Current Adverse Drug Reactions News and Events

Current Adverse Drug Reactions News and Events, Adverse Drug Reactions News Articles.
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What is COVID-19's impact on Black and Latino persons living with HIV?
Study looks at COVID-19 effects on engagement in HIV care, HIV medication use, and overall well-being among low-income Black and Latino individuals who have lived with HIV for many years. (2021-02-22)

Periodontal disease increases risk of major cardiovascular events
People with periodontitis are at higher risk of experiencing major cardiovascular events, according to new research from Forsyth Institute and Harvard University scientists and colleagues. (2021-02-21)

Ultrafast electron dynamics in space and time
Often depicted as colourful balloons or clouds, electron orbitals provide information on the whereabouts of electrons in molecules, a bit like fuzzy snapshots. In order to understand the exchange of electrons in chemical reactions, it is not only important to know their spatial distribution but also their motion in time. Scientists from Julich, Marburg, and Graz have now made huge progress in this direction: They successfully recorded orbital images with an extremely high temporal resolution. (2021-02-18)

Scientists able to see how potential cancer treatment reacts in single cell
Using a 185 metre beamline at the Diamond synchrotron, researchers could see how Osmium, a rare precious metal that could be used for cancer treatments, reacts in a single human lung cancer cell. This is a major step forward in discovering new anti-cancer drugs for researchers at the University of Warwick. (2021-02-17)

Quickly identify high-performance multi-element catalysts
Catalysts consisting of at least five chemical elements could be the key to overcoming previous limitations in the production of green hydrogen, fuel cells, batteries or CO2 reduction. However, finding the optimal composition of these multi-element catalysts is like looking for a needle in a haystack: testing thousands to millions of possible combinations cannot be realized. (2021-02-17)

IU study finds unintended consequences of state, opioid policies
Study reveals the unintended and negative consequences of policies designed to reduce the supply of opioids in the population for overdose. (2021-02-17)

Breakthrough in organic chemistry: Asymmetric syntheses of useful, unique chiral compounds
''N?C axially chiral compounds'' are important chiral molecules with various applications in medicinal chemistry and chiral technology. However, there is a scarcity of research on ways to synthesize them in an enantioselective (asymmetric) manner, to obtain useful forms of the compounds. Researchers at Shibaura Institute of Technology, Japan, have rectified this, by developing a catalytic enantioselective method to synthesize various N?C axially chiral compounds. A recent article in Accounts of Chemical Research summarizes their achievements. (2021-02-16)

The water surface is a fantastic place for chemical reactions
Using an advanced technique, scientists from the RIKEN Cluster for Pioneering Research have demonstrated that a chemical reaction powered by light takes place ten thousand times faster at the air-water interface--what we usually call the water surface--than in the bulk of the water, even when the light has equivalent energy. This finding could help our understanding of the many important chemical and biological processes that take place at the water surface. (2021-02-15)

Immunotherapy -- targeted drug combination improves survival in advanced kidney cancer
Patients with advanced kidney cancer, who received a targeted drug combined with a checkpoint-blocker immunotherapy agent had longer survival than patients treated with the standard targeted drug, said an investigator from Dana-Farber Cancer Institute, reporting results from a phase 3 clinical trial. (2021-02-13)

Flowers of St. John's Wort serve as green catalyst
An interdisciplinary team of scientists from the School of Science at TU Dresden has for the first time used dried flowers of St. John's Wort (genus Hypericum) as an active catalyst in various photochemical reactions. This conceptually new and sustainable process was registered as a German patent and presented in the journal 'Green Chemistry'. (2021-02-12)

Get a load of ZIF! Better delivery of cancer immunotherapy
An antibody loaded onto a porous metal organic framework is released by the acidic environment that surrounds tumors, avoiding the adverse effects of administering the antibody alone. (2021-02-11)

Combination of pine scent and ozone as super source of particulate emissions
Scientists have managed to figure out why conifer forests produce so many fine particles into the atmosphere. Aerosol particles are particularly abundant when ?-pinene, the molecule responsible for the characteristic pattern of pine trees reacts with atmospheric ozone. (2021-02-11)

Metabolism: Researchers first to shed light on structure of huge enzyme complex
A new method has enabled the natural structure of particularly large and complex enzymes to be revealed. Scientists at Martin Luther University Halle-Wittenberg (MLU) and TU Berlin have published their findings in the journal Cell Reports. They investigated a multi-enzyme complex that plays an essential role in metabolism and have discovered that it functions differently than previously thought. This will help scientists better understand certain diseases. (2021-02-10)

Texas A&M researchers discover energy drinks' harmful effects on heart
A team of researchers, led by a Texas A&M University professor, has found that some energy drinks have adverse effects on the muscle cells of the heart. (2021-02-10)

Peanut allergy affects even more U.S. adults than children
Peanut allergy affects at least 4.5 million adults in the U.S., many of whom report developing their first allergy symptoms during adulthood. Although three out of four Americans with peanut allergy are over 17 years old, peanut allergy is often considered a predominantly pediatric concern. There are currently no FDA-approved therapies for patients with adult-onset food allergy. (2021-02-09)

Researchers identify a new molecular mechanism related to severe anaphylaxis
In a study led by researchers of the University of Barcelona and IDIBAPS, researchers analyzed the mutation of a gen detected in a patient who suffered from recurrent anaphylactic shocks caused by the allergy to paper wasp venom (Polistes dominula). The results, published in the Journal of Allergy and Clinical Immunology, revealed a new molecular mechanism that can control the degree of severity in an anaphylactic reaction. (2021-02-09)

Chemists developed a simplified method for pharmaceutical compounds synthesizing
A team of chemists from Immanuel Kant Baltic Federal University and Saint Petersburg State University developed a simple and efficient method to synthesize tetrahydroisoquinolines--important organic molecules for drug discovery. The method consists of just three steps. (2021-02-09)

Understanding catalytic couplings: not all synergies are simple
Negishi cross-coupling reactions have been widely used to form C-C bonds since the 1970s and are often perceived as the result of two metals (i.e zinc and palladium/nickel) working in synergy. Researchers from the Martin group at ICIQ have delved into the Negishi cross-coupling of aryl esters using nickel catalysis to understand how this reaction works at the molecular level and how to improve it. The results have been published in Nature Catalysis. (2021-02-08)

Mast cells: Sentinels and high-speed messengers of the immune defense
A team of scientists at the Institute for Molecular and Clinical Immunology at the Otto-von-Guericke University Magdeburg unravels a crucial mechanism of cell-cell-communication during the defense against pathogens. (2021-02-04)

A single-molecule guide to understanding chemical reactions better
Scientists at Tokyo Institute of Technology (Tokyo Tech) report measurement of electrical conductivity of single DNA molecules as a way of monitoring the formation of double-stranded DNA on a gold surface. In their latest paper, they investigate the time evolution of the reaction and report findings not observed previously, demonstrating the suitability of the single-molecule approach in elucidating reaction pathways and exploring novel chemical processes. (2021-02-04)

Mysterious organic scum boosts chemical reaction efficiency, may reduce chemical waste
Chemical manufacturers frequently use toxic solvents such as alcohols and benzene to make products like pharmaceuticals and plastics. Researchers are examining a previously overlooked and misunderstood phenomenon in the chemical reactions used to make these products. This discovery brings a new fundamental understanding of catalytic chemistry and a steppingstone to practical applications that could someday make chemical manufacturing less wasteful and more environmentally sound. (2021-02-04)

The Lancet: Study reports preliminary efficacy and safety results from interim analysis of Russian COVID-19 phase 3 vaccine trial
An interim analysis of data from the phase 3 trial of the COVID-19 vaccine from Russia (Gam-COVID-Vac) suggests that a two-dose regimen of the adenovirus-based vaccine offers 91.6% efficacy against symptomatic COVID-19. The preliminary findings, published in The Lancet, are based on analysis of data from nearly 20,000 participants, three-quarters of whom received the vaccine and one quarter received a placebo. (2021-02-02)

Toward safer steroids: Scientists devise method for improving safety of drug used to treat COVID-19, autoimmune disorders and more
Scripps Research scientists bring together multiple technologies to engineer potentially safer glucocorticoids, drugs used to treat COVID-19 and other conditions. (2021-02-02)

Extreme UV laser shows generation of atmospheric pollutant
Hokkaido University scientists show that under laboratory conditions, ultraviolet light reacts with nitrophenol to produce smog-generating nitrous acid. (2021-02-02)

Batteries that can be assembled in ambient air
POSTECH-Ulsan College joint research team develops a multi-functional separator membrane that traps impurities in the air. Opens the possibility of a battery manufacturing environment that reduces processing costs without a dry room. (2021-02-01)

BU researchers identify promising therapeutic agent against melanoma
There have been great advances in treating melanoma over the past five years, however, even with these treatments many patients quickly develop drug resistance and die from their disease. A new study from Boston University School of Medicine (BUSM) has discovered that a drug (YK-4-279) that was previously created to target one specific type of protein has much broader use against a family of proteins that act to promote melanoma. (2021-02-01)

LCMC3: Neoadjuvant atezolizumab safe, meets primary endpoint of pathologic response rate
Primary analysis of the Lung Cancer Mutation Consortium (LCMC) 3 study revealed that neoadjuvant atezolizumab prior to lung cancer surgery was well tolerated by patients and met its primary endpoint of 20% major pathologic response rate, according to research presented today at the International Association for the Study of Lung Cancer's World Conference on Lung Cancer. (2021-01-30)

Making wheat and peanuts less allergenic
Research uses plant breeding and biotechnology to remove proteins associated with food allergies. (2021-01-27)

Well connected through amides
Linking molecular components through amide bonds is one of the most important reactions in research and the chemical industry. In the journal Angewandte Chemie, scientists have now introduced a new type of reaction for making amide bonds. Called an ASHA ligation, this reaction is fast, efficient, works under mild aqueous conditions, and is broadly applicable. (2021-01-27)

Offer COVID-19 vaccines to pregnant or breastfeeding people
People who are pregnant, breastfeeding or trying to conceive should be offered the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine based on ethical grounds, argue authors of a commentary in CMAJ (Canadian Medical Association Journal) (2021-01-27)

Gut microbiota reveals whether drug therapies work in inflammatory bowel diseases
A study recently completed at the University of Helsinki indicates that the gut microbiota of patients suffering from inflammatory gastrointestinal disorders can be used to predict whether they will benefit from expensive therapies. The study also confirms the key role of therapies that have a beneficial effect on the gut microbiota in inflammatory bowel diseases. (2021-01-26)

Nixing bone cancer fuel supply offers new treatment approach, mouse study suggests
An innovative approach to treating bone tumors - starving cancer cells of the energy they need to grow - could one day provide an alternative to a commonly used chemotherapy drug without the risk of severe side effects, suggests a new study from Washington University School of Medicine in St. Louis. (2021-01-26)

Bioorthogonally catalyzed lethality strategy generates targeting drugs within tumor
Selectively killing tumor while not causing damage to normal cells still remains a challenge in cancer chemotherapy. Professor Hongke Liu from Nanjing Normal University together with Professor Jing Zhao and Professor Zijian Guo from Nanjing University developed a novel strategy---bioorthogonally-catalyzed lethality to generate efficient anticancer species between two non-toxic components only within cancer cells and tumors without external catalysts, realizing the precise and efficient anticancer chemotherapy. (2021-01-25)

Boosting the efficiency of carbon capture and conversion systems
Researchers at MIT have developed a method to boost the performance of carbon capture systems that use catalytic surfaces to enhance the rates of carbon-sequestering electrochemical reactions. (2021-01-25)

Light pollution linked to preterm birth increase
Scientists conducted the first study to examine the fetal health impact of light pollution based on a direct measure of skyglow, an important aspect of light pollution. Using an empirical regularity discovered in physics, called Walker's Law, a team from Lehigh University, Lafayette College and the University of Colorado Denver in the U.S., found evidence of reduced birth weight, shortened gestational length and preterm births. (2021-01-25)

Potential combined drug therapy for lung cancer
Researchers at Kanazawa University report in Clinical Cancer Research that in the most common type of lung cancer, certain secondary mutations occurring with another gene alteration known as ALK make the efficacy of alectinib, an otherwise commonly used drug for treating lung cancer, become unfavorable. Combining alectinib with another kind of drug can overcome this adverse effect, however. (2021-01-22)

University of Cincinnati research unveils possible new combo therapy for head and neck cancer
Researchers at the University of Cincinnati have tested a new combination therapy in animal models to see if they could find a way to make an already effective treatment even better. Since they're using a Food and Drug Administration-approved drug to do it, this could help people sooner than later. (2021-01-22)

Immunology - Functionality of immune cells in early life
A study by Ludwig-Maximilians-Universitaet (LMU) in Munich researchers shows that putatively immature dendritic cells found in young children are able to induce robust immune responses. The results could lead to improved vaccination protocols. (2021-01-21)

Tough childhood damages life prospects
An adverse upbringing often impairs people's circumstances and health in their adult years, especially for couples who have both had similar experiences. This is shown by a new study, carried out by Uppsala University researchers, in which 818 mothers and their partners filled in a questionnaire one year after having a child together. The study is now published in the scientific journal PLOS ONE. (2021-01-21)

Do antidepressants help chronic back pain and osteoarthritis?
Antidepressants are commonly used worldwide to treat pain, however new research from the University of Sydney shows they offer little to no help for people suffering chronic back pain and osteoarthritis and may even cause harm. (2021-01-20)

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