Popular Transplant News and Current Events

Popular Transplant News and Current Events, Transplant News Articles.
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Lung transplant patients face elevated lung cancer risk
In an American Journal of Transplantation study, lung cancer risk was increased after lung transplantation, especially in the native (non-transplanted) lung of single lung transplant recipients. (2018-12-19)

Scientists take aging cardiac stem cells out of semiretirement to improve stem cell therapy
With age, the chromosomes of our cardiac stem cells compress as they move into a state of safe, semiretirement. (2016-10-03)

Small changes to organ procurement system could lead to more life-saving transplants
Slight changes to the system for allocating deceased-donor kidneys could result in higher rates of organ procurement and lead to more kidney transplants across the country, according to new research co-authored by an Indiana University Kelley School of Business professor. (2017-11-17)

New technique improves outcome for living donor liver transplants
Thanks to a review paper done at the University of Alberta radiologists at the University of Alberta Hospital are now using CT imaging for living-donor liver transplantation. CT imaging allows surgeons to plan the operation more accurately, which increases the likelihood for organ graft survival in recipients and reduces complication rates in donors. (2008-03-18)

Moffitt researchers identify new target to reduce risk of GVHD
Moffitt Cancer Center researchers are trying to identify new drug targets to reduce the risk of GVHD. Their new study, published last week in the Proceedings of the National Academy of Sciences, shows a drug that targets the protein JAK2 may reduce the risk of GVHD. (2018-02-05)

Mutations in bone cells can drive leukemia in neighboring stem cells
DNA mutations in bone cells that support blood development can drive leukemia formation in nearby blood stem cells. This neighbor cell effect was observed in a mouse model of Noonan syndrome. In mice, drugs can stop the effect and potentially could combat leukemia progression/recurrence. (2016-10-26)

New hope for treating heart failure
Heart failure patients who are getting by on existing drug therapies can look forward to a far more effective medicine in the next five years or so, thanks to University of Alberta researchers. (2017-03-07)

Scientists use gene editing to eliminate viruses in live pigs
Scientists have edited the pig genome to deactivate a family of retroviruses. The results hold important implications for transplant medicine in humans. (2017-08-10)

Advanced therapy offers cure for relapsed cancer patient
Testicular cancer patients who do not respond to traditional therapy can be cured with high-dose chemotherapy and a stem cell transplant, according to an Indiana University School of Medicine study by Lawrence Einhorn, M.D.; Stephen Williams, M.D.; Rafat Abonour, M.D., and colleagues published in the July 26 issue of the New England Journal of Medicine. Although the number of relapsed testicular cancer patients in the US is small, the IU Simon Cancer Center treats a majority of them. (2007-07-25)

What is known -- and not known -- about heart muscle diseases in children
Cardiomyopathies (heart muscle diseases) in children are the focus of a new scientific statement from the American Heart Association that provides insight into the diagnosis and treatment of the diseases as well as identifying future research priorities. It is published in the American Heart Association's journal Circulation. (2019-05-28)

Researchers shed light on why exercise slows progression of Parkinson's disease
While vigorous exercise on a treadmill has been shown to slow the progression of Parkinson's disease in patients, the molecular reasons behind it have remained a mystery. (2017-12-22)

U of M begins nation's first clinical trial using T-reg cells from cord blood in leukemia treatment
University of Minnesota researchers have initiated a ground breaking clinical trial to determine the optimal dose and safety of T regulatory cells (T-regs) to decrease the risk of immune reactions common in patients undergoing blood and marrow transplantation. (2007-09-05)

Method assesses how well dialysis clinics refer patients for transplantation
A new method is useful for assessing how well individual dialysis facilities are referring patients for kidney transplantation. When the method was applied to dialysis facilities in Georgia, researchers found that most of the variation in referrals for transplantation were due to characteristics within the dialysis facilities rather than patient characteristics. (2018-01-25)

Bristol researchers use gene editing to improve red blood cell transfusion compatibility
Synthetic biologists at the University of Bristol have succeeded in generating laboratory-made red blood cells with rare blood group types that could one day be used to help patients who cannot be matched with donor blood. (2018-04-27)

Retina transplants show promise in patients with retinal degeneration
Preliminary research shows encouraging results with transplantation of retinal cells in patients with blindness caused by retinitis pigmentosa and age-related macular degeneration, according to a report in the August issue of American Journal of Ophthalmology. (2008-07-10)

Cellular barcoding helps scientists understand the behavior of stem cells
By tagging bone marrow cells of mice with a genetic label, or barcode, researchers were able to track and describe the family tree of individual blood cells as they form in their natural environment. (2018-01-03)

Bedside art therapy decreases pain and anxiety in patients with cancer
A brief bedside visual art intervention (BVAI) facilitated by art educators improved mood and reduced pain and anxiety in a study of inpatients with hematological cancers. (2018-04-19)

A new tool for improving uterine transplant surgery
Future Science Group (FSG) today announced the publication of an article in Future Science OA demonstrating the first use of multispectral imaging in gynecology, in a uterine transplant setting. (2018-02-12)

US study reports dramatic reduction in likelihood of liver transplantation in patients with hepatoce
ILC 2018: Although hepatocellular carcinoma is now the leading indication for liver transplantation in the USA, the probability of patients receiving a transplant has declined significantly in recent years. (2018-04-13)

HCV-related liver transplantation and post-transplant survival rates in Europe have improved rapidly in the era of direct-acting antiviral drugs
HCV-related liver transplantation and post-transplant survival rates in Europe have improved rapidly in the era of direct-acting antiviral drugs. (2018-04-13)

Dana-Farber/Boston Children's opens immunotherapy trial for children with leukemia
Dana-Farber/Boston Children's Cancer and Blood Disorders Center has joined a clinical trial of immunotherapy for children with relapsed or treatment-resistant acute lymphoblastic leukemia (ALL). Led by Memorial Sloan Kettering Cancer Center, the trial is one of several nationally that are evaluating an approach that triggers a patient's immune system to attack cancer. Dana-Farber/Boston Children's is the only New England site offering this experimental approach for children and adolescents with relapsed/refractory ALL. (2015-05-11)

Biomarker tests could someday help improve outcomes for organ transplant patients
Organ transplants save lives, but the story doesn't end when a patient emerges from the operating room. Rejection episodes, in which the immune system rallies against the new organ, can occur. According to an article in Chemical & Engineering News (C&EN), the weekly newsmagazine of the American Chemical Society, researchers are turning to biomarkers to help them get a better idea of which patients are more likely to have an episode. (2018-01-31)

Study concludes no racial disparities in long-term outcomes in recipients of liver transplants
New research published in the Journal of the American College of Surgeons shows long-term survival and liver rejection rates are equivalent for African-American liver transplant patients as compared with patients of other races. The study also suggests that although other factors such as liver cancer or hepatitis may negatively influence long-term survival, race does not. (2008-05-19)

Mayo Clinic study finds heart transplant patients benefit from new approach to immunosuppression
A new immunosuppression regimen for heart transplant patients can improve kidney function and prevent transplant coronary artery disease, according to two new Mayo Clinic studies. Mayo researchers will report their findings on April 26 at the International Society for Heart & Lung Transplantation Annual Meeting and Scientific Session in San Francisco. (2007-04-26)

Alternatives to whole liver transplants for children have become safer, study finds
In a new Johns Hopkins study of patient and graft survival trends for pediatric liver transplant recipients between 2002 and 2015, researchers found that outcomes for alternatives to whole liver transplantation (WLT), such as splitting a liver for two recipients or using a part of a liver from a living donor, have improved significantly. (2018-02-12)

Educational video may increase public willingness to become face transplant donors
After watching a brief educational video, members of the public are more likely to say they would be willing to donate a facial transplant to a severely disfigured patient, reports a study in the January issue of Plastic and Reconstructive Surgery, the official medical journal of the American Society of Plastic Surgeons (ASPS). (2018-01-02)

Urinary markers may indicate prognosis after kidney transplantation
A new British Journal of Clinical Pharmacology study indicates that certain markers can help predict which patients may experience problems after receiving an organ transplant. (2017-09-07)

Marijuana use has no effect on kidney transplant outcomes
A new study published in Clinical Kidney Journal indicates that the usage of marijuana by kidney donors has no measurable effect upon the outcomes of kidney transplants for donors or recipients. This study is the first to investigate the effect of marijuana use by live kidney donors. (2018-11-15)

Curve-eye-ture: How to grow artificial corneas
Research reveals corneal cells grown on curved surfaces arrange themselves in a regular lattice structure giving the artificial cornea strength and transparency like that normally found in the human eye. (2017-10-19)

Combating chronic kidney disease with exercise
A University of Delaware research team is combating chronic kidney disease (CKD) with exercise. The team had patients engage in a specially designed exercise program and found that it improved their blood vessel health and exercise capacity. (2017-06-28)

Feinstein Institute study looks at impact of a popular pre-heart transplant therapy on the kidney
Scientists, nephrologists and cardiac surgeons from The Feinstein Institute for Medical Research and Northwell Health's Department of Internal Medicine, Cardiology and Cardio-Thoracic Surgery examined the impact of a popular pre-heart transplant therapy on the kidney in a study published today by The Clinical Journal of the American Society of Nephrology. (2017-10-25)

Vitamin D and immune cells stimulate bone marrow disease
The bone marrow disease myelofibrosis is stimulated by excessive signaling from vitamin D and immune cells known as macrophages, reveals a Japanese research team. These findings could help to develop alternative treatments that do not target problem genes. The findings were published on Feb. 4 in the online edition of Blood. (2019-02-08)

Scleroderma study: Hope for a longer life for patients with rare autoimmune disorder
The approach could represent the first new treatment to improve survival in patients with severe scleroderma in more than four decades. (2018-01-12)

Racial and ethnic disparities in live donor kidney transplants
Despite efforts over the past two decades to increase the number of black and Hispanic patients receiving kidney transplants from related or unrelated living donors, these racial/ethnic minority patients are still much less likely to undergo such transplants than white patients, Johns Hopkins researchers report. In fact, the investigators say, the disparities have worsened in the last 20 years. (2018-01-23)

Researchers overcome obstacle for future stem cell therapies
Researchers have discovered a new technique that overcomes one of the major challenges of stem cell therapy. A drug, co-created by UBC researchers, might overcome one of the major challenges of stem cell therapy -- their tendency to differentiate, becoming specific tissue cells too early and too quickly. (2018-01-25)

Understanding the Berlin patient's unexpected cure
Researchers have a new way to understand the much-studied Berlin patient's unexpected cure from HIV and improve outcomes of stem cell transplants for patients with other blood-related diseases such as leukemia and sickle-cell disease. A team at Oregon Health & Science University has shown a species of monkey called Mauritian cynomolgus macaques can successfully receive stem cell transplants. (2017-11-10)

Are dialysis patients being over-screened for colon cancer?
Colonoscopies are being performed more often on healthier dialysis patients than on those with more limited life expectancies; however, overall, dialysis patients are being screened at a much higher rate relative to their life expectancy than their counterparts without kidney failure. (2017-03-23)

Research shows cord blood comparable to matched bone marrow
University of Minnesota researchers report that umbilical cord blood transplants may offer blood cancer patients better outcomes than bone marrow transplants, according to an analysis of outcome data performed at the Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee. (2007-06-07)

Older donor lungs should be considered for transplantation
With a scarcity of lungs available for transplantation, the use of lungs from donors older than age 60 has been shown to achieve reasonable outcomes and should be considered as a viable option, according to research published online today in The Annals of Thoracic Surgery. (2017-11-09)

Researchers identify the types of genetic mutations associated with nephrotic syndrome
By analyzing the most common genetic variants, Brazilian scientists aim at improving diagnosis nad treatment for the disease, which presents high resistance to drugs as well as relapse in post-transplant scenario. The work made possible an in-depth study of the proteins involved in the glomerular filtration barrier, a structure which is damaged by the syndrome. (2018-02-28)

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