Popular Psoriasis News and Current Events | Page 2

Popular Psoriasis News and Current Events, Psoriasis News Articles.
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How was Mediterranean diet associated with severity of psoriasis?
Adherence to a Mediterranean diet, an eating plan filled with fruits and vegetables, legumes, cereals, bread, fish, fruit, nuts and extra-virgin olive oil, may be associated with the severity of the skin condition psoriasis. (2018-07-25)

New strategy against osteoporosis
An international research team has found a new approach that may be able to reduce bone loss in osteoporosis and maintain bone health. (2020-08-05)

Treatment has no sufficient effect in 1 of 5 psoriasis patients
A substantial part of people, one in five, undergoing systemic treatment for psoriasis (i.e. pills taken orally, injections or infusions) still have considerable problems with their disease. This is according to a study with 2,646 Swedish psoriasis patients conducted by researchers at Umeå University and the Swedish Institute for Health Economics, and recently published in the Journal of Dermatological Treatment. (2017-02-02)

Cancer patients may experience delayed skin effects of anti-PD-1 therapy
Cancer patients receiving anti-PD-1 therapies who develop lesions, eczema, psoriasis, or other forms of auto-immune diseases affecting the skin may experience those adverse reactions on a delay -- sometimes even after treatment has concluded. (2018-07-18)

Double-bridged peptides bind any disease target
EPFL scientists have developed a new type of 'double-bridged peptide' that can be tailored to bind tightly to disease targets of interest. The peptides' highly efficient binding, combined with their small size and high stability make them ideal for drug therapies. The work is published in Nature Chemistry. (2018-04-30)

Major genetic breakthrough for ankylosing spondylitis brings treatment hope
Research funded by the Wellcome Trust and the Arthritis Research Campaign has identified two genes implicated in the disease ankylosing spondylitis, a common disease primarily causing back pain and progressive stiffness. The research, published online today in Nature Genetics, suggests that a treatment currently being trialled for Crohn's disease may also be applied to this disease. (2007-10-21)

A repurposed drug could open door to more stem cell transplants
Etanercept, a drug used to treat arthritis and psoriasis, boosted the survival of blood stem cells in a mouse model. The findings provide a strong basis for a clinical trial to see whether etanercept or a similar drug would improve outcomes for people receiving blood stem cell transplants. (2017-12-20)

New psoriatic arthritis treatment guideline presented at the 2017 ACR/ARHP Annual Meeting
Authors of the new American College of Rheumatology (ACR) / National Psoriasis Foundation (NPF) treatment guideline for psoriatic arthritis (PsA) will present their draft recommendations during a session at the 2017 ACR/ARHP Annual Meeting this week in San Diego. The guideline includes pharmacologic and non-pharmacologic recommendations for treating adult patients with active psoriatic arthritis. Both the ACR and NPF anticipate the guideline will play an important role in improving outcomes for individuals living with PsA. (2017-11-04)

Secukinumab in children with plaque psoriasis: Study unsuitable for benefit assessment
Secukinumab in children with plaque psoriasis: study unsuitable for benefit assessment The comparator group was not treated appropriately. Firstly, therapy in this group remained unchanged despite non-response, and secondly, it was continued for longer than approved. (2020-12-04)

Vaccinations not a risk factor for multiple sclerosis
Data from over 12,000 multiple sclerosis (MS) patients formed the basis of a study by the Technical University of Munich (TUM) which investigated the population's vaccination behavior in relation to MS. It showed that five years before their diagnosis, MS patients were statistically less likely to receive vaccinations than comparator groups. Consequently, there was no positive correlation between vaccinations and the development of MS. (2019-07-31)

Lipid that aids normal skin turnover may help psoriasis
Topical application of the lipid phosphatidylglycerol, or PG, on a mouse model of psoriasis reduced inflammation as well as characteristic, raised skin lesions, they report in the Journal of Investigative Dermatology. (2018-11-27)

Normal tissue BRCA1 methylation associated with risk for high-grade ovarian cancer
Normal tissue BRCA1 methylation is associated with risk for high-grade ovarian cancer and may occur as a prenatal event. These findings are published in Annals of Internal Medicine. (2018-01-15)

National rheumatology and psoriasis organizations release joint guideline for psoriatic arthritis
The American College of Rheumatology (ACR) and National Psoriasis Foundation (NPF) have released a joint treatment guideline for psoriatic arthritis (PsA) that provides evidence-based pharmacologic and non-pharmacologic recommendations on caring for treatment-naïve patients with active PsA and patients who continue to have active PsA despite treatment. (2018-12-03)

Protect the skin, build barriers: Old acquaintance in a new role
To ensure the barrier function of the skin, mutual regulation of connections between epidermal cells and a receptor for growth factors is necessary. These findings can help to reduce the effects of inflammatory skin diseases and the decreased barrier function of the aged skin. The mechanism was described by a team of researchers led by Carien Niessen of the Cluster of Excellence for aging research, CECAD/Cologne. The results have been published in Nature Communications. (2017-11-08)

Providers show interest in prescribing therapeutic cannabinoids
A team from the GW School of Medicine and Health Sciences found many dermatologists are interested in learning more about and recommending therapeutic cannabinoids to their patients. (2018-12-10)

When good cells go bad: Regulating the ms-causing properties of Th17 cells
Multiple sclerosis (MS) and other inflammatory autoimmune diseases are characterized by localized inflammation in various tissues, including the brain. Using a mouse model of MS, a team led by researchers from Osaka University identified a major regulator of Th17 cell-associated pathogenic inflammatory processes. The protein, Satb1, enhances the expression of genes promoting inflammation and suppresses genes needed to prevent autoimmunity. By targeting this protein, novel therapies may be able to attenuate inflammatory autoimmune diseases. (2019-02-13)

New potential approach to treat atopic dermatitis
How does the immune system respond to fungi on our skin? Researchers at the University of Zurich have demonstrated that the same immune cells that protect us against skin fungi also encourage the inflammatory symptoms of atopic dermatitis. An antibody therapy could alleviate this chronic inflammatory skin disease. (2019-03-18)

The skinny on lipid immunology
In a new study published in Science Immunology, researchers from Brigham and Women's Hospital and Monash University in Australia reveal new insights into the basis for T cell receptor (TCR) autoreactivity to self-phospholipids, with implications for autoimmune diseases. (2017-10-20)

An agent used to treat psoriasis may be aimed at the wrong target
The antibody ustekinumab is being used successfully for the treatment of psoriasis since 2009. It inhibits the underlying inflammation by neutralizing certain messengers of the immune system. Researchers at the University of Zurich and the Center of Allergy and Environment in Munich have now shown that one of these messengers could actually be helpful in battling the disease. (2016-11-30)

Scientists uncover new genetic variations linked to psoriasis
Two international teams of researchers have made significant gains in understanding the genetic basis of psoriasis, a chronic skin condition that can be debilitating in some patients. Their research, involving thousands of patients, is reported in two studies published this week in the advance online Nature Genetics. (2009-01-26)

How the skin becomes inflamed
Publishing online this week in Cell Host & Microbe, researchers at Johns Hopkins report the discovery of a key underlying immune mechanism that explains why to how our skin becomes inflamed from conditions such as atopic dermatitis, more commonly known as eczema. Toxin-producing bacteria on the surface of our skin induces a protein that causes our own cells to react and cause inflammation. (2017-11-08)

Shedding light on the reaction mechanism of PUVA light therapy for skin diseases
Together with their Munich-based colleagues, a team of physical chemists from Heinrich Heine University Düsseldorf (HHU) has clarified which chemical reactions take place during PUVA therapy. The therapy involves light-induced damage to the DNA of diseased cells. The team working under Prof. Dr. Peter Gilch has now published its findings in the Journal of the American Chemical Society. (2019-08-20)

New drug clears psoriasis in clinical trials
About 80 percent of patients with moderate to severe psoriasis saw their disease completely or almost completely cleared with a new drug called ixekizumab, according to three large, long-term clinical trials led by Northwestern Medicine. (2016-06-09)

Not just for children: Study shows high prevalence of atopic dermatitis among US adults
As many as 16.5 million adults in America suffer from a skin disease known as atopic dermatitis, an inflammatory disease that results in red, itchy skin. The estimate comes from a new study from the Perelman School of Medicine at the University of Pennsylvania, which also projected 6.6 million of these adults have disease that would be classified as moderate to severe, leading to a decrease in quality of life. (2018-10-30)

Possible psoriasis drug target identified by Stanford researchers
Psoriasis is one of the most common human skin diseases. People with severe cases sometimes resort to immunosuppressive treatment to quell the skin scaling, itching and joint arthritis that are hallmarks of the disorder. But long-term administration of the medication can leave them vulnerable to infection and other unwanted side effects. (2016-06-13)

Cell division and inflammatory disease link revealed
A ground-breaking study by University of Manchester and Liverpool scientists and published in the journal eLife has identified a new link between inflammation and cell division. Two of the most important processes in the human body, their accurate control is a holy grail for scientists researching the prevention of infection, inflammatory disease and cancer. (2016-05-17)

Stigmatizing views and myths about psoriasis are pervasive in the United States
The stigma associated with the autoimmune disease psoriasis may lead people to avoid patients who show signs of the condition, including not wanting to date, shake hands, or have people in their homes if they suffer from the disease. New multidisciplinary research involving both psychologists and dermatologists from the Perelman School of Medicine at the University of Pennsylvania is the first to examine how common this stigma may be among the general population of the United States as well as among medical students. (2018-08-30)

Combining biologic and phototherapy treatments for moderate-to-severe psoriasis
Although the efficacy and safety of biologic and phototherapeutic treatments in treating moderate-to-severe psoriasis are well known, not all patients respond well to monotherapy and may require a combination of both types of therapy. There have been few studies investigating the safety and efficacy of combination treatment; now, a review published in the journal Psoriasis Targets and Therapy shows that combination treatment is safe and viable. (2016-08-09)

Dermatology students improve Wikipedia entries on skin disease
A group of medical students recruited to improve Wikipedia articles on skin-related diseases, saw millions more views of those stories following their editing, highlighting the value of expert input on the popular web encyclopedia. (2019-04-03)

U-M researchers receive largest single collection of psoriasis DNA samples
Millions of Americans struggling with psoriasis and psoriatic arthritis are one step closer to a cure with the release of the first National Psoriasis Victor Henschel BioBank DNA samples for use in research at the University of Michigan Health System; research that hopes to uncover the unknowns about the genetics of psoriasis and psoriatic arthritis. (2010-09-01)

Researchers identify 4 genetic hotspots associated with psoriasis
A genomewide scan of millions of genetic mutations has revealed four new DNA (2009-01-26)

Phosphorylation of Regnase-1 lets IL-17 run amok
A research team led by Osaka University found that the cytokine interleukin (IL)-17 triggers the phosphorylation of mRNA-degrading enzyme Regnase-1, resulting in excessive inflammation. By blocking this phosphorylation, novel therapies may be able to prevent the development or severity of IL-17-associated autoimmune diseases such as inflammatory bowel disease, multiple sclerosis, and psoriasis. (2019-06-03)

Tildrakizumab shows promising efficacy and safety in psoriatic arthritis
The results of a phase 2B study presented today at the Annual European Congress of Rheumatology (EULAR 2019) demonstrate superior efficacy and comparable safety of tildrakizumab versus placebo in patients with psoriatic arthritis. (2019-06-14)

How do ketogenic diets affect skin inflammation?
Not all fats are equal in how they affect our skin, according to a new study in the Journal of Investigative Dermatology, published by Elsevier. The investigators found that different ketogenic diets impacted skin inflammation differently in psoriasiform-like skin inflammation in mice. Ketogenic diets heavy in medium-chain triglycerides (MCTs) such as coconut, especially in combination with omega-3 fatty acids from fish oil and plant sources like nuts and seeds, exacerbated psoriasis. (2019-10-17)

Promising new target for treatment of psoriasis is safe, study shows
A protein known to play a significant role in the development of psoriasis can be prevented from functioning without posing a risk to patients, scientists at King's College London have found. The study confirmed that a group of inflammatory proteins called 'IL-36' play a significant role in the development of psoriasis and can, in theory, be blocked without posing a risk to patients. (2017-10-11)

Researchers shed light on pathway from virus to brain disease
Why people on immunosuppressant drugs for autoimmune conditions have a higher incidence of an often-fatal brain disease may be linked to a mutation in a common virus, according to researchers at Penn State College of Medicine. (2016-05-18)

Study examines sex differences in potential link between psoriasis and metabolic disorders
An analysis published in the Journal of the European Academy of Dermatology and Venereology revealed considerable sex differences when considering links between psoriasis and metabolic disorders. (2019-12-04)

New study shows therapy for psoriasis can reduce heart plaque
Late-breaking clinical science shows common therapy options for psoriasis (PSO) can help reduce coronary plaque. The authors found that not only do the treatments reduce the volume of the plaque, but also the plaque becomes less inflammatory over time harboring fewer characteristics prone to rupture and cause a heart attack. (2018-04-26)

Could genetic breakthrough finally help take the sting out of mouth ulcers?
A large breakthrough has been made in the genetic understanding of mouth ulcers which could provide potential for a new drug to prevent or heal the painful lesions. Mouth ulcers affect up to 25 percent of young adults and a higher proportion of children. Previous research has shown that mouth ulcers are partially heritable, but until now there has been little evidence linking specific genes or genomic regions to mouth ulcers. (2019-03-05)

What makes psoriasis sore: Novel role of immune system in the disease
More than 130 million people around the globe suffer from psoriasis vulgaris, a chronic condition characterized by skin inflammation, scales, and dry patches. However, its pathology is not fully clear. In a recent study, dermatology researchers from Japan have uncovered a complex cellular mechanism responsible for the onset of psoriasis and highlighted potential therapeutic targets for future treatment. (2020-12-03)

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