Popular Transplantation News and Current Events

Popular Transplantation News and Current Events, Transplantation News Articles.
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Comprehensive pediatric CAR T guidelines developed by MD Anderson and PALISI
Almost one year after the US Food and Drug Administration (FDA) approval of chimeric antigen receptor (CAR) T-cell therapy for children with acute lymphoblastic leukemia (ALL), researchers at The University of Texas MD Anderson Cancer Center and the Pediatric Acute Lung Injury and Sepsis Investigators Network (PALISI) today published treatment guidelines for managing the treatment in the online issue of Nature Reviews Clinical Oncology. (2018-08-06)

Transplanting adult spinal cord tissues: A new strategy of repair spinal cord injury
Spinal cord injury repair is one of the most challenging medical problems, and no effective therapeutic methods has been developed. Now researchers from China reported transplantation of adult spinal cord tissue for treatment of adult complete spinal cord injury. This work provided valuable information for future clinical application. (2019-03-27)

Lung transplant patients face elevated lung cancer risk
In an American Journal of Transplantation study, lung cancer risk was increased after lung transplantation, especially in the native (non-transplanted) lung of single lung transplant recipients. (2018-12-19)

Surprising research result: All immature cells can develop into stem cells
New sensational study conducted at the University of Copenhagen disproves traditional knowledge of stem cell development. The study reveals that the destiny of intestinal cells is not predetermined, but instead determined by the cells' surroundings. The new knowledge may make it easier to manipulate stem cells for stem cell therapy. The results have just been published in Nature. (2019-05-16)

New technique improves outcome for living donor liver transplants
Thanks to a review paper done at the University of Alberta radiologists at the University of Alberta Hospital are now using CT imaging for living-donor liver transplantation. CT imaging allows surgeons to plan the operation more accurately, which increases the likelihood for organ graft survival in recipients and reduces complication rates in donors. (2008-03-18)

Practical hair regeneration technology
Researchers have developed a method for the mass preparation of cellular aggregates, also known as 'hair follicle germs (HFGs)', that may lead to a new treatment for hair loss. (2018-02-01)

Improving cell transplantation after spinal cord injury: When, where and how?
Spinal cord injuries are mostly caused by trauma, often incurred in road traffic or sporting incidents, often with devastating and irreversible consequences. According to a systematic analysis of 49 animal studies published this week in PLOS Biology by Ralf Watzlawick, Jan Schwab and colleagues, after experimental spinal cord injury, transplanting olfactory ensheathing cells (OECs) into the site of damage significantly improves locomotor performance. (2016-05-31)

Scientists use gene editing to eliminate viruses in live pigs
Scientists have edited the pig genome to deactivate a family of retroviruses. The results hold important implications for transplant medicine in humans. (2017-08-10)

Gut microbiome in digestive health: a new frontier in research
Research on the gut microbiome is one of the most promising areas of science today. In a new special issue of Clinical Gastroenterology and Hepatology, the American Gastroenterological Association (AGA) has taken the deep-dive into the gut microbiome that both scientists and the public are looking for to help them better understand the effects of the microbiome on health and disease. Clinical Gastroenterology and Hepatology is the clinical practice journal of the AGA. (2019-01-04)

Breakthrough in the production of dopamine neurons for Parkinson's disease
Researchers at Lund University, Sweden, are rapidly moving towards the first ever transplantations of embryonic stem cell derived dopamine neurons in persons with Parkinson's disease. New findings published in Cell Stem Cell present how a more refined understanding of normal development leads to an improved method for obtaining the dopamine neurons needed for the first clinical trials. (2016-10-28)

Technology may help increase number of kidneys transplanted
Many deceased donor kidneys are declined for transplantation because of concerns over their quality, but a new BJS (British Journal of Surgery) study found that a technique called normothermic machine perfusion can assess the quality of a kidney and determine its suitability for transplantation. (2017-12-06)

Osteochondral allograft transplantation effective for certain knee cartilage repairs
Isolated femoral condyle lesions account for 75 percent of the cartilage repair procedures performed in the knee joint, and physicians have a variety of techniques to consider as part of surgical treatment. Osteochondral allograft transplantation (OCA) is a valuable and successful approach for this condition, as described by research presented today at the American Orthopaedic Society for Sports Medicine's Specialty Day in New Orleans. (2018-03-10)

Method assesses how well dialysis clinics refer patients for transplantation
A new method is useful for assessing how well individual dialysis facilities are referring patients for kidney transplantation. When the method was applied to dialysis facilities in Georgia, researchers found that most of the variation in referrals for transplantation were due to characteristics within the dialysis facilities rather than patient characteristics. (2018-01-25)

iPS cell-derived inner ear cells may improve congenital hearing loss
A Japanese research group has successfully grafted human iPS cell-derived inner ear cells that express human-derived proteins into the inner ears of embryonic mice. Hereditary hearing loss accounts for about half of all congenital hearing loss cases, and this work is a major contribution toward research that targets the embryonic inner ear. (2018-02-08)

Protective effect of genetically modified cord blood on spinal cord injury in rats
Researchers of Kazan Federal University genetically modified cord blood which managed to increase tissue sparing and numbers of regenerated axons, reduce glial scar formation and promote behavioral recovery when transplanted immediately after a rat contusion spinal cord injury. (2016-04-08)

Long-term prevention of organ rejection
The Konstanz immunologist Professor Marcus Groettrup and his team have developed a procedure for preventing organ rejection in rats after renal transplantation, and for suppressing the creation of antibodies in the recipients' immune systems. Immunoproteasome inhibition, which suppresses the production of antibodies, is crucial to this process. The research results were published in Kidney International. The title of the original publication is: 'Immunoproteasome inhibition prevents chronic antibody-mediated allograft rejection in renal transplantation.' (2017-12-08)

A new tool for improving uterine transplant surgery
Future Science Group (FSG) today announced the publication of an article in Future Science OA demonstrating the first use of multispectral imaging in gynecology, in a uterine transplant setting. (2018-02-12)

US study reports dramatic reduction in likelihood of liver transplantation in patients with hepatoce
ILC 2018: Although hepatocellular carcinoma is now the leading indication for liver transplantation in the USA, the probability of patients receiving a transplant has declined significantly in recent years. (2018-04-13)

Cellular barcoding helps scientists understand the behavior of stem cells
By tagging bone marrow cells of mice with a genetic label, or barcode, researchers were able to track and describe the family tree of individual blood cells as they form in their natural environment. (2018-01-03)

Retina transplants show promise in patients with retinal degeneration
Preliminary research shows encouraging results with transplantation of retinal cells in patients with blindness caused by retinitis pigmentosa and age-related macular degeneration, according to a report in the August issue of American Journal of Ophthalmology. (2008-07-10)

HCV-related liver transplantation and post-transplant survival rates in Europe have improved rapidly in the era of direct-acting antiviral drugs
HCV-related liver transplantation and post-transplant survival rates in Europe have improved rapidly in the era of direct-acting antiviral drugs. (2018-04-13)

Fecal microbiota transplantation produces sustained improvements in cognitive and clinical outcomes
Long-term results of a randomized study demonstrate sustained improvements in hepatic encephalopathy episodes, hospitalizations, and cognitive performance compared with standard-of-care. (2018-04-14)

Researchers develop new technique to model transplantation of the human liver
A novel technology developed by researchers at the Massachusetts General Hospital enables the model-ing of human liver transplantation in an experimental setting. (2017-11-29)

Alternatives to whole liver transplants for children have become safer, study finds
In a new Johns Hopkins study of patient and graft survival trends for pediatric liver transplant recipients between 2002 and 2015, researchers found that outcomes for alternatives to whole liver transplantation (WLT), such as splitting a liver for two recipients or using a part of a liver from a living donor, have improved significantly. (2018-02-12)

Older donor lungs should be considered for transplantation
With a scarcity of lungs available for transplantation, the use of lungs from donors older than age 60 has been shown to achieve reasonable outcomes and should be considered as a viable option, according to research published online today in The Annals of Thoracic Surgery. (2017-11-09)

Educational video may increase public willingness to become face transplant donors
After watching a brief educational video, members of the public are more likely to say they would be willing to donate a facial transplant to a severely disfigured patient, reports a study in the January issue of Plastic and Reconstructive Surgery, the official medical journal of the American Society of Plastic Surgeons (ASPS). (2018-01-02)

Viagra helps mobilize bone marrow stem cells for transplantation in mice
The combination of two clinically approved drugs -- Viagra and Plerixafor -- rapidly and efficiently mobilizes blood stem cells from the bone marrow into the bloodstream in mice, researchers report Oct. 10 in the journal Stem Cell Reports. This strategy is almost as effective as the current standard protocol for hematopoietic stem cell mobilization. (2019-10-10)

Mayo Clinic study finds heart transplant patients benefit from new approach to immunosuppression
A new immunosuppression regimen for heart transplant patients can improve kidney function and prevent transplant coronary artery disease, according to two new Mayo Clinic studies. Mayo researchers will report their findings on April 26 at the International Society for Heart & Lung Transplantation Annual Meeting and Scientific Session in San Francisco. (2007-04-26)

Study concludes no racial disparities in long-term outcomes in recipients of liver transplants
New research published in the Journal of the American College of Surgeons shows long-term survival and liver rejection rates are equivalent for African-American liver transplant patients as compared with patients of other races. The study also suggests that although other factors such as liver cancer or hepatitis may negatively influence long-term survival, race does not. (2008-05-19)

Effective pediatric cancer treatment is possible in the midst of a refugee crisis
Six years into Lebanon's refugee crisis, St. Jude Children's Research Hospital and the Children's Cancer Center of Lebanon at the American University of Beirut Medical Center offer a blueprint for effective childhood cancer treatment during turmoil. (2018-02-28)

New study confirms protective effect of diabetes drugs against kidney failure
A new meta-analysis published in Lancet Diabetes and Endocrinology has found that SGLT2 inhibitors can reduce the risk of dialysis, transplantation, or death due to kidney disease in people with type 2 diabetes. (2019-09-05)

Curve-eye-ture: How to grow artificial corneas
Research reveals corneal cells grown on curved surfaces arrange themselves in a regular lattice structure giving the artificial cornea strength and transparency like that normally found in the human eye. (2017-10-19)

Does brain tissue regeneration depend on maturity of stem cells used for transplantation?
New research has shown that the success of transplanting stem cells into the brain to regenerate tissue damaged by stroke may depend on the maturity of the neuronal precursor cells used for transplantation. (2017-09-13)

Urinary markers may indicate prognosis after kidney transplantation
A new British Journal of Clinical Pharmacology study indicates that certain markers can help predict which patients may experience problems after receiving an organ transplant. (2017-09-07)

Hearing restoration may be possible with cochlear repair after transplant of human cord blood cells
Hearing loss due to cochlear damage may be repaired by transplanting human umbilical cord hematopoietic stem cells. This study, using animal models of chemical and auditory cochlear damage, found that when transplanted stem cells migrated to the damaged area, (2008-09-03)

Menstrual blood -- a valuable source of multipotential stem cells?
Researchers suggest that stromal cells derived from menstrual blood may represent a potentially unlimited, ethically unencumbered, easily collectable and inexpensive source of stem cells for use in regenerative medicine. The study found that MenSCs are easily expandable to clinical relevance and express multipotent markers at both the molecular and cellular level. The abundance and plasticity of MenSCs suggest a potential role for MenSCs in regenerative transplantation therapies for many different organs and tissues. (2008-04-23)

Feinstein Institute study looks at impact of a popular pre-heart transplant therapy on the kidney
Scientists, nephrologists and cardiac surgeons from The Feinstein Institute for Medical Research and Northwell Health's Department of Internal Medicine, Cardiology and Cardio-Thoracic Surgery examined the impact of a popular pre-heart transplant therapy on the kidney in a study published today by The Clinical Journal of the American Society of Nephrology. (2017-10-25)

New clues discovered to lung transplant rejection
Researchers at Washington University School of Medicine in St. Louis have discovered clues to a particularly deadly form of rejection that can follow lung transplantation. Called antibody-mediated rejection, the condition remains impervious to available treatments and difficult to diagnose. The researchers have identified, in mice, a process that may prevent the condition and lead to possible therapies to treat it. (2019-02-04)

Hepatocellular carcinoma: Resection vs. transplantation
Liver transplantation is the gold standard for treating early hepatocellular cancers. Because of the lack of donors, this option is, however, available to a limited degree only. Curative liver resection is an alternative in this setting. Markus B. Schoenberg, Julian N. Bucher, and coauthors investigated whether liver resection can yield results that are comparable to those of liver transplantation. (2017-09-08)

Racial and ethnic disparities in live donor kidney transplants
Despite efforts over the past two decades to increase the number of black and Hispanic patients receiving kidney transplants from related or unrelated living donors, these racial/ethnic minority patients are still much less likely to undergo such transplants than white patients, Johns Hopkins researchers report. In fact, the investigators say, the disparities have worsened in the last 20 years. (2018-01-23)

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