Popular Neuroblastoma News and Current Events

Popular Neuroblastoma News and Current Events, Neuroblastoma News Articles.
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Nuclear protein causes neuroblastoma to become more aggressive
Aggressive forms of neuroblastoma contain a specific protein in their cells' nuclei that is not found in the nuclei of more benign forms of the cancer, and the discovery, made through research from the University of Rochester Medical Center, could lead to new forms of targeted therapy. (2016-10-06)

UofL offers vaccine trial for children with relapsed tumors at Kosair Children's Hospital
Children with relapsed tumors and their parents are finding hope in a Phase I research study led by Kenneth G. Lucas, M.D., at the University of Louisville who is making progress in developing a vaccine that one day could possibly prevent recurrence of some cancers. (2015-07-16)

Scientists discover potential way to treat and prevent cancer in children (neuroblastoma)
The MYCN oncogene is known to be a key cause of a number of deadly solid tumour cancers, including neuroblastoma which claims more lives of children under 5 than any other cancer. In new research, a team led by Professor Michelle Haber AM, Executive Director, and Professor Murray Norris AM, Deputy Director, Children's Cancer Institute, Australia, has uncovered a previously unknown crucial link between polyamines and MYCN, offering a new way to target childhood cancers. (2019-02-01)

Tumor-targeting viral therapy slows neuroblastoma, malignant peripheral nerve sheath tumors
Researchers in a multi-institutional study led by Cincinnati Children's Hospital Medical Center slowed the growth of two particularly stubborn solid tumor cancers -- neuroblastoma and peripheral nerve sheath tumors -- without harming healthy tissues by inserting instructions to inhibit tissue growth into an engineered virus, according to study results published in the Feb. 15 Cancer Research. (2008-02-15)

Children with neuroblastoma have an elevated risk of long-term psychological difficulties
A new study reveals that pediatric neuroblastoma patients are at elevated risk for long-term psychological impairment. In addition, those who experience such impairment as they get older tend to require special education services and to not go on to college. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society. (2018-06-11)

TTUHSC researchers publish preclinical data on new drug combination to treat neuroblastoma
Neuroblastoma, the most common cancer outside of the brain in infants and young children, often fails to respond to therapy. To improve treatment outcomes for these patients, C. Patrick Reynolds, M.D., Ph.D., director of the Texas Tech University Health Sciences Center School of Medicine's Cancer Center, and a team of colleagues completed a study using fenretinide to boost the effects of venetoclax, an inhibitor of a protein (BCL-2) that helps neuroblastoma cells survive and grow. (2019-11-08)

Scientists close in on method to fight deadly childhood cancer
Focusing on a gene known as ALK in human cell lines and tissue samples, scientists used a small-molecule inhibitor to block abnormalities that apparently cause neuroblastomas, a type of cancer responsible for 15 percent of all cancer deaths in children. (2008-10-15)

New biomarkers for neuroblastoma, a type of cancer in children
Two new biomarkers for a type of cancer in children called neuroblastoma have been identified in a study published in the journal Cancer Cell. The findings are expected to have immediate significance for disease prognosis, and eventually also for treatment. (2018-03-19)

Researchers identify promising gene target for neuroblastoma therapy
Researchers at Dana-Farber Cancer Institute have identified a set of previously unknown mutations in a single gene in 8 percent of neuroblastomas, tumors of the nervous system that occur in young children and account for approximately 15 percent of all childhood cancer deaths. The discovery is intriguing because a small (2008-10-15)

A double-barreled immune cell approach for neuroblastoma
Adding an artificial tumor-specific receptor to immune system cells called T-lymphocytes that target a particular virus extended and improved the cells' ability to fight a form of childhood cancer called neuroblastoma, said researchers form Baylor College of Medicine and Texas Children's Hospital in a report that appears online today in the journal Nature Medicine. (2008-11-02)

Muscle gene mutations implicated in human nasal/sinus cancer
By sequencing the entire genomes of tumor cells from six people with a rare cancer of the nose and sinus cavity, Johns Hopkins researchers report they unexpectedly found the same genetic change -- one in a gene involved in muscle formation -- in five of the tumors. (2019-02-27)

Understanding the molecular mechanisms of ALS
Scientists have revealed more details of the molecular mechanism behind neuronal cell death in amyotrophic lateral sclerosis (ALS), a step forward to find ways to control progression of the disease. (2017-12-26)

New nanoparticle targets tumor-infiltrating immune cells, flips switch
A team of Vanderbilt University bioengineers today announced a major breakthrough in penetrating the cells inside tumors and flipping on a switch that tells them to start fighting. (2019-01-21)

Childhood cancer: The four survival strategies of tumor cells
Cancer cells in children tend to develop by following four main trajectories -- and two of them are linked to relapse of the disease, research led by Lund University in Sweden shows. The four strategies can occur simultaneously in a single tumor, according to the study that is now published in Nature Genetics. (2018-06-04)

Oestrogen causes neuroblastoma cells to mature into neurons
The female sex hormone oestrogen can perform an important role in neuroblastoma, a form of cancer mainly affecting young children. In laboratory experiments, researchers at Karolinska Institutet in Sweden demonstrate that oestrogen treatment and overexpression of the oestrogen receptor cause malignant neuroblastoma cells to mature into neuron-like cells. The study, which is published in PNAS, gives hope of new treatment possibilities. (2018-01-29)

Fluorescent fish genes light path to neuroblastoma
Neurodevelopmental biologist Rosa Uribe, a CPRIT Scholar who was recruited to Rice University in 2017 with a grant from the Cancer Prevention and Research Institute of Texas, has a new tool in the search for the origins of neuroblastoma, the third-most common pediatric cancer in the United States. (2018-07-09)

Discovery by NUS researchers improves understanding of cellular aging and cancer development
A team of researchers led by Dr Dennis Kappei, a Special Fellow from the Cancer Science Institute of Singapore at the National University of Singapore, has discovered the role of the protein ZBTB48 in regulating both telomeres and mitochondria, which are key players involved in cellular ageing. The results of the study will contribute to a better understanding of the human ageing process as well as cancer development. (2017-06-13)

Medical researchers find protein that marks difference between cancer and non-cancer cells
A discovery sheds light on how cancerous cells differ from healthy ones, and could lead to the development of new strategies for therapeutic intervention for difficult-to-treat cancers in the future. (2018-03-08)

New biomarker for Alzheimer's disease found thanks to the CRISPR technique
The scientists have found a deficiency in the protein STIM1 in brain tissue from patients with Alzheimer's disease. Its involvement in neurodegenerative processes has been verified thanks to the technique CRISPR / Cas9. Up to now, the effects of a deficiency in this protein critical to sporadic Alzheimer's were not known, and so this research provides a new biomarker for the illness, an indicator of the progression of the neurodegenerative process. (2018-10-09)

Anti-RAS antibodies show poor reliability in recognizing RAS proteins
Researchers from the Greehey Children's Cancer Research Institute at UT Health San Antonio co-authored a paper published Sept. 26 in Science Signaling that looks at the reliability of a common research tool to study RAS cancer mutations. (2017-10-05)

More children survive neuroblastoma
Both the survival rate and the incidence of neuroblastoma have increased in the last decennia in the Netherlands, as was shown by a study from the Princess Máxima Center. The improved chance of survival and the increase in the number of patients has been greatest in the high risk group; children older than 18 months with a stage 4 neuroblastoma. (2019-11-18)

Scientists tackle the aberrant epigenetic programming underlying childhood cancers
Researchers at UFRGS and the US NIH have targeted proteins that regulate chromatin in Ewing sarcoma cells, hindering malignant tumor growth. They induced chromatic relaxation by treating the cells with histone deacetylase inhibitors, reducing expression of the EWSR1-FLI-1 oncogene and other pluripotency/cell viability genes, while impairing sarcoma cell survival and growth. Decreased survival of stem-like cancer cells and re-expression of a neuronal differentiation marker were also observed. (2018-02-20)

Unlocking the mystery of the duck-billed platypus' venom
Abandon any notion that the duck-billed platypus is a soft and cuddly creature -- maybe like Perry the Platypus in the Phineas and Ferb cartoon. The males can deliver a mega-sting that causes immediate, excruciating pain, like hundreds of hornet stings, leaving victims incapacitated for weeks. Now scientists are reporting an advance toward deciphering the chemical composition of the venom, with the first identification of a dozen protein building blocks. (2010-01-13)

Uncovering molecular targets for childhood cancer therapeutics
Neuroblastoma (NB) is the most common solid tumor found in children and is associated with poor prognosis; however, little is known regarding the molecular targets located in the long arm of chromosome 11 (11q). Tokyo Medical and Dental University (TMDU)-centered researchers revealed the loss or imbalance of genes ATM, MRE11A, H2AFX, and/or CHEK1 in 11q in 20.7% of NBs. Furthermore, they found 83.3% NB-derived cell lines exhibited sensitivity to PARP inhibitors. (2017-12-28)

Breakthrough in understanding common childhood cancer
Scientists studying one of the most common forms of childhood cancer have made an important breakthrough in understanding how the disease progresses. (2019-11-25)

Researchers create novel combination as potential therapy for high-risk neuroblastoma
Researchers at VCU Massey Cancer Center in Richmond, Virginia, have identified a promising target to reverse the development of high-risk neuroblastoma and potentially inform the creation of novel combination therapies for the disease. (2018-06-18)

New insight into the genetics of brain tumor formation
In a G&D paper published online ahead of its April 1 print publication date, Dr. William Kaelin (Dana Farber Cancer Institute) and colleagues identify a potential new neuronal tumor suppressor. (2008-03-17)

VRK1: a protein that reduces the survival of patients with neuroblastoma
Researchers have characterised the function of VRK1 in neuroblastoma tumour cells and have determined that this protein is essential for tumour cell growth and proliferation. ''By studying the expression of this protein in tumours, we were able to identify a priori patients where tumour progression is going to be worse, even in groups where current tools do not predict that behaviour,'' notes Francisco M. Vega. (2020-12-11)

Energy storehouses in the brain may be source of Alzheimer's, targets of new therapy
In a new study, researchers at the ASU-Banner Neurodegenerative Disease Research Center examine the effects of the disease on the functioning of mitochondria -- structures performing a variety of essential tasks, including supplying cells with energy. (2018-01-23)

Drug therapy reduces neuroblastoma tumor growth in pre-clinical investigation
Researchers from the Children's Cancer Hospital at the University of Texas M. D. Anderson Cancer Center have discovered a new drug combination that significantly hinders tumor growth in neuroblastoma, a childhood cancer. The study was presented today at the 22nd Annual Meeting of the American Society of Pediatric Hematology/Oncology. (2009-04-24)

Antibody-drug conjugate shows efficacy against cell surface protein in neuroblastoma
Physician-scientists in the Cancer Center at Children's Hospital of Philadelphia have developed a preclinical, potent therapy attached to an antibody that targets a surface protein expressed in most childhood neuroblastomas, effectively killing cancer cells. (2019-03-13)

Researchers find new way to target childhood cancer
An Australian-led international research effort has broken fresh ground in the race to find more effective treatments for the childhood cancer neuroblastoma, by uncovering a new and as-yet unexploited target in cancer cells that therapeutic drugs can be aimed at. (2019-11-12)

Mayo Clinic researchers identify genes fueling neuroblastoma spread
For the first time, Mayo Clinic researchers and colleagues present data on how nervous system tumors, called neuroblastomas, spread. Their paper, published in Cancer Cell, clarifies the relationship between two genes that fuel the aggressive spread of neuroblastomas. (2017-08-31)

Proton therapy shows efficacy, low toxicity in large cohort of children with high-risk neuroblastoma
Researchers from Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania analyzed the largest cohort to date of pediatric patients with high-risk neuroblastoma treated with proton radiation therapy (PRT), finding both that proton therapy was effective at reducing tumors and demonstrated minimal toxicity to surrounding organs. (2019-04-09)

A step forward in the struggle against neuroblastoma, a type of childhood cancer
A protein called CD44 makes it possible to identify the population of mother cells that are responsible for the aggressive nature and low survival rate of neuroblastoma, a type of childhood cancer that mainly affects children of two and three years old. (2019-11-27)

Breakthrough in generating embryonic cells that are critical for human health
Critical for human development and health, neural crest cells arise early in the development of vertebrates. They migrate extensively inside the embryo, and differentiate to give rise to a wide array of diverse derivatives. Accessing these cells, however, is difficult. Work done by a research team led by a UC Riverside biomedical scientist now provides a fast, simple and cost-effective method to generate neural crest cells, facilitating research in basic sciences and clinical applications alike. (2016-02-03)

New model for predicting neuroblastoma outcomes incorporates early developmental signals
Motivated by a desire to better understand the molecular circuitry underlying neuroblastoma and limitations of current methods for predicting disease progression and outcome, researchers from the Kulesa Lab at the Stowers Institute for Medical Research and collaborators at the University of Michigan and Oxford University set out to construct a logic-based model incorporating information about developmental signaling pathways implicated in the disease. (2018-07-06)

Loss of a microRNA family, let-7, found key in neuroblastoma
A study led by researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center, finds that a microRNA called let-7 plays a central role in curbing neuroblastoma and could focus efforts to find a targeted, nontoxic alternative to chemotherapy. (2016-07-07)

Cell surface protein may offer big target in treating high-risk childhood cancers
Oncology researchers studying high-risk children's cancers have identified a protein that offers a likely target for immunotherapy -- harnessing the immune system in medical treatments. In cell cultures and animal models, a potent drug attached to an antibody selectively zeroes in on cancer cells without harming healthy cells. (2017-09-11)

Study reveals elevated cancer risk in children with birth defects
A collaborative team of scientists led by Baylor College of Medicine has assembled the largest study to date to evaluate cancer risk in children with birth defects. (2019-06-25)

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