Popular Tumor Growth News and Current Events

Popular Tumor Growth News and Current Events, Tumor Growth News Articles.
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Not silent at all
The so-called 'silent' or 'synonymous' genetic alterations do not result in altered proteins. But they can nevertheless influence numerous functions of the cell and thus also disease processes. Scientists from the German Cancer Consortium, German Cancer Research Center, and the University of Freiburg have now created a comprehensive database of all synonymous mutations ever found in cancer. This is a 'reference book' that provides cancer researchers with all available information on each of these supposedly 'silent' mutations at a glance. (2019-06-12)

Outcompeting cancer
Suppressing the capacity of tumors to destroy the healthy tissue that surrounds them is essential for fighting cancer-induced morbidity and mortality. Now, a new study in human-derived tumors reveals a potential way of doing just that. The study reveals a competition mechanism used by human cancer cells for killing their neighbors and demonstrates that combining substances that block this mechanism with chemotherapy results in more effective tumor elimination. These findings may lead to the development of novel cancer therapies. (2019-07-24)

Sound waves could provide 'liquid biopsies'
Using sound waves, researchers have developed a gentle, contact-free method for separating circulating tumor cells from blood samples that is fast and efficient enough for clinical use. The ability to quickly and efficiently harvest and grow these cells from a blood sample would enable 'liquid biopsies' capable of providing individualized diagnosis, prognosis and suggestions for treatment strategies. (2018-07-03)

Study shows new treatment pathway to prevent and treat endometrial cancer recurrence
In a new study led by Yale Cancer Center, researchers demonstrate sex hormones and insulin growth factors are associated with recurrence risk of endometrial cancer. (2021-02-23)

Stealth virus for cancer therapy
Scientists from the University of Zurich have redesigned an adenovirus for use in cancer therapy. To achieve this they developed a new protein shield that hides the virus and protects it from being eliminated. Adapters on the surface of the virus enable the reconstructed virus to specifically infect tumor cells. (2018-01-31)

UCI researchers uncover cancer cell vulnerabilities; may lead to better cancer therapies
A new University of California, Irvine-led study reveals a protein responsible for genetic changes resulting in a variety of cancers, may also be the key to more effective, targeted cancer therapy. (2020-06-12)

Leading cancer research organizations to host international cancer immunotherapy conference
The Cancer Research Institute, the Association for Cancer Immunotherapy, the European Academy of Tumor Immunology, and the American Association for Cancer Research will join forces to sponsor the first International Cancer Immunotherapy Conference at the Sheraton New York Times Square Hotel in New York, Sept. 16-19, 2015. (2015-08-03)

Gene medication to help treat spinal cord injuries
The two-gene medication has been proven to recover motor functions in rats. After several months of treatment, rodents were able to use previously paralyzed limbs. Researchers at Kazan Federal University are now seeking pre-clinical trial investment. (2019-03-18)

Metabolite that promotes cancer cell transformation and colorectal cancer spread identified
Osaka University researchers revealed that the metabolite D-2-hydroxyglurate (D-2HG) promotes epithelial-mesenchymal transition of colorectal cancer cells, leading them to develop features of lower adherence to neighboring cells, increased invasiveness, and greater likelihood of metastatic spread. The finding highlights the value of targeting D-2HG to establish new therapeutic approaches against colorectal cancer. (2016-12-01)

How physical activity and sedentary time affect adolescents' bones
A large prospective study in 309 adolescent boys and girls underscores the importance of physical activity for developing bone strength during growth. Adolescents who participated in moderate to intense physical activity during growth spurt years exhibited greater bone mass in areas that contribute to superior bone strength. The study also found mixed effects of sedentary time. (2017-03-22)

Moffitt Cancer Center researchers identify one way T cell function may fail in cancer
Moffitt Cancer Center researchers have discovered a mechanism by which one type of immune cell, CD8+ T cells, can become dysfunctional, impeding its ability to seek and kill cancer cells. (2019-04-04)

UC San Diego cancer scientists identify new drug target for multiple tumor types
A dysfunctional enzyme involved in building cancer cell membranes helps fuel tumor growth; when it's disabled or depleted in mouse models, tumors shrank significantly. (2019-07-11)

UH Cancer Center researcher finds new driver of an aggressive form of brain cancer
University of Hawai'i Cancer Center researchers have identified an essential driver of tumor cell invasion in glioblastoma, the most aggressive form of brain cancer that can occur at any age. The discovery can help researchers create novel targeted therapies potentially reducing deaths from this devastating cancer. (2016-11-14)

Professional surfer back in the water after successful surgery to treat rare bone cancer
When professional surfer Richie Lovett began experiencing hip pain at 31, he attributed it to his athletic lifestyle. But after months of discomfort and preliminary tests, the Australian native learned the pain was caused by a cancerous tumor in his femur or thigh bone. (2014-05-13)

Enhanced glow
Tumor cells circulating in blood are markers for the early detection and prognosis of cancer. However, detection of these cells is challenging because of their scarcity. In the journal Angewandte Chemie, scientists have now introduced an ultrasensitive method for the direct detection of circulating tumor cells in blood samples. It is based on the amplified, time-resolved fluorescence measurement of luminescent lanthanide ions released from nanoparticles that bind specifically to tumor cells. (2019-08-07)

Huntington's disease provides new cancer weapon
Patients with Huntington's disease, a fatal genetic illness that causes the breakdown of nerve cells in the brain, have up to 80 percent less cancer than the general population. Scientists have discovered why Huntington's is so toxic to cancer cells and harnessed it for a novel approach to treat cancer, a new study reports. (2018-02-12)

For patients with esophageal cancer, status of lymph nodes after preoperative therapy determines survival
The status of lymph nodes rather than the status of the primary tumor following preoperative neoadjuvant chemotherapy or chemoradiation therapy is the most important factor that determines whether patients with locally advanced esophageal cancer will survive. The study presented at the AATS 98th Annual Meeting indicates that while preoperative chemotherapy and radiation therapy improve survival of patients with esophageal cancer, patients with malignant lymph nodes following therapy were less likely to survive than patients with no cancer in the lymph nodes. (2018-05-01)

Engineering a better device to capture -- and release -- circulating tumor cells
Yaling Liu, of Lehigh University, has created an innovative microfluidic device that uses magnetic particles and wavy-herringbone design to capture and release circulating tumor cells with an 80-95% capture efficiency rate at different tumor cell concentrations. Liu will present some of his findings today, April 18th, at a conference taking place in Istanbul, Turkey called The Future of Medicine hosted by Royal Academy of Science International Trust (RASIT) and Bahçe?ehir University. (2018-04-18)

Anti-tumor and Immune-potentiating Enterococcus faecalis-2001 β-glucans
Background: Enterococcus faecalis 2001 is a probiotic lactic acid bacterium and has been used as a biological response modifier (BRM). From physiological limitation of bacterial preservation in storage and safety, the live E. faecalis 2001 has been heat-treated and the BRM components containing high level of β-glucan, named EF-2001, were prepared. (2017-11-17)

Breast tissue tumor suppressor PTEN: A potential Achilles heel for breast cancer cells
A highly collaborative team of researchers at the Medical University of South Carolina and Ohio State University report in Nature Communications that they have identified a novel pathway for connective tissue PTEN in breast cancer cell response to radiotherapy. (2018-08-01)

Immune cells halt fungal infection by triggering spore suicide
To protect the body from infection, immune cells in the lungs can exploit cell death programs in inhaled fungal pathogens, scientists have revealed, helping explain why most people aren't harmed by breathing in mold spores, and potentially offering new therapeutic strategies for people who do get infected. (2017-09-07)

First use of graphene to detect cancer cells
By interfacing brain cells onto graphene, researchers at the University of Illinois at Chicago have shown they can differentiate a single hyperactive cancerous cell from a normal cell, pointing the way to developing a simple, noninvasive tool for early cancer diagnosis. (2016-12-19)

Molecular imaging holds promise for early intervention in common uterine cancer
A promising new molecular imaging technique may provide physicians and patients with a noninvasive way to learn more information about a type of cancer of the uterus lining called (2009-10-01)

MD Anderson study confirms protein as potential cause of most common type of pancreatic cancer
An oncogene, UPS21, has been confirmed as a frequently amplified gene in pancreatic ductal adenocarcinoma, the most common and often lethal form of pancreatic cancer. The discovery could lead to new treatment options. (2019-09-04)

Huntsman Cancer Institute research holds promise for personalized lung cancer treatments
New research from scientists at Huntsman Cancer Institute (HCI) at the University of Utah uncovered distinct types of tumors within small cell lung cancer that look and act differently from one another. Scientists also identified a targeted drug combination that worked well with one specific tumor type. The study was published today in Cancer Cell. The findings suggest small cell lung cancer should not be treated as a uniform disease. (2017-01-12)

Nanoparticles deliver anticancer cluster bombs
Scientists have devised a triple-stage 'cluster bomb' system for delivering the chemotherapy drug cisplatin, via tiny nanoparticles designed to break up when they reach a tumor. (2016-03-29)

Jumbled chromosomes may dampen the immune response to tumors
How well a tumor responds to immunotherapy may depend in part on whether its chromosomes are intact or in a state of disarray, a new study reports. The finding could help doctors better pinpoint which cancer patients would benefit from immunotherapy. (2017-01-19)

Novel cancer vaccine strategy blocks death of tumor-specific cytotoxic T cells
A novel cancer vaccine strategy blocks death of tumor-specific cytotoxic T cells. (2018-05-01)

HKBU Chinese medicine scholars develop HKBU Chinese medicine scholars develop
Chinese Medicine scholars at Hong Kong Baptist University (HKBU) have succeeded in developing a novel targeted delivery system for CRISPR/Cas9 to achieve therapeutic genome editing of VEGFA in osteosarcoma (OS). (2017-11-10)

ECOG-ACRIN discovers a simple blood test may predict recurrence of breast cancer
Late recurrence five+ years after surgery accounts for at least half of all breast cancer recurrences. There are no tests that identify who is at highest risk. ECOG-ACRIN Cancer Research Group researchers studied a blood test for circulating tumor cells, finding that in women cancer-free five after diagnosis, 5% had a positive test, which was associated with a 35% recurrence risk after two years, compared with only 2% with a negative test. Findings require follow-up. (2017-12-08)

Neurons modulate the growth of blood vessels
A team of researchers at Karlsruhe Institute of Technology shake at the foundations of a dogma of cell biology. By detailed series of experiments, they proved that blood vessel growth is modulated by neurons and not, as assumed so far, through a control mechanism of the vessel cells among each other. The results are groundbreaking for research into and treatment of vascular diseases, tumors, and neurodegenerative diseases. The study will be published in the prestigious journal Nature Communications. (2017-01-10)

To starve pancreatic tumors, researchers seek to block 'self-eating,' other fuel sources
UNC Lineberger Comprehensive Cancer Center researchers and their collaborators are reporting preclinical findings for a potential two-treatment strategy to block multiple mechanisms of cancer cell metabolism in pancreatic cancer at the American Association for Cancer Research Annual Meeting in Chicago. The findings will be presented from 8 a.m. to noon on Wednesday. (2018-04-13)

Glioblastoma nanomedicine crosses into brain in mice, eradicates recurring brain cancer
A new synthetic protein nanoparticle capable of slipping past the nearly impermeable blood-brain barrier in mice could deliver cancer-killing drugs directly to malignant brain tumors, new research from the University of Michigan shows. (2020-11-10)

Researchers develop new technology platform for cancer immunotherapy
Johns Hopkins scientists invent multifunctional antibody-ligand traps (Y-traps), a new class of cancer immunotherapeutics. They develop Y-traps comprising an antibody targeting an immune checkpoint (CTLA-4 or PD-L1) fused to a TGFβ trap. In humanized mouse models, these Y-traps reverse immune suppression and inhibit growth of tumors that do not respond to current immune checkpoint inhibitors. (2018-02-22)

Novel genomics tool enables more accurate identification of rare mutations in cancer cells
A new computational method developed by researchers at the New York Genome Center (NYGC) allows scientists to identify rare gene mutations in cancer cells with greater accuracy and sensitivity than currently available approaches. The technique, reported in today's Communications Biology from Nature Research publishing, is called Lancet and represents a major advance in the identification of tumor cell mutations, a process known as somatic variant calling. (2018-03-22)

Tumor-killing virus selectively targets diseased brain cells
New findings show that a specialized virus with the ability to reproduce its tumor-killing genes can selectively target tumors in the brains of mice and eliminate them. Healthy brain tissue remained virtually untouched, according to a Feb. 20 report in the Journal of Neuroscience. With more research, the technique could one day offer a novel way of treating brain cancer in humans. (2008-02-19)

Researchers report four new insights into diet and health
What we eat plays a significant role in our health. The Experimental Biology 2018 meeting (EB 2018) will showcase new research into how diet could be used to fight cancer and how specific eating patterns can encourage weight loss. (2018-04-22)

Tests with topical treatment strategy for fighting skin cancer yield positive results
The methodology developed in Brazil combines low-intensity electric current with a formulation containing nanoencapsulated chemotherapy. According to preliminary results of the study, cancer-induced mice treated with this new approach presented a significantly greater reduction in the size of the tumor than those that received it through injection. (2017-10-06)

How climate change alters plant growth
Global warming affects more than just plant biodiversity -- it even alters the way plants grow. A team of researchers at Martin Luther University Halle-Wittenberg (MLU) joined forces with the Leibniz Institute for Plant Biochemistry (IPB) to discover which molecular processes are involved in plant growth. In the current edition of the internationally renowned journal (2018-01-12)

Russian chemists discovered a surprising effect of a well-known leukemia drug
Researchers from RUDN University and Institute of Biomedical Chemistry of the Russian Academy of Sciences have identified an alternative mechanism for the effective antitumor drug -- an enzyme called L-asparaginase. Some isoenzymes of L-asparaginase block the growth of telomeres (region of repetitive nucleotide sequences at each end of a chromosome) on DNA molecules, and this limits the number of divisions of a cancer cell. This effect is reported in the Biochemical and Biophysical Research Communications. (2017-11-10)

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