Popular Placenta News and Current Events

Popular Placenta News and Current Events, Placenta News Articles.
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Maternal inflammation boosts serotonin and impairs fetal brain development in mice
Fighting the flu during pregnancy sickens a pregnant woman, but it may also put the fetus at a slightly increased risk for neurodevelopmental disorders like autism later in life. A new study in pregnant mice, published June 1 in The Journal of Neuroscience, offers a potential mechanism explaining why: Inflammation alters neurotransmitters and impairs growth of nerve cells in the developing fetal brain. (2016-05-31)

Scientists culture human placenta stem cells for first time
Scientists have derived and grown trophoblast stem cells for the first time, which will lead to better understanding of the human placenta. (2018-01-24)

A candidate genetic factor for the effects of prenatal alcohol exposure has been found
Researchers at the University of Helsinki have found a genetic variation, which associates with the damage caused by maternal alcohol consumption. This genetic variation clarifies the role of genetic factors in the alcohol-induced developmental disorders and could be useful in future diagnostics. (2017-10-05)

Study reveals Viagra to be 'ineffective' for fetal growth restriction
A University of Liverpool led international clinical trial has found an anti-impotence drug to be ineffective at improving outcomes for pregnancies complicated by fetal growth restriction. (2017-12-08)

Study reveals how antiepileptic drug causes problems during pregnancy
During pregnancy, use of the antiepileptic drug valproic acid has been associated with worse outcomes -- including fetal loss, impaired growth, major congenital malformations, increased risk of developmental problems, and autism -- compared with all other antiepileptic drugs. (2018-04-19)

Clues to ancestral origin of placenta emerge in Stanford study
Researchers at the Stanford University School of Medicine have uncovered the first clues about the ancient origins of a mother's intricate lifeline to her unborn baby, the placenta, which delivers oxygen and nutrients critical to the baby's health. (2008-04-14)

Preeclampsia triggered by an overdose of gene activity
Preclampsia, the most dangerous form of hypertension during a pregnancy, is known to originate in the placenta. But the root causes remain largely a mystery. Findings from MDC scientists reveal that it is not a single disease caused solely by genetic factors: Epigenetically regulated genes play an important role. The Berlin research team also developed an in vitro model of the disorder which demonstrates the dysregulation of an important transcription factor. (2017-10-06)

All in the family: Relatives of Zika virus may cause birth defects
Relatives of Zika virus can damage developing fetuses in mice and were able to replicate in human maternal and fetal tissues, researchers report. (2018-01-31)

Induced labor after 39 weeks in healthy women may reduce the need for cesarean birth
In a study presented today at the Society for Maternal-Fetal Medicine's (SMFM) annual meeting, researchers unveiled findings that suggest that induction of labor at 39 weeks of gestation among healthy, first-time mothers reduces the rate of cesarean birth as compared to expectant management among the same population. (2018-02-01)

Penis development needs more than just testes and testosterone
Proper development of the fetal penis requires not just testosterone from the testes, but a second hormone produced by other tissues, including the placenta, according to a new study publishing Feb. 14 in the open-access journal PLOS Biology from Paul Fowler of the University of Aberdeen, Michelle Bellingham of the University of Glasgow, and colleagues in the UK, France and Sweden. The results reveal a previously unknown pathway of masculinization of the external genitals. (2019-02-14)

Penn engineers test drug transfer using placenta-on-a-chip
Researchers at the University of Pennsylvania's School of Engineering and Applied Science have demonstrated the feasibility of their 'organ-on-a-chip' platform in studying how drugs are transported across the human placental barrier. (2018-02-16)

Blood sample breakthrough good news for pregnant women
A wide range of fetal genetic abnormalities could soon be detected in early pregnancy thanks to a world-first study led by University of South Australia researchers using lab-on-a-chip, noninvasive technology. (2018-07-11)

Studies of autism spectrum disorder reveal new avenues of neuroscience research
Advances in the study of cognitive disorders, including Autism Spectrum Disorder (ASD), may pave the way for future treatments. The findings were presented at Neuroscience 2019, the annual meeting of the Society for Neuroscience and the world's largest source of emerging news about brain science and health. (2019-10-21)

Depression during pregnancy can double risk of preterm delivery
Depressed pregnant women have twice the risk of preterm delivery than pregnant women with no symptoms of depression, finds a Kaiser Permanente study in Oxford University Press's journal Human Reproduction. The study, which is among the first to examine depression and pre-term delivery in a diverse population, provides a clear look at the link between depression and preterm delivery because the majority of the women in the study did not use anti-depressants. (2008-10-23)

Placental ALLO levels rise during pregnancy and peak as fetuses approach full term
The placenta ramps up ALLO production in the second trimester of pregnancy and achieves peak production just as fetuses approach full term, according to multi-institutional research presented during the Pediatric Academic Societies (PAS) 2018 annual meeting. (2018-05-05)

Immune response to Zika virus contributes to fetal harm
The same proteins that mount a potent immune response to Zika viral infection can also harm the placenta and fetal development, according to a Yale-led study published in Science Immunology. (2018-01-05)

Placenta consumption offers few benefits for new moms
UNLV research finds that consuming encapsulated placentas has little to no effect on postpartum mood and maternal bonding; detectable changes shown in hormones. (2017-12-01)

Mammalian development: Blastocyst architecture
The mechanisms that underlie early embryonic development in humans and cattle are very similar. Therefore, Ludwig-Maximilians-Universitaet (LMU) in Munich researchers argue that bovine embryos might well be a better model for early human development than the mouse system. (2018-03-02)

Vaginal progesterone reduces preterm birth and neonatal complications in women with a mid-trimester short cervix
Prematurity is the main complication of pregnancy, and 15 million babies are born preterm worldwide each year. Physicians worldwide have investigated whether vaginal progesterone administration to women with a mid-trimester sonographic short cervix reduces the rate of preterm birth. Now physicians and researchers have found that when all available information is considered in an individual patient data meta-analysis, the results are clear: vaginal progesterone reduces the rate of preterm birth at <28, <30, <32, <34, <35, and <36 weeks. (2017-11-17)

New research: Increased stress on fathers leads to brain development changes in offspring
New research in mice has found that a father's stress affects the brain development of his offspring. This stress changes the father's sperm, which can then alter the brain development of the child. This new research provides a much better understanding of the key role that fathers play in the brain development of offspring. (2018-02-16)

Study: Maternal placenta consumption causes no harm to newborns
A joint UNLV and Oregon State University study found mothers who consumed their placenta passed on no harm to their newborn babies when compared to infants of mothers who did not consume their placenta. (2018-05-03)

Exposure to chemical during pregnancy may cause health problems for offspring
A chemical called bisphenol A -- BPA -- used in plastic packaging and in the linings of food and beverage cans, may be passed from a mother to her offspring during pregnancy and cause changes in the gut bacteria of the offspring, according to an international team of researchers. (2017-11-08)

Supplement for pregnant women with malaria could improve birth outcomes
Pregnant women infected with malaria have lower levels of an essential amino acid called L-arginine, which may help to explain why these women are more likely to experience complications such as stillbirths and low birth weight infants. (2018-03-07)

Improving birth outcomes one amino acid at a time
A simple dietary supplement (L-arginine) was found to improve birth outcomes, paving the way for future clinical trials to test this inexpensive and safe intervention. (2018-03-08)

Scientists identify mechanism that may explain why males are more at risk than females for neurodevelopmental disorders
Researchers have recently begun to realize that biological sex plays a key role in disease risk. Sex plays a role in hypertension, diabetes, arthritis -- and in many neurological and psychiatric disorders. Depression and anxiety affect females more, while neurodevelopmental disorders, including autism spectrum disorders, early onset schizophrenia, and attention deficit hyperactivity, affect more males. Males are also more sensitive to prenatal insults, such as gestational stress, maternal infection and drug exposure. (2018-07-03)

Immune cells in the uterus help nourish fetus during early pregnancy
Natural killer cells are among the most abundant immune cells in the uterus during the first trimester of pregnancy, but their numbers decline substantially after the placenta forms. An Immunity study shows that this cell population helps to optimize maternal nourishment of the fetus at early stages of development. The researchers identified uterine natural killer cells that secrete growth-promoting factors, and demonstrated that transfer of these cells can reverse impaired fetal growth in pregnant mice. (2017-12-19)

Inducing labor at 39 weeks reduces risks of C-section and other complications
Little has been known about what happens to a fetus between 39 and 41 weeks. Through extensive study, researchers found the chances of C-section greatly increase if mothers deliver at 41 weeks, rather than inducing labor at 39 weeks. (2018-04-25)

Alleviating complications of babies born smaller: Is a growth factor injection the answer?
Researchers have found a new potential treatment that may alleviate complications of babies born smaller than they should be, also called fetal growth restriction, which refers to poor growth of the fetus in the mother's womb during pregnancy. The findings were published in The Journal of Physiology. (2017-12-13)

Placenta defects a factor in prenatal deaths
The role of the placenta in fetal development is being seriously under-appreciated according to scientists in Cambridge and London. The team studied 103 mutations linked to prenatal death in mice and showed that almost 70 percent affect the placenta. The team also found that some placenta defects could be directly linked to the cause of death. As such, a significant number of prenatal deaths may be due to the placenta, not just the embryo. (2018-03-14)

Placental accumulation of flame retardant chemical alters serotonin production in rats
An NC State-led research team has shown a connection between exposure to a widely used flame retardant chemical mixture and disruption of normal placental function in rats, leading to altered production of the neurotransmitter serotonin. (2018-01-22)

Researchers evaluate pMSCs sheets for engineered repair and regeneration of heart tissue
The placenta offers an abundant source of placenta-derived mesenchymal stem cells (pMSCs), which a new study has shown can readily form cell sheets that could be implanted in children with congenital heart defects and offer benefits for heart repair and regeneration compared to commonly used synthetic material-based scaffolds. (2018-12-07)

Placental function linked to brain injuries associated with autism
Allopregnanolone, a hormone made by the placenta late in pregnancy, is such a potent neurosteroid that disrupting its steady supply to the developing fetus can leave it vulnerable to brain injuries associated with autism spectrum disorder, according to Children's research presented during the Pediatric Academic Societies 2019 Annual Meeting. (2019-04-27)

Endometriosis increases risk of complications during pregnancy and delivery
A new meta-analysis shows that pregnant women with endometriosis are at greater risk for a host of complications during pregnancy and at delivery, including preterm birth and cesarean section. (2017-09-13)

Marmoset monkey model of Zika virus infection offers new insights into the human condition
A novel marmoset model of human Zika virus infection offers new opportunities for better understanding of how the virus causes congenital disease in humans. (2018-05-03)

Older wombs linked to complications in pregnant mice
Deciding to start a family later in life could be about more than just the age of your eggs. The risks of complications during pregnancy all increase with age. A new study our today is one of the first to look at the effects of age on womb health. The results, which studied pregnant mice of different ages, showed that ageing of the womb itself can contribute to an increased risk of complications. (2017-09-05)

Genes, environment and schizophrenia: new study finds the placenta is the missing link
New research shines a spotlight on the placenta's critical role in the nature versus nurture debate and how it confers risk for schizophrenia and likely other neurodevelopmental disorders including ADHD, autism, and Tourette syndrome. This new scientific frontier, with far-reaching implications for maternal and child health, creates the possibility that scientists can more accurately predict who is at risk of mental illness, and develop strategies to prevent or lessen their occurrence by increasing the resiliency and health of the placenta. (2018-05-28)

Breaking the code: How is a mother's immunity transferred to her baby?
A study based at the Ragon Institute of MGH, MIT and Harvard has determined how a pregnant woman's vaccine-induced immunity is transferred to her child, which has implications for the development of more effective maternal vaccines. (2019-06-13)

Variations in placental microbiota appear related to premature birth
A team of researchers from the United Kingdom has found a surplus of pathogenic bacteria in placentas from premature births, supporting the hypothesis that maternal infection may cause preterm birth. The research is published in Applied and Environmental Microbiology, a journal of the American Society for Microbiology. (2018-05-18)

Placentas adapt when mothers have poor diets or low oxygen during pregnancy
Cambridge researchers have discovered the placenta regulates how much oxygen and nutrients it transports to babies during challenging pregnancies in the first study of its kind. The placenta is one of the least understood human organs and it is notoriously difficult to study. This new research focused on analysing the placental mitochondria and it is hoped the new findings could lead to tests to determine whether a mother's placenta is functioning properly. (2019-01-18)

NICHD-Funded Researchers Find Possible Mechanism Of Preeclampsia
A team of investigators has discovered that preeclampsia--a life threatening complication of pregnancy--results from a failure of the placenta to invade the wall of the uterus and to appropriately mimic the tissue which lines blood vessels. The reasearch, funded by the National Institute of Child Health and Human Development, appears in the May 1 issue of the Journal of Clinical Investigation (1997-04-30)

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