Popular Ulcerative Colitis News and Current Events

Popular Ulcerative Colitis News and Current Events, Ulcerative Colitis News Articles.
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Texas A&M AgriLife study shows BPA risk factor for inflammatory bowel disease
A recent study in a preclinical model of inflammatory bowel disease shows dietary exposure to bisphenol-A, or BPA, found in polycarbonate plastics and epoxy resins, can increase mortality and worsen its symptoms. (2018-07-05)

Discovery of a crucial immune reaction when solid food is introduced that prevents inflammatory disorders
In newborn infants, gut microbiota is first conditioned by breast milk components. When solid food is introduced, gut microbiota develops and bacteria proliferate. Scientists have discovered that a key immune response is generated in mice when solid food is introduced and microbiota expands. But, above all, they have shown that this immune reaction is essential as it is involved in educating the immune system and leads to low susceptibility to inflammatory disorders in adulthood. (2019-03-19)

Statins associated with reduced morbidity and mortality in patients with primary sclerosing cholangitischolangi
An award-winning register-based study reports a reduced risk of all-cause mortality, liver transplantation, liver cancer, and variceal bleeding in patients with primary sclerosing cholangitis exposed to statins. (2018-04-12)

Ustekinumab Phase 3 data show long-term improvement of chronic plaque psoriasis
One-year data from a second double-blind, placebo-controlled Phase 3 study showed therapy with ustekinumab given every 12 weeks provided sustained, clinically meaningful improvement in the treatment of moderate to severe psoriasis. According to findings presented at the Annual Meeting of the American Academy of Dermatology, 87 percent and 91 percent of patients responding to ustekinumab 45 mg or 95 mg maintenance therapy, respectively, sustained at least a 75 percent improvement in psoriasis through one year. (2008-02-02)

Exercise changes gut microbial composition independent of diet, team reports
Two studies -- one in mice and the other in human subjects -- offer the first definitive evidence that exercise alone can change the composition of microbes in the gut. The studies were designed to isolate exercise-induced changes from other factors -- such as diet or antibiotic use- - that might alter the intestinal microbiota. (2017-12-04)

An epidemiologic study of microscopic colitis in Turkey
Microscopic colitis is a chronic diarrheal disease with normal colonoscopic but abnormal histopathologic features. It is a disease with two subtypes of similar clinical but different histological features: Lymphocytic colitis, which is characterized by pronounced colonic mucosal lymphocyte infiltration. Collagenous colitis, which is characterized by increased subepithelial collagenous band thickness. A group from Turkey investigated the prevalence and demography of microscopic colitis in patients with diarrhea of unknown etiology and normal colonoscopy in Turkey. (2008-10-07)

Researchers recommend specific diets for preventing colorectal cancer in high-risk groups
Researchers at the Spanish National Cancer Research Centre (CNIO) have discovered that the amount of protein in our diet may be an important factor in the prevention of colorectal cancer in different risk groups. People already suffering from inflammatory bowel disease could benefit from a high-protein diet; however, in contrast, low protein consumption may be the best option for those people who have a genetic predisposition to develop colon cancer. (2017-12-21)

Vitamin D deficiency common in patients with IBD, chronic liver disease
The 73rd Annual Scientific Meeting of the American College of Gastroenterology in Orlando found patients with inflammatory bowel disease or chronic liver disease were at increased risk of developing Vitamin D deficiencies. Two separate studies highlight the importance of regular Vitamin D checkups in the evaluation of patients with certain digestive diseases. (2008-10-06)

Gut reaction: Repeated food poisoning triggers chronic disease
Small bacterial infections that may go unnoticed and which the body easily clears without treatment, such as occurs during mild food poisoning, nevertheless can start a chain of events that leads to chronic inflammation and potentially life-threatening colitis. (2017-12-21)

Inflammatory bowel disease increases likelihood of a heart attack
An analysis of medical-record data from more than 17.5 million patients found that people with inflammatory bowel disease (IBD) are at elevated risk for a heart attack, regardless of whether or not they have traditional risk factors for heart disease such as high cholesterol, high blood pressure and smoking. People between the ages of 18 and 24 are at the highest risk, according to research presented at the American College of Cardiology's 67th Annual Scientific Session. (2018-03-01)

Seeking a better way to design drugs
With a three-year, $346,000 award from the National Institutes of Health, a research team at Worcester Polytechnic Institute. Led by Marion Emmert, Ph.D., will seek to advance the development of a chemical process that could significantly improve the ability to design new pharmaceuticals and streamline the manufacturing of existing drugs. The early-stage technology may yield a more efficient and predictable way of bonding aromatic and benzylic amines to a drug molecule. (2015-09-23)

Fecal microbiota transplantation produces sustained improvements in cognitive and clinical outcomes
Long-term results of a randomized study demonstrate sustained improvements in hepatic encephalopathy episodes, hospitalizations, and cognitive performance compared with standard-of-care. (2018-04-14)

PET detects neuroinflammation in multiple sclerosis
The triggers of autoimmune inflammation in multiple sclerosis (MS) have eluded scientists for many years, but molecular imaging is bringing researchers closer to identifying them, while providing a means of evaluating next-generation therapies for MS, say researchers introducing a study at the 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging. (2016-06-12)

Immunotherapy combination and chemotherapy show encouraging results in Phase II acute myeloid leukemia study
A triple therapy combining two immune checkpoint inhibitors (ICPIs) with the standard-of-care chemotherapy, a hypomethylating agent called azacitidine, has shown promising results for treatment of relapsed or refractory acute myeloid leukemia (AML), according to findings from a Phase II study at The University of Texas MD Anderson Cancer Center. (2018-11-13)

New strategies to improve the quality of inflammatory bowel disease (IBD) care
1.6 million Americans suffer. As with many chronic conditions, IBD patients often require frequent hospital visits due to rapid changes in their illness and can struggle with finding the balance between their health and their work/social life. Doctors and researchers will come together at the Crohn's & Colitis Congress™ to explore new strategies to improve the care provided to IBD patients, which will ultimately improve patients' quality of life. (2018-01-19)

Beyond drugs for IBD: Improving the overall health of IBD patients
1.6 million Americans suffer from IBD. Identifying the best medical treatment leads to improved disease management, but IBD patients also experience mental, emotional and other physical side effects that need to be understood and managed to improve the overall health of IBD patients. Research presented at the Crohn's & Colitis Congress™ helps health care providers understand how to better manage their patients' overall health and mental well-being to increase the quality of their lives. (2018-01-19)

Precision editing of gut bacteria: Potential way to treat colitis
UT Southwestern Medical Center researchers have used precision editing of the bacterial populations in the gut to prevent or reduce the severity of inflammation in a mouse model of colitis. (2018-01-04)

Analysis challenges link between pain medications and inflammatory bowel disease
Contrary to generally accepted belief, a recent review and analysis of published studies did not reveal a consistent association between the use of nonsteroidal anti-inflammatory drugs (NSAIDs) or acetaminophen and exacerbation of Crohn's disease and ulcerative colitis. (2018-04-05)

Microbes seen controlling action of host's genes
Duke researchers have shown that microbes can control their animal hosts by manipulating the molecular machinery of their cells, triggering patterns of gene expression that consequently contribute to health and disease. The work, which was conducted in zebrafish and mice cells, could have implications for human inflammatory bowel diseases like Crohn's disease and ulcerative colitis. (2017-05-17)

Scientific study review presents health promoting potential of mangoes
Research continually unveils new insights about mangoes and their role in the diet for health. According to a comprehensive review of the available scientific literature published in the May issue of Food & Function, mangoes and their individual components have anti-inflammatory and antioxidative properties, which may help to reduce risk for chronic disease. (2017-09-06)

Scientists discover how gene mutation triggers immune disease
Scientists discovered how a gene mutation affects T cell function to promote immune disorders and then tested a treatment based on the discovery--successfully fixing donated immune cells from a 16-year-old boy with an abnormally low level of white blood cells called lymphopenia. Researchers report their findings Jan. 30 in Nature Communications. (2018-01-30)

Solving the gut inflammation puzzle
Inflammatory bowel disease (IBD), an umbrella term for a number of gut disorders -- including ulcerative colitis and Crohn's disease -- remains a clinical challenge. Now, researchers from Sanford Burnham Prebys Medical Discovery Institute (SBP), in collaboration with scientists at Technion - Israel Institute of Technology, have identified a protein that drives intestinal inflammation. This finding highlights new opportunities for creating targeted therapeutics. The study published today in Cell Reports. (2018-09-18)

New study shows sitting, watching TV linked to colorectal cancer risk before age 50
A new study in JNCI Cancer Spectrum has identified a connection between prolonged time spent sitting while watching TV and increased risk of colorectal cancer for younger Americans. (2019-02-05)

Inflammatory bowel disease linked to prostate cancer
Men with inflammatory bowel disease have four to five times higher risk of being diagnosed with prostate cancer. This is the first report to show these men have higher than average PSA values and a significantly higher risk of potentially dangerous prostate cancer. They need to be screened more carefully for prostate cancer. About 1 million men have inflammatory bowel disease in the U.S., a common chronic condition that includes Crohn's disease and ulcerative colitis. (2018-12-07)

New drugs for inflammatory bowel disease (IBD)
1.6 million Americans suffer from IBD. There is no cure for these chronic, life-long conditions. While several effective treatments are available, 40 to 55 percent of patients have no response to current therapies. There is a dire need for new drugs for all patients that are highly safe and effective. Based on research being presented at the Crohn's & Colitis Congress™, we are hopeful that future IBD patients will have new and effective treatment options. (2018-01-19)

Novel PET imaging noninvasively pinpoints colitis inflammation
A novel positron emission tomography (PET) imaging method shows promise for noninvasively pinpointing sites of inflammation in people with inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease. The University of California, Los Angeles (UCLA), study is featured in the June issue of The Journal of Nuclear Medicine. (2018-06-04)

Newly-discovered anti-inflammatory substances may potentially treat variety of diseases
Researchers have discovered a new family of substances which has been found to display highly potent activity against the release of pro-inflammatory cytokines and the toxicity induced by reactive oxygen species (ROS). The novel compounds synthesized and evaluated belong to a family of low molecular weight substances named indolines. In early experiments, these compounds have shown promising activity in the treatment of acute pancreatic inflammation, acute fatty liver damage, and diabetes. (2018-05-03)

Humira does not improve aortic vascular inflammation in psoriasis patients
An antibody used to treat the skin disease psoriasis and other chronic autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease has no effect on aortic inflammation -- a key marker of future risk of major cardiovascular events -- unlike other antibodies that target different aspects of the immune system. (2018-05-18)

Potent new mechanism of action for treatment of inflammatory bowel disease revealed
Through research on the small molecule analogue of E6007 which is under clinical development as a treatment for inflammatory bowel disease, a novel mechanism of action was revealed in which this analogue inhibited the adhesion and infiltration of various leukocytes through the blockade of the interaction between calreticulin and the leukocyte adhesion molecule integrin α by associating with calreticulin. (2018-05-25)

HIV-1 regulation via protective human leukocyte antigen (HLA) haplotypes
HIV-1 regulation by the HLA-B*52:01 allele has been established for some time. However, evidence of regulation by its companion, the HLA-C*12:02 allele, has been difficult to produce due to the strong linkage. Researchers from the Center for AIDS research in Kumamoto University, Japan have produced the first evidence of HLA-C's control of HIV-1, but they note that it comes with a price. Namely, the possibility of a different autoimmune disease. (2017-12-12)

New genetic markers for ulcerative colitis identified, researchers report in Nature Genetics
An international team of researchers has identified genetic markers associated with risk for ulcerative colitis. The findings, which appear today as an advance online publication of the journal Nature Genetics, bring researchers closer to understanding the biological pathways involved in the disease and may lead to the development of new treatments that specifically target them. (2009-01-04)

Gut bacteria: It can be good, and bad, for health
A new study found that impairing a rare group of cells (called Paneth cells) in the small intestine allows gut bacteria to invade the organ and cause major inflammation. The study was conducted in mice, but has implications for the treatment of inflammatory bowel disease (IBD), a group of disorders characterized by chronic inflammation in the digestive track. (2018-02-08)

Social stress leads to changes in gut bacteria, study finds
Exposure to psychological stress in the form of social conflict alters gut bacteria in Syrian hamsters, according to a new study by Georgia State University. (2018-03-08)

Artificial sweetener Splenda could intensify symptoms in those with Crohn's disease
In a study that has implications for humans with inflammatory diseases, researchers have found that, given over a six-week period, the artificial sweetener sucralose, known by the brand name Splenda, worsens gut inflammation in mice with Crohn's disease, but had no substantive effect on those without the condition. (2018-03-15)

Therapeutic drug monitoring does not improve remission for patients starting infliximab
New research presented at ACR Convergence, the American College Rheumatology's annual meeting, showed that patients with rheumatic diseases whose infliximab treatment was individually assessed and adjusted with a new strategy called therapeutic drug monitoring did not achieve remission at higher rates compared to those who received standard care. (2020-11-06)

New tool uses UV light to control inflammation
Cornell researchers have developed a chemical tool to control inflammation that is activated by ultraviolet (UV) light. (2016-12-02)

A cellular tango: Immune and nerve cells work together to fight gut infections
Nerve cells in the gut play a crucial role in the body's ability to marshal an immune response to infection, according to a new study from Weill Cornell Medicine scientists. (2017-09-07)

Potential new therapy for Crohn's, colitis identified
Researchers at Washington University School of Medicine in St. Louis have found a compound that may treat inflammatory bowel disease without directly targeting inflammation. The compound tamps down the activity of a gene linked to blood clotting. They discovered that the gene was turned on at sites of intestinal inflammation and damage, and blocking its activity reduces IBD symptoms in mice. (2019-03-06)

What's the best way for patients with inflammatory bowel disease to address abdominal pain
When researchers analyzed published studies on how to treat recurrent abdominal pain among patients with inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis, stress management appeared to be a promising strategy. (2017-05-09)

University of Cincinnati finds new option for liver transplant patients
Budesonide, a drug commonly used to treat Crohn's Disease, may offer fewer side effects and work at least as well as prednisone as an anti-organ rejection medication in liver transplant patients. (2019-11-08)

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