Popular Retinitis Pigmentosa News and Current Events

Popular Retinitis Pigmentosa News and Current Events, Retinitis Pigmentosa News Articles.
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A new generation of artificial retinas based on 2D materials
Scientists report they have successfully developed and tested the world's first ultrathin artificial retina that could vastly improve on existing implantable visualization technology for the blind. The flexible 2-D material-based device could someday restore sight to the millions of people with retinal diseases. The researchers will present their results today at the 256th National Meeting & Exposition of the American Chemical Society. (2018-08-20)

Zooming into cilia sheds light into blinding diseases
A new study reveals an unprecedented close-up view of cilia linked to blindness. (2019-11-05)

Retina transplants show promise in patients with retinal degeneration
Preliminary research shows encouraging results with transplantation of retinal cells in patients with blindness caused by retinitis pigmentosa and age-related macular degeneration, according to a report in the August issue of American Journal of Ophthalmology. (2008-07-10)

Molecular traffic jam may underlie rare kidney disease, other protein misfolding disorders
Researchers have discovered that some protein-misfolding disorders may arise from a single, previously unrecognized cause: a jam at a specific step in a cellular shipping network called the secretory pathway, which delivers proteins either to the cell surface or one of the cell's protein-disposal systems. They have also found a compound that corrects for this in lab and animal models. (2019-07-25)

Scientists successfully awaken sleeping stem cells
Scientists at Schepens Eye Research Institute have discovered what chemical in the eye triggers the dormant capacity of certain non-neuronal cells to transform into progenitor cells, a stem-like cell that can generate new retinal cells. The discovery, published in the March issue of Investigative Ophthalmology and Visual Science, offers new hope to victims of diseases that harm the retina, such as macular degeneration and retinitis pigmentosa. (2008-03-18)

Overlooked cell key player in preventing age-related vision loss
Researchers have pinpointed a new therapeutic target for macular degeneration, an eye disease that affects over 10 million Americans and is the leading cause of blindness in adults over 60. The findings show that tree-shaped retinal cells called Müller glia play a key role in preventing degenerative vision loss in rats. (2018-03-06)

Genome surgery for eye disease moves closer to reality
Researchers from Columbia University have developed a new technique for the powerful gene editing tool CRISPR to restore retinal function in mice afflicted by a degenerative retinal disease, retinitis pigmentosa. (2018-05-11)

The CRISPR Journal debuts with articles by Rodolphe Barrangou, Fyodor Urnov, et al.
The CRISPR Journal, a new peer-reviewed journal from Mary Ann Liebert, Inc., publishers announces the publication of its groundbreaking inaugural issue. (2018-02-15)

Mass. Eye and Ear performs first FDA-approved gene therapy procedure for inherited disease
Massachusetts Eye and Ear made medical history on Tuesday by performing the first post-FDA approval gene therapy for patients with a form of inherited blindness. The occasion marks the beginning of a new era in medicine, as it is the first time any FDA-approved gene therapy has been given to a patient for any inherited disease. (2018-03-20)

First 'pathoconnectome' could point toward new treatments for neurodegenerative diseases
Scientists from the John A. Moran Eye Center at the University of Utah have achieved another first in the field of connectomics, which studies the synaptic connections between neurons. The lab has produced the first pathoconnectome, showing how eye disease alters retinal circuitry. (2020-09-29)

The CRISPR Journal inaugural issue published, with content from Rodolphe Barrangou, et al
The CRISPR Journal, a groundbreaking new peer-reviewed journal from Mary Ann Liebert, Inc., publishers, announces the publication of its inaugural issue. (2018-02-15)

Nerve growth factor: Early studies and recent clinical trials
NGF is the first discovered member of a family of neurotrophic factors, collectively indicated as neurotrophins, (which include brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin 4/5). NGF was discovered for its action on the survival and differentiation of selected populations of peripheral neurons. (2019-01-18)

Atomic-resolution views suggest function of enzyme that regulates light-detecting signals in eye
An atomic resolution view of an enzyme found only in the eye is providing clues about how the enzyme is activated. The enzyme, PDE6, is critical to the way light entering the retina is converted into signals to the brain. (2008-10-07)

Safety study indicates gene therapy for blindness improves vision
No significant adverse effects were reported during a safety trial testing gene therapy on three patients with a type of hereditary blindness called Leber congenital amaurosis type 2. In addition, the subjects said the vision in their treated eyes was slightly improved in dim lighting conditions. The study was conducted by the University of Pennsylvania and the University of Florida with support from the National Eye Institute. (2008-09-08)

Blindness study shows how gene causes middle-age sight loss
Chemical changes in the eye that can lead to blindness have been identified by scientists, a conference has heard. (2017-09-06)

NIH scientists combine technologies to view the retina in unprecedented detail
By combining two imaging modalities -- adaptive optics and angiography -- investigators at the National Eye Institute (NEI) can see live neurons, epithelial cells, and blood vessels deep in the eye's light-sensing retina. Resolving these tissues and cells in the outermost region of the retina in such unprecedented detail promises to transform the detection and treatment of diseases such as age-related macular degeneration (AMD), a leading cause of blindness among the elderly. (2018-11-14)

Immune cells in the retina can spontaneously regenerate
Immune cells called microglia can completely repopulate themselves in the retina after being nearly eliminated, according to a new study in mice from scientists at the National Eye Institute (NEI). (2018-03-21)

Strategy prevents blindness in mice with retinal degeneration
New research published in Nature Communications outlines a strategy that in mouse models significantly delayed the onset of blindness from inherited retinal degeneration such as retinitis pigmentosa. (2018-05-01)

USC study finds blindness and visual impairment will double by 2050
Visual impairment and blindness prevalence in the US to double by 2050 according to study by USC Roski Eye Institute researchers. Key study findings include: growing population of aging baby boomers leads to increase in vision loss and blindness in the US; women and minority populations, especially Latinos, carry the largest burden; and Mississippi, Louisiana will top list for blindness; Florida, Hawaii will lead visual impairment. (2016-05-19)

Gene behind long-recognized mitochondrial disease has highly varied effects
Mutations in the mitochondrial gene mt-ATP6, which encodes an essential part of the mitochondrial motor known as ATP synthase that generates cellular energy, are much more variable than previously thought. This prompts the need to develop more precise clinical tests that can better determine the course of treatment for patients affected by mitochondrial disorder. (2019-03-12)

Experimental drug, implanted in eye, could fight glaucoma
An experimental drug, consisting of cells manufactured and implanted in the eye to stimulate optic nerve growth and activity, could be an entirely new way of fighting glaucoma, according to BrightFocus Foundation. (2016-10-14)

Gene therapy shows promise for reversing blindness
Most causes of untreatable blindness occur due to loss of the millions of light sensitive photoreceptor cells that line the retina, similar to the pixels in a digital camera. (2017-10-02)

Therapy could improve and prolong sight in those suffering vision loss
Ganglion cells in the eye generate noise as the light-sensitive photoreceptors die in diseases such as retinitis pigmentosa. Now, UC Berkeley neurobiologists have found a drug and gene therapy that can tamp down the noise, improving sight in mice with RP. These therapies could potentially extend the period of useful vision in those with degenerative eye diseases, including, perhaps, age-related macular degeneration. (2019-03-13)

Blindness, Kaposi's Sarcoma And Extraocular Complications Of CMV Are Delayed In AIDS Patients Given Antiviral Pill And Eye Implant
Simultaneously giving AIDS patients the antiviral ganciclovir via pill as well as in a tiny pellet implanted in the eye delays or prevents complications of cytomegalovirus say Daniel F. Martin, MD, during his presentation at the Sixth European Conference on Clinical Aspects and Treatment of HIV Infection. (1997-10-14)

Genetic treatment for blindness may soon be reality
Patients who had lost their sight to an inherited retinal disease could see well enough to navigate a maze after being treated with a new gene therapy, according to research presented today at AAO 2017, the 121st Annual Meeting of the American Academy of Ophthalmology. (2017-11-10)

Discovery in monkeys could lead to treatment for blindness-causing syndrome
A genetic mutation that leads to a rare, but devastating blindness-causing condition called Bardet-Biedl Syndrome has been discovered in monkeys for the first time. The finding offers a promising way to develop gene and cell therapies that could treat people with the condition, which leads to vision loss, kidney disfunction, extra fingers or toes, and other symptoms. (2019-10-25)

On the trail of rare genetic disease, scientists uncover key immune regulator
Scientists at Scripps Research have found an important immune system-regulating protein that in principle could be targeted to treat cancers and chronic viral infections. (2018-11-27)

Restoring vision by gene therapy
Latest scientific findings give hope for people with incurable retinal degeneration. (2020-06-04)

Commonalities in late stages of inherited blinding diseases suggest targets for therapy
In studying the late stages of disease in two different canine models of retinitis pigmentosa, a group of progressive and inherited blinding diseases, University of Pennsylvania researchers found commonalities, specifically involving the innate immune system. The findings point to potential new treatment options for the conditions. (2017-12-20)

Study explains why light worsens migraine headaches
Scientists at Beth Israel Deaconess Medical Center have identified a new visual pathway that underlies sensitivity to light during migraine in both blind individuals and in individuals with normal eyesight. (2010-01-10)

Retinal prion disease study redefines role for brain cells
National Institutes of Health scientists studying the progression of inherited and infectious eye diseases that can cause blindness have found that microglia, a type of nervous system cell suspected to cause retinal damage, surprisingly had no damaging role during prion disease in mice. In contrast, the study findings indicated that microglia might delay disease progression. (2019-03-27)

Researchers find potential new gene therapy for blinding disease
Scientists funded by the National Eye Institute (NEI) report a novel gene therapy that halts vision loss in a canine model of a blinding condition called autosomal dominant retinitis pigmentosa (adRP). The strategy could one day be used to slow or prevent vision loss in people with the disease. (2018-08-20)

With single gene insertion, blind mice regain sight
People left blind by retinal degeneration have one option: electronic eye implants. UC Berkeley neuroscientists have developed an alternative: gene therapy that, in tests, restored vision in blind mice. A gene for green opsin delivered via virus gave blind mice enough sight to discern patterns on an iPad at a resolution sufficient for humans to read. Given existing AAV eye therapies already approved, this new therapy could be ready for clinical trials in three years. (2019-03-15)

After blindness, the adult brain can learn to see again
More than 40 million people worldwide are blind, and many of them reach this condition after many years of slow and progressive retinal degeneration. Little is known about whether the brain of blind people retains residual capacity to process restored or artificial visual inputs. A new study publishing Oct. 25 in the open-access journal PLOS Biology investigates the brain's capability to process visual information after many years of total blindness, by studying blind patients. (2016-10-25)

Scientists develop method to tweak tiny 'antenna' on cells
Scientists at Johns Hopkins Medicine and the National Tsing Hua University in Taiwan say they have found a fast way to manipulate a cell's cilia, the tiny, fingerlike protrusions that 'feel' and sense their microscopic environment. The experiments, performed in mouse cells, may advance scientists' efforts to not only understand how the nanosized antennae work, but also how to repair them. (2018-05-15)

A new path to fixing genes in living organisms
A gene-editing method shows promise for using targeted gene-replacement therapy in living organisms. (2017-01-30)

NIH scientists deploy CRISPR to preserve photoreceptors in mice
Silencing a gene called Nrl in mice prevents the loss of cells from degenerative diseases of the retina, according to a new study. The findings could lead to novel therapies for preventing vision loss from human diseases such as retinitis pigmentosa. The study was conducted by researchers at the National Eye Institute (NEI), part of the National Institutes of Health, and was published online today in Nature Communications. (2017-03-14)

Lab-on-a-chip device mimics eye damage due to intense light
Houston Methodist researchers developed a new lab-on-a-chip technology that could quickly screen possible drugs to repair damaged neuron and retinal connections, like what is seen in people with macular degeneration or who've had too much exposure to the glare of electronic screens. (2018-05-09)

Oxford student creates first synthetic retina for the visually impaired
A synthetic, soft tissue retina developed by an Oxford University student could offer fresh hope to visually impaired people. Until now, all artificial retinal research has used only rigid, hard materials. The new research, by Vanessa Restrepo-Schild, a 24 year old D.phil student and researcher at the Oxford University, Department of Chemistry, is the first to successfully use biological, synthetic tissues, developed in a laboratory environment. (2017-05-04)

Retinitis pigmentosa may be treated by reprogramming sugar metabolism
Columbia University researchers slowed vision loss in mice with a form of retinitis pigmentosa by reprogramming the metabolism of photoreceptors in the retina. (2016-11-14)

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