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Shark cancers cast more doubt on cartilage pills
New research debunks the myth that sharks don't get cancer and casts further doubt on the use of shark cartilage pills for cancer prevention and treatment. (2000-04-04)

Early-phase trial demonstrates shrinkage in pediatric neural tumors
In an early-phase clinical trial of a new oral drug, selumetinib, children with the common genetic disorder neurofibromatosis type 1 (NF1) and plexiform neurofibromas, tumors of the peripheral nerves, tolerated selumetinib and, in most cases, responded to it with tumor shrinkage. (2016-12-28)

Better treatment for kidney cancer thanks to new mouse model
Research in the field of kidney cancer, also called renal cancer, is vital, because many patients with this disease still cannot be cured today. Researchers from the University of Zurich have now identified some of the gene mutations that contribute to the development of carcinomas in the kidneys. They also developed a mouse model that will contribute to progress in the research and treatment of this type of cancer. (2017-05-30)

New tumor tracking technique may improve outcomes for lung cancer patients
Thomas Jefferson University researchers have shown that a real-time tracking technique can better predict and track tumor motion and deliver higher levels of radiation to lung cancer patients and others with moving tumor targets, and also successfully be implemented into existing clinical equipment. (2012-11-19)

UMN research identifies potential proteins to target in osteosarcoma treatment
New models developed at the Masonic Cancer Center, University of Minnesota reveal the genes and pathways that, when altered, can cause osteosarcoma. The information could be used to better target treatments for the often-deadly type of cancer. The new research is published in Nature Genetics. (2015-05-27)

Barrow researchers identify a new approach to detect the early progression of brain tumors
Researchers at Barrow Neurological Institute at St. Joseph's Hospital and Medical Center recently participated in a pilot study with the Montreal Neurological Institute that suggests a certain type of MRI scanning can detect when a patient is failing brain tumor treatment before symptoms appear. The results of the study pave the way for a proactive treatment approach. (2008-08-28)

Two new trials for pediatric brain cancer open at UTHealth/Children's Memorial Hermann
Two new clinical trials for pediatric brain cancer have begun at The University of Texas Health Science Center at Houston (UTHealth) and Children's Memorial Hermann Hospital. (2017-01-31)

A crystal ball for brain cancer?
UCLA researchers have uncovered a new way to scan brain tumors and predict which ones will be shrunk by the drug Avastin -- before the patient ever starts treatment. By linking high water movement in tumors to positive drug response, the UCLA team predicted with 70 percent accuracy which patients' tumors were the least likely to grow six months after therapy. (2009-07-30)

Researchers pinpoint origin of deadly brain tumor
Scientists have identified the type of cell that is at the origin of brain tumors known as oligodendrogliomas, which are a type of glioma -- a category that defines the most common type of malignant brain tumor. The tumor originates in and spreads through cells known as glial progenitor cells -- cells that are often referred to as (2011-01-07)

PharmaMar will be present at AACR Congress with novelties in its compounds
PharmaMar will present the latest data obtained on its compounds of marine origin, lurbinectedin, plitidepsin and PM184 at the Annual Congress of the American Association of Cancer Research, that will be held in New Orleans April 16-20. Under the heading 'Delivering Cures Through Cancer Science,' oncologists and investigators from around the world will interchange know-how and reinforce the links between research and the advancements in patient care. (2016-04-14)

Study identifies biomarker that safely monitors tumor response to new brain cancer treatment
A specific biomarker, a protein released by dying tumor cells, has been identified as an effective tool in an animal model to gauge the response to a novel gene therapy treatment for glioblastoma mulitforme. (2009-07-01)

Selenium may prevent high risk-bladder cancer
A study published in the December issue of Cancer Prevention Research, a journal of the American Association for Cancer Research, suggests that selenium, a trace mineral found in grains, nuts and meats, may aid in the prevention of high-risk bladder cancer. (2008-12-08)

Blue light used to harden tooth fillings stunts tumor growth
A blue curing light used to harden dental fillings also may stunt tumor growth, Medical College of Georgia researchers say. (2008-06-24)

A lifetime of paying it forward
William Shapiro, M.D., and Joan Rankin Shapiro, Ph.D., have collaborated for 20 years to help build a world-renowned brain tumor research center at Barrow Neurological Institute at St. Joseph's Hospital and Medical Center. After years of dedicated patient care and research, the Shapiros have established a $1.5 million endowed chair dedicated to neuro-oncology research. (2009-02-27)

PMH researchers create an organic nanoparticle that uses sound and heat to find and treat tumors
A team of scientists from Princess Margaret Hospital have created an organic nanoparticle that is completely non-toxic, biodegradable and nimble in the way it uses light and heat to treat cancer and deliver drugs. (A nanoparticle is a minute molecule with novel properties). (2011-03-20)

Study demonstrates the reasons to screen children with cancer for inherited cancer genes
Experts at MSK Kids, the pediatric oncology program at MSK, have found that inherited cancer genes are more common than expected in children with cancer. (2021-02-16)

UCLA discovery will aid in treatment of patients with a deadly brain cancer
Researchers at UCLA's Jonsson Cancer have identified key characteristics in certain deadly brain tumors that make them 51 times more likely to respond to a specific class of drugs than tumors in which the molecular signature is absent. (2005-11-09)

Scientists Close To Finding Gene That Controls Growth Of Lung Cancer
In what may move scientists a step closer to locating a gene that helps control the growth of lung cancer, researchers at Duke University Medical Center have found in a new study that fragments of a portion of a human chromosome slow tumor growth in mice and in cell cultures. (1997-11-10)

Linking risk factors and disease origins in breast cancer
Researchers from the Geisel School of Medicine at Dartmouth have found that epigenetic changes to DNA are associated with aging in disease-free breast tissues and are further altered in breast tumors. Epigenetic changes describe heritable alterations caused by mechanisms other than by changes in DNA sequence. The discovery, published in the Feb. 2014 issue of Epigenetics, illustrates how cancer and aging are tightly interconnected processes by identifying epigenetic alterations present in the normal aging breast that may increase disease risk in cancer-free individuals. (2013-11-20)

A molecular switch is linked to a common breast cancer
Researchers have discovered that a molecular switch in the protein-making machinery of cells is linked to one of the most common forms of lethal breast cancer worldwide. The discovery by researchers at NYU School of Medicine could lead to new therapies for the cancer, called locally advanced breast cancer. (2007-11-08)

Malignant brain tumors most common cause of cancer deaths in adolescents and young adults
A new report published in the journal Neuro-Oncology and funded by the American Brain Tumor Association (ABTA) finds that malignant brain tumors are the most common cause of cancer-related deaths in adolescents and young adults aged 15-39 and the most common cancer occurring among 15-19 year olds. (2016-02-24)

Photoacoustic imaging and photothermal cancer therapy using BR nanoparticles
Sangyong Jon, a professor in the Department of Biological Sciences at KAIST, and his team developed combined photoacoustic imaging and photothermal therapy for cancer by using Bilirubin (BR) nanoparticles. The team expects this research, which shows high biocompatibility as well as outstanding photoacoustic imaging and photothermal therapy, to be an appropriate system in the field of treatment for cancer. (2017-09-25)

Duke team finds missing immune cells that could fight lethal brain tumors
Researchers at Duke Cancer Institute have tracked the missing T-cells in glioblastoma patients. They found them in abundance in the bone marrow, locked away and unable to function because of a process the brain stimulates in response to glioblastoma, to other tumors that metastasize in the brain and even to injury. (2018-08-13)

Research shows molecular, protein targeting therapies may be best treatment for certain lung cancer
University of Cincinnati Cancer Institute researchers have found that using therapies specifically targeting the molecular profile of non-small-cell lung cancer with the mutated cancer-causing protein KRas is the most effective treatment strategy for patients with the condition. (2014-01-07)

Scientists show how molecular switch helps pancreatic cancer beat drugs
Researchers at the Moores Cancer Center at the University of California, San Diego, have found one reason that pancreatic cancer tumors are so difficult to treat with drugs. They have shown how a molecular switch steps up pancreatic cancer cell survival as well as resistance to a standard chemotherapy drug, and have identified alternate routes cancer cells take to avoid the effects of the therapy. (2010-01-28)

Johns Hopkins scientists crack genetic code for form of pancreatic cancer
Scientists at Johns Hopkins have deciphered the genetic code for a type of pancreatic cancer, called neuroendocrine or islet cell tumors. The work, described online in the Jan. 20 issue of Science Express, shows that patients whose tumors have certain coding (2011-01-21)

Scientists move in on genes conferring susceptibility, resistance to cancer
UCSF Comprehensive Cancer Center researchers have identified genetic regions in mice that confer susceptibility and resistance to a human-like skin cancer, suggesting, they say, that mouse studies may reveal genetic markers of susceptibility and resistance to cancer in humans. (2000-04-03)

T cell channel could be targeted to treat head and neck cancers
Researchers at the University of Cincinnati have discovered that an ion channel, active within T cells (white blood cells), could be targeted to reduce the growth of head and neck cancers. (2016-11-17)

Researchers identify phosphorylation process vital to cancer growth
Scientists at VIB-KU Leuven have identified a new mechanism that impacts tumor growth. The typical lack of oxygen in tumors doesn't only stimulate proliferation, but also offsets the important role of the protein PHD2 as 'cancer cell killer.' A possible solution lies in blocking the enzyme PP2A/B55, which restores the function of PHD2 and consequently slows down cancer growth. The research, led by Professor Massimiliano Mazzone, is published in the leading scientific journal Cell Reports. (2017-02-14)

Removing cancer cell debris improves conventional cancer treatments
Cancer therapies are designed to kill tumor cells, but produce tumor cell debris in the process. In a study published in The Journal of Experimental Medicine, researchers from Brigham and Women's Hospital and colleagues show that leftover debris can stimulate inflammation and tumor growth, but that molecules called resolvins can block that unwanted inflammatory response. The findings point towards a new way to enhance the effectiveness of current cancer therapies and potentially prevent tumor recurrence. (2017-12-04)

Organoids (in vitro brains) to study pediatric brain tumors
Hundreds of miniature brains were grown in the laboratories of the University of Trento to study the genetic mechanisms responsible for the most common brain cancer affecting children. The results of a collaborative research effort, coordinated by the University of Trento and carried out with Sapienza University and Ospedale pediatrico Bambino Gesù in Rome and Irccs Neuromed, were published today in Nature Communications. (2020-01-29)

Scientists develop free computer program to map blood flow 'landscape' in tumors
Johns Hopkins Medicine researchers have created a computer program for scientists at no charge that lets users readily quantify the structural and functional changes in the blood flow networks feeding tumors. (2020-03-05)

Protein involved in nerve-cell migration implicated in spread of brain cancer
The invasion of brain-tumor cells into surrounding tissue requires the same protein molecule that neurons need to migrate into position as they differentiate and mature, according to new research from the University of Illinois at Chicago College of Medicine and published Aug. 7 in the online journal PLOS ONE. (2013-08-07)

Women with breast cancer detected by mammography screening have better outcomes
Women who have breast cancer detected by mammography screening have a reduced risk of distant tumor recurrence than women with breast cancer detected outside of screening, according to a study in the September 1 issue of JAMA. (2004-08-31)

Wake Forest Baptist researchers find novel way to induce pancreatic cancer cell death
Pancreatic cancer, most frequently pancreatic ductal adenocarcinoma, is the most lethal and aggressive of all cancers. Unfortunately, there are not many effective therapies available other than surgery, and that is not an option for many patients. (2017-04-10)

Does stronger initial response to cancer treatment predict longer overall survival?
It seems like such a simple question: Do patients whose tumors shrink more in response to targeted treatment go on to have better outcomes than patients whose tumors shrink less? But the implications of a recent study demonstrating this relationship are anything but simple and could influence both the design of future clinical trials and the goals of oncologists treating cancer. (2017-08-14)

Researchers capture first images of oxygen in cancer tumors during radiation therapy
Oxygen in cancer tumors is a known major factor in the success of radiation therapy, but currently there are no good ways to monitor tumor oxygenation during this treatment. With specialty cameras and injection of an oxygen probe drug, researchers at Dartmouth's and Dartmouth-Hitchcock's Norris Cotton Cancer Center have demonstrated the first way to directly monitor the full range of oxygen distributions within the tumor right at the time when radiation therapy is happening. (2020-01-29)

Immunoscore guided cold tumors acquire temperature through integrating methods
In this review article the authors Jing Liu, Mengze Xu and Zhen Yuan from University of Macau, Macau SAR, China consider immunotherapy for the treatment of tumors. (2020-05-12)

Algorithms uncover cancers' hidden genetic losses and gains
Limitations in DNA sequencing technology make it difficult to detect some major mutations often linked to cancer, such as the loss or duplication of parts of chromosomes. Now, methods developed by Princeton computer scientists will allow researchers to more accurately identify these mutations in cancerous tissue, yielding a clearer picture of the evolution and spread of tumors than was previously possible. (2020-09-17)

$7.5 million to JAX from South Korean government for cancer genomics project
The Jackson Laboratory, in collaboration with Seoul National University, will receive a five-year, $7.5 million grant from the South Korean government for a large-scale cancer genomics project employing the latest sequencing technology and special JAX mouse models that can host human tumors. (2014-01-22)

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