Current Aging News and Events

Current Aging News and Events, Aging News Articles.
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For breakthroughs in slowing aging, scientists must look beyond biology
A trio of recent studies highlight the need to incorporate behavioral and social science alongside the study of biological mechanisms in order to slow aging. The three papers, published in concert in Ageing Research Reviews, emphasized how behavioral and social factors are intrinsic to aging. (2021-02-22)

Gut microbiome implicated in healthy aging and longevity
The gut microbiome is an integral component of the body, but its importance in the human aging process is unclear. ISB researchers and their collaborators have identified distinct signatures in the gut microbiome that are associated with either healthy or unhealthy aging trajectories, which in turn predict survival in a population of older individuals. The work is set to be published in the journal Nature Metabolism(2021-02-18)

A machine-learning approach to finding treatment options for Covid-19
MIT researchers have developed a machine-learning approach to identify drugs that could be repurposed to fight Covid-19. The advance could boost clinical trial efforts, and it could be adapted to a broader range of diseases. (2021-02-15)

Unlocking the mystery behind skeletal aging
Researchers from the UCLA School of Dentistry have identified the role a critical enzyme plays in skeletal aging and bone loss, putting them one step closer to understanding the complex biological mechanisms that lead to osteoporosis, the bone disease that afflicts some 200 million people worldwide. Findings, published online in the journal Cell Stem Cell, could hold an important key to developing more effective treatments for osteoporosis and improving the lives of an aging population. (2021-02-15)

Male sex, BMI, smoking and depression all increase biological age
A 'biological age' score predicts that being male, overweight, a smoker and having depression all contribute to biological aging, a study published today in eLife reports. (2021-02-09)

Research establishes a new method to predict individual risk of cognitive decline
This work shows that direct measures of brain signatures during mental activity are more sensitive and accurate predictors of memory decline than current standard behavioral testing. (2021-02-05)

DNA-based technique allows researchers to determine age of living beluga whales in Alaska
Researchers can now determine the age and sex of living beluga whales in Alaska's Cook Inlet thanks to a new DNA-based technique that uses information from small samples of skin tissue. (2021-02-04)

Aging-US: Sulforaphane promotes C. elegans longevity and healthspan
'The results in this Aging-US research output, indicate that sulforaphane prolongs the lifespan and healthspan of C. elegans through insulin/IGF-1 signaling.' (2021-02-03)

Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders
A collaborative research group led by Professor Makoto Nakanishi of the Institute of Medical Science, The University of Tokyo (IMSUT) has identified an inhibitor of the glutamate metabolic enzyme GLS1 so that its administration selectively eliminates senescent cells in vivo. They confirmed that the GLS1 inhibitor eliminated senescent cells from various organs and tissues in aged mice, ameliorating age-associated tissue dysfunction and the symptoms of obese diabetes, arteriosclerosis, and NASH. The results of this research were published in 'Science' on January 15, 2021. (2021-02-03)

Oncotarget: The goal of geroscience is life extension
Dr. Mikhail V. Blagosklonny from The Roswell Park Cancer Institute said, ''Although we do not know everything about aging, we now know enough to start its pharmacologic suppression using clinically approved drugs.'' (2021-02-02)

Aging-US: A pro-diabetogenic mtDNA polymorphism in mitochondrial-derived peptide
'The m.1382A>C polymorphism is associated with susceptibility to T2D in men, possibly interacting with exercise, and contributing to the risk of T2D in sedentary males by reducing the activity of MOTS-c.' (2021-02-02)

Aging-US: Anserine protected against cognitive decline
The Aging-US results suggest that anserine protects elderly persons with MCI from cognitive declines by suppressing MPO-mediated neuroinflammatory responses. (2021-02-02)

Aging-US: Screening Alzheimer's disease by facial complexion using artificial intelligence
This Aging-US study showed that deep learning programs such as Xception have the ability to differentiate the faces of patients with mild dementia from that of patients without dementia. (2021-02-02)

An integrated approach for an effective prevention of Alzheimer´s disease
Recent studies demonstrate that styles of life involving interdependent actions of exercise, oriental practices such as QiGong, nutrition, mental and social activity and mindfulness are effective in preventing Alzheimer´s disease and other forms of dementia (2021-02-01)

Scientists publish a blueprint to apply artificial intelligence to extend human longevity
The international team of artificial intelligence experts and medical doctors propose a framework for the application of next-generation AI to extend human longevity (2021-01-27)

A compound that slows bone loss, and a resource for developing treatments to slow aging
A compound that extends lifespan in a tiny nematode worm slows bone loss in aging mice. That surprising result comes from a longitudinal and functional study of 700 aging mice at the Buck Institute, a project that provides a treasure trove of data for researchers aiming to develop therapeutics to slow aging and age-related diseases. The study is currently online in the Journal of Bone and Mineral Research Plus. (2021-01-26)

Aging-US: Growth factor beta type 1 and hypoxia-inducible factor 1 transcription complex
''The Aging-US authors report for the first time that in human breast cancer, AML and embryonic cells, HIF-1 and AP-1 upregulate the expression of TGF-β'' (2021-01-25)

Aging-US: PAM (PIK3/AKT/mTOR) signaling in glia: potential contributions to brain tumors
'The consideration of aberrant PIK3/AKT/mTOR signaling in glia during aging elucidates several therapeutic opportunities for brain tumors'. (2021-01-25)

Aging-US: Nicotinamide mononucleotide in degenerative model of retinal detachment
'This Aging-US article concludes that NMN administration exerts neuroprotective effects on photoreceptors' (2021-01-25)

Hair aging differs by race, ethnicity
While aging is an unavoidable biological process with many influencing factors that results in visible changes to the hair, there is limited literature examining the characteristics of hair aging across the races. Now a new study describes the unique characteristics of hair aging among different ethnicities that the authors hope will aid in a culturally sensitive approach when making recommendations to prevent hair damage during one's life-time. (2021-01-21)

'Attitude of gratitude' keeps older people in Japan feeling hopeful as they age
Older people in Japan have an 'attitude of gratitude' which keeps them feeling hopeful despite the challenges of aging, a new study says. (2021-01-21)

'Aging well' greatly affected by hopes and fears for later life, OSU study finds
If you believe you are capable of becoming the healthy, engaged person you want to be in old age, you are much more likely to experience that outcome, a recent Oregon State University study shows. (2021-01-21)

Severe menopause symptoms often accompany premature ovarian insufficiency
Hot flashes, insomnia, and vaginal dryness are commonly reported symptoms that accompany the menopause transition. A new study suggests that such symptoms--especially psychological and sexual problems--are worse for women who have premature ovarian insufficiency (POI) than for women undergoing natural menopause. Study results are published online today in Menopause, the journal of The North American Menopause Society (NAMS). (2021-01-20)

University of Kentucky researchers link low blood amylin level to reduced progression of Alzheimer's
The team's work shows that early pathological processes in the brains of individuals who are genetically predisposed to develop Alzheimer's disease are modulated by a pancreatic hormone called amylin. This study is the first to show that the brains of patients with familial AD accumulate amyloid-forming amylin secreted by the pancreas. (2021-01-20)

NAD+ can restore age-related muscle deterioration
Scientists at EPFL have discovered that Alzheimer's-like protein aggregates underly the muscle deterioration seen in aging. But the aggregates can be reversed by boosting the levels of nicotinamide adenine dinucleotide (NAD+), which turns on the defense systems of mitochondria in cells and restores muscle function. (2021-01-19)

How dietary choice influences lifespan in fruit flies
Having a choice of foods may accelerate aging and shorten the lifespan of fruit flies, according to a study published today in the open-access eLife journal. (2021-01-19)

Better diet and glucose uptake in the brain lead to longer life in fruit flies
Researchers from Tokyo Metropolitan University have discovered that fruit flies with genetic modifications to enhance glucose uptake have significantly longer lifespans. Looking at the brain cells of aging flies, they found that better glucose uptake compensates for age-related deterioration in motor functions, and led to longer life. The effect was more pronounced when coupled with dietary restrictions. This suggests healthier eating plus improved glucose uptake in the brain might lead to enhanced lifespans. (2021-01-16)

Physical frailty syndrome: a cacophony of multisystem dysfunction
Aging experts synthesize converging evidence that the aging-related pathophysiology underpinning the clinical presentation of phenotypic frailty is a state of lower functioning due to severe dysregulation of the complex dynamics in our bodies that maintains health and resilience. When severity passes a threshold, the clinical syndrome and its phenotype are diagnosable. This paper summarizes evidence meeting criteria for physical frailty as a product of complex system dysregulation distinct from the cumulative-deficit-based frailty index of multimorbiditys. (2021-01-14)

Can menopause be blamed for increased forgetfulness and lack of attention?
If you're a bit more forgetful or having more difficulty processing complex concepts than in the past, the problem may be your menopause stage. A new study claims that menopause stage is a key determinant of cognition and, contrary to previous studies, shows that certain cognitive declines may continue into the postmenopause period. Study results are published online today in Menopause, the journal of The North American Menopause Society (NAMS). (2021-01-13)

GSA publishes seven new research articles on COVID-19 and aging
The Gerontological Society of America's highly cited, peer-reviewed journals are continuing to publish scientific articles on COVID-19. The following were published between December 5 and January 6; all are free to access. (2021-01-13)

Researchers identify promising model for studying human aging
The research team plans to study how the changes observed in animal models mimic the deterioration of muscle function in aging humans. (2021-01-13)

A CNIO study links severe COVID-19 disease to short telomeres
The data show that telomeres are shorter in patients suffering more severe COVID-19 pathologies. The researchers propose that one of the consequences of the viral infection is shortening of the telomeres, which, in turn, hampers the regeneration of lung tissue and causes prolonged sequelae in some patients. The study, published in the journal 'Aging', suggests the usefulness of a possible therapy for patients with post-COVID pulmonary injury based on activation of the enzyme telomerase. (2021-01-11)

Sexual dysfunction hits some women harder than others as they age
Sexual dysfunction often accompanies the menopause transition. Yet, not all women experience it the same. A new study identified the determinants that affect a woman's risk of sexual dysfunction and sought to determine the effectiveness of hormone therapy in decreasing that risk and modifying sexual behavior. Study results are published online in Menopause, the journal of The North American Menopause Society (NAMS). (2021-01-06)

Self-controlled children tend to be healthier middle-aged adults
Self-control of one's thoughts, feelings and behaviors is one of the personality traits that makes a child ready for school. And, it turns out, ready for life as well. A large New Zealand study tracking 1,000 people from birth through age 45 has determined that people who had higher levels of self-control as children were aging more slowly than their peers at age 45. Their bodies and brains were healthier and biologically younger. (2021-01-05)

Scientists explore deficits in processing speed in individuals with spinal cord injury
This study is the first to examine the neural mechanisms of higher order cognitive tasks of individuals with SCI.''Our ability to observe brain activation while the individual performs specific cognitive tasks provides new information on the mechanisms that underlie the cognitive deficits that we now know affect a substantial proportion of the SCI population,'' Dr. Wylie said. ''Developing treatments targeted to these deficits depends on our pursuit of this line of research, which may benefit other populations affected by delayed processing speed.'' (2020-12-30)

Discovery of aging mechanism for hematopoietic stem cells
By transferring mouse aged hematopoietic stem cells (aged HSCs) to the environment of young mice (bone marrow niche), it was demonstrated that the pattern of stem cell gene expression was rejuvenated to that of young hematopoietic stem cells. (2020-12-24)

Blood pressure drug may be key to increasing lifespan, new study shows
A stress response of mitochondria, the part of our cells that produce energy to power bodily functions, is important to a longer life. A team of scientists from Osaka City University, Japan, searched through a chemical ''library'' of existing drugs to find one that can activate this stress response in the worm Caenorhabditis elegans. They found that an anti-hypertension drug called metolazone prolongs C. elegans lifespan, marking the first step in developing anti-aging pharmaceuticals. (2020-12-18)

Optogenetic method can reveal how gut microbes affect longevity
Optogenetics offers a direct way to manipulate gut bacterial metabolism in a temporally, quantitatively and spatially controlled manner and enhance host fitness. (2020-12-17)

Scientists publish the first human psychological aging clock using artificial intelligence
Scientists at Deep Longevity published the first set of psychomarkers of aging developed using deep learning to track the changes in human psychology and assess the effectiveness of interventions, life events, and external events. The new PsychoAge and SubjAge aging clocks were linked to mortality risk. (2020-12-16)

Aging journal fills knowledge gaps on race, mental health
A new special issue of the journal Innovation in Aging, titled ''Race and Mental Health Among Older Adults: Within- and Between-Group Comparisons,'' is expressly devoted to much-needed research on aging and mental health within racial and ethnic minority populations (e.g., African Americans, Latinx, and Asian Americans, as well as subgroups within these larger pan-ethnic categories). (2020-12-16)

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