Current Acute Myeloid Leukemia News and Events | Page 25

Current Acute Myeloid Leukemia News and Events, Acute Myeloid Leukemia News Articles.
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Link between alcohol consumption and cardiac arrhythmias
Researchers who studied beer drinkers at the Munich Octoberfest have found that the more alcohol consumed the higher was the likelihood of developing abnormal heart rhythms called cardiac arrhythmias. The research, which is published in the European Heart Journal, is important because it is thought that arrhythmias can, in some circumstances, lead to atrial fibrillation, an irregular heart beat that can result in severe discomfort and, in the long run, more serious consequences such as heart failure and stroke. (2017-04-25)

Studying a catalyst for blood cancers
Researchers at Sylvester today published a paper in the prestigious journal Nature Communications, which describes how TET2 loss can open the door for mutations that drive myeloid, lymphoid, and other cancers. (2017-04-25)

Methadone may reduce need for opioids after surgery
Patients undergoing spinal fusion surgery who are treated with methadone during the procedure require significantly less intravenous and oral opioids to manage postoperative pain, reports a new study published in the May issue of Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists (ASA). (2017-04-24)

Study identifies a distinct type of common gastrointestinal bleeding
In an article published online on April 21, 2017 by the Journal of Investigative Medicine, researchers at the Medical University of South Carolina and elsewhere have identified a unique bleeding syndrome associated with cirrhosis and portal hypertension. The investigators have coined a term for the syndrome: acute on chronic bleeding. Clinicians should be aware of the association of this presentation with cirrhosis and portal hypertension for appropriate diagnosis and treatment. (2017-04-21)

Second cancers deadlier in young patients
Second cancers in children and adolescents and young adults (AYA) are far deadlier than they are in older adults and may partially account for the relatively poor outcomes of cancer patients ages 15-39 overall, a new study by UC Davis researchers has found. Study will be published April 20 in JAMA Oncology. (2017-04-20)

More Americans being hospitalized for a hypertensive emergency, but fewer are dying
A new article published in the American Journal of Hypertension finds a rising trend in hospitalization for hypertensive emergency with reduction in hospital mortality during the last decade. The presence of acute cardiorespiratory failure, chest pain, stroke, acute chest pain, and aortic dissection were most predictive of higher hospital mortality among other complications. (2017-04-20)

City of Hope researchers successfully prevent graft-versus-host disease
City of Hope researchers believe they may have found a way to prevent graft-versus-host disease after stem cell transplants while retaining the transplants' positive effects on fighting leukemia and lymphoma. The preclinical study results were published in the Journal of Clinical Investigation. (2017-04-17)

Nanoparticles reprogram immune cells to fight cancer
Study in Nature Nanotechnology describes new method to transform immune cells, while inside the body, into leukemia-fighting powerhouses. (2017-04-17)

UNC researchers identify a new HIV reservoir
A UNC research team has identified a new cell in the body where HIV persists despite treatment. This discovery has major implications for cure research. (2017-04-17)

Worldwide survey finds 16 percent rate of acute neurological conditions in critically ill children
Sixteen percent of children in pediatric intensive care units (ICUs) have acute neurological conditions with brain damage due to cardiac arrest, traumatic brain injury, or other causes, reports an international survey study in Pediatric Critical Care Medicine. The journal is published by Wolters Kluwer. (2017-04-13)

SLU heart failure expert pens editorial for New England Journal of Medicine
In patients experiencing a worsening of heart failure, the primary objective of treatment should be the patient-centric goal of symptom relief, says the author of an editorial in the current issue of the New England Journal of Medicine. (2017-04-12)

Researchers reveal developmental mechanisms behind rare bone marrow disorder
Myelodysplastic syndrome is an umbrella term used to describe disorders characterized by the bone marrow's inability to produce normal blood cells. Researchers from Charité - Universitätsmedizin Berlin have found that a mutation in a specific tumor suppressor gene is one possible reason why children with a very rare genetic disorder develop myelodysplastic syndrome. Results from this research have been published in the current edition of the Journal of Clinical Investigation. (2017-04-12)

The Lancet Haematology: Global inequalities in survival for childhood leukaemia persist, highlighting need for better care
Although global inequalities in survival from childhood leukaemia have narrowed, they still persist with five-year survival in some countries nearly twice as high as in others for children diagnosed during 2005-2009, according to a study published in The Lancet Haematology. (2017-04-11)

Spinal manipulation treatment for low back pain associated with modest improvement in pain, function
Among patients with acute low back pain, spinal manipulation therapy was associated with modest improvements in pain and function at up to six weeks, with temporary minor musculoskeletal harms, according to a study published by JAMA. (2017-04-11)

New study offers hope for more effective treatment of leukemia
The discovery of a protein signature that is highly predictive of leukemia could lead to novel treatments of the leading childhood cancer, according to new study showing that competition among certain proteins causes an imbalance that leads to leukemia. (2017-04-11)

Study examines stroke hospitalization rates, risk factors
A new article published by JAMA Neurology examines acute stroke hospitalization rates in younger adults 18 to 64 by stroke type and patient age, sex and race/ethnicity, along with associated risk factors. (2017-04-10)

Cancer commandeers immature immune cells to aid its successful spread
More typically, these immature immune cells might help us fight cancer, but scientists have now shown cancer can commandeer the cells to help it spread. (2017-04-06)

Inflammation: It takes two to tango
Signal molecules called chemokines often work in tandem to recruit specific sets of immune cells to sites of tissue damage. A systematic analysis of their interactions by researchers from Ludwig-Maximilians-Universitaet in Munich pinpoints potential targets for new therapies. (2017-04-06)

New study sheds light on 'lung sparing effect'
A new study suggests that in cases of severe malnutrition, the body may prioritize lung development at the expense of other less vital growth. (2017-04-05)

Researchers develop novel flu test to speed up respiratory treatment
Doctors and researchers in Southampton have developed a novel way of using a swab test which can rapidly diagnose flu and other viral infections in patients with severe respiratory conditions -- resulting in shorter courses of antibiotics and less time in hospital. (2017-04-05)

Gallbladder removal is common -- but is it necessary?
Johns Hopkins researchers say that the findings they published in the current edition of The American Journal of Gastroenterology could have important implications for the field of personalized medicine. (2017-04-03)

Telomere length predicts cancer risk
The length of the 'caps' of DNA that protect the tips of chromosomes may predict cancer risk and be a potential target for future therapeutics, University of Pittsburgh Cancer Institute scientists will report today at the American Association for Cancer Research Annual Meeting. Longer-than-expected telomeres -- which are composed of repeated sequences of DNA and are shortened every time a cell divides -- are associated with an increased cancer risk. (2017-04-03)

An epigenetic lesion could be responsible for acute T-cell leukemia
Researchers from the Epigenetics and Cancer Biology Program (PEBC) led by Dr. Manel Esteller at IDIBELL have discovered how an epigenetic lesion can lead to T-cell acute lymphoblastic leukemia. The article, published in the journal Leukemia, correlates the lesion with the activation of a powerful oncogen capable of malignizing this type of cells of the immune system. (2017-03-30)

Vanderbilt study finds natural chemical helps brain adapt to stress
A natural signaling molecule that activates cannabinoid receptors in the brain plays a critical role in stress-resilience -- the ability to adapt to repeated and acute exposures to traumatic stress, according to researchers at Vanderbilt University Medical Center. (2017-03-29)

Interferon-beta producing stem cell-derived immune cell therapy on liver cancer
Induced pluripotent stem (iPS) cell-derived myeloid cells (iPS-ML) that produce the anti-tumor protein interferon-beta (IFN-beta) have been produced and analyzed by researchers from Kumamoto University, Japan. Using human iPS-ML in a mouse model, they found that the cells migrate to and deliver IFN-beta to liver tumors thereby reducing cancer proliferation and increasing survival time. (2017-03-28)

Researchers show p300 protein may suppress leukemia in MDS patients
Scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have shown that p300, a protein that increases gene expression by attaching acetyl molecules to DNA, may stop myelodysplastic syndrome (MDS) from developing into acute myeloid leukemia (AML). (2017-03-27)

Analysis of antibiotics, appendectomy for uncomplicated appendicitis in kids
An analysis of several studies including 404 pediatric patients suggests antibiotic treatment for acute uncomplicated appendicitis was safe and effective in the majority of patients but the risk that antibiotic treatment would fail increased in patients with appendicolith, a calcified deposit in the appendix, according to a new article published online by JAMA Pediatrics. (2017-03-27)

Are arm measurements better than BMI to assess nutrition status in child cancer survivors?
Arm anthropometry is a simple method to determine if a person is overweight or obese, and because it can distinguish between fat and muscle mass, unlike body mass index (BMI), it is a valuable method for assessing muscle loss in long-term survivors of childhood cancer. (2017-03-23)

AML study correlates gene mutations with 34 disease subgroups
A large, new study of adults with acute myeloid leukemia (AML) correlates 80 cancer-related gene mutations with five subtypes of AML, which are defined by the presence of specific chromosomal abnormalities. The findings might help guide mutation testing and treatment decisions in the future. (2017-03-21)

Scientists find possible Achilles heel of treatment-resistant cancers
Scientists identify two signaling proteins in cancer cells that make them resistant to chemotherapy, and show that blocking the proteins along with chemotherapy eliminate human leukemia in mouse models. Reporting results March 20 in Nature Medicine, researchers at Cincinnati Children's Hospital Medical Center suggest that blocking the signaling proteins c-Fos and Dusp1 as part of combination therapy might cure several types of kinase-driven, treatment-resistant leukemia and solid tumor cancers. (2017-03-20)

Revised understanding of graft-versus-host disease origins offers new direction for potential therapy
An international research team led by the University of Michigan Life Sciences Institute is changing the understanding of the key cellular and molecular events that trigger graft-versus-host disease, an often fatal complication of bone marrow transplants. (2017-03-20)

Penn researchers find patients' annual financial burden under Medicare Part D is 'too much too soon'
A study released today by researchers at the Perelman School of Medicine at the University of Pennsylvania documents the patient out-of-pocket cost burden under Medicare prescription drug plans (known as Medicare Part D) and finds that despite having insurance, Medicare patients using specialty drugs paid thousands of dollars in out-of-pocket costs in a calendar year. Study authors also propose policy changes that would help patients better predict monthly bills for critical medications. (2017-03-17)

Delirium is associated with 5-fold increased mortality in acute cardiac patients
Delirium is associated with a five-fold increase in mortality in acute cardiac patients, according to research published today in European Heart Journal: Acute Cardiovascular Care. Delirium was common and affected over half of acute cardiac patients aged 85 years and older. (2017-03-16)

Vitamin E may decrease the risk of acute kidney injury after coronary catheterization
Acute kidney injury is quite a common adverse effect that associates with coronary angiography and percutaneous coronary interventions. Vitamin E may decrease the risk of acute kidney injury by up to 62 percent according to a meta-analysis of three randomized trials published in the American Journal of Kidney Diseases. (2017-03-15)

New driver, target in advanced mucosal melanoma
A University of Colorado Cancer Center study published March 15, 2017, in the journal Melanoma Research uses the unique resource of over 600 melanoma samples collected at the university to demonstrate, for the first time, novel mutations involved in mucosal melanoma, paving the way for therapies to treat this overlooked subtype. (2017-03-15)

Breathtaking gene discovery in Dalmatian dogs
University of Helsinki researchers have uncovered a novel gene associated with acute respiratory distress syndrome in dogs. The new research on this fatal disease may also help us understand the mechanisms of respiratory diseases in humans. (2017-03-14)

For some, high blood pressure associated with better survival
Patients with both type 2 diabetes and acute heart failure face a significantly lower risk of death but a higher risk of heart failure-related hospitalizations if they had high systolic blood pressure on discharge from the hospital compared to those with normal blood pressure, according to a study scheduled for presentation at the American College of Cardiology's 66th Annual Scientific Session. (2017-03-08)

Drug resistance of cancer cells crucially affected by expression levels of ABC-transporters
How is drug resistance of cancer cells affected by ABC-transporters? A new research paper, published in the open-access journal BioDiscovery, looks at the complex relationship between the second generation of tyrosine kinase inhibitor (TKI) -- Dasatinib (DAS), and the expression of ATP-binding cassette (ABC) transporters, ABCB1 and ABCG2, to assess whether these drug transporters might compromise therapeutic effect. (2017-03-08)

Cancer-causing benzene found in e-cigarette vapors operated at high power
Portland State University scientists have found that significant levels of cancer-causing benzene in e-cigarette vapors can form when the devices are operated at high power. The finding by a research team headed by chemistry professor James F. Pankow were published March 8, 2017 in the online journal PLOS ONE. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0173055 (2017-03-08)

New England Journal of Medicine publishes long-term results of Gleevec®
Today the New England Journal of Medicine published results from a nearly 11-year follow-up study, that showed an estimated overall survival rate of 83.3 percent. According to the National Cancer Institute, prior to Gleevec's 2001 FDA approval, fewer than one in three CML patients survived five years past diagnosis. (2017-03-08)

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