in the Beilstein Journal of Nanotechnology. (2021-02-04)

New technology makes 3-D imaging quicker, easier
Technology invented by scientists from The Johns Hopkins University and Ben-Gurion University of the Negev can make 3-D imaging quicker, easier, less expensive and more accurate. (2008-02-17)

NIST unveils forensic technique to measure mechanical properties of evidence
Judging forensic evidence such as hair by looks alone can be deceiving, as well as vague and subjective. Instead, what if investigators could precisely measure a hair's mechanical properties -- its stiffness and stickiness? In fact, they can, according to recent experiments at the National Institute of Standards and Technology, which is developing science-based methods to help ensure rigorous forensic practices. (2016-11-01)

Determining risk for pancreatic cancer
In the latest clinical trial for a technique to detect pancreatic cancer, researchers found they could differentiate cells that are cancerous from those that are benign, pre-cancerous, or even early stage indicators called mucinous cystic lesions. (2009-02-24)

Cutting-edge imaging techniques for neuroscientists available in latest laboratory manual
Neuroscientists have long pioneered the use of new visualization techniques. (2011-07-20)

Next-generation holographic microscope for 3-D live cell imaging
Professor YongKeun Park of the Physics Department at the Korea Advanced Institute of Science and Technology and his research team have developed a powerful method for 3-D imaging of live cells without staining. The researchers announced the launch of their new microscopic tool, the holotomography (HT)-1, to the global marketplace through a Korean start-up that Professor Park co-founded, TomoCube. (2016-03-28)

Alzheimer-linked protein complex at super resolution
With the advent of super-resolution microscopy, scientists can study close protein associations better than ever before. In the latest edition of eLife, the team of Wim Annaert (VIB-KU Leuven) combines state-of-the-art imaging techniques to investigate the distribution of γ-secretase, a protein complex associated with both Alzheimer's disease and cancer. (2020-07-09)

A glimpse inside the atom
Scientists at TU Wien have calculated how it is possible to look inside the atom to image individual electron orbitals. (2016-07-18)

Vision researchers find that photon receptors pair up in neat rows
Using atomic-force microscopy, vision researchers have taken pictures of some of the eye's photon receptors in their natural state, and have analyzed their packing arrangement. Their findings, published in the Jan. 9 issue of Nature, offer insight on how light signaling might be controlled in the retina's outer edge. (2003-01-24)

Massive weight loss patients create mass appeal for body contouring procedures
More than 106,000 body contouring procedures were performed in 2004, up 77 percent over the last five years according to statistics released today by the American Society of Plastic Surgeons. Massive weight loss patients, who accounted for nearly 56,000 procedures, continue to drive the growth in body contouring; however, more patients are choosing these procedures as awareness grows and as plastic surgeons apply improved surgical techniques. (2005-03-16)

Migraine surgery offers good long-term outcomes
Surgery to (2011-02-02)

Robin Clark to receive inaugural Franklin-Lavoisier Prize
CHF and the Fondation de la Maison de la Chimie are pleased to announce that Robin J. H. Clark will be the recipient of the inaugural Franklin-Lavoisier Prize on Wednesday, Jan. 28, 2009, at the Fondation de la Maison de la Chimie in Paris. Clark is the Sir William Ramsay Professor of Chemistry at University College London and the pioneer in the use of raman microscopy for pigment identification on art and artifacts. (2009-01-27)

Scientists illuminate mysterious molecular mechanism powering cells in most forms of life
A team led by structural biologists at The Scripps Research Institute has taken a big step toward understanding the intricate molecular mechanism of a metabolic enzyme produced in most forms of life on Earth. The finding concerns nicotinamide nucleotide transhydrogenase, an ancient evolutionary enzyme that is part of a process key to maintaining healthy cells and has also recently been linked to diseases such as diabetes and cancer. (2015-01-08)

From pomegranate peel to nanoparticles
Food waste is a growing problem in many parts of the world, but discarded fruit peel, in the case of pomegranates, could be put to good use in the burgeoning field of nanotechnology according to research published in the International Journal of Nanoparticles. (2012-06-19)

Fungi that evolved to eat wood offer new biomass conversion tool
Twenty years ago, microbiologist Barry Goodell, now a professor at UMass Amherst, and colleagues discovered a unique system that some microorganisms use to digest and recycle wood. Three orders of 'brown rot fungi' have now been identified that can break down biomass, but details of the mechanism were not known. Now, using several complementary research tools, Goodell and colleagues report new details of an unexpected mechanism at work, one that surprisingly does not involve enzymes, the usual accelerators of chemical reactions. (2017-07-24)

Important biomedical microscopy technique can now image deeper into tissue
A recently developed technique known as light-sheet fluorescence microscopy has led to many biological discoveries by allowing researchers to create 3-D images of tissue, even live animal embryos, using fluorescent tags. (2018-10-31)

Innovative mechanobiology research expands understanding of cells
Researchers have developed a new technology that allows them to probe cell changes without disturbing the cell's physiology -- a major advancement that helps scientists look more closely at cell changes to solve human health problems, according to a new paper in Cell Reports. This technology, known as deformation microscopy, allows scientists to more accurately assess the interplay between biological systems and the mechanical environment in treating musculoskeletal, cardiac and neural diseases. (2019-05-08)

'Firefly' imaging method zooms in on 'the forces within us'
Scientists have developed a new technique using tools made of luminescent DNA, lit up like fireflies, to visualize the mechanical forces of cells at the molecular level. (2020-09-22)

Ultra-sensitive nanothermometer under ambient conditions
Nanoscale temperature measurement with high sensitivity is important to studying many phenomena ranging from heat dissipation in nanocircuits to thermal processes in live systems. The most sensitive nanothermometer working under ambient conditions is demonstrated by hybridizing the critical magnetism of magnetic nanoparticles and the ultra-sensitive diamond-based magnetometer. The sensitivity of the hybrid nanothermometer is as high as 76 uK/sqrt(Hz). The ultra-sensitive nanothermometer offers a new tool to investigate thermal processes in nanoscale systems. (2020-10-14)

Researchers identify when Parkinson's proteins become toxic to brain cells
Observation of the point at which proteins associated with Parkinson's disease become toxic to brain cells could help identify how and why people develop the disease, and aid in the search for potential treatments. (2016-03-14)

Brown computer scientists receive grant to speed Internet use
A team of researchers led by Brown computer scientist Stanley Zdonik will search for a way to make using the Internet faster with a $3.2-million grant from the National Science Foundation. The research will focus on creating user (2000-09-20)

Researchers gain detailed insight into failing heart cells using new nano technique
Researchers have been able to see how heart failure affects the surface of an individual heart muscle cell in minute detail, using a new nanoscale scanning technique developed at Imperial College London. The findings may lead to better design of beta-blockers, the drugs that can slow the development of heart failure, and to improvements in current therapeutic approaches to treating heart failure and abnormal heart rhythms. (2010-02-25)

7.0T NMR assesses changes in hippocampal neurons in animal models of Alzheimer's disease
Magnetic resonance spectroscopy can quantitatively analyze in vivo abnormalities of biochemical metabolism within brain tissue in a noninvasive and non-radioactive manner. Compared with 3.0T magnetic resonance spectroscopy, high-field magnetic resonance spectroscopy (≥ 7.0T) exhibits high spatial resolution and density resolution, microscopic imaging of the living body, and obtains both high scanning resolution and result precision within a shorter scan time, thus providing a higher value in clinical diagnosis. (2014-08-04)

New research sets stage for noninvasive monitoring of HIV-induced peripheral neuropathy
Corneal nerve fiber assessment has great potential as a tool to diagnose and monitor peripheral neuropathy induced by HIV, say scientists at the Johns Hopkins University School of Medicine. The results of their study are published in the American Journal of Pathology. (2014-05-12)

New structure identified in membrane of disease-causing bacteria
Mycobacteria cause a number of dangerous, difficult-to-treat diseases including leprosy and tuberculosis, and progress has been slow in eradicating them. But new strategies for combating these bacteria may eventually emerge from better understanding their basic structure and mechanisms, say molecular microbiologist Yasu Morita and his doctoral student Jennifer Hayashi at the University of Massachusetts Amherst. (2016-04-25)

From the renowned Cold Spring Harbor Laboratory course
'Molecular Neuroscience: A Laboratory Manual' includes protocols used in the Advanced Techniques in Molecular Neuroscience course offered annually at Cold Spring Harbor Laboratory, as well as protocols drawn from its best-selling lab manuals. It is an essential resource for all neuroscientists, from graduate students upward, who seek to use molecular techniques to probe the complexities of the nervous system. (2014-09-25)

ASCB launches 'The Cell: An Image Library' to inspire discovery and improve human health
The American Society for Cell Biology, in collaboration with Glencoe Software Inc. and the Open Microscopy Environment today announce the launch of (2010-12-13)

A researcher identifies the parasites responsible for Chagas and Leishmaniasis epidemics
Both diseases have already been recognized by the WHO as a public health problem. They affect around 30 million people throughout the world, particularly in South America. Although no specific medicines have been developed yet, this study conducted by the University of Granada will be an important step towards the discovery of a treatment. (2007-06-04)

How do atoms vibrate in graphene nanostructures?
Researchers from the University of Vienna, the Advanced Institute of Science and Technology in Japan, the company JEOL and La Sapienza University in Rome have developed a method capable to measure all phonons existing in a nanostructured material. This is a breakthrough in the analysis of nanoscale functional materials and devices. (2019-08-12)

Towards sustainability -- from a by-product of the biodiesel industry to a valuable chemical
Scientists at Tokyo Institute of Technology (Tokyo Tech) and the National Taiwan University of Science and Technology (Taiwan Tech) develop a cheap and efficient copper-based catalyst that can be used to convert glycerol, one of the main by-products of the biodiesel industry, into a valuable compound called dihydroxyacetone. In addition, this same process produces hydrogen molecules from water, and these could be used as a clean type of fuel, further highlighting the impact of this research in terms of energy sustainability. (2020-01-08)

A new piece of the HIV infection puzzle explored
Researchers from the European Molecular Biology Laboratory and Heidelberg University Hospital combine high-resolution imaging to observe the infection process in cell nuclei, opening the door for new therapeutics. (2021-02-18)

Caltech engineers build smart petri dish
The cameras in our cell phones have dramatically changed the way we share the special moments in our lives, making photographs instantly available to friends and family. Now, the imaging sensor chips that form the heart of these built-in cameras are helping engineers at the California Institute of Technology transform the way cell cultures are imaged by serving as the platform for a (2011-10-03)

Cell on a chip reveals protein behavior
A simplified version of an artificial cell produces functional proteins and even sorts them. (2013-03-18)

Pittsburgh scientists identify human source of stem cells with potential to repair muscle
For the first time, scientists at Children's Hospital of Pittsburgh of UPMC have discovered a unique population of adult stem cells derived from human muscle that could be used to treat muscle injuries and diseases such as heart attack and muscular dystrophy. (2007-09-04)

New DNA stain lights up living cells
EPFL scientists have developed a new DNA stain that can be used to image living cells. (2015-10-01)

Xpert® MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults
The updated review assessing the accuracy of Xpert® MTB/RIF includes new studies published since the original Cochrane Review was published in January last year. Led by Karen Steingart, an Editor with the Cochrane Infectious Diseases Group at Liverpool School of Tropical Medicine, the researchers found that Xpert® MTB/RIF is more accurate than smear microscopy for diagnosing tuberculosis and also accurate for detecting rifampicin resistance. (2014-01-22)

Polarized microscopy technique shows new details of how proteins are arranged
By harnessing the unique properties of polarized light, Rockefeller scientists have developed a new technique that can help deduce the orientation of specific proteins within a cell. (2011-04-17)

Super-resolution at all scales with active thermal detection
IBS research team found the temperature increase caused by the probe beam could be utilized to generate a signal per se for detecting objects. Notably, this so-called 'active thermal detection' enables super-resolution imaging at all scales. (2019-12-22)

New super-resolution method reveals fine details without constantly needing to zoom in
Since the early 1930s, electron microscopy has provided unprecedented access to the alien world of the extraordinarily small, revealing intricate details that are otherwise impossible to discern with conventional light microscopy. But to achieve high resolution over a large specimen area, the energy of the electron beams needs to be cranked up, which is costly and detrimental to the specimen under observation. (2020-08-12)

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