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New, persistent opioid use common after surgery
Among about 36,000 patients, approximately 6 percent continued to use opioids more than three months after their surgery, with rates not differing between major and minor surgical procedures, according to a study published by JAMA Surgery. (2017-04-12)

New pain treatment tested in humans
Nerve growth factor signals through receptors of the tropomyosin-related kinase (Trk) family, and research in animals has shown that inhibitors of Trks A, B, and C can reduce pain. (2017-11-27)

Peripheral nerve block provides some with long-lasting pain relief for severe facial pain
A new study has shown that use of peripheral nerve blocks in the treatment of Trigeminal Neuralgia (TGN) may produce long-term pain relief. (2018-08-13)

Opioids produce analgesia via immune cells
Opioids are the most powerful painkillers. Researchers at the Charité -- Universitätsmedizin Berlin have now found that the analgesic effects of opioids are not exclusively mediated by opioid receptors in the brain, but can also be mediated via the activation of receptors in immune cells. Results from this research have been published in the journal Brain, Behavior, and Immunity. (2017-01-17)

Becoming more sensitive to pain increases the risk of knee pain not going away
A new study by researchers in Montreal and Boston looks at the role that pain plays in osteoarthritis, a disease that affects over 300 million adults worldwide. (2018-10-30)

New study to investigate role of sleep in chronic pain
Washington State University will lead a study to understand the relationship between sleep and chronic pain, part of a nationwide effort to address the rising abuse of opioid pain relievers and expand the arsenal of non-drug treatment options. (2016-12-05)

CT angiography highly accurate, multicenter trials show
Computed tomography angiography is as accurate as an invasive angiogram in detecting coronary artery disease, according to findings from the first two prospective multicenter 64-slice scanner trials. (2007-11-26)

Surgery for back pain reduces problems with sex life-related pain
For patients with degenerative spinal disease, surgery is more effective in reducing pain that interferes with sexual activity, compared to nonsurgical treatment, reports a study in the Nov. 15 issue of Spine, published by Wolters Kluwer. (2016-11-11)

New target for chronic pain relief confirmed by scientists
A research group at Hiroshima University observed a potential new target for chronic pain treatment. Further research using this receptor could lead to new, more effective drugs to use in pain-relieving treatment for chronic pain. (2019-03-07)

Acupuncture possible treatment for dental anxiety
Researchers have found evidence that acupuncture could help people who experience dental anxiety. (2018-05-01)

Menopause symptoms nearly double the risk of chronic pain
In addition to the other health conditions affected by estrogen, it has also been shown to affect pain sensitivity. This finding was the basis of a study of more than 200,000 records from the Veterans Health Administration that demonstrated a link between menopause symptoms and chronic pain. Study results are published online today in Menopause, the journal of The North American Menopause Society (NAMS). (2019-03-06)

It's not just a pain in the head -- facial pain can be a symptom of headaches too
A new study finds that up to 10% of people with headaches also have facial pain. The study is published in the Aug. 21, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology. (2019-08-21)

Chronic pain common in people living with HIV
All people living with HIV should be screened for chronic pain, which affects 39 to 85 percent of people with the condition, recommend new HIVMA guidelines. Those who have chronic pain should be treated using a multidisciplinary approach focused on non-drug options ranging from yoga to physical therapy, note the guidelines. Opioids should never be a first-line treatment. (2017-09-14)

Medical marijuana gets wary welcome from older adults, poll shows
Few older adults use medical marijuana, a new national poll finds, but the majority support its use if a doctor recommends it, and might talk to their own doctor about it if they developed a serious health condition. And two-thirds say the government should do more to study the drug's health effects. (2018-04-03)

Multiple sclerosis drug could reduce painful side effects of common cancer treatment
Researchers from the Saint Louis University School of Medicine have discovered why many multiple myeloma patients experience severe pain when treated with the anticancer drug bortezomib. The study, which will be published April 27 in the Journal of Experimental Medicine, suggests that a drug already approved to treat multiple sclerosis could mitigate this effect, allowing myeloma patients to successfully complete their treatment and relieving the pain of myeloma survivors. (2018-04-27)

Bedside art therapy decreases pain and anxiety in patients with cancer
A brief bedside visual art intervention (BVAI) facilitated by art educators improved mood and reduced pain and anxiety in a study of inpatients with hematological cancers. (2018-04-19)

Opioid controlled substance agreements safely reduce health care visits, Mayo study finds
The medical community has long known that patients on long-term opioid therapy often have significantly more health care visits. But adhering to a standardized care process model for opioid prescriptions appears to reduce the overall number of health care visits for these patients while maintaining safety, shows new research published in Mayo Clinic Proceedings. (2018-09-20)

Clocking in with malaria parasites
Discovery of a malaria parasite's internal clock could lead to new treatment strategies. (2020-06-09)

Poor and less educated suffer the most from chronic pain
Poorer and less-educated older Americans are more like to suffer from chronic pain than those with greater wealth and more education, but the disparity between the two groups is much greater than previously thought, climbing as high as 370 percent in some categories, according to new research by a University at Buffalo medical sociologist. (2017-02-08)

Study shows pine bark naturally reduces knee osteoarthritis
According to the Center for Disease Control, osteoarthritis, the most common type of arthritis, is on the rise. A new study published in the August journal of Phytotherapy Research, reveals pycnogenol, bark extract from the French maritime pine tree, reduced overall knee osteoarthritis symptoms by 20.9 percent and lowered pain by 40.3 percent. (2008-09-03)

Morris Animal Foundation study shows drug comes up short in osteoarthritis pain relief
Morris Animal Foundation-funded researchers from the University of Georgia, have found that tramadol was ineffective in alleviating signs of pain associated with osteoarthritis in dogs. The research team published their results in the Journal of the American Veterinary Medical Association. (2018-05-02)

Can staying active help to prevent chronic pain? Physical activity affects pain modulation in older adults
Older adults with higher levels of physical activity have pain modulation patterns that might help lower their risk of developing chronic pain, reports a study in PAIN®, the official publication of the International Association for the Study of Pain (IASP). The journal is published by Wolters Kluwer. (2017-02-24)

Quality of life predicts cancer survival, U-M study finds
Head and neck cancer patients who reported lower physical quality of life were more likely to die from their disease, according to a new study from the University of Michigan Comprehensive Cancer Center. The findings could mean that identifying patients with poor quality of life could also identify patients with particularly aggressive tumors. (2008-05-29)

The anatomy of pain
Emotions consist of general components that are also elicited by similar impressions and specific components. (2016-03-23)

Studies provide new insights on mosquito-borne chikungunya virus infection
The frequency of chronic joint pain after infection with chikungunya in a large Latin-American cohort was 25 percent at a median of 20-months post-infection. (2017-12-20)

Is back pain killing us?
Older people who suffer from back pain have a 13 per cent increased risk of dying from any cause, University of Sydney research has found. Published in the European Journal of Pain, the study of 4390 Danish twins aged more than 70 years investigated whether spinal pain increased the rate of all-cause and disease-specific cardiovascular mortality. (2017-02-23)

Patient satisfaction with pain management linked to nurse staffing
Hospital patients' satisfaction with pain management is linked to nurse staffing, according to an article authored by nurse researchers from the Connell School of Nursing at Boston College and published in the journal Pain Management Nursing. (2017-09-06)

Tai chi as good as or better than aerobic exercise for managing chronic pain
The ancient martial art of tai chi has similar or greater benefits than aerobic exercise for people with the chronic pain condition fibromyalgia, finds a trial published by The BMJ today. (2018-03-21)

Chronic opioid therapy can disrupt sleep, increase risk of sleep disorders
Patients and medical providers should be aware that chronic opioid use can interfere with sleep by reducing sleep efficiency and increasing the risk of sleep-disordered breathing, according to a position statement from the American Academy of Sleep Medicine. (2019-11-19)

Study shows that chronic grief activates pleasure areas of the brain
Most of us experience the grief associated with the loss of a loved one at some point in our lives. New research from UCLA now suggests that people who never get over their loss, who never (2008-06-20)

Health-related quality of life for patients with vascular malformations
Patients with vascular malformations, which include blood vessel, artery and lymph vessel abnormalities, appear to have more pain and mental health distress than the general US population and that can contribute to poor health-related quality of life. (2018-03-21)

Which pain medication is safest for arthritis patients?
In a recent Alimentary Pharmacology & Therapeutics study, arthritis patients taking nonsteroidal anti-inflammatory drugs (NSAIDs) for pain plus a stomach acid-reducing medicine called esomeprazole had infrequent gastrointestinal side effects. (2018-04-19)

Understanding pain exacerbation with Opioid use
A new study published in JNeurosci advances understanding of how the potent opioid analgesic fentanyl can increase pain sensitivity in animals. These findings could inform the development of treatments for chronic pain that minimize the side effects of these powerful pain-relieving drugs. (2018-02-05)

Smoking, diabetes and high blood pressure increase women's risk of heart attack
Smoking, diabetes and high blood pressure increase the risk of a heart attack more in women than in men, new research from The George Institute for Global Health at the University of Oxford has found. (2018-11-07)

Neuropathic pain unmasks subliminal excitation in pain processing circuits
Research by Steven Prescott, at Toronto's Hospital for Sick Children, sheds new light on the mechanism underlying the establishment of neuropathic pain. Experiments by Kwan Lee and Stéphanie Ratté in the Prescott lab show that dysregulation of chloride reduces inhibition across pain processing circuits, unmasking vast amounts of subliminal excitation in neurons that promote transmission of pain signals. These results were presented at the 10th Annual Canadian Neuroscience Meeting, on June 1, in Toronto. (2016-06-01)

Pain researchers get a common language to describe pain
Pain researchers around the world have agreed to classify pain in the mouth, jaw and face according to the same system. According to a participant from Aarhus University in Denmark, this means more precise diagnoses and improved treatment of people suffering from pain. (2020-03-10)

Randomized clinical trial examines therapies for chronic spinal pain
In a randomized clinical trial of patients with chronic spinal pain, a program that combined education to help patients think differently about pain with an exercise program that increasingly introduced movements patients feared or avoided (pain neuroscience education plus cognition-targeted motor control training) appeared better than usual care (combining education on back and neck pain and general exercise therapy) at reducing pain and improving function and thoughts of pain. (2018-04-16)

Mayo Clinic study: 20% of patients are prescribed opioids after cardiac device implantation surgery
One in five patients is prescribed opioids after having a pacemaker or similar device implanted, according to a large US study conducted at Mayo Clinic published in HeartRhythm. Eighty percent of patients who were prescribed opioids had never taken them before. Investigators stress the importance of improving postoperative pain management following cardiac device procedures to reduce use of prescription opioids. (2019-10-21)

When it comes to weight loss in overweight and obese adults with knee osteoarthritis, more is better
Researchers previously showed that overweight and obese individuals with knee osteoarthritis can reduce pain by 50 percent and significantly improve function and mobility with a 10 percent or more weight loss over an 18-month period. (2018-06-18)

Study: Patients only use about half of Opioids prescribed after hysterectomy
Doctors may be prescribing nearly twice the number of opioids than what the average patient needs after a hysterectomy, a new study suggests. (2017-12-04)

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