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Current Activation News and Events, Activation News Articles.
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Violent video games alter brain function in young men
Sustained changes in the region of the brain associated with cognitive function and emotional control were found in young adult men after one week of playing violent video games, according to study results presented by Indiana University School of Medicine researchers at the annual meeting of the Radiological Society of North America. (2011-12-01)

Violent video games alter brain function in young men
A functional magnetic resonance imaging analysis of long-term effects of violent video game play on the brain has found changes in brain regions associated with cognitive function and emotional control in young adult men after one week of game play. (2011-11-30)

Cobblestones fool innate immunity
Coating the surface of an implant such as a new hip or pacemaker with nanosized metallic particles reduces the risk of rejection, and researchers at the University of Gothenburg, Sweden, can now explain why: they fool the innate immune system. The results are presented in the International Journal of Nanomedicine. (2011-11-29)

Kessler Foundation reports benefits of behavioral technique for cognitive rehabilitation in MS
Impairments in cognitive processing, eg, new learning and memory, are common deficits in MS and have been shown to negatively impact everyday life. Few studies have attempted to remediate these cognitive deficits to improve everyday functioning. Research from Kessler Foundation shows that the modified Story Memory Technique significantly improves new learning and memory in MS. (2011-11-16)

Glioblastoma multiforme in the Dock
Glioblastoma multiforme is the most common malignant brain cancer in humans. Patients with this highly aggressive form of cancer have a poor prognosis because it is commonly resistant to current therapies. Researchers have now identified a molecular pathway that drives the aggressive cancerous nature of a many glioblastomas; specifically, those that overexpress the protein PDGFR-alpha. This pathway could represent a novel and attractive therapeutic target for treating individuals with glioblastomas that over-express PDGFR-alpha. (2011-11-14)

Neurological and executive function impairment associated with breast cancer
Women who survive breast cancer show significant neurological impairment, and outcomes appear to be significantly poorer for those treated with chemotherapy, according to a report in the November issue of the Archives of Neurology, one of the JAMA/Archives journals. (2011-11-14)

USC researchers discover key aspect of process that activates breast cancer genes
Researchers at the Keck School of Medicine of the University of Southern California have discovered key processes by which estrogen, the female sex hormone, activates genes in breast-cancer cells. Greater understanding of how this occurs is expected to eventually lead to new treatments for the disease. (2011-11-14)

Metabolic protein plays unexpected role in tumor cell formation and growth
The embryonic enzyme pyruvate kinase M2 (PKM2) has a well-established role in metabolism and is highly expressed in human cancers. Now, a team led by researchers at the University of Texas MD Anderson Cancer Center reports in advance online publication of the journal Nature that PKM2 has important non-metabolic functions in cancer formation. (2011-11-06)

Gladstone scientists identify gene critical for cell responses to oxygen deprivation
Scientists at the Gladstone Institutes have identified a protein that kick-starts the response to low levels of oxygen, suggesting new lines of research relevant to a variety of potentially fatal disorders associated with diminished oxygen supply, including cancer, heart disease, stroke and other neurological conditions that affect millions of people worldwide. (2011-11-03)

Precise early diagnosis of psychotic disorders possible
Functional psychosis can be diagnosed from the first indications of the patient, thanks to affective symptomatology. Depressive moods, hyperactivity and lack of concentration are affective symptoms that can present themselves during the first psychotic episodes, and the presence or absence of any of them may contribute to differentiating, at an early stage, between the different variations of the mental disease. Thus concludes researcher Marta Arrasate. (2011-11-02)

Aluminum alloy overcomes obstacles on the path to making hydrogen a practical fuel source
A team of researchers from the University of Texas at Dallas and Washington State University in Pullman, WA, has made the counter-intuitive discovery that aluminum, with a minor modification, is able to both break down and capture individual hydrogen atoms, potentially leading to a robust and affordable fuel storage system. (2011-11-01)

Evidence for spinal membrane as a source of stem cells may advance spinal cord treatment
Italian and Spanish scientists studying the use of stem cells for treating spinal cord injuries have provided the first evidence to show that meninges, the membrane which envelops the central nervous system, is a potential source of self-renewing stem cells. The research, published in STEM CELLS, develops the understanding of cell activation in central nervous system injuries; advancing research into new treatments for spinal injuries and degenerative brain disorders. (2011-10-28)

Moffitt Cancer Center researchers find more clues to causes of breast cancer
Publishing in the current issue of the Journal of Biological Chemistry, researchers at Moffitt Cancer Center in Tampa, Fla., have discovered additional mechanisms of (2011-10-27)

Brain study reveals how successful students overcome math anxiety
Using brain-imaging technology for the first time with people experiencing mathematics anxiety, scientists have gained new insights into how some students are able to overcome their fears and succeed in math. For the highly math anxious, researchers found a strong link between math success and activity in a network of brain areas in the frontal and parietal lobes involved in controlling attention and regulating negative emotional reactions. (2011-10-20)

Gene variant leads to better memory via increased brain activation
Carriers of the so-called KIBRA T allele have better memories than those who don't have this gene variant. This means we can reject the theory that the brain of a non-bearer compensates for this. This is shown by researchers from UmeƄ University in the Journal of Neuroscience. (2011-10-17)

La Jolla Institute discovers previously unknown cell interaction key in immune system attacks
Most of the time, the immune system is the body's protector. But in autoimmune diseases, the immune system does an about face, turning on the body and attacking normal cells. A major discovery by La Jolla Institute scientist Amnon Altman, Ph.D., and his colleagues, of a previously unknown molecular interaction that is essential for T lymphocyte activation, could have major implications for stopping this aberrant immune system behavior and the accompanying undesirable immune responses that cause autoimmune diseases and allergies. (2011-10-02)

Factor in keeping 'good order' of genes discovered
A factor that is crucial for the proper positioning of genes in the cell nucleus has been discovered by a team of researchers from the Alexander Silberman Institute of Life Sciences at the Hebrew University of Jerusalem and the Friedrich Miescher Institute for Biomedical Research in Basel, Switzerland. (2011-10-02)

Fatty acid test: Why some harm health, but others help
In a paper published in the Sept. 30 issue of the journal Cell, researchers at the University of California San Diego School of Medicine and colleagues offer an explanation, and a framework that could lead to dietary supplements designed to treat obesity at the molecular level. (2011-09-29)

Louisiana State University Health Sciences Center research discovers key to survival of brain cells
Nicolas G. Bazan, M.D., Ph.D, Boyd Professor and Director of the Neuroscience Center of Excellence at Louisiana State University Health Sciences Center New Orleans, and David Stark, an M.D./Ph.D student working in his lab, have discovered how a key chemical neurotransmitter that interacts with two receptors in the brain promotes either normal function or a disease process -- determining whether brain cells live or die. (2011-09-28)

Stimulation of female genital regions produces strong activation of various brain sites
A new study published in the Journal of Sexual Medicine reveals that for the first time, stimulation of the vagina, cervix or clitoris was shown to activate three separate and distinct sites in the sensory cortex. (2011-09-12)

Body clock found to regulate platelet function
Researchers at Brigham and Women's Hospital have demonstrated that the circadian system, the body's internal clock, regulates human platelet function and causes a peak in platelet activation corresponding to the known morning peak in adverse cardiovascular events. (2011-09-09)

USC scientists identify key protein linked to acute liver failure
Research shows that inhibition of Sab protein prevents liver damage associated with acetaminophen overdose Results suggest that inhibition of Sab protein can protect against various types of cellular death in any organ (2011-09-07)

Activating your ABCs might help prevent AD (Alzheimer disease)
Alzheimer disease (AD) is the most common cause of dementia among older people. One of the main features of AD is the presence in the brain of abnormal clumps of the protein fragment beta-amyloid. Researchers have now identified a way to reduce the amount of beta-amyloid in the brains of mice with a disease that models AD, providing hope that a similar approach could benefit patients with this devastating condition. (2011-09-01)

Parasite-infected rodents attracted to cat odor study finds
New research shows how a brain parasite can manipulate rodent fear responses for the parasite's own benefit. (2011-08-17)

Defect in A20 gene expression causes rheumatoid arthritis
Researchers from VIB (Flanders Institute for Biotechnology) and Ghent University have shown that a defective gene can contribute to the onset of rheumatoid arthritis, an often-crippling inflammation of the joints that afflicts about 1 percent of the world's population. (2011-08-16)

Signaling pathway reduces stress resilience in models of depression and addiction
Now, new research, published by Cell Press in the Aug. 11 issue of the journal Neuron, uncovers a previously unappreciated role for p38alpha, a mitogen-activated protein kinase better known for its role in cellular stress, in the regulation of mood disorders, and risk for addiction. (2011-08-10)

Pitt team finds molecular pathway that leads to inflammation in asthma
Researchers at the University of Pittsburgh School of Medicine have identified a molecular pathway that helps explain how an enzyme elevated in asthma patients can lead to increased mucus production and inflammation that is characteristic of the lung condition. Their findings, reported online in this week's Proceedings of the National Academy of Sciences, reveal unique interactions between biological molecules that could be targeted to develop new asthma treatments. (2011-08-08)

Trauma drama: K-State professor researches drama queen of immune system
Sherry Fleming, a Kansas State University associate professor in the Division of Biology, is using a $140,000 grant from the American Heart Association to identify the molecule responsible for the overreaction that can cause cell death in the intestines after trauma. (2011-08-08)

Key growth factor identified in T cell leukemia
Blocking a growth factor receptor cripples cancer growth in a form of T cell leukemia, according to a study published online on August 1 in the Journal of Experimental Medicine. (2011-08-01)

Pregnancy hormone has unprecedented, powerful effect on spinal muscular atrophy
Although spinal muscular atrophy is caused by the loss of a specific gene, all infants and children with SMA have an untouched highly similar gene within their genetic make up. Activation of this copy gene has the potential to treat SMA, and today researchers at the Children's Hospital of Eastern Ontario Research Institute in Ottawa report the strongest such activation yet observed with attendant benefit on mice genetically engineered to have SMA. (2011-07-25)

New clues to the structural dynamics of BK channels
BK channels (large-conductance, Ca2+-dependent K+ channels) are essential for the regulation of important biological processes such as smooth muscle tone and neuronal excitability. New research shows that BK channel activation involves structural rearrangements formerly not understood. The study appears in the August 2011 issue of the Journal of General Physiology. (2011-07-14)

PXR: A stepping stone from environmental chemical to cancer?
Several chemicals that can accumulate to high levels in our body (for example BPA and some pesticides) have been recently linked to an increased risk of cancer and/or impaired responsiveness to anticancer drugs. Researchers have now identified a potential mechanistic link between environmental exposure to these foreign chemicals (xenogens) and cancer drug therapy response and survival. (2011-07-11)

Researchers identify early biomarker for future atopy in asymptomatic children
The signs of atopy may be present long before symptoms begin, even in month-old babies, according to a new research study from Denmark. The study found that the level of urinary eosinophil protein-X, a marker of inflammatory cells, in newborn babies was linked to higher risk of allergic sensitization, nasal eosinophilia and eczema at six years. (2011-07-06)

Abatacept slows loss of insulin-producing beta-cells in type 1 diabetes, but only for first 6 months
In type 1 diabetes, autoimmunity destroys the insulin-producing beta-cells in the pancreas. The T-cells of the immune system require a co-stimulating signal to be fully active, and thus interventions to prevent this co-stimulation could prevent further beta-cell loss in recently diagnosed type 1 diabetes patients. A study published online first by the Lancet shows that abatacept helps modulate this co-stimulation. (2011-06-28)

Plants teach humans a thing or two about fighting diseases
Avoiding germs to prevent sickness is commonplace for people. Wash hands often. Sneeze into your elbow. Those are among the tips humans learn. But plants, which are also vulnerable to pathogens, have to fend it alone. They grow where planted, in an environment teeming with microbes and other substances ready to attack. Texas AgriLife Research scientists have learned from plants' immune response new information that could help understand humans' ability to ward off sickness. (2011-06-16)

New research provides clues on why hair turns gray
A new study by researchers at NYU Langone Medical Center has shown that, for the first time, Wnt signaling, already known to control many biological processes, between hair follicles and melanocyte stem cells can dictate hair pigmentation. The study was published in the June 11, 2011, issue of the journal Cell. (2011-06-14)

Sleepiness may impair the brain's inhibitory control when viewing high-calorie foods
Daytime sleepiness may affect inhibitory control in the brain when viewing tantalizing, high-calorie foods, suggests a research abstract that will be presented Monday, June 13, in Minneapolis, Minn., at SLEEP 2011, the 25th Anniversary Meeting of the Associated Professional Sleep Societies LLC. (2011-06-13)

New research may lead to improved diagnosis of autism
Functional magnetic resonance imaging may provide an early and objective indicator of autism, according to researchers at Columbia University in New York City, who used the technique to document language impairment in autistic children. (2011-05-31)

Precision-tinted lenses offer real migraine relief, reveals new study
For the first time, researchers have shown why precision-tinted lenses reduce headaches for migraine sufferers, a finding that could help improve treatment options for patients battling the debilitating ailment. Jie Huang of Michigan State University's Department of Radiology used functional magnetic resonance imaging, or fMRI, to reveal how precision-tinted lenses normalize brain activity in patients with migraine headaches, preventing such attacks. (2011-05-26)

Why people with schizophrenia may have trouble reading social cues
Impairments to a brain area responsible for processing social stimuli may help explain why individuals with schizophrenia have trouble reading social cues. (2011-05-24)

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