Current Acute Myeloid Leukemia News and Events

Current Acute Myeloid Leukemia News and Events, Acute Myeloid Leukemia News Articles.
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New drug combination shows promise as powerful treatment for AML
Scientists have identified two drugs that are potent against acute myeloid leukemia (AML) when combined, but only weakly effective when used alone. The researchers were able to significantly enhance cancer cell death by jointly administering the drugs that are only partially effective when used as single-agent therapies. (2021-01-19)

Heart attack patients in England 'fearful' of seeking medical help amid COVID crisis
Data analysis is revealing a second sharp drop in the number of people admitted to hospital in England with acute heart failure or a heart attack. The decline began in October, as the numbers of COVID-19 infections began to surge ahead of the second lockdown, which came into force in early November. (2021-01-19)

Timing is of the essence when treating brain swelling in mice
Researchers from the National Institutes of Health have discovered Jekyll and Hyde immune cells in the brain that ultimately help with brain repair but early after injury can lead to fatal swelling, suggesting that timing may be critical when administering treatment. These dual-purpose cells, which are called myelomonocytic cells and which are carried to the brain by the blood, are just one type of brain immune cell that NIH researchers tracked, watching in real-time as the brain repaired itself after injury. (2021-01-18)

CHOP researchers Find NTRK fusions more common than expected in pediatric tumors
Researchers from Children's Hospital of Philadelphia (CHOP) have found that NTRK fusions are more common in pediatric tumors and also involve a wider range of tumors than adult cancers, information that could help prioritize screening for NTRK fusions in pediatric cancer patients who might benefit from treatment with TRK inhibitors. (2021-01-15)

Cancer research reveals how mutations in a specific gene cause different types of disease
Leading cancer expert solve long-standing question of how various types of mutations in just one gene cause different types of diseases (2021-01-14)

Acute itching in eczema patients linked to environmental allergens
New research from Washington University School of Medicine in St. Louis indicates that allergens in the environment often are to blame for episodes of acute itch in eczema patients, and that the itching often doesn't respond to antihistamines because the itch signals are being carried to the brain along a previously unrecognized pathway that current drugs don't target. (2021-01-14)

Scientists study use of abundant enzyme in tumor cells to monitor cancer treatment
After 14 years studying the action of the enzyme LMWPTP in tumor cells, Brazilian researchers conclude that the molecule is associated with chemotherapy resistance and metastasis. (2021-01-12)

Acta Pharmaceutica Sinica B volume 10, issue 11 publishes
Acta Pharmaceutica Sinica B Volume 10, Issue 11 Publishes Special Issue: Tumor Microenvironment and Drug Delivery Guest Editors: Huile Gao, West China School of Pharmacy, Sichuan University, Chengdu, China; Zhiqing Pang, Fudan University, Shanghai, China and Wei He, China Pharmaceutical University, Nanjing, China (2021-01-11)

Oncotarget: Targeted lymphodepletion with a CD45-directed antibody radioconjugate
''Here the Oncotarget authors describe the results of preclinical studies with an anti-mouse CD45 antibody 30F11'' (2021-01-11)

A potent weapon against lymphomas
MDC researchers have developed a new approach to CAR T-cell therapy. The team has shown in Nature Communications that the procedure is very effective, especially when it comes to fighting follicular lymphomas and chronic lymphocytic leukemia, the most common type of blood cancer in adults. (2021-01-11)

Large study finds higher burden of acute brain dysfunction for COVID-19 ICU patients
COVID-19 patients admitted to intensive care in the early months of the pandemic were subject to a significantly higher burden of delirium and coma than is typically found in patients with acute respiratory failure. Choice of sedative medications and curbs on family visitation played a role in increasing acute brain dysfunction for these patients. (2021-01-08)

IU research findings could reduce treatment-related complication for blood cancer patients
Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center published promising findings today in the New England Journal of Medicine on preventing a common complication to lifesaving blood stem cell transplantation in leukemia. (2021-01-07)

Scientists create ON-OFF switches to control CAR T cell activity
Scientists at Dana-Farber Cancer Institute and Mass General Cancer Center have created molecular ON-OFF switches to regulate the activity of CAR T cells, a potent form of cell-based immunotherapy that has had dramatic success in treating some advanced cancers, but which pose a significant risk of toxic side effects. (2021-01-06)

COVID-19 infection linked with higher death rate in acute heart failure patients
Patients with acute heart failure nearly double their risk of dying if they get COVID-19, according to research published today in ESC Heart Failure, a journal of the European Society of Cardiology (ESC).1 The small, single centre study highlights the need for patients with heart failure to take extra precautions to avoid catching COVID-19. ''Our results support prioritising heart failure patients for COVID-19 vaccination once it is available,'' said study lead investigator Dr. Amardeep Dastidar. (2021-01-06)

Bedside EEG test can aid prognosis in unresponsive brain injury patients
Assessing the ability of unresponsive patients with severe brain injury to understand what is being said to them could yield important insights into how they might recover, according to new research. (2021-01-05)

Some English bulldogs thought to have cancer may have newly identified syndrome
Some English bulldogs diagnosed with a common cancer may instead have a newly described, non-cancerous syndrome called polyclonal B?cell lymphocytosis. The discovery was made by Morris Animal Foundation-funded researchers at Colorado State University during a study to better understand B-cell chronic lymphocytic leukemia (BCLL). The team published their findings in the Journal of Veterinary Internal Medicine. (2021-01-05)

Global trial reveals life saving drug for acute myeloid leukemia
Results from a global trial across 148 sites in 23 countries, showing a 30 per cent improvement in survival in patients with acute myeloid leukemia (AML), significantly improving survival in older patients, over the age of 55, with the disease. AML is the most acute blood cancer in adults and its incidence increases with age, with a poor prognosis. (2020-12-23)

Palliative care improves quality of life for patients with advanced blood cancer
A first-of-its-kind intervention integrating palliative care early in the course of cancer therapy for patients with advanced acute myeloid leukemia (AML), a highly aggressive cancer of the blood and bone marrow, resulted in substantial improvements in patients' quality of life, mood and end-of-life care, a team of investigators has found. (2020-12-17)

Protein linked to progressive lung scarring in scleroderma patients
Osteopontin is discovered as the culprit behind systemic sclerosis patients' main cause of death: lung fibrosis. However, a repurposed immunosuppressive drug may combat the pro-inflammatory protein. (2020-12-17)

Proenkephalin (penKid®) included in the ADQI consensus statements publication as functional kidney biomarker for the management of AKI patients
The Acute Disease Quality Initiative (ADQI) recommends the use of novel biomarkers for AKI management, including functional biomarkers as penKid®. (2020-12-16)

Clowns may help children cope with the pain and anxiety of hospital treatment
Hospital clowns might help improve physical symptoms and psychological wellbeing in children and adolescents having treatment for acute or chronic conditions, finds a study in the Christmas issue of The BMJ. (2020-12-16)

Cancer researchers identify potential new class of drugs to treat blood and bone marrow cancers
CLEVELAND - A new study by researchers in Cleveland Clinic's Taussig Cancer Institute and Lerner Research Institute describes a novel class of targeted cancer drugs that may prove effective in treating certain common types of leukemia. The results first appeared online in Blood Cancer Discovery. (2020-12-15)

Point of Care testing can improve the detection and treatment of influenza
Southampton-led research has shown that implementing point-of-care testing in hospitals to diagnose influenza can lead to better treatment and faster recovery for patients. The researchers are now calling for routine use of these tests to become standard for patients admitted with acute respiratory symptoms during the influenza season. (2020-12-14)

Hematoxylin as a killer of CALR mutant cancer cells
Patients with myeloproliferative neoplasm (MPN) often have a carcinogenic mutated form of the calreticulin gene (CALR). Scientists of the research group of Robert Kralovics, Adjunct Principal Investigator at CeMM and group leader at the Medical University of Vienna, have now identified hematoxylin as a novel CALR inhibitor. The study, published in the renowned journal Blood, shows how hematoxylin compounds affect a specific domain of CALR and selectively kill those CALR mutant cells. The discovery has enormous therapeutic potential and gives hope for new treatment options. (2020-12-10)

Listen to the birds: illegal diet pill DNP might kill you on the long run
DNP, a weight loss agent withdrawn from the market in the late 1930s due to acute toxicity, has become increasingly popular in recent years through online illegal sales. A new study using a lifelong DNP treatment in an avian model found that while no obvious toxic effects were detected on the short to medium-term, DNP reduces lifespan by 20% on the long run. (2020-12-09)

Rutgers reports first instance of COVID-19 triggering recurrent Guillain-Barré Syndrome
Researchers at Rutgers Robert Wood Johnson Medical School have reported the first instance of COVID-19 triggering a recurrence of Guillain-Barré Syndrome - a rare disorder where the body's immune system attacks nerves and can lead to respiratory failure and death. (2020-12-08)

CRISPR-edited CAR T cells enhance fight against blood cancers
Knocking out a protein known to stifle T cell activation on CAR T cells using the CRISPR/Cas9 technology enhanced the engineered T cells' ability to eliminate blood cancers. (2020-12-07)

Chemotherapy and blinatumomab improves survival for patients with B-cell acute lympho
A study led by The University of Texas MD Anderson Cancer Center showed that first-line treatment with a regimen of chemotherapy combined with the monoclonal antibody blinatumomab resulted in increased survival and achieved a high rate of measurable residual disease (MRD) negativity for patients who were newly diagnosed with a high-risk form of acute lymphoblastic leukemia (ALL) known as Philadelphia chromosome-negative B-cell ALL (Ph-negative B-ALL). (2020-12-07)

Venetoclax added to standard treatments shows promise in high-risk myeloid blood cancers
The novel oral drug venetoclax can be safely added to standard therapies for some high-risk myeloid blood cancers and in early studies the combination shows promise of improved outcomes, say scientists from Dana-Farber Cancer Institute. (2020-12-05)

Kidney injury in diabetic ketoacidosis linked to brain injury
Researchers have identified factors that make children with diabetic ketoacidosis more likely to experience acute kidney injury. Analyzing data from a large, multicenter clinical trial, the researchers also found that children who experience acute kidney injury are more likely to also experience subtle cognitive impairment and demonstrate lower IQ scores, suggesting a pattern of multiple organ injury. (2020-12-04)

Donor stem cell transplant shown to improve survival in older patients with MDS
A new clinical trial offers the most compelling evidence to date that a donor stem cell transplant can improve survival rates for older patients with higher-risk myelodysplastic syndrome (MDS), Dana-Farber Cancer Institute investigators report at the virtual 62nd American Society of Hematology (ASH) Annual Meeting. (2020-12-04)

Genetically engineered T cells could lead to therapies for autoimmune diseases
University of Arizona Health Sciences immunobiologists have created a five-module chimeric antigen receptor T cell that is showing early potential to fight Type 1 diabetes. (2020-12-03)

Octapharma presents results of study on Octagam® 10% for severe COVID-19 patients at ASH
Clinical research presented by Octapharma USA at the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition will highlight the investigational use of high-dose Octagam® 10% [Immune Globulin Intravenous (Human)] for the most severe COVID-19 patients. Octapharma's intravenous immunoglobulin (IVIg) portfolio also will be featured in a study design poster focused on primary infection prophylaxis in patients with chronic lymphocytic leukemia during ASH, to be held virtually December 5 - 8 due to the coronavirus pandemic. (2020-12-02)

How thyroid function affects stress-related heart problems
Chest pain, shortness of breath, heart flutter and palpitations: these symptoms are not only characteristic of a heart attack, but can also be caused by another, as yet little researched condition. So-called Takotsubo cardiomyopathy is a rare but life-threatening disease of the heart that can occur during extreme stress events. Heart and hormone research teams in Bochum and Mannheim have now shown that there is apparently a strong link between the occurrence of Takotsubo syndrome and impaired thyroid function in patients. (2020-12-01)

Radboud university medical center research: Most lungs recover well after COVID-19
Lung tissue of patients who suffered severely from COVID-19 shows good recovery in most cases. This was revealed by a study carried out by the Radboud university medical center that has now been published in Clinical Infectious Diseases. A striking conclusion is that the group who was referred by a GP did not recover as well as patients who were admitted to the hospital's Intensive Care Unit (ICU). (2020-11-25)

Early trial hints CAR T cells may combat solid tumors in children with neuroblastoma
A phase 1 trial involving 12 children with relapsed neuroblastoma - a hard-to-treat pediatric cancer - shows that anticancer CAR T cells displayed signs of efficacy against these tumors while avoiding damage to nerve tissue. (2020-11-25)

Home health care improves COVID-19 outcomes
Survivors of COVID-19 are a vulnerable population who often have health ramifications from their illness and hospital stay. Upon returning home from acute care, large proportions of survivors experience functional dependencies, pain, dyspnea, and exhaustion. Until now, no data has been available on the outcomes of COVID-19 patients discharged home after hospitalization and their recovery needs. (2020-11-23)

WeChat group of chest pain center for patients with acute ST-segment elevation myocardial infarction
In a new publication from Cardiovascular Innovations and Applications; DOI https://doi.org/10.15212/CVIA.2019.0590, Liu Yue, Qin Zhu-Yun, Yang Xin, Tang Rong and Gao Ling-Yun from the The First Affiliated Hospital of Chongqing Medical University, Chongqing, China consider the use of a social media platform (WeChat) to provide faster treatment and improve prognoses for a group of patients with acute ST-segment Elevation Myocardial Infarction. (2020-11-19)

The challenges of treating acute myocardial infarction due to variant angina
In a new publication from Cardiovascular Innovations and Applications; DOI https://doi.org/10.15212/CVIA.2019.1262, Wen-Yuan Ding, Jia-Min Li, Fei Zheng, Li-Li Wang, Xin-Yi Wei and Guo-Hua Li from Shandong Provincial Qianfoshan Hospital, Ji'nan, China, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Ji'nan, China and Shandong First Medical University, Tai'an, China consider the challenges of treating acute myocardial infarction due to variant angina. (2020-11-19)

The long road to dementia
Alzheimer's disease develops over decades. It begins with a fatal chain reaction in which masses of misfolded beta-amyloid proteins are produced that in the end literally flood the brain. Researchers from the Hertie Institute for Clinical Brain Research and the German Center for Neurodegenerative Diseases show in the journal Nature Neuroscience that this chain reaction starts much earlier in mice than commonly assumed. (2020-11-17)

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