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Popular Peripheral Neuropathy News and Current Events, Peripheral Neuropathy News Articles.
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Double honors for diabetes researchers
Two University of Manchester scientists have been awarded international prizes for their research into the peripheral nerve damage suffered by people with diabetes. (2007-06-26)

Why are T cells tolerant to hepatitis B virus?
Many viral infections such as hepatitis B virus, hepatitis C virus can develop into persistent viremia of patients. Previous reports demonstrated that during chronic virus infection the virus specific T cells fail to clear infectious pathogen. Recently, one of the potential mechanisms contributed to the T cell tolerance was identified as the inhibitory programmed death-1/ programmed death -ligand 1 pathway, which can transduce negative signals to effector T cells. (2008-10-13)

Society of Interventional Radiology Foundation receives support from Boston Scientific
The Society of Interventional Radiology Foundation's Discovery Campaign, which seeks to further the growth of minimally invasive medicine into new areas of discovery, announced a major corporate pledge to that initiative. Boston Scientific, a global leader in medical devices for cardiovascular and peripheral interventions, pledged $100,000 and is a (2012-03-27)

Polyphenols could yield small benefit for people with PAD
Polyphenols -- compounds found in cocoa and other foods may help people with peripheral artery disease walk a little longer and farther before pain sets in. More research is needed to see whether long-term use of these compounds in dark chocolate can improve circulation and aid patients. (2014-07-02)

Moffitt researcher says no survival advantage with peripheral blood stem cells versus bone marrow
Claudio Anasetti, M.D., chair of the Department of Blood & Marrow Transplant at Moffitt Cancer Center, and colleagues from 47 research sites in the Blood and Marrow Transplant Clinical Trials Network conducted a two-year clinical trial comparing two-year survival probabilities for patients transplanted with peripheral blood stem cells or bone marrow stem cells from unrelated donors. (2012-10-19)

Groundbreaking transplantation surgery at Yale attempts to repair central nervous system in MS patients
Researchers at Yale School of Medicine have performed the first central nervous system transplantation to repair the myelin-forming cells in a woman with multiple sclerosis (MS). The transplantation is part of a phase I clinical trial that is testing whether cells found in the body's peripheral nerves can safely repair the damaged cells in the brain and spinal cord that result in myelin disorders such as MS. In MS, the immune system attacks the brain's nerve fibers and strips away myelin, the protective sheath around nerve fibers in the spinal cord and brain, making it difficult for the nerves to transmit messages. (2001-07-25)

Trial success for diabetic nerve therapy
A potentially ground-breaking treatment for nerve damage caused by diabetes has shown promising results in preclinical and early patient trials. (2006-05-30)

New molecular mechanism of neuropathic pain in mice
A research group from Hiroshima University demonstrated that the downregulation of spinal astrocyte connexin43 expression causes sustained neuropathic pain following peripheral nerve injury. Controlling the Cx43 expression using pharmacological approaches or gene therapy might serve as novel therapeutic strategies ameliorate neurological disorders in general and neuropathic pain in particular. (2015-07-14)

JCI online early table of contents: April 1, 2009
This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, April 1st, 2009, in the JCI, including: Active component of marijuana has anticancer effects; Lithium protects brain cells during cranial radiation; Girls lacking the protein ITK at risk from fatal viral infection; Nerve disorder following critical illness can be rapidly reversible; and A mouse model of the kidney disease focal and segmental glomerulosclerosis. (2009-04-01)

First clinical results reported for Sangamo's ZFP therapeutic
Sangamo will present the first publicly reported human clinical trial data of a ZFP TherapeuticTM, SB-509, for the treatment of diabetic neuropathy (DN) at the American Academy of Neurology meeting. SB-509 represents a new approach in treating DN, designed to protect and restore nerve function by upregulating the expression of the vascular endothelial growth factor (VEGF-A) gene in patients suffering from peripheral neuropathy. All safety endpoints were met and improvements in clinical effects were observed. (2006-04-06)

New initiative to develop a system that controls prosthetic limbs naturally
Using beams of light to allow amputees not only to control but also to feel the movement of prosthetic limbs is the ambitious goal of a new $5.6 million Department of Defense initiative. (2010-11-17)

Morphine-like drugs could offer relief for amputees
Fifty to 80 percent of all amputees experience pain in their stumps or what feels like the missing limbs long after surgical wounds have healed. Now new research from Johns Hopkins suggests the two pains have different sources, bringing us a step closer in understanding what types of drugs might help. (2001-10-16)

McGill professor awarded grant to continue neuropathy research
Dr. Gary J. Bennett, a professor at McGill University's department of anesthesia, has been awarded a scientific research grant by The Neuropathy Association, a US patient-based nonprofit organization headquartered in New York City. Peripheral neuropathy results from injury to the peripheral nervous system, disrupting the body's ability to communicate with its muscles, organs and tissues. (2008-11-10)

UT Dallas professor wins $2.3 million NIH award
Dr. Robert Gregg, an assistant professor of mechanical engineering and bioengineering at UT Dallas, received the award based on his creative, innovative and potentially impactful work to improve prosthetic limbs and orthotic devices. (2013-11-22)

DES in diabetic patients
Diabetes is increasingly viewed as a coronary artery disease equivalent. Patients with diabetes mellitus have an increased risk when undergoing percutaneous coronary interventions. Need for studies specifically targeting diabetic patients. (2008-08-31)

Mice point to a therapy for Charcot-Marie-Tooth disease
VIB researchers have developed a mouse model for Charcot-Marie-Tooth (CMT) neuropathy, a hereditary disease of the peripheral nervous system. They also found a potential therapy for this incurable disease. The treatment not only halted the damage to the nerves and the atrophy of the muscles, it even succeeded in reversing the symptoms. The research was published in Nature Medicine. (2011-08-02)

Treatment for overactive bladder and irritable bowel syndrome advanced through pioneering research
Researchers at the University of Surrey have discovered how the receptors responsible for contractions in the bladder, regulate the body's clock genes. The new study, published today in The FASEB Journal, has found that this clock activity in turn regulates the cycle of all cells in the body. The team of researchers also discovered that the local biological clock and its control are weakened in aging bladders, demonstrating the importance of the clock in bladder physiology and aging. (2014-08-21)

Complementary, alternative therapies for neurological disorders detailed in new book
A new book by Barry Oken, M.D., a neurologist at Oregon Health & Science University's School of Medicine, recommends complementary and alternative medicine therapies as part of a (2004-03-03)

Burn injuries rapidly deplete vitamin E
Severe burn injuries in children have been shown to rapidly deplete the levels of vitamin E in their body's adipose, or fat tissues, a new clinical study has found. Stored levels of this important antioxidant were reduced more in a few weeks than might normally be possible in years. (2010-10-20)

Two distinct molecular pathways can make regulatory immune cells
Finding a way to bypass the molecular events involved in autoimmunity -- where the body's immune system mounts a self-directed attack -- could lead to new treatments for autoimmune disorders and chronic infections. A study published in this week's issue of PLoS Biology describes genetic evidence that two distinct molecular pathways control the formation of regulatory T cells, a cell type vitally important in limiting undesirable immune responses. (2009-03-02)

Gene therapy offers new hope for treatment of peripheral neuropathy
Researchers from the University of Pittsburgh School of Medicine report that they have successfully used gene therapy to block the pain response in mice with neuropathic pain, a type of chronic pain in people for which there are few effective treatments. These findings are being presented at the 10th annual meeting of the American Society of Gene Therapy, being held May 30 to June 3 at the Washington State Convention & Trade Center, Seattle. (2007-05-31)

Scripps Research scientists uncover new role for gene in maintaining steady weight
Against the backdrop of the growing epidemic of obesity in the United States, scientists from the Florida campus of the Scripps Research Institute have made an important new discovery regarding a specific gene that plays an important role in keeping a steady balance between our food intake and energy expenditure. The study may help scientists better understand the keys to fighting obesity and related disorders such as diabetes. (2011-11-23)

Bristol-Meyers Squibb submits NDA for new formulation of once daily videx(R)(didanosine)
Bristol-Myers Squibb has submitted a New Drug Application with the U.S. Food and Drug Administration for a new formulation of VIDEX (R), also known as ddI, 1991 for the treatment of HIV/AIDS. The new capsules contain enteric coated VIDEX beadlets designed to protect VIDEX from degrading until it has passed through the stomach, thus eliminating the need for a buffer. If approved, VIDEX capsules will further reduce pill burden from two tablets to a single capsule dosed once a day. (2000-01-30)

Using a deacetyl chitin conduit and short-term electrical stimulation for PNI
Previous studies have demonstrated that deacetyl chitin conduit nerve bridging or electrical stimulation shows therapeutic effect on peripheral nerve injury. Dr. Peixun Zhang, Peking University People's Hospital, China and his team bridged the injured right rat sciatic nerve using a deacetyl chitin conduit combined with electrical stimulation (0.1 ms, 3 V, 20 Hz, for 1 hour). (2014-07-18)

SLU researcher finds a turtle eye muscle adapts to deal with obstructed vision
While researchers expected that the pond turtle's eyes would operate like other animals with eyes on the side of their heads, this particular species of turtle appears to have characteristics of both front and side-eyed animals. (2013-09-19)

NC State first university in nation to offer canine bone marrow transplants
Dogs suffering from lymphoma will be able to receive the same type of medical treatment as their human counterparts, as North Carolina State University becomes the first university in the nation to offer canine bone marrow transplants in a clinical setting. (2008-09-03)

Researchers identify hormone that reduces calorie burning, contributes to obesity
Brown adipose tissue, widely known as brown fat, is located around the collarbone and acts as the body's furnace to burn calories. It also keeps the body warm. Obese people have less of it, and its activity is decreased with age. Until now, researchers haven't understood why. (2014-12-08)

Over 40,000 lives lost worldwide every year
The 'humble' aspirin, which has been known for at least a decade to prevent heart attacks and strokes in thousands of people at high risk of cardiovascular disease, is still massively underused, according to new UK research published (Friday Jan 11) in the British Medical Journal. (2002-01-10)

JCI online early table of contents: Feb. 6, 2012
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, Feb. 6, 2012, in the JCI: The heart can make 'bad' fat burn calories; How a stomach-colonizing bacterium protects against asthma; A sticky problem for stomach cancer; New controller of cancer cell multiplication identified; Promoting instability in cancer cells; and Site-specific nerve damage explained. (2012-02-06)

One gene, two eye diseases?
Scientists are a step closer to understanding the genetics of macular degeneration, a disease of the retina that affects 13 million Americans, and causes the loss of central vision. A new study shows that a gene associated with one retinal disease, retinitis pigmentosa, also causes a form of macular degeneration. The finding raises an intriguing question: How can a single gene cause two very different eye diseases, each affecting a different segment of vision? (2002-08-01)

Drug shown to improve sight for patients with inherited blindness
A condition which robs patients of their sight has for the first time been reversed with a drug, giving some people legally certified as blind, useful vision to improve everyday life. (2011-07-25)

Peripheral artery disease is underdiagnosed and undertreated
Only half of people with peripheral artery disease (PAD), a condition where blood vessels in the arms and legs can become clogged with cholesterol, are appropriately diagnosed and treated, a Johns Hopkins expert says. (2001-09-04)

Comorbidities increase risk of mortality in COPD patients
Comorbidities are common among patients with chronic obstructive pulmonary disease (COPD), and a number of these comorbidities are independently associated with an increased mortality risk, according to a new study. (2012-05-04)

Virtual 'forest' used to measure navigation skills
A new study recently published in Journal of Vision, an online, free access publication of the Association for Research in Vision and Ophthalmology (ARVO), shows that an individual's navigation skills can be measured by using an immersive virtual 'forest' in which peripheral visual field losses are simulated. (2006-04-26)

Hormone, oxytocin, shows potential as weight-loss treatment
A reproductive hormone helps regulate food intake and energy metabolism without causing adverse effects, a new animal study finds. The results will be presented Monday at the Endocrine Society's 94th Annual Meeting in Houston. (2012-06-25)

Chinese club moss extract (Huperzine A) may improve cognition in Alzheimer's disease
Existing evidence suggests that patients with Alzheimer's disease who have taken Huperzine A have improved general cognitive function, global clinical status, functional performance and reduced behavioral disturbance compared to patients taking placebos. (2008-04-15)

Five-year survival data: Brentuximab vedotin may be curative in some with Hodgkin lymphoma
This multinational Phase II study examines brentuximab vedotin (BV) in patients with Hodgkin lymphoma who relapsed after stem cell transplant. The study reports that 13 of 34 (38 percent) patients who achieved complete remission have remained disease-free for over five years and may be cured. Of those patients, nine received only single-agent BV. These data were published in Blood, the journal of the American Society of Hematology (ASH). (2016-07-18)

Neuroscientists prove ultrasound can be tweaked to stimulate different sensations
Virginia Tech Carilion Research Institute scientists have proven with fMRI and EEG that ultrasound applied to the periphery, such as fingertips, can stimulate sensory pathways to the brain. The discovery has bearing on diagnosing and treating neuropathy, which affects millions. (2012-12-06)

In diabetic eye disease, peripheral lesions in the retina point to risks of progression
Investigators at the Joslin Diabetes Center now have shown that eyes with diabetic retinal lesions predominantly in peripheral areas of the retina that are seen in UWF images but not in traditional retinal photographs show surprisingly higher risks of progressing to advanced stages of vision-threatening diabetic retinopathy. (2015-08-27)

UM College of Arts and Sciences student is awarded AACR-Thomas J. Bardos Science Education Award
University of Miami College of Arts and Sciences student Raul Caso (Microbiology and Immunology) has won an AACR-Thomas J. Bardos Science Education Award for Undergraduate Students. (2011-03-23)

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